Children autonomously make sound moral judgments based on internal criteria, but they tend to make erroneous judgments in the presence of social influences, and the reasons for these errors are not well understood. Thus, the current research investigated how the presence of observers who can see and listen to 3-year-old children’s judgments but who do not present their opinions influences children’s conformity in moral judgment behavior. In Experiment 1, the children ( N = 30) were presented with pictures depicting prosocial behaviors and asked whether the behaviors were acceptable. The children’s tendency to change their answers after hearing the counterintuitive opinions of informants was then measured. The results showed that the children’s moral judgments were more likely to conform to that of the group in the presence of observers. Experiment 2 aimed to determine the reason children were more likely to conform to a group when being watched by observers in Experiment 1. Children ( N = 30) were randomly assigned to two conditions with different observer conditions as follows. Observers were either wearing headsets, indicating that they could not hear the children’s responses, or had them hanging around their necks, indicating that they could. The results showed that children’s conformity behavior depended on whether observers could hear what they were saying. The current findings are expected to help elucidate not only social factors that affect children’s moral judgments but also the developmental mechanism of an observer effect.
Introduction and Objectives Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) is briefly defined as an AML which have multilineage dysplasia (MLD), a history of myelodysplastic syndrome (MDS) and/or an MDS-related cytogenetic abnormalities. Recent study showed that AML-MRC exhibits a worse clinical outcome than AML not otherwise specified (AML-NOS). Though allogenic hematopoietic stem cell transplantation (allo-SCT) is believed to improve the outcome of AML-MRC, few reports had referred to its benefit. The purpose of this study was to clarify the outcome and the prognostic factors of patients (pts) with AML-MRC who underwent allo-SCT. Methods Between January 2008 to December 2017, a total of 138 consecutive AML-MRC (n = 50) and AML-NOS (n = 88) pts who underwent allo-SCT in Japanese Red Cross Nagoya Daiichi Hospital were retrospectively analyzed. The classifications of diagnoses were made according to the criteria of the 2008 WHO classification and data of clinical, pathologic and cytogenetic features were collected. Results Among 138 pts, the median age at SCT was 45.5 years (range, 17 to 66 years), and 59 (43%) pts were female. Performance status was 2-4 for 7 (5%) pts and HCT-CI was ≧3 for 14 (10%) pts. The cytogenetic features were classified as intermediate risk for 78 (57%) pts and high or unknown risk for 60 (43%) pts according to the Southwest Oncology Group (SWOG) criteria. Ninety-five (69%) pts were in complete remission (CR) at SCT. Twenty-four (17%) pts had related donor and 71 (51%), 31 (22%), and 36 (26%) pts received bone marrow, peripheral blood stem cell, and cord blood, respectively. Myeloablative conditioning was performed in 87 (63%) pts. The median follow-up period for survivors was 51 months (range, 3 to 108 months). Compared to AML-NOS pts, pts with AML-MRC had significantly low frequency of CR at SCT (48% vs 81%, p Subgroup analysis was performed and SWOG high risk cytogenetics was identified as independent prognostic factor in the pts with AML-NOS (HR 2.31, p = 0.01). Among pts with AML-MRC, MDS-related cytogenetics (HR 4.52, p Conclusion Here we show that cytogenetic features, but not a diagnosis of AML-MRC, is one of the most important prognostic factors when performing allo-SCT,
We tested the hypothesis that de novo copy number variation (CNV) is associated with autism spectrum disorders (ASDs). We performed comparative genomic hybridization (CGH) on the genomic DNA of patients and unaffected subjects to detect copy number variants not present in their respective parents. Candidate genomic regions were validated by higher-resolution CGH, paternity testing, cytogenetics, fluorescence in situ hybridization, and microsatellite genotyping. Confirmed de novo CNVs were significantly associated with autism (P = 0.0005). Such CNVs were identified in 12 out of 118 (10%) of patients with sporadic autism, in 2 out of 77 (3%) of patients with an affected first-degree relative, and in 2 out of 196 (1%) of controls. Most de novo CNVs were smaller than microscopic resolution. Affected genomic regions were highly heterogeneous and included mutations of single genes. These findings establish de novo germline mutation as a more significant risk factor for ASD than previously recognized.
