Meenu Mehta

University of Technology Sydney

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Saurabh Satija

University of Wollongong

Kamal Dua

University of Technology Sydney

Dinesh Kumar Chellappan

International Medical University

Gaurav Gupta

Ajman University

Harish Dureja

Maharshi Dayanand University

Philip M. Hansbro

Hunter Medical Research Institute

Murtaza M. Tambuwala

Ras al-Khaimah Medical and Health Sciences University

Keshav Raj Paudel

Centenary Institute

Parteek Prasher

University of Petroleum and Energy Studies

Monica Gulati

University of Technology Sydney

Cooperative Institutions

Lovely Professional University

International Medical University

Michigan United

University of Technology Sydney

National University of Malaysia

Maharshi Dayanand University

Universiti Teknologi MARA

Post Graduate Institute of Medical Education and Research

Amity University

University of Malaya

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Nanotechnologies for Boswellic Acids

American Journal of Drug Discovery and Development (2013)

Meenu Mehta Saurabh Satija Arun Nanda Munish Garg

10.3923/ajdd.2014.1.11

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Citations (30)

An Overview of Vaccine Development for COVID-19

Therapeutic Delivery (2021)

Seyed Hossein Shahcheraghi Jamshid Ayatollahi Alaa A. A. Aljabali Madhur D. Shastri Shakti D. Shukla

The COVID-19 pandemic continues to endanger world health and the economy. The causative SARS-CoV-2 coronavirus has a unique replication system. The end point of the COVID-19 pandemic is either herd immunity or widespread availability of an effective vaccine. Multiple candidate vaccines - peptide, virus-like particle, viral vectors (replicating and nonreplicating), nucleic acids (DNA or RNA), live attenuated virus, recombinant designed proteins and inactivated virus - are presently under various stages of expansion, and a small number of vaccine candidates have progressed into clinical phases. At the time of writing, three major pharmaceutical companies, namely Pfizer and Moderna, have their vaccines under mass production and administered to the public. This review aims to investigate the most critical vaccines developed for COVID-19 to date.

Pandemic

Coronavirus

Attenuated vaccine

Herd Immunity

10.4155/tde-2020-0129

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Citations (73)

Perfluorocarbons Therapeutics in Modern Cancer Nanotechnology for Hypoxiainduced Anti-tumor Therapy

Current Pharmaceutical Design (2021)

Saurabh Satija Prabal Sharma Harpreet Kaur Daljeet Singh Dhanjal Reena Singh Chopra

With an estimated failure rate of about 90%, immunotherapies that are intended for the treatment of solid tumors have caused an anomalous rise in the mortality rate over the past decades. It is apparent that resistance towards such therapies primarily occurs due to elevated levels of HIF-1 (Hypoxia-induced factor) in tumor cells, which are caused by disrupted microcirculation and diffusion mechanisms. With the advent of nanotechnology, several innovative advances were brought to the fore; and, one such promising direction is the use of perfluorocarbon nanoparticles in the management of solid tumors. Perfluorocarbon nanoparticles enhance the response of hypoxia-based agents (HBAs) within the tumor cells and have been found to augment the entry of HBAs into the tumor micro-environment. The heightened penetration of HBAs causes chronic hypoxia, thus aiding in the process of cell quiescence. In addition, this technology has also been applied in photodynamic therapy, where oxygen self-enriched photosensitizers loaded perfluorocarbon nanoparticles are employed. The resulting processes initiate a cascade, depleting tumour oxygen and turning it into a reactive oxygen species eventually to destroy the tumour cell. This review elaborates on the multiple applications of nanotechnology based perfluorocarbon formulations that are being currently employed in the treatment of tumour hypoxia.

