L M Kunnova

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Igor A. Sobenin

National Medical Research Center of Cardiology

Alexander N. Orekhov

Institute for Atherosclerosis Research

V.V. Pryanishnikov

Bakulev Scientific Center for Cardiovascular Surgery Russian Academy of Medical Sciences

НЕ

Н. Е. Гайдамакина

City Clinical Hospital

E A Radinovich

I F Patrusheva

Institute of Experimental Cardiology

Danik Martirosyan

University of California, Merced

АИ

А. И. Тарзиманова

Sechenov University

Ella Rabinovich

Yevgeny A Rabinovich

Cooperative Institutions

City Clinical Hospital

Sechenov University

Institute of Experimental Cardiology

National Medical Research Center of Cardiology

Ministry of Health of the Russian Federation

Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences

Russian Scientific Center of Surgery

University of California, Merced

George Mason University

Santa Clara University

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Изменение инотропной функции миокарда у больных с рецидивирующей формой фибрилляции предсердий

CARDIOVASCULAR THERAPY AND PREVENTION (2006)

Н. Е. Гайдамакина L M Kunnova А. И. Тарзиманова А. В. Ветлужский И. Г. Фомина

Aim. To study inotropic myocardial function of left and right ventriculum (LV, RV) in patients with recurrent atrial fibrillation (AF), according to balanced radionuclide ventriculography (BRVG) data. Material and methods. The study included 72 patients: 30 individuals with coronary heart disease (CHD) and recurrent AF (Group I), as well as 42 CHD patients without cardiac arrhythmias (Group II). Participants’ age varied from 39 to 79 years (mean age 60.3±2.5 years). To assess systolic and diastolic LV and RV function, all participants underwent BRVG. Results. LV and RV ejection fraction was normal in all subjects. LV peak filling velocity was significantly reduced in patients with recurrent AF, comparing to arrhythmia-free individuals (p<0.05). LV end-diastolic volume in Group I was substantially lower than in Group II (p<0.05). At echocardiography, left and right atrium sizes were increased in patients with recurrent AF. Conclusion. Heart remodeling in patients with recurrent AF manifested by diastolic LV and RV dysfunction, combined with atrium size increase.

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The effects of time-released garlic powder tablets on multifunctional cardiovascular risk in patients with coronary artery disease

Lipids in Health and Disease (2010)

Igor A. Sobenin V.V. Pryanishnikov L M Kunnova Yevgeny A Rabinovich Danik Martirosyan

The double-blinded placebo-controlled randomized study has been performed in 51 coronary heart disease (CHD) patients to estimate the effects of time-released garlic powder tablets Allicor on the values of 10-year prognostic risk of acute myocardial infarction (fatal and non-fatal) and sudden death, with the respect of secondary CHD prevention. It has been demonstrated that 12-month treatment with Allicor results in the significant decrease of cardiovascular risk by 1.5-fold in men (p < 0.05), and by 1.3-fold in women. The above results were equitable also in terms of relative risks. The main effect that played a role in cardiovascular risk reduction was the decrease in LDL cholesterol by 32.9 mg/dl in men (p < 0.05), and by 27.3 mg/dl in women. Thus, the most significant effects were observed in men, while in women the decrease of cardiovascular risk appeared as a trend that might be due presumably to the insufficient sample size. Since Allicor is the remedy of natural origin, it is safe with the respect to adverse effects and allows even perpetual administration that may be crucial for the secondary prevention of atherosclerotic diseases in CHD patients.

Lipidology

Clinical nutrition

Secondary Prevention

10.1186/1476-511x-9-119

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W16-P-069 Allicor in the primary prevention of cardiovascular disease

Atherosclerosis Supplements (2005)

V.V. Pryanishnikov Igor A. Sobenin L M Kunnova Ella Rabinovich Alexander N. Orekhov

Primary (astronomy)

Primary Prevention

10.1016/s1567-5688(05)80465-9

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Reduction of cardiovascular risk in primary prophylaxy of coronary heart disease

Igor A. Sobenin V V Prianishnikov L M Kunnova E A Radinovich Alexander N. Orekhov

The purpose of the study was to evaluate the effects of Allicor, an Allium sativum (garlic) preparation with prolonged activity, on 10-year prognostic risk of coronary heart disease (CHD), acute myocardial infarction (MI) and sudden death in patients with elevated and high risk of CHD. 79 patients with elevated and high risk of CHD were included in a double blind randomized placebo-controlled study. They underwent multifactor evaluation of cardiovascular risk by algorithms based on the results of Framingham and Munster studies. Prolonged (12 months) administration of Allicor significantly reduced the multifactor risk, which was demonstrated by a 13.2% (p = 0.005) reduction of prognostic 10-year risk of CHD in men, and a 7.1% (p = 0.040) reduction of the same parameter in women. Prognostic 10-year risk of MI and sudden death in men was reduced by 26.1% (p = 0.025) and did not change significantly in women. In men the main factor of cardiovascular risk reduction was the decrease of cholesterol and low-density lipoprotein concentration by 23.5 +/- 6.6 mg/dl (p = 0.004), and in women - the increase of high-density lipoprotein level by 2.8 +/- 1.5 mg/dl (p = 0.040). The results of the study demonstrate that prolonged Allicor therapy can be applied to the large category of patients who are in need of atherosclerosis prevention.

Sudden Death

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[Treatment of patients with arterial hypertension in Moscow].

PubMed (2001)

А П Юренев I F Patrusheva М. Д. Смирнова L M Kunnova

To analyze treatment for arterial hypertension in Moscow.1056 case histories of hypertensive patients referred to Moscow city cardiological hospital in 1999 were analysed. The analysis covered the following issues: frequency of use of antihypertensive drugs depending on the disease stage; adequacy of the doses; changes in the treatment due to the presence of hypertrophy of the left ventricular myocardium, cardiac failure, vascular complications, diabetes mellitus.Treatment of hypertension was not adequate in many patients. Often, inadequate decisions were made on the drugs doses, course regimens, monotherapy.Insufficiently effective treatment of arterial hypertension can result in aggravation of the disease and frequent complications.

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