Gaurav Muktesh

Post Graduate Institute of Medical Education and Research

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Rakesh Kochhar

Post Graduate Institute of Medical Education and Research

Jayanta Samanta

Post Graduate Institute of Medical Education and Research

Pankaj Gupta

Post Graduate Institute of Medical Education and Research

Saroj K. Sinha

Post Graduate Institute of Medical Education and Research

Jahnvi Dhar

Post Graduate Institute of Medical Education and Research

Vikas Gupta

Post Graduate Institute of Medical Education and Research

Thakur Deen Yadav

Post Graduate Institute of Medical Education and Research

Phulen Sarma

All India Institute of Medical Sciences Raipur

Jimil Shah

Post Graduate Institute of Medical Education and Research

Narendra Dhaka

Post Graduate Institute of Medical Education and Research

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Post Graduate Institute of Medical Education and Research

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Institute of Post Graduate Medical Education and Research

University Gastroenterology

Creative Commons

All India Institute of Medical Sciences

Asian Institute of Gastroenterology

University College of Medical Sciences

Institute of Medical Sciences

Chandigarh University

Guru Teg Bahadur Hospital

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EUS-GUIDED RENDEZVOUS TECHNIQUE VERSUS PRECUT PAPILLOTOMY AS SALVAGE TECHNIQUE IN PATIENTS OF BENIGN BILIARY DISEASE WITH DIFFICULT BILIARY CANNULATION: A RANDOMIZED CONTROLLED TRIAL.

Gastrointestinal Endoscopy (2022)

arup choudhury Jayanta Samanta Gaurav Muktesh Jahnvi Dhar Antriksh Kumar

10.1016/j.gie.2022.04.1296

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Citations (0)

Unusual Sites of Necrotic Collections in Acute Necrotizing Pancreatitis: Association with Parenchymal Necrosis and Clinical Outcomes

Digestive Diseases and Sciences (2020)

Pankaj Gupta Mandeep S. Virk Ajay Gulati Gaurav Muktesh Jimil Shah

Necrotizing pancreatitis

Transplant surgery

Parenchyma

10.1007/s10620-020-06526-6

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Citations (9)

EUS- GUIDED RENDEZVOUS TECHNIQUE VERSUS PRECUT PAPILLOTOMY AS SALVAGE TECHNIQUE IN PATIENTS OF BENIGN BILIARY DISEASE WITH DIFFICULT BILIARY CANNULATION: A RANDOMIZED CONTROLLED TRIAL

Endoscopy (2022)

Arup Choudhury Joydeep Samanta Gaurav Muktesh Jahnvi Dhar Akhil Kumar

Aims Standard salvage technique used for difficult bile duct cannulation (DBDC) is pre-cut papillotomy (PcP), while endoscopic ultrasound-guided rendezvous technique (EUS-RV) is a relatively newer modality. Prospective comparative data between these two techniques as salvage for biliary access in patients of benign biliary disease with DBDC is lacking and hence, this study was planned.

Rendezvous

Biliary disease

Endoscopic Ultrasound

10.1055/s-0042-1744562

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Citations (2)

A study to determine Pharmacogenomic predictors of efficacy and safety of Azathioprine therapy in patients with IBD

Proceedings for Annual Meeting of The Japanese Pharmacological Society (2018)

Phulen Sharma Gaurav Muktesh Shringika Soni Abhishek Mishra Rahul Singh

Introduction The present study, designed to evaluate pharmacogenomic and metabolomics parameters as a bio-marker of azathioprine safety and efficacy in Indian population.

