Forty-two children with portal vein obstruction (cavernoma) and without liver disease had a portosystemic surgical shunt performed at different ages. All of them had severe gastrointestinal hemorrhage prior to surgery. To evaluate the long-term neurological and psychological effects of shunt procedures in children with normal liver function, they were studied up to 24 years postoperatively with psychometric testing. A comparison with two control groups as to the impact of surgery, family situation, and neonatal events was considered. Twenty-four children with portal vein obstruction who were not operated on and 19 children splenectomized for hematological reasons acted as the control groups. No differences were observed in schooling and employment. Psychometric tests were almost identical in shunted patients and in the control groups. Minimal portal systemic encephalopathy appeared to be undetectable clinically either by electroencephalogram or by venous ammonia levels. The results of psychometric tests appear to show no loss of intellectual and psychological capacity in patients operated on for portal obstruction. Only visual memory and spatiotemporal tests showed slightly worse results in those children who underwent this procedure. Further longitudinal studies are required to substantiate these findings.

Portacaval shunt

Portosystemic shunt

Hepatic Encephalopathy

Liver disease

Neuropsychological Assessment

Liver function

10.1097/00005176-198611000-00006

Cite

Citations (41)

Food and mortality pattern in Belgium.

PubMed (1977)

Joossens Jv E Brems-Heyns J Carlier Anneloes Raes

Source

Cite

Citations (0)

[Pseudodiverticulum of the thoracic esophagus in a silicotic].

PubMed (1954)

L Courty J Carlier M Desitter

Source

Cite

Citations (0)

[Pharmacokinetics of gitaloxin in healthy man and in the renal insufficiency patient].

PubMed (1982)

Michel Lesne Philippe Jacqmin El Allaf D J Carlier

Source

Cite

Citations (2)

Effects of age on the pharmacokinetics of mexiletine.

PubMed (1986)

El Allaf D J Carlier A Dressé

Mexiletine (1-methyl-2-(2, 6-xylyloxy)ethylamine hydrochloride) is an antiarrhythmic drug eliminated primarily by hepatic metabolism. The influence of age on the plasma pharmacokinetics of mexiletine was assessed in seven young and ten elderly healthy subjects. Mexiletine (50 mg) was administered orally three times daily for 10 days. The use of low doses of mexiletine was possible owing to the development of a new fluorescence high performance liquid chromatography method with a limit of sensitivity lower than 20 ng/ml. No differences in the pharmacokinetic parameters of mexiletine related to age were observed. At steady-state plasma concentrations were 0.121 +/- 0.033 microgram-ml in the young volunteers, and 0.135 +/- 0.150 microgram/ml in the older subjects. The elimination t 1/2 was 11.4 +/- 1.78 h in the young subjects and 10.48 +/- 3.06 h in the elderly. The data provide no justification for lowering the recommended dose of mexiletine for older patients.

Mexiletine

Antiarrhythmic agent

Microgram

Source

Cite

Citations (11)

[Clinical experimentation with intravenously administered disopyramide].

PubMed (1975)

Renaud Vandenbosch N Lisin M Andriange J. E. Gach J Carlier

The intravenous injection of disopyramide (1.5 mg/kg) induces the return to sinus rhythm in about 60% of arrhythmias. When there exist perturbations of the cardiac rhythm, secondary to recent myocardial infarction, the percentage of success reaches 70%. The drug induces the disappearance of the extrasystoles in 80% of the cases, whatever the nature of the underlying cardiopathy. Although the secondary effects of the drug are slight, it is advisable to administer the substance in a slow intravenous injection (5 minutes), while controlling the arterial pressure and the E.C.G.

Disopyramide

Source

Cite

Citations (8)

Pharmacokinetic Study of Gitoformate in Renal-insufficiency

Drugs under experimental and clinical research (1980)

J Carlier Michel Lesne

Source

Cite

Citations (6)

[INFUNDIBULAR SYSTOLIC PRESSURE GRADIENTS IN THE NORMAL DOG].

PubMed (1964)

J Carlier

Pressure gradient

Systole

Source

Cite

Citations (0)

Mexiletine in the treatment of ventricular arrhythmias.

PubMed (1980)

L Henrard J Carlier

The effect of mexiletine, a new antiarrhythmic drug, was studied by oral (600 to 1200 mg/day) or intravenous (250 mg in 10 minutes) route in 45 patients; most of them had coronary insufficiency. Our results show that mexiletine is a potent ventricular antiarrhythmic drug which is efficient on several types of xylocaine resistant ventricular arrhythmias. In our experience, mexiletine is reliable when administered intravenously; there are frequent and sometimes severe side-effects when given orally.

Mexiletine

Antiarrhythmic agent

Source

Cite

Citations (8)