Research on early word learning reveals that verbs present a unique challenge. While English-acquiring 24-month-olds can learn novel verbs and extend them to new scenes, they perform better in rich linguistic contexts (when novel verbs appear with fully lexicalized noun phrases naming the event participants) than in sparser linguistic contexts (Arunachalam & Waxman, 2011; Waxman et al., 2009). However, in languages like Korean, where noun phrases are often omitted when their referents are highly accessible, rich linguistic contexts are less frequent. The current study investigates the influence of rich and sparse linguistic contexts in verb learning in Korean-acquiring 24-month-olds. In contrast to their English-acquiring counterparts, 24-month-olds acquiring Korean perform better when novel verbs appear in sparse linguistic contexts. These results, which provide the first experimental evidence on early verb learning in Korean, indicate that the optimal context for verb learning depends on many factors, including how event participants are typically referred to in the language being acquired.
본 연구에서는 싱가포르 과학교육과정의 주제(theme)와 캐나다 온타리오 주의 과학과 기술 교육과정에 제시되어 있는 본질적 개념(fundamental concepts), 미국의 과학교육내용표준(NGSS, Next Generation Science Standards)에 제시되어 있는 학문 간 교차개념(crosscutting concepts)을 살펴보고, 통합개념과 관련된 각 국의 성취목표에 어떤 과학 내용 요소들이 포함되어 있으며, 학년 별로 어떻게 구성되어 있는지 분석하였다. 분석 결과, 각 국에서 제시하고 있는 통합개념은 그 나라 교육과정의 특성을 반영하며, 통합개념의 특성에 따라 통합개념에 포함되는 과학 내용 요소들은 달라질 수 있다는 것과 학년 별로 제시되는 통합개념에는 차이가 있음을 알 수 있었다. 이를 바탕으로 통합개념을 중심으로 통합교육과정을 설계할 때 고려해야 하는 몇 가지 사항을 다음과 같이 제안할 수 있다. 주요 과학 내용을 포함해야 하는 통합개념의 수는 적정하게 선정되어야 하며, 통합개념이 의미하는 바를 명확히 규정하고 해당 통합개념에 어떤 분과적인 내용 요소들이 포함될 수 있는지 신중하게 검토하면서 통합개념을 선정하는 과정이 필요하다. 또한 모든 통합개념이 모든 학년에서 고르게 다루어지는 것이 바람직한지, 또는 특정 통합개념이 특정 학년에서 집중적으로 다루어지는 것이 필요한지 등을 숙고하여 내용을 선정하고 조직하는 것이 필요하다. The feasibility of integrated concepts as a key element in designing integrated science curriculum has been investigated by analysing science contents included in performance expectations stated at different grades. The science curriculum of Singapore and the state of Ontario in Canada, and next generation of science standard (NGSS) were selected. Each of them presents theme, fundamental concepts, and crosscutting concepts, which has the characteristics of integrated concepts proposed in the study. Analysis showed that theme, fundamental concepts, and crosscutting concepts were influenced by the characteristics of each curriculum. In addition, science contents related to integrated concepts at different grades varied with the nature of integrated concepts. Based on results, some suggestions were made. First, the total number of integrated concepts should be considered for designing integrated curriculum. Second, the nature of integrated concepts and science contents associated with the integrated concepts should be considered. The integrated concepts should be vast and deep enough in the meaning to contain various content knowledge of different science domains. Third, it should be considered that how the integrated concepts have to be presented at different grades.
Hospital visitation has become challenging during the coronavirus disease 2019 pandemic because of quarantine measures and fear of infection. Consequently, newly diagnosed patients may present with more severe diseases during the pandemic. The present study analyzed the differences in the initial clinical presentations of newly diagnosed patients with type 1 diabetes (T1D) and type 2 diabetes (T2D), comparing pre-pandemic and pandemic periods.
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