XX Zhai

Jiangxi University of Traditional Chinese Medicine

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CY Xiao

Jiangxi University of Traditional Chinese Medicine

QH Lin

Jiangxi University of Traditional Chinese Medicine

WJ Yuan

Jiangxi University of Traditional Chinese Medicine

Gang Ren

Jiangxi University of Traditional Chinese Medicine

WF Yi

Jiangxi University of Traditional Chinese Medicine

Guangxiang Ren

Jiangxi University of Traditional Chinese Medicine

JW He

Jiangxi University of Traditional Chinese Medicine

M Li

Jiangxi University of Traditional Chinese Medicine

Jian‐Xin Zhu

Los Alamos National Laboratory

Y M Zhang

Jiangxi University of Traditional Chinese Medicine

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Jiangxi University of Traditional Chinese Medicine

Nankai University

Xiaomi (China)

State Key Laboratory of Medicinal Chemical Biology

Yibin University

University of Mississippi

University of Hawaii at Hilo

Ministry of Natural Resources

Zhejiang University

Nanyang Medical College

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Prenylated 2-Arylbenzofurans From Artorpus Styracifolius

Planta Medica (2016)

Gang Ren QH Lin WF Yi WJ Yuan Jian‐Xin Zhu

Artorpus styracifolius Pierre, arbor of the genus Artocarpus (Moraceae), is mainly distributed in several southern provinces of China and is also called “Hongfenghe”. The root of A. styracifolius was used to treat disease in folk medicine. In this study, two new prenylated 2-arylbenzofurans, namely astostyracins D and E (1 – 2, resp), together with a known one (3), were isolated from the root of A. styracifolius. Their structures were determined by spectroscopic methods (1D and 2D NMR, UV, IR, and HR-ESI-MS). These compounds will be tested for their inhibitory effect on Cathepsin K.

Moraceae

Folk medicine

10.1055/s-0036-1578770

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Prenylated Stilbenes From Artocarpus Styracifolius

Planta Medica (2016)

Gang Ren WF Yi JW He WJ Yuan M Li

Artocarpus styracifolius Pierre (Moraceae), an evergreen arbor tree distributed in the southern part of China, is traditionally used in folk medicine for the treatment of rheumatoid arthritis, psoatic strain, hemiplegia and fracture [1]. A series of isoprenoid-substituted phenolic compounds, including flavonoids and 2-arybenzofurans, has been reported from the various parts of the plant [2 – 3]. In the present study, a re-examination of the 95% EtOH extract of the root barks of this plant provided four unusual isoprenylated stilbene derivatives 1 – 4, together with five known stilbenes 5 – 9. Their structures were determined by spectroscopic methods (1D and 2D NMR, CD, UV, IR, and HR-ESI-MS). In addition, the possible biosynthetic pathway for these compounds was proposed.

Moraceae

Artocarpus

10.1055/s-0036-1578769

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Flavonoids From The Roots Of Artocarpus Heterophyllus And Their Inhibitory Activity Against Cathepsin K

Planta Medica (2016)

Guangxiang Ren WJ Yuan Y M Zhang XX Zhai QH Lin

As part of our project for discovering structurally interesting and bioactive phenolic compounds from Artocarpus plants (Moraceae), we performed a phytochemical investigation on Artocarpus heterophyllus. Four new flavonoids, artoheteroids A-D (1 – 4) were isolated from the roots of this plant. The structures were elucidated by spectroscopic methods, including 1D and 2D NMR, UV, IR, CD, and HR-ESI-MS. All the isolates (1 – 4) were evaluated for their inhibitory activity against Cathepsin K, and compounds 1 – 3 exhibited significantly suppressive effect on Cathepsin K with IC50 values of 6.03, 12.52, 13.65µM, respectively.

Artocarpus

Moraceae

Phytochemical

IC50

Nutraceutical

10.1055/s-0036-1578768

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