Sang‐Seon Yun

University of British Columbia

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Weiming Li

Michigan State University

Alexander P. Scott

Centre for Environment, Fisheries and Aquaculture Science

David A. Close

University of Pittsburgh

Michael J. Siefkes

Great Lakes Fishery Commission

Nicholas S. Johnson

United States Geological Survey

Andrew J. Wildbill

Confederated Tribes of Warm Springs

Barbara S. Zielinski

University of Windsor

Brian Riddell

Pacific Salmon Foundation

Shigehiko Urawa

Japan Fisheries Research and Education Agency

Jackie King

Washington University in St. Louis

Cooperative Institutions

Michigan State University

University of British Columbia

Michigan Department of Natural Resources

Fisheries and Oceans Canada

United States Geological Survey

NOAA National Marine Fisheries Service

University of Washington

United States Fish and Wildlife Service

University of Windsor

Great Lakes Science Center

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Development and application of LC/MS based analysis for marine algal toxins in Hood Canal

Sang‐Seon Yun Aaron Bentson-Royal Kenneth E. Collins Seth Book Ron Figlar-Barnes

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Dose–response relationship of 15α-hydroxylated sex steroids to gonadotropin-releasing hormones and pituitary extract in male sea lampreys (Petromyzon marinus)

General and Comparative Endocrinology (2006)

B. Young Mara Bryan Jessica R. Glenn Sang‐Seon Yun Alexander P. Scott

Petromyzon

Gonadotropin

10.1016/j.ygcen.2006.12.005

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Citations (20)

15α-Hydroxytestosterone produced in vitro and in vivo in the sea lamprey, Petromyzon marinus

General and Comparative Endocrinology (2003)

Mara Bryan Alexander P. Scott Ivan Černý Sang‐Seon Yun Weiming Li

Petromyzon

Tritiated water

10.1016/s0016-6480(03)00104-7

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Citations (24)

GREAT LAKES FISHERY COMMISSION 2004 Project Completion Report 1 Purification and characterization of anti-microbial bioactive peptides from sea lamprey

Sang‐Seon Yun Weiming Li

Abstract In fish, it is well established that the innate immunity plays an important role in defense. Antimicrobial peptides have been isolated and characterized from several species of fish. We made an attempt to isolate some antimicrobial peptides from sea lamprey blood cells after challenge with some bacterial strains. An acetic acid extraction of blood cells from challenged fish were subjected to a series of separation methods such as solid phase extraction, cation-exchange chromatography, gel filtration chromatography and reversed phase high performance liquid chromatography combined with the antimicrobial assay. Surprisingly, the substance in the antimicrobial fractions turned out to be an aminosterol, called squalamine , originally identified from the dogfish shark. Further chromatographic and mass spectrometry data confirmed that the active fraction from the sea lamprey blood cells was identical to squalamine. This compound has been known to have anti-angiogenic property and been being developed as a cancer therapeutic agent. It can be postulated that squalmine may have an important role in defending against microbial invasion as part of innate immune system. Furthermore, it is very interesting to find a compound known to be present in other lineage of fish. This finding may indicate that squalamine is originated from an ancient fish species, sea lamprey and that this category of biomolecules is widespread throughout the vertebrates.

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Regulation of a putative corticosteroid, 17,21-dihydroxypregn-4-ene,3,20-one, in sea lamprey, Petromyzon marinus

General and Comparative Endocrinology (2013)

Brent W. Roberts Wes Didier Satbir Rai Nicholas S. Johnson Scot Libants

Petromyzon

Corticosterone

Lampetra

10.1016/j.ygcen.2013.11.008

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Investigations of Novel Unsaturated Bile Salts of Male Sea Lamprey as Potential Chemical Cues

Journal of Chemical Ecology (2014)

Nicholas S. Johnson Sang‐Seon Yun Weiming Li

Petromyzon

10.1007/s10886-014-0511-4

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Identification of putative migratory pheromones from Pacific lamprey (Lampetra tridentata)

Canadian Journal of Fisheries and Aquatic Sciences (2011)

Sang‐Seon Yun Andrew J. Wildbill Michael J. Siefkes Mary L. Moser Andrew H. Dittman

