Hang Yin

Tsinghua University

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Xiaohui Wang

Chinese Academy of Sciences

Xiao Hu

Shanxi Medical University

Linda R. Watkins

University of Colorado Boulder

Julie Chao

Medical University of South Carolina

Kui Cheng

Southern Medical University

Lee Chao

Medical University of South Carolina

Mark R. Hutchinson

University of Adelaide

Andrew D. Hamilton

Yale University

Xiaobei Li

Shandong Academy of Sciences

William F. DeGrado

University of California, San Francisco

Cooperative Institutions

Chinese Academy of Sciences

153

Tsinghua University

137

University of Colorado Boulder

125

Peking University

118

Capital Medical University

103

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

Zhejiang University

Center for Life Sciences

University of Chinese Academy of Sciences

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Bioactive 3D porous cobalt-doped alginate/waterborne polyurethane scaffolds with a coral reef-like rough surface for nerve tissue engineering application

Journal of Materials Chemistry B (2020)

Yue Chen Xirui Long Weiwei Lin Bohong Du Hang Yin

Bioactive 3D porous cobalt-doped alginate/waterborne polyurethane scaffolds with a coral reef-like rough surface were prepared for nerve tissue engineering application.

Sponge

10.1039/d0tb02347g

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Citations (26)

Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles

Stem Cells Translational Medicine (2017)

Agnes T. Reiner Kenneth W. Witwer Bas W. M. van Balkom Joel de Beer Chaya Brodie

Abstract Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of best-practice models for EV therapies.

Extracellular Vesicles

Extracellular vesicles

Clinical Practice

10.1002/sctm.17-0055

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Citations (302)

Tissue Kallikrein and Kinin Infusion Rescues Failing Myocardium After Myocardial Infarction

Journal of Cardiac Failure (2007)

Yuyu Yao Hang Yin Bo Shen Lee Chao Julie Chao

Brain natriuretic peptide

Ventricular remodeling

10.1016/j.cardfail.2007.04.009

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Citations (36)

Characteristic Analysis of DC and AC Fractional Order RLβCα Circuits for Stability Control and Performance Optimization.

International Conference on Software Testing, Verification, and Validation (2020)

Zhengmao Ye Hang Yin Wanjun Wang Shuju Bai Habib Mohamadian

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Research on Visual Perception of Gender Identification Elements in Water Cup Design

Frontiers in artificial intelligence and applications (2023)

Zuolong Wang Hang Yin

In light of the market trend of using design means to guide enterprise resource allocation in order to improve efficiency, this paper investigates the consumer’s gender perception of water cup design elements using morphological analysis and analytic hierarchy process, and verifies the difference of priority among design elements in the process of consumer’s perception, and each design element has different influence weights in consumer’s gender perception recognition. The research contributes to the transmission of experience in gender-differentiated water cup design and creates efficiency advantages for enterprises competing in the gender-differentiated cup market.

Identification

10.3233/faia220737

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Short Antimicrobial Lipo‐α/γ‐AA Hybrid Peptides

ChemBioChem (2014)

Yaqiong Li Christina Smith Haifan Wu Peng Teng Yan Shi

Abstract The last two decades have seen the rise of antimicrobial peptides (AMPs) to combat emerging antibiotic resistance. Herein we report the solid‐phase synthesis of short lipidated α/γ‐AA hybrid peptides. This family of lipo‐chimeric peptidomimetics displays potent and broad‐spectrum antimicrobial activity against a range of multi‐drug resistant Gram‐positive and Gram‐negative bacteria. These lipo‐α/γ‐AA hybrid peptides also demonstrate high biological specificity, with no hemolytic activity towards red blood cells. Fluorescence microscopy suggests that these lipo‐α/γ‐AA chimeric peptides can mimic the mode of action of AMPs and kill bacterial pathogens via membrane disintegration. As the composition of these chimeric peptides is simple, therapeutic development could be economically feasible and amenable for a variety of antimicrobial applications.

