Chengpei Zhu

Shanxi Agricultural University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Haitao Zhao

Peking Union Medical College Hospital

Xiaobo Yang

Chinese Academy of Medical Sciences & Peking Union Medical College

Xinting Sang

Peking Union Medical College Hospital

Nan Zhang

Peking Union Medical College Hospital

Longhao Zhang

Chinese Academy of Medical Sciences & Peking Union Medical College

Jingnan Xue

Huzhou University

Ziyu Xun

Peking Union Medical College Hospital

Jiashuo Chao

Peking Union Medical College Hospital

Yunchao Wang

Shandong First Medical University

Anqiang Wang

Peking University

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

105

Peking Union Medical College Hospital

Nanjing Medical University

Peking University

Fudan University

Chinese Academy of Sciences

Academy of Medical Sciences

Huazhong University of Science and Technology

Shanghai Jiao Tong University

Tianjin Medical University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

A Novel Cuproptosis-Related Gene Signature for Overall Survival Prediction in Patients with Hepatocellular Carcinoma

SSRN Electronic Journal (2022)

Fan Yang Shitao Jiang Y. Liu Ting Zhang Chengpei Zhu

It is challenging to predict the prognosis of hepatocellular carcinoma (HCC), which is a highly heterogeneous disease. Cuproptosis-regulated cell death is distinct from known death mechanisms in human cells and is affected by mitochondrial respiration. Cuproptosis-related genes may provide new ideas for prognosis prediction of HCC. Public databases provided the mRNA expression profiles and clinical data of HCC patients used in this study. We constructed a multigene signature using a least absolute shrinkage and selection operator (LASSO) Cox regression model. HCC patients from the ICGC cohort were used for validation. A large proportion of cuproptosis-related genes was differentially expressed between HCC and adjacent normal tissues in the TCGA cohort. The analysis of univariate Cox regression revealed five differentially expressed genes (DEGs) were associated with overall survival (OS). The four-gene signature was used to stratify patients into two risk groups. There was a significant difference between patients in the high-risk group and those in the low-risk group regarding OS (P < 0.001 in the TCGA cohort and P = 0.025 in the ICGC cohort). A multivariate Cox regression analysis showed the risk score to be an independent predictor for HCC patients. Based on the functional analysis, immune-associated pathways were enriched, and immune status differed between two risk groups. Cuproptosis-related gene signatures can be used to predict prognosis of HCC patients. Targeting the cuproptosis pathway may provide new approaches for the treatment of HCC.Funding Information: The work was supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (CIFMS) (No. 2020-I2M-C&T-B-026), the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (CIFMS) (No. 2020-I2M-C&T-B-019), CHEN XIAO-PING Foundation for the development of science and technology of HUBEI province (CXPJJH1200008-10), WBE Liver Fibrosis Foundation (CFHPC 2020021) ，Beijing Municipal Natural Science Foundation Project (Grant No. 7222130).Conflict of Interests: The authors declare that there are no conflicts of interest.

Gene signature

Signature (topology)

10.2139/ssrn.4156271

Cite

Citations (0)

Nutritional characterization and changes in quality of Salicornia bigelovii Torr. during storage

LWT (2009)

LU Dong-he Min Zhang Shaojin Wang Jinlong Cai Xiang Sean Zhou

Asparagus

10.1016/j.lwt.2009.09.021

Cite

Citations (124)

Clinical outcomes of lenvatinib plus transarterial chemoembolization with or without programmed death receptor-1 inhibitors in unresectable hepatocellular carcinoma

World Journal of Gastroenterology (2023)

Yanyu Wang Xu Yang Yun-Chao Wang Junyu Long Huishan Sun

Lenvatinib

10.3748/wjg.v29.i10.1470

Cite

Citations (0)

Prenatal phthalate exposure and performance on the Neonatal Behavioral Assessment Scale in a multiethnic birth cohort

Carolina Digital Repository (University of North Carolina at Chapel Hill) (2009)

Stephanie M. Engel Chengpei Zhu Gertrud S. Berkowitz Antonia M. Calafat Maria João Silva

10.17615/zfva-tm12

Cite

Citations (0)

Preoperative total parathyroid volume is an independent marker to predict recurrence for secondary hyperparathyroidism

Annals of Medicine (2024)

Zhongkui Wang Fuquan Zhang Chengpei Zhu Chaoying Wu X.C. Meng

Purpose This study aimed to explore the value of preoperative total parathyroid volume (TPV) as a marker for predict recurrence of renal secondary hyperparathyroidism (SHPT).