Hypoxia

Tumor Hypoxia

Cancer Therapy

10.2174/1381612827666210830100907

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International Journal of Green Pharmacy (2018)

Amandeep Singh Varinder Singh Meenu Mehta Sanchit Mahajan Saurabh Satija

Introduction: Ficus infectoria popularly known as a white fig in India and is used in folk medicine to treat various physiological disorders. The pharmacological significance of this traditional Indian medicinal plant has also been justified in the literature by its rich chemical diversity. Due to its rich biochemical properties, plant material was used unauthentically as the traditional medicinal plant product in Indian market. Despite the fact that these plants are sold in the local market by a traditional medicinal healer, we did not find any authenticated data on its quality. Materials and Methods: In the present study, quality standards of plant leaves were developed by performing morphological, microscopical, physicochemical, phytochemical, and high-performance thin-layer chromatography (HPTLC) studies using CAMAG Linomat 5 instruments. Results: Microscopical studies of leaf and petiole of plant drug showed an arc of centrally located meristele surrounded by lignified parenchymatous tissue. Surface characteristic study of leaf lamina confirms the presence of a paracytic type of stomata. HPTLC data revealed that the primary component in the crude methanolic extract was found at Rf 0.02, 0.12, and 0.52 with the respective peak area of 22.63%, 12.22%, and 13.02%, respectively. Conclusion: This study highlighted essential characters which contribute to the standardization, identification, and authentication of plant drugs.

Phytochemical

Petiole (insect anatomy)

10.22377/ijgp.v12i02.1823

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Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update

Inflammopharmacology (2020)

Meenu Mehta Daljeet Singh Dhanjal Keshav Raj Paudel Bhupender Singh Gaurav Gupta

Pathogenesis

10.1007/s10787-020-00698-3

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Citations (312)

Rutin loaded liquid crystalline nanoparticles inhibit lipopolysaccharide induced oxidative stress and apoptosis in bronchial epithelial cells in vitro

Toxicology in Vitro (2020)

Keshav Raj Paudel Ridhima Wadhwa Meenu Mehta Dinesh Kumar Chellappan Philip M. Hansbro

10.1016/j.tiv.2020.104961

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Citations (49)

Comparison Between HPLC and HPTLC Densitometry for the Determination of 11-keto-Beta-boswellic acid and 3- acetyl-11-keto-Beta-boswellic acid from Boswellia serrata Extract.

Indian Journal of Pharmaceutical Education and Research (2016)

Meenu Mehta Saurabh Satija Munish Garg

Abstract: Objective: Boswellic acids (BAs) are active constituents of plant Boswellia serrata. In the present study boswellic acids were extracted from Boswellia serrata and dry methanolic extracts were quantified by HPLC and HPTLC. Method: A gradient HPLC method was used for the quantification of the boswellic acids; 11-keto-β-boswellic acid (KBA) and 3- acetyl-11-keto-β-boswellic acid (AKBA). A direct HPTLC assay was developed for the determination of KBA and AKBA at 254 nm. The UV detection of analytical assays were used to examine the purity of KBA and AKBA peaks and compared with the standards. Results: The quantitative results of both analytical methods did not show any major differences between content of KBA and AKBA, although a trend to slightly lower values were found for content of KBA and AKBA in HPLC. The amount of KBA and AKBA in the Boswellia serrata extract was found to be about 3.3 % and 4.6 % by HPTLC and 3.03% and 3.87% by HPLC respectively. Conslusion: Both methods are simple and effective for quantification of KBA and AKBA in Boswellia serrata extracts and their pharmaceutical formulations. Key words: Boswellic acids, Quantification, Extraction, Boswellia serrata extract.

Boswellia serrata

10.5530/ijper.50.3.15

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Citations (16)

Oxidative Stress and Immunological Complexities in Multidrug-Resistant Tuberculosis

Springer eBooks (2020)

Ridhima Wadhwa Nikita Sehgal G. Naresh Taru Aggarwal Saurabh Satija

10.1007/978-981-15-1568-2_7

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Citations (3)

1218P Characterization of GI toxicities and their impact on efficacy in patients (pts) with EGFR exon 20 insertion+ (ex20ins+) non-small cell lung cancer (NSCLC) treated with mobocertinib (TAK-788) who previously received platinum chemotherapy

Annals of Oncology (2021)