Pharmacogenomics

10.1254/jpssuppl.wcp2018.0_po3-14-22

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S91 A Systematic Review and Meta-analysis of Opioids vs Non-Opioids in Acute Pancreatitis

The American Journal of Gastroenterology (2021)

Alfred D. Nelson Nahyr Lugo‐Fagundo Soumya Jagannath Mahapatra Karn Wijarnpreecha Gaurav Muktesh

Introduction: Although abdominal pain is one of the major criteria to diagnose acute pancreatitis (AP) there are no standardized guidelines to treat this troublesome symptom in the hospital setting. With the growing opioid epidemic, there is a pressing need to minimize opioid use. Methods: To conduct a trial-based meta-analysis, to assess the efficacy of non-opioids vs opioids for pain management in AP. We searched the medical literature through May 2021 to identify randomized controlled trials (RCTs) that examined the efficacy of opioids with non-opioids in AP pain management. Efficacy was reported as odds ratio (OR) with 95% confidence intervals (CIs) of each comparison tested. Results: We identified 7 eligible RCTs, containing 389 patients. No significant difference in terms of pain intensity at day 1 (OR 0.82, 95% CI -2.55 to 4.19) was found between opioids and non-opioids (Figure 1). Non-opioids has a significant higher risk of supplementary analgesic use compared to opioids. However, this significance is not seen when comparing non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol vs opioids (OR 0.59, 95% CI 0.28 to 1.25) (Figure 2). Opioids did not show a significant increase in the complications of pancreatitis, nausea and vomiting, sedation, and deaths when compared with non-opioids. Conclusion: We found non-opioids especially NSAIDs and paracetamol can provide adequate pain relief in patients with AP with no change in supplementary analgesic use and adverse events when compared to opioids. Further research is needed to optimize the use of non-opioids along or in combination with opioids for better pain control in AP patients.Figure 1.: A. Comparison between opioids vs non-opioids of pain intensity by VAS at day 1. B. Sensitivity analysis of supplementary analgesic use with non-opioids (NSAIDs and paracetamol) vs opioids.

Sufentanil

10.14309/01.ajg.0000772344.60540.bf

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Endoscopic Ultrasound-Guided Rendezvous Technique Versus Precut Sphincterotomy as Salvage Technique in Patients With Benign Biliary Disease and Difficult Biliary Cannulation

Annals of Internal Medicine (2024)

Arup Choudhury Jayanta Samanta Gaurav Muktesh Jahnvi Dhar Antriksh Kumar

The standard salvage technique used for difficult bile duct cannulation is precut sphincterotomy, whereas endoscopic ultrasound-guided rendezvous technique (EUS-RV) is a relatively newer method. Prospective comparative data between these 2 techniques as salvage for biliary access in patients with benign biliary disease and difficult bile duct cannulation is lacking.

Rendezvous

Biliary disease

Endoscopic Ultrasound

10.7326/m24-0092

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Citations (3)

Terlipressin-induced Peripheral Ischemic Gangrene in a Diabetic Patient.

PubMed (2017)

Phulen Sarma Gaurav Muktesh Narender Dhaka Rakesh Ruhela Abhishek Mishra

Terlipressin is used commonly in the management of hepatorenal syndrome and acute variceal bleeding. Like its parent compound vasopressin, it is also notorious for its ischemic complications. Terlipressin-induced ischemic complications can virtually affect any part of the body, but the incidence of serious complications is less than its parent compound vasopressin. Here, we report a case of terlipressin-induced peripheral ischemic gangrene in a diabetic male, which ultimately led to death of the patient.

Terlipressin

Gangrene

10.4103/jpp.jpp_42_17

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Effect of gluten‐free diet and compliance on quality of life in pediatric celiac disease patients

JGH Open (2019)