Pacific lamprey, Lampetra tridentata , has declined precipitously throughout their range in the Columbia River basin of North America. Tribal Nations and Federal and State agencies are engaged in efforts to restore these fish. Understanding whether Pacific lamprey emit and detect migratory pheromones is particularly important for these restoration efforts. Using behavioural assays, we demonstrated that migratory adult Pacific lamprey are attracted to odors emanating from their larval conspecifics. We then identified putative pheromones released by larval Pacific lamprey. Chemical analysis of the conditioned water from larval lamprey using liquid chromatography – mass spectrometry (LC–MS) revealed that the Pacific lamprey can release petromyzonamine disulfate (PADS), petromyzosterol disulfate (PSDS), and petromyzonol sulfate (PZS). Electro-olfactogram studies further demonstrated that adult Pacific lamprey can smell those bile acid compounds. Our data strongly indicate that the Pacific lamprey employ a chemical communication system mediated by a mixture of bile acids, as evidenced by pheromonal functions of the bile acid compounds in guiding migratory adult sea lamprey to the spawning streams. Comprehensive understanding of the chemical communications involved in lamprey migratory behavior may lead to improved scientific approaches for restoration efforts.

Lampetra

Petromyzon

10.1139/f2011-140

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In vitro biosynthesis of novel 5β-reduced steroids by the testis of the round goby, Neogobius melanostomus

General and Comparative Endocrinology (2004)

Wesley J. Arbuckle A. J. Belanger Lynda D. Corkum Barbara S. Zielinski Weiming Li

Etiocholanolone

Round goby

Neogobius

10.1016/j.ygcen.2004.09.014

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Localization of the SALMFamide neuropeptides in the starfishMarthasterias glacialis

Animal Cells and Systems (2011)

Sang‐Seon Yun Michael C. Thorndyke

Abstract In echinoderms, the SALMFamide neuropeptides sharing the SxL/FxFamide motif seem widespread throughout the phylum and may be important signalling molecules that mediate various physiological functions. Recent identification of S1 and its analogues, MagS3 and MagS4, along with the S2 analogue, MagS2 from the starfish Marthasterias glacialis, indicated that SALMFamides in the class Asteroidea are more diverse than previously thought. Further, isolation of the neuropeptides from the radial nerve cord and studies on pharmacological actions of the neuropeptides on the cardiac stomach warrant studies on the tissue distributions of these peptides in both the nervous and digestive systems. In the present study, antisera raised against an S1 analogue, KYSALMFamide, and an S2 analogue, KYSGLTFamide, were used to localize the distribution patterns of the S1- and S2-like immunoreactivities (S1-IR/S2-IR) in the nervous and digestive systems of the starfish. In the nervous system, cell bodies in the ectoneural part were immunostained for both S1 and S2 peptides, while in the digestive system, the basi-epithelial plexus and mucosal cell bodies were immunoreactive. These immunocytochemical data support the notion that the SALMFamides may play a neuroendocrine role in mediating feeding behaviour of the starfish. Further studies including identification of peptide binding sites and differential expression pattern of mRNAs encoding the peptides are required to elucidate their physiological functions.

Ventral nerve cord

10.1080/19768354.2011.630753

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A synthesized pheromone induces upstream movement in female sea lamprey and summons them into traps

Proceedings of the National Academy of Sciences (2009)

Nicholas S. Johnson Sang‐Seon Yun Henry T. Thompson Cory O. Brant Weiming Li

Female insect pheromone blends induce robust tracking responses in males and direct them into traps. In vertebrates, pheromones that induce strong and precise tracking responses in natural habitats have rarely been described. Here, we show in the sea lamprey ( Petromyzon marinus ), a vertebrate invader of the Laurential Great Lakes, that a synthesized component of the male mating pheromone, 7α, 12α, 24-trihydroxy-5α-cholan-3-one 24-sulfate (3kPZS), when released into a stream to reach concentrations of 10 −14 , 10 −13 , 10 −12 , 10 −11 , or 10 −10 M, triggers robust upstream movement in ovulated females drawing ≈50% into baited traps. Experiments conducted in diverse stream segments demonstrate the level of behavioral response was not affected by habitat conditions and is effective over hundreds of meters. 3kPZS is equally effective at luring ovulated females as the whole pheromone blend released by males between 10 −14 and 10 −11 M. 3kPZS diverts ovulated females away from and disrupts orientation to male washings when applied at concentrations higher than washings. Indeed, a single pheromone compound is able to redirect female sea lampreys away from a natural pheromone source and lure them into traps, which should be more effective than targeting males when applied in population control. Our findings may spur the discovery of other potent and environmentally benign agents to combat biological invasion, a process accelerated by globalization, exacerbated by climate change, and costing the global economy US$ 1.4 trillion of damage annually.

Petromyzon

10.1073/pnas.0808530106

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Citations (180)