10.1080/07853890.2024.2428435

Cite

Citations (0)

Comparison of harmonic scalpel and conventional technique in the surgery for breast cancer: A systematic review and meta-analysis

Indian Journal of Cancer (2018)

Zili Zhang Lin Li Yi Pang Qi Li Chun-Li Guo

Harmonic scalpel is considered as a promising surgical tool for breast cancer, while its advantage over conventional approach is still controversial. Therefore, we performed this meta-analysis to compare the outcomes of harmonic scalpel and conventional tools in the surgery for breast cancer.Studies reporting the outcomes of harmonic scalpel and conventional technologies were systematically searched from online databases, PubMed and EMBASE up to April 30, 2018. Data were presented as odds ratio, risk ratio (RR), and mean difference (MD) with 95% confidence interval (CI).Intraoperative blood loss (I2 = 96%, P < 0.05, MD = -68.78, 95% CI -93.31 to -44.24), seroma (I2 = 3%, P = 0.41, RR = 0.63, 95% CI 0.46-0.86) and hematoma formation (I2 = 0%, P = 0.64, RR = 0.41, 95% CI 0.23-0.73), drainage volume (I2 = 89%, P < 0.05, MD = -105.33, 95% CI -161.33 to -49.33) and time (I2 = 93%, P < 0.05, MD = -2.18, 95% CI -3.75 to -0.61), necrosis (I2 = 35%, P = 0.20, RR = 0.37, 95% CI 0.16-0.86), surgical duration (I2 = 79%, P < 0.05, MD = -8.49, 95% CI -16.56 to -0.43), and hospital stay (I2 = 97%, P < 0.05, MD = -0.94, 95% CI -1.74 to -0.14) are significantly different between the two groups.Harmonic scalpel is superior to conventional tools in terms of decreasing intraoperative blood loss, seroma and hematoma formation, drainage volume and time, necrosis prevalence, surgical duration, and hospital stay, which should be strongly recommended in the surgery for breast cancer.

Seroma

Harmonic scalpel

10.4103/ijc.ijc_306_18

Cite

Citations (14)

Coffee and cancer risk: A meta-analysis of prospective observational studies

Scientific Reports (2016)

Anqiang Wang Shanshan Wang Chengpei Zhu Hanchun Huang Liangcai Wu

Meta-analyses on coffee and cancer incidence mainly restricted to limited cancers. We carried out a more comprehensive meta-analysis of cohort studies to explore association between coffee and most cancer types. We conducted comprehensive search and summarized relative risk (RR) and 95% confidence intervals for the highest versus lowest coffee intake and cancer using STATA12. We conducted dose-analysis if result suggested significant association. The publication bias was evaluated with begg's and egger's test. Finally, 105 individual prospective studies were included. Inverse associations were observed on oral, pharyngeal, colon, liver, prostate, endometrial cancer and melanoma, with RR 0.69 (95% CI = 0.48-0.99, I2 = 73.4%, P = 0.044), 0.87 (95% CI = 0.78-0.96, I2 = 28.4%, P = 0.007), 0.46 (95% CI = 0.37-0.57, I2 = 0%, P = 0), 0.89 (95% CI = 0.84-0.93, I2 = 30.3%, P = 0.003), 0.73 (95% CI = 0.67-0.80, I2 = 0%, P = 0) and 0.89 (95% CI = 0.80-0.99, I2 = 0%, P = 0.031) respectively. However, the relative risk for lung cancer is 2.18 (95% CI = 1.26-3.75, I2 = 63.3%, P = 0.005). The summary relative risk for increment of 2 cups of coffee were RR = 0.73, 95% CI = 0.67-0.79 for liver cancer, RR = 0.97, 95% CI = 0.96-0.98 for prostate cancer and RR = 0.88, 95% CI = 0.85-0.92 for endometrial cancer. Accordingly, coffee intake was associated with reduced risk of oral, pharynx, liver, colon, prostate, endometrial cancer and melanoma and increased lung cancer risk.

10.1038/srep33711

Cite

Citations (77)

A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling

Scientific Reports (2016)

Liangcai Wu Qianqian Xu Haohai Zhang Ming Li Chengpei Zhu

Abstract Estrogen receptor signalling plays important regulatory roles in multiple mammalian physiological processes. Dysregulation of estrogen receptor (ER) expression and/or its associated signalling pathway is strongly associated with the development, progression, transition and endocrine-resistance of breast cancer. Non-coding transcripts are essential regulators of almost every level of gene regulation. However, few long non-coding transcripts (lncRNAs) associated with the estrogen receptor signalling pathway have been well-described. We used array-based methods to identify 33 estrogen receptor agitation-related (ERAR) lncRNAs. A coding–non-coding gene co-expression network analysis suggested that 15 ERAR lncRNAs were associated with mitosis, DNA damage and DNA repair. Kaplan–Meier analysis indicated that five ERAR lncRNAs selected using the Random Forest-Recursive Feature Elimination algorithm were significantly correlated with endocrine resistance-free survival and distant metastasis-free survival as well as disease free survival. Our results suggest that ERAR lncRNAs may serve as novel biomarkers for guiding breast cancer treatment and prognosis. Furthermore, our findings reveal a new avenue by which estrogen receptor signalling can be further explored.

