Djamila Onésime

Microbiologie de l’alimentation au service de la santé

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Co-Authors

Daniel Ruben Akiola Sanya

Microbiologie de l’alimentation au service de la santé

N. Dhanasekaran

Temple University

Jean-Marie Beckerich

Food Process Engineering and Microbiology

Jean‐Marc Nicaud

Microbiologie de l’alimentation au service de la santé

Cécile Neuvéglise

Microbiologie de l’alimentation au service de la santé

Julie Aubert

AgroParisTech

Pascal Bonnarme

AgroParisTech

Dominique Swennen

ParisTech

Françoise Irlinger

AgroParisTech

Bernard Henrissat

Technical University of Denmark

Cooperative Institutions

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

AgroParisTech

Université Paris-Saclay

Centre National de la Recherche Scientifique

Institut National de la Recherche Agronomique

Microbiologie de l’alimentation au service de la santé

Food Process Engineering and Microbiology

Temple University

Interdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes – Région Est

Institució Catalana de Recerca i Estudis Avançats

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Apoptosis of ovarian granulosa cells: Correlation with the reduced activity of ERK-signaling module

Journal of Cellular Biochemistry (1999)

Gerd Gebauer Augustine T. Peter Djamila Onésime N. Dhanasekaran

Apoptosis of the ovarian granulosa cells plays a crucial role in the determination of the number of follicles destined to ovulate in each reproductive cycle. While the activation of specific apoptotic pathway or the inactivation of cell survival pathway can initiate apoptosis, the signaling mechanism(s) involved in initiating the onset of apoptosis in granulosa cells is not fully understood. In the present study, using granulosa cells derived from eCG-primed immature rats, we investigated the temporal signaling events involved in the onset of apoptosis in the granulosa cells. The administration of 15 IU of eCG to 21-day-old immature female rats stimulate the growth and development of ovarian follicles until 72 h, after which the granulosa cells of the ovarian follicles undergo apoptosis due to the waning levels of tropic hormonal support. An analysis of the signaling events leading to apoptosis indicates that the DNA fragmentation can be seen in these cells from 96 h. A small increase in the levels of the pro-apoptotic factor Bax can be seen from 96 h while an increase in the activity of JNK can be seen from 108 h onwards. By contrast, a reduction in ERK signaling can be seen by 48 h. Similar reduction in Raf-1 kinase activity can be discerned from 48 h onwards. A concomitant decrease in the phosphorylated form of Bad can also be detected. These findings taken together, suggest that the loss of tropic hormone support is translated into the attenuation of Raf-1-MEK-ERK signaling pathway and this reduction along with a reduction in the levels of phosphorylated form of Bad triggers the onset of apoptosis in the ovarian granulosa cells.

Granulosa cell

10.1002/(sici)1097-4644(19991215)75:4<547::aid-jcb1>3.0.co;2-5

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Citations (54)

A review of approaches to control bacterial leaf blight in rice

World Journal of Microbiology and Biotechnology (2022)

Daniel Ruben Akiola Sanya Sharifah Farhana Syed-Ab-Rahman Ai‐Qun Jia Djamila Onésime Kyung‐Min Kim

Bacterial disease

Disease management

Xanthomonas

10.1007/s11274-022-03298-1

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Citations (20)

Chemical sensing of DNT by engineered olfactory yeast strain

Nature Chemical Biology (2007)

V. Radhika Tassula Proikas‐Cezanne Muralidharan Jayaraman Djamila Onésime Ji Hee Ha

10.1038/nchembio882

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Citations (134)

Apoptosis of ovarian granulosa cells: Correlation with the reduced activity of ERK‐signaling module

Journal of Cellular Biochemistry (1999)

Gerd Gebauer Augustine T. Peter Djamila Onésime N. Dhanasekaran

Granulosa cell

10.1002/(sici)1097-4644(19991215)75:4<547::aid-jcb1>3.3.co;2-x

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Citations (5)

Transcriptomic response of Debaryomyces hansenii during mixed culture in a liquid model cheese medium with Yarrowia lipolytica

International Journal of Food Microbiology (2017)

Reine Malek Pascal Bonnarme Françoise Irlinger Pascale Frey‐Klett Djamila Onésime

Yarrowia

Debaryomyces hansenii

Kluyveromyces lactis

Cheese ripening

10.1016/j.ijfoodmicro.2017.10.026

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Citations (5)

CandidaDB: a genome database for Candida albicans pathogenomics

Nucleic Acids Research (2004)

