It is the scientific basis of instructing the project to produce and operate that the deformation is monitored, and the analysis and prediction in constructing and operating of project is one of the important jobs. In order to analyze and predict the deformation of the project more timely and accurately, the paper analyzed and established the feasibility of wavelet-grey predicting model on the basis of the grey system theory in modeling limitations and the characteristics of wavelet transformation. With the comparison of predictive datas in two kinds of models, the results show, the predictive datas of the wavelet-grey model are more accurately than grey model’s, and has achieved good results in prediction of the engineering, is a feasible method.
The research of "3S" integration of the deformation monitoring system, is one of the important development trend of the deformation monitoring technology. This text analyzed the key technology of the application of GPS/GIS integration, realized the effective integration of the mass of datas of GPS and GIS technology, and to establish the GPS/GIS integration of deformation monitoring system provides important technical support.
In this paper, an effective digital signal processing method based on the merger of the increasing and decreasing time-series sequences (MIDS) is introduced. On the basis of the merging of EEG signals, a new IED (Interictal Epileptiform Discharges) detection method is proposed. The first step of this new method is to establish a database by selecting peaked wave fragments. Then, the similarity between pending test fragment and peaked wave samples in the database is calculated. When the maximum similarity is greater than a certain threshold, the fragment is judged to be a peaked wave. Finally, the wave type i.e. spike wave, sharp wave, spike-and-slow wave or sharp-and-slow wave can be determined by whether there is a subsequent slow wave or not. Continuous sharp wave can be viewed as spike rhythm. In this research, 92 IED fragments from 4 suspected epilepsy patients are collected to establish the sample database. The proposed method was tested on EEG recordings from other 31 suspected patients. The results show that 98.11% of the IED fragments marked by doctors were detected. The experimental results show that this method performs well at IED detection in the clinical EEG data. The similarity is measured based on the comparison between fragments of different time length and can be viewed as a novel approach for the detection of typical EEG waveform. This research draws two conclusions: (1) the waveform of individual peaked wave is stable during 24-hour EEG recording process; (2) the database containing a small number peaked wave samples can be used to detect IED fragments.
Little is known about the duration of combination therapy for patients with chronic hepatitis B (CHB) and suboptimal response to nucleos(t)ide analogues(NAs) monotherapy.This study aimed to assess whether monotherapy could be used for treatment of CHB patients, who poorly responded to Adefovir Dipivoxil (ADV) but obtained good responses after at least 12-month lamivudine (LAM) or telbivudine (LdT) add-on therapy.Forty-five patients were enrolled, and the baseline time-point was determined according to enrollment data. Twenty-six patients chose to continue combination therapy (LAM+ADV or LdT+ADV, Group A) and 19 patients switched to single-drug maintenance therapy (LAM or LdT or ADV, Group B).There were no significant differences between two groups in baseline characteristics (P > 0.05). At 12th month, sustained virological response rate was greater in group A compared to group B (96.2% vs. 47.4%, P < 0.001), and the rates of NAs-associated resistance were 0% in group A and 15.8% in group B. Alanine aminotransferase normalization rate was also significantly higher in group A compared with group B (92.3% vs. 36.8%, P < 0.001). Among hepatitis positive patients with Be antigen (HBeAg)-, 40% (4/10) in group A and 9.1% (1/11) in group B achieved HBeAg seroconversion at the 12th month. Of patients in group B with positive-HBeAg before the previous combination therapy and detectable HBV DNA at 6 months of previous combination therapy were associated with high risks of viral relapse after switching to single-drug maintenance therapy.Prematurely switching to single-drug maintenance therapy would be resulted in viral relapse, and prolonged combination therapy was effective to maintain sustained responses for patients with initial suboptimal response to ADV.
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