Signalling

Estrogen receptor alpha

10.1038/srep31716

Cite

Citations (13)

Clinical outcomes of lenvatinib plus transarterial chemoembolization with or without programmed death receptor-1 inhibitors in unresectable hepatocellular carcinoma

World Journal of Gastroenterology (2023)

Yanyu Wang Xu Yang Yun-Chao Wang Junyu Long Huishan Sun

Programmed death receptor-1 (PD-1) inhibitors have been approved as second-line treatment regimen in hepatocellular carcinoma (HCC), but it is still worth studying whether patients can benefit from PD-1 inhibitors as first-line drugs combined with targeted drugs and locoregional therapy.To estimate the clinical outcome of transarterial chemoembolization (TACE) and lenvatinib plus PD-1 inhibitors for patients with unresectable HCC (uHCC).We carried out retrospective research of 65 patients with uHCC who were treated at Peking Union Medical College Hospital from September 2017 to February 2022. 45 patients received the PD-1 inhibitors, lenvatinib, TACE (PD-1-Lenv-T) therapy, and 20 received the lenvatinib, TACE (Lenv-T) therapy. In terms of the dose of lenvatinib, 8 mg was given orally for patients weighing less than 60 kg and 12 mg for those weighing more than 60 kg. Of the patients in the PD-1 inhibitor combination group, 15 received Toripalimab, 14 received Toripalimab, 14 received Camrelizumab, 4 received Pembrolizumab, 9 received Sintilimab, and 2 received Nivolumab, 1 with Tislelizumab. According to the investigators' assessment, TACE was performed every 4-6 wk when the patient had good hepatic function (Child-Pugh class A or B) until disease progression occurred. We evaluated the efficacy by the modified Response Evaluation Criteria in Solid Tumors (mRECIST criteria). We accessd the safety by the National Cancer Institute Common Terminology Criteria for Adverse Events, v 5.0. The key adverse events (AEs) after the initiation of combination therapy were observed.Patients with uHCC who received PD-1-Lenv-T therapy (n = 45) had a clearly longer overall survival than those who underwent Lenv-T therapy (n = 20, 26.8 vs 14.0 mo; P = 0.027). The median progression-free survival time between the two treatment regimens was also measured {11.7 mo [95% confidence interval (CI): 7.7-15.7] in the PD-1-Lenv-T group vs 8.5 mo (95%CI: 3.0-13.9) in the Lenv-T group (P = 0.028)}. The objective response rates of the PD-1-Lenv-T group and Lenv-T group were 44.4% and 20% (P = 0.059) according to the mRECIST criteria, meanwhile the disease control rates were 93.3% and 64.0% (P = 0.003), respectively. The type and frequency of AEs showed little distinction between patients received the two treatment regimens.Our results suggest that the early combination of PD-1 inhibitors has manageable toxicity and hopeful efficacy in patients with uHCC.

Lenvatinib

Combination therapy

Regimen

Salvage therapy

10.3748/wjg.v29.i10.1614

Cite

Citations (17)

A cluster of CYP6 gene family associated with the major quantitative trait locus is responsible for the pyrethroid resistance in Culex pipiens pallen

Insect Molecular Biology (2019)

Zou Ff Qi Guo Bo Shen Chengpei Zhu

Abstract The emergence and rapid spread of insecticide resistance in several mosquito species has become a significant obstacle in management of mosquito‐borne diseases, including deltamethrin resistance in Culex pipiens pallens . Previous study identified a major deltamethrin resistance quantitative trait locus (DR‐6) that alone explained 62% of the genetic variance. In this study, the marker L4B1.102 and L4B1.175 associated with the DR‐6 were characterized. We searched for potential candidate genes in the flank region of two markers in the genome sequence and showed that a cluster of CYP6 cytochrome P450 genes ( CYP6BB4 , CYP6BB3 , CYP6CC2 , CYP6P14 , CYP6BZ2 , CYP6AA9 , CYP6AA8 , CYP6AA7 ) was in the vicinity of DR‐6. Significant differences in the expression of these P450s in the larval and adult stages were identified in the resistant strains compared with the susceptible strain. For CYP6AA9 and CYP6BB4 , the correlation analysis showed a highly positive correlation between relative gene expression quantification and the resistance level in different strains. Knockdown of CYP6BB4 increased the sensitivity of mosquitoes to deltamethrin. We identified that the deltamethrin resistance was in a cluster of CYP6 genes in C. pipiens pallens , and CYP6BB4 may play a significant role in the development of deltamethrin resistance.

Culex pipiens

Trait

10.1111/imb.12571

Cite

Citations (10)