It was shown that the splenocytic response to mitogens in guinea pigs was activated 7 days following immunization thereof with a gamma-irradiated brucellar protective agent (gamma-BPA), while nonirradiated BPA inhibited lymphocyte proliferation under the effect of mitogens. gamma-BPA, as compared with BPA, circulated in blood for a longer time, induced a more rapid and prolonged synthesis of antibodies, and provided the development of a more intensive immunity.
A total of 269 coronary patients with arrhythmias were followed up for 6 months to 12 years. Coronaroventriculography was performed in 264 patients. The five-year survival rate was shown to be directly proportionate to the site and spread of postinfarction cardiosclerosis in arrhythmic coronary patients. In patients with aneurysms of the heart, it was 40.6%, with a further decline over the years. Left-ventricular final diastolic pressure (FDP) and outflow fraction is an objective indicator of myocardial contractility. Five-year survival is 69.3% in cases of the normal FDP, and drops significantly (by 20 %) where it is elevated. As a rule, survival rates were much higher in postoperative patients (following aortocoronary shunts or left-ventricular aneurysm resections), irrespective of myocardial contractility values.
In spite of the fact that clinical condition in 85.6% of coronary patients subjected to aortocoronary shunting has improved against their preoperative status, only 43.3% of them resume work. Invalidity in these patients increases two-fold mounting to 94.4%. The causes of the discrepancy between the expected and real performance are scrutinized with due consideration of clinical and social factors essential for the patients' decision to resume or give up work.
The sensitizing properties of brucella 31 kD and 31+15 kD protein antigens produced by Escherichia coli cell carrying and expressing the corresponding brucella genes were compared. In experiments evaluating the test of mouse feet oedema in CBA line animals the property of the 31 kD antigen preparation to induce the specific oedema effect was demonstrated on the level comparable with the one produced by the brucella outer membrane proteins preparation. The obtained data were confirmed in the experiments on adoptive transfer of prolonged type hypersensitivity via the spleen cells from the sensitized donors to intact recipient animals. The future of molecular cloning technique usage for obtaining the homogeneous stable preparations of brucella antigens with low reactivity and high specificity is discussed.
The comparative study of the chemical composition, immunobiological activity and some physico-chemical properties of lipopolysaccharide (endotoxin) of Brucella cultures isolated from myomorph rodents in the North Caucasus has been carried out. Lipopolysaccharide obtained from these cultures has been found to be most similar to B. suis lipopolysaccharide. The authors suggest that the strains isolated from myomorph rodents outside the foci of brucellosis affecting livestock should be regarded as a separate biotype of B. suis.
The paper gives the results of monitoring the circulation of influenza viruses in the 2010-2011 season, that covers the second year of circulation of pandemic A(H1N1)v virus strains, and their interaction with seasonal A (H3N2) and B strains. Unlike the previous season, the beginning of an increase in morbidity was recorded in January 2011; its peak in the most of contiguous areas was noted at 5-7 weeks of 2011, with its further decline to threshold levels at week 11 of 2011. Preschool and school children were most involved in the epidemic process. Three influenza virus strains (A(H1N1)v, A(H3N2), and B) were found to circulate. Differences were found in the level of participation of the isolated strains in individual areas of the Russian Federation. Detailed typing of the isolated strains determined the compliance of the vast majority of them with vaccine viruses. The pandemic influenza A(H1N1)v virus strains retained their susceptibility to oseltamivir and were resistant to rimantadine. The participation of non-influenza acute respiratory viral infection pathogens was estimated as follows: 11.9% for parainfluenza viruses, 5.9% for adenoviruses, and 3.5% for PC viruses, and 0.7% for pneumonia Mycoplasma, which was comparable with the previous epidemic seasons.