Deepak Chellan Gaurav Muktesh Kim Vaiphei Neha Berry Narendra Dhaka

Background Quality of life (QOL) in children with celiac disease (CD) has been sparsely studied. Aims We aimed to study QOL in pediatric CD and the effect of a gluten‐free diet (GFD) in a North Indian population. Methods QOL was assessed at baseline and 6 months after GFD using a pediatric symptom checklist (PSC) score. The effect of GFD was assessed using a CD‐specific questionnaire on domains such as dietary compliance, parental behavior and perceptions, children's feeling, and difficulty identifying gluten‐free foods. Results A total of 60 CD children (age 6.03 ± 0. 42 years, range: 2–12 years, M:F 2:1) were prospectively enrolled. The median PSC score at baseline was 11.5 (2–35), which showed a statistically significant improvement after GFD to 2.5 (0–34) ( P < 0.001). Significant concerns regarding specific domains emerged: difficulty in maintaining GFD 26.2%, at school 14.3%, at parties 43.2%, poor taste 11.4%, special diet a burden 28.5%, felt left out at school or friend's home 40.9%, felt different from other kids 40.9%, felt embarrassed to bring GFD to parties 54.6%, felt angry about following a special diet 56.8%, felt not invited out for meals because of CD 13.6%, and difficulty determining if food available was gluten free in 75%. Conclusion GFD has a significant impact on emotional, behavioral, and psychosocial domains in children with CD. Proper labeling of commercially available food items, counseling, and patient support groups are the need of the hour.

Gluten free

10.1002/jgh3.12172

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Citations (14)

Can high-frequency mini-probe endoscopic ultrasonography predict outcome of endoscopic dilation in patients with benign esophageal strictures?

Endoscopy International Open (2020)

Philip B. Daniel Jayanta Samanta Ajay Gulati Pankaj Gupta Gaurav Muktesh

Background and study aims Endoscopic dilation is first-line management for benign esophageal strictures (ES). Depth of involvement of the esophageal wall on endosonography using high frequency mini-probe (EUS-M) may predict response to dilation. This study evaluated EUS-M characteristics to predict response of ES to endoscopic dilation. Patients and methods EUS-M was used to measure the total esophageal wall thickness (EWT), involved EWT, percentage of involved wall and layers of wall involved in consecutive patients of benign ES. After a maximum of five sessions of endoscopic dilation, the cohort was divided into responders and refractory strictures. EUS-M characteristics were compared for underlying etiology as also between responders and refractory strictures. Results Of the 30 strictures (17 females, age: 47.16 ± 15.86 yrs.) 13 were anastomotic, eight corrosive, seven peptic and 2 others. Corrosive strictures had the highest involved EWT and percentage of involved wall (3.51 ± 1.36 mm; 76.38 %) followed by anastomotic (2.73 ± 1.7 mm; 65.54 %) and peptic (1.39 ± 0.62 mm; 40.71 %) ( P = 0.026 and 0.021 respectively). After five dilations, 22 were classified as responders and eight as refractory. Wall involvement > 70 % had a greater proportion of refractory strictures ( P = 0.019). Strictures with involved EWT of ≥ 2.85 mm required more dilations ( P = 0.011). Fewer dilations were required for stricture resolution with only mucosal involvement compared to deeper involvement such as submucosa and muscularis propria (2.14 vs. 5.80; P = 0.001). Conclusion EUS-M evaluation shows that corrosive and anastomotic strictures have greater depth of involvement compared to peptic strictures. Depth of esophageal wall involvement in a stricture predicts response to dilation.

Endoscopic ultrasonography

Submucosa

Peptic

Refractory (planetary science)

Dilation (metric space)

Balloon dilation

10.1055/a-1223-1377

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Citations (3)

A Systematic Review and Meta-analysis of Opioids vs Nonopioids in Acute Pancreatitis

Gastro Hep Advances (2022)

Alfred D. Nelson Nahyr Lugo‐Fagundo Soumya Jagannath Mahapatra Wisit Cheungpastiporn Charat Thongprayoon

Although abdominal pain is one of the major criteria to diagnose acute pancreatitis (AP), there are no standardized guidelines to treat this troublesome symptom in the hospital setting. The aims of the study are to conduct a meta-analysis and to assess the efficacy of nonopioids vs opioids for pain management in AP.

10.1016/j.gastha.2021.09.006

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Citations (6)