Christophe d’Enfert Sophie Goyard S. Rodriguez-Arnaveilhe Lionel Frangeul Louis Jones

CandidaDB is a database dedicated to the genome of the most prevalent systemic fungal pathogen of humans, Candida albicans. CandidaDB is based on an annotation of the Stanford Genome Technology Center C.albicans genome sequence data by the European Galar Fungail Consortium. CandidaDB Release 2.0 (June 2004) contains information pertaining to Assembly 19 of the genome of C.albicans strain SC5314. The current release contains 6244 annotated entries corresponding to 130 tRNA genes and 5917 protein-coding genes. For these, it provides tentative functional assignments along with numerous pre-run analyses that can assist the researcher in the evaluation of gene function for the purpose of specific or large-scale analysis. CandidaDB is based on GenoList, a generic relational data schema and a World Wide Web interface that has been adapted to the handling of eukaryotic genomes. The interface allows users to browse easily through genome data and retrieve information. CandidaDB also provides more elaborate tools, such as pattern searching, that are tightly connected to the overall browsing system. As the C.albicans genome is diploid and still incompletely assembled, CandidaDB provides tools to browse the genome by individual supercontigs and to examine information about allelic sequences obtained from complementary contigs. CandidaDB is accessible at http://genolist.pasteur.fr/CandidaDB.

Genome browser

Sequence assembly

10.1093/nar/gki124

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Citations (90)

Yeasts of the Blastobotrys genus are promising platform for lipid-based fuels and oleochemicals production

Applied Microbiology and Biotechnology (2021)

Daniel Ruben Akiola Sanya Djamila Onésime Volkmar Passoth Mrinal K. Maiti Atrayee Chattopadhyay

Lipogenesis

Metabolic Engineering

Lipid droplet

Metabolic pathway

10.1007/s00253-021-11354-3

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Citations (4)

Overview of a Surface-Ripened Cheese Community Functioning by Meta-Omics Analyses

PLoS ONE (2015)

Éric Dugat‐Bony Cécile Straub Aurélie Teissandier Djamila Onésime Valentin Loux

Cheese ripening is a complex biochemical process driven by microbial communities composed of both eukaryotes and prokaryotes. Surface-ripened cheeses are widely consumed all over the world and are appreciated for their characteristic flavor. Microbial community composition has been studied for a long time on surface-ripened cheeses, but only limited knowledge has been acquired about its in situ metabolic activities. We applied metagenomic, metatranscriptomic and biochemical analyses to an experimental surface-ripened cheese composed of nine microbial species during four weeks of ripening. By combining all of the data, we were able to obtain an overview of the cheese maturation process and to better understand the metabolic activities of the different community members and their possible interactions. Furthermore, differential expression analysis was used to select a set of biomarker genes, providing a valuable tool that can be used to monitor the cheese-making process.

Cheese ripening

10.1371/journal.pone.0124360

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Citations (125)

A Yarrowia lipolytica Strain Engineered for Pyomelanin Production

Microorganisms (2021)

Macarena Larroude Djamila Onésime Olivier Rué Jean‐Marc Nicaud Tristan Rossignol

The yeast Yarrowia lipolytica naturally produces pyomelanin. This pigment accumulates in the extracellular environment following the autoxidation and polymerization of homogentisic acid, a metabolite derived from aromatic amino acids. In this study, we used a chassis strain optimized to produce aromatic amino acids for the de novo overproduction of pyomelanin. The gene 4HPPD, which encodes an enzyme involved in homogentisic acid synthesis (4-hydroxyphenylpyruvic acid dioxygenase), was characterized and overexpressed in the chassis strain with up to three copies, leading to pyomelanin yields of 4.5 g/L. Homogentisic acid is derived from tyrosine. When engineered strains were grown in a phenylalanine-supplemented medium, pyomelanin production increased, revealing that the yeast could convert phenylalanine to tyrosine, or that the homogentisic acid pathway is strongly induced by phenylalanine.

Homogentisic acid

Yarrowia

Transamination

Orcinol

Strain (injury)

10.3390/microorganisms9040838

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Citations (16)

Oncogenic mutant of Gα12 stimulates cell proliferation through cycloxygenase-2 signaling pathway

Oncogene (1999)

Jonathan M. Dermott MV Ramana Reddy Djamila Onésime E. Premkumar Reddy N. Dhanasekaran

Gq alpha subunit

10.1038/sj.onc.1203345

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Citations (27)