Flavia Cornacchia

University of Pavia

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Antonio Dal Canton

Istituti di Ricovero e Cura a Carattere Scientifico

Ciro Esposito

Federico II University Hospital

Gianluca Fasoli

University of Pavia

Tiziana Mazzullo

MultiMedica

Annalisa Foschi

Ospedale Civile di Voghera

Andreana De Mauri

Azienda Ospedaliero Universitaria Maggiore della Carita

Alessia Fornoni

University of Miami

Annarita Plati

Ospedale Papa Giovanni XXIII

Liliane J. Striker

National Institutes of Health

Anna Rita Plati

Ospedale Papa Giovanni XXIII

Cooperative Institutions

University of Pavia

Istituti di Ricovero e Cura a Carattere Scientifico

University of Miami

Policlinico San Matteo Fondazione

Fondazione Salvatore Maugeri

National Institutes of Health

Icahn School of Medicine at Mount Sinai

University of Naples Federico II

Istituti Clinici Scientifici Maugeri

Ospedale Maggiore

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Effect of calcineurin inhibitors on extracellular matrix turnover in isolated human glomeruli

Transplantation Proceedings (2004)

Ciro Esposito Annalisa Foschi Bina Parrilla Flavia Cornacchia Gianluca Fasoli

10.1016/j.transproceed.2004.03.013

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Citations (19)

Cyclosporin A affects extracellular matrix synthesis and degradation by mouse MC3T3‐E1 osteoblasts in vitro

Nephrology Dialysis Transplantation (2001)

Alessia Fornoni Flavia Cornacchia Guy A. Howard Bernard A. Roos Gary E. Striker

Background. Immunosuppressant therapy is thought to be a major contributor to post‐transplant bone disease. Histological data and serum parameters suggest that Cyclosporin A (CsA) treatment causes osteopenia as a result of an altered bone turnover, but the pathogenic mechanisms of this process remain unclear. We investigate if CsA affects cell turnover and extracellular matrix (ECM) synthesis and degradation in MC3T3‐E1 osteoblasts, as a surrogate model for in vivo events.

Osteopenia

Bone remodeling

Matrix (chemical analysis)

10.1093/ndt/16.3.500

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Citations (38)

Glomerulosclerosis is transmitted by bone marrow–derived mesangial cell progenitors

Journal of Clinical Investigation (2001)

Flavia Cornacchia Alessia Fornoni Anna Rita Plati Alton Thomas Yingcai Wang

We found that ROP Os/+ (Os/+) mice had diffuse glomerulosclerosis and glomerular hypertrophy and that their mesangial cells (the vascular smooth muscle cells of the glomerulus) displayed an apparent sclerosing phenotype. Since mesangial cells are the major source of scar tissue in glomerulosclerosis, we postulated that the sclerosis phenotype was carried by mesangial cell progenitors and that this phenotype could be derived from the bone marrow (BM). Therefore, we transplanted BM from Os/+ mice into congenic ROP +/+ mice (+/+ mice), which have normal glomeruli. We found that glomeruli of +/+ recipients of Os/+ marrow contained the Os/+ genotype, were hypertrophied, and contained increased extracellular matrix. Clones of recipient glomerular mesangial cells with the donor genotype were found in all +/+ recipients that developed mesangial sclerosis and glomerular hypertrophy, whereas +/+ recipients of +/+ BM had normal glomeruli. Thus, the sclerotic (Os/+) or normal (+/+) genotype and phenotype were present in, and transmitted by, BM-derived progenitors. These data show that glomerular mesangial cell progenitors are derived from the BM and can deliver a disease phenotype to normal glomeruli. Glomerular lesions may therefore be perpetuated or aggravated, rather than resolved, by newly arriving progenitor cells exhibiting a disease phenotype.

Glomerulosclerosis

Renal glomerulus

Mesangial cell

Glomerulus

Mesangial proliferative glomerulonephritis

10.1172/jci12916

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Citations (29)

[Cyclosporine and proteinuria: the hidden connection].