Peptidomimetic

Gram-Negative Bacteria

Mode of Action

10.1002/cbic.201402264

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Citations (44)

ZDHHC18 negatively regulates cGAS‐mediated innate immunity through palmitoylation

The EMBO Journal (2022)

Chengrui Shi Xikang Yang Ye Liu Hong Peng Li Huiying Chu

Palmitoylation

10.15252/embj.2021109272

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Citations (45)

Analysis of clinicians' attitude towards the “Drug and Medical Service Separation” reform in Beijing

Zhonghua yiyuan guanli zazhi (2014)

Jie Song Guosheng Feng Hang Yin

Objective To learn the clinicians'attitude towards the “Drug and Medical Service Separation” reform in Beijing.Methods A number of pilot hospitals of “Drug and Medical Service Separation” reform in Beijing were pinpointed,for a random questionnaires survey among 800 clinicians,to learn their awareness,evaluation and attitudes to the reform.Results The clinicians were found with good awareness and understanding of the reform,with an awareness rate of 99.5％ ; 72.0％ of them hold that the pricing of “medical service charge” of the reform as reasonable; most of them believe that the reform plays a positive role in relieving the difficulties of seeing doctors and affordability of medical treatment; their approval rate for the reform pilot project is 97.3％; their satisfaction for the reform implementation is 90.8％,and their support for full implementation of the reform is 94.0％.Conclusion The clinicians from those pilot hospitals are sufficiently aware of and understand this policy,and are supportive of the pilot with useful suggestions.The recommended strengthened publicity and training,higher medical service charges,better pay for medical workers,improved incentive mechanism and evaluation mechanism,and better clinicians' satisfaction. Key words: Beijing; Drug and Medical Service Separation; Clinician; Attitude

Questionnaire

10.3760/cma.j.issn.1000-6672.2014.04.017

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Citations (0)

Formation control for multiple unmanned aerial vehicles in constrained space using modified artificial potential field

Mathematical Modelling and Engineering Problems (2017)

Hang Yin Léa Cam Utpal Roy

This paper addresses a formation tracking control issue for multiple Unmanned Aerial Vehicles (UAV) flying through a constrained space.Based on the Formation Potential Field (FPF), a Modified Artificial Potential Field (MAPF) technique is proposed, which guarantees to generate and maintain a given formation while avoiding collisions.The technique has two phases.UAVs are gathered around the formation center first during Phase 1, and the formation is then achieved in Phase 2. Furthermore, an obstacle repulsive potential field is introduced into this approach to deal with collision avoidance under environmental constraints.By doing so, discontinuities of the original Formation Potential Field can be avoided, and the stability of formation generation could be enhanced.Simulation results are presented to illustrate the validity of proposed approach.

Potential field

10.18280/mmep.040207

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Citations (7)

[Risk factors for chronic allograft failure in renal transplant recipients].

PubMed (2014)

Xiaobei Li Wei Wang Hang Yin Yong Wang Xiaodong Zhang

To identify the potential risk factors for the development of chronic renal allograft failure in renal transplant recipients.The data of 235 renal transplant recipients followed up for over 1 year were observed prospectively. And their risk factors were identified with multivariate Logistic regression analysis.Forty-seven patients were diagnosed as chronic allograft failure (CAF). Multivariate risk factor analyses revealed that early (OR, 2.12; P < 0.01) and late (OR, 4.54; P < 0.001) acute rejection episodes, HLA-mismatch ( ≥ 3), HLA antibody production, viral infection, proteinuria, high serum triglyceride, recipient age (OR, 2.24; P < 0.01) and males (OR, 1.63; P < 0.05) were significant risk factors.Late acute rejection (>3 months post-transplantation) was more important than early acute rejection with regards to the development of CAF. Delayed graft function and cyclosporine concentration were not associated with the development of CAF.Both immunologic and non-immunologic risk factors are involved in the development of CAF. Predicating the risks of developing CAF at an early stage, before any deterioration of graft function, is of vital importance for the improvement of renal allograft survival and may guide individualized therapy.

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Citations (1)