PubMed (2009)

Flavia Cornacchia

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[Model's short life and murine resistance, another ''no'' revolution].

Giornale Italiano di Nefrologia (2007)

Flavia Cornacchia

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Risk Factors for Chronic Renal Dysfunction in Lung Transplant Recipients

Transplantation (2007)

Ciro Esposito Andreana De Mauri Patrizio Vitulo Tiberio Oggionni Flavia Cornacchia

Several factors predispose to renal dysfunction (RD), a common complication of solid organ transplants. We evaluated the impact of clinical and laboratory parameters on the decline of renal function in lung and heart-lung transplant recipients. We enrolled 45 patients who survived more than 6 months after transplantation, had normal renal function and urinalysis before the surgery. The prognostic value of variables for the occurrence of RD was calculated by univariate analysis. Thirty patients developed RD, defined as doubling of serum creatinine or creatinine steadily >1.5 mg/dL after a median time of 12 months. Serum creatinine above 0.9 mg/dL during the month preceding lung transplant, systolic blood pressure above 130 mmHg, and pretransplant idiopathic pulmonary hypertension were significantly associated with the development of RD. Our findings indicate that increased systolic blood pressure, reduced glomerular filtration rate, and idiopathic pulmonary hypertension are risk factors for chronic RD in lung transplant recipients.

Univariate analysis

10.1097/01.tp.0000295989.63674.53

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Citations (29)

Effect of tacrolimus on human epithelial cell proliferation and extracellular matrix turnover

Journal of the American Society of Nephrology 12(Program and Abstract Issue) (2001)

Carla Esposito Mariarosaria Conte Annalisa Foschi Flavia Cornacchia Annarita Plati

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Glomerulosclerosis is transmitted by bone marrow–derived mesangial cell progenitors

Journal of Clinical Investigation (2001)

Flavia Cornacchia Alessia Fornoni Anna Rita Plati Alton Thomas Yingcai Wang

Glomerulosclerosis

Renal glomerulus

Mesangial cell

Glomerulus

Mesangial proliferative glomerulonephritis

10.1172/jci200112916

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Citations (129)

Development of Albuminuria and Glomerular Lesions in Normoglycemic B6 Recipients of db/db Mice Bone Marrow

Diabetes (2004)

Feng Zheng Flavia Cornacchia Ivonne Hernandez Schulman Anita Banerjee Qing-li Cheng

The pathologic hallmarks of diabetic nephropathy are excess mesangial extracellular matrix (ECM) and mesangial cell proliferation. We previously showed that mesangial cell phenotypic changes play an important role in the pathogenesis of diabetic nephropathy. We concluded that phenotypic changes were present in bone marrow (BM)-derived mesangial cell progenitors, as transplantation of BM from db/db mice, a model of type 2 diabetic nephropathy, transferred the db genotype and a nephropathy phenotype to naive B6 mice recipients. The recipients did not develop diabetes; however, they did develop albuminuria and glomerular lesions mirroring those in the donors (i.e., glomerular hypertrophy, increased ECM, and increased cell number with cell proliferation). We found that matrix metalloproteinase 2 (MMP-2) facilitated invasion of the mesangial cells into ECM and proliferation in vitro. Thus, increased MMP-2 activity in db/db mesangial cell progenitors may partially explain increased mesangial cell repopulation and proliferation in B6 recipients of db/db BM. In summary, BM-derived mesangial cell progenitors may play a crucial role in the development and progression of ECM accumulation and mesangial cell proliferation in this model of diabetic nephropathy in type 2 diabetes.

Mesangial cell

Albuminuria

10.2337/diabetes.53.9.2420

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Citations (48)

[Is more always better? Treatment of acute renal failure in the critical patient: in search of the lost target].

Giornale Italiano di Nefrologia (2008)

Flavia Cornacchia

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