Javad Heshmati

University of Ottawa

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Mojgan Morvaridzadeh

Université de Sherbrooke

Mahdi Sepidarkish

Babol University of Medical Sciences

Farzad Shidfar

Iran University of Medical Sciences

Nazli Namazi

Tehran University of Medical Sciences

Siavash Fazelian

Shahrekord University of Medical Sciences

Farnaz Farsi

Iran University of Medical Sciences

Elnaz Daneshzad

Jahrom University of Medical Sciences

Ana Beatriz Pizarro

Fundación Valle del Lili

Motahareh Hasani

Golestan University of Medical Sciences

Mehran Rahimlou

Zanjan University of Medical Sciences

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Tehran University of Medical Sciences

150

Iran University of Medical Sciences

110

Shahid Beheshti University of Medical Sciences

Kermanshah University of Medical Sciences

Isfahan University of Medical Sciences

Tabriz University of Medical Sciences

University of Tehran

Jahrom University of Medical Sciences

Alborz University of Medical Sciences

National Nutrition and Food Technology Research Institute

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Evaluating macro‐ and micronutrients and food groups intake with the risk of developing inflammatory bowel disease: Is there any association?

Food Science & Nutrition (2022)

Farnaz Farsi Negin Tahvilian Azadeh Heydarian Sara Karimi Sara Ebrahimi

Growing clinical evidence represented that certain dietary components are involved in inflammatory bowel disease (IBD) development and progression. This research, therefore, aimed to evaluate whether there exists any relationship between nutrients and IBD. This case-control study from 2017 to 2019 was performed on 145 newly diagnosed IBD patients and 145 BMI-, sex-, and age-matched healthy controls who were recruited from a hospital clinic. A validated 168-item food frequency questionnaire was completed by each participant. Anthropometric measurements and physical activity levels were measured for all participants. Stata software was used to analyze all data. Of the 234 study individuals who participated, 112 were IBD patients and 122 were healthy people. The higher amount of seafood and cholesterol was related to an increased risk of IBD and ulcerative colitis development; however, individuals who had a higher intake of calcium were less likely to have Crohn's compared to the healthy group. There was a positive relation between honey and jam, seafood, organ meats, salt, fruits on trees, fruit juice, olives, and nuts and the probability of IBD, but there was a negative association between refined grains, potatoes, salty snacks, legumes, dairy, and cruciferous and the probability of IBD. Higher consumption of seafood and cholesterol was positively connected with a higher risk of IBD development in the current case-control study. A substantial association was seen between honey and jam, seafood, organmeats, salt, fruit on trees, fruit juice, olives, and nut consumption and IBD developement.

Cruciferous vegetables

10.1002/fsn3.2988

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Citations (6)

High-Density Lipoprotein Metabolism and Function in Cardiovascular Diseases: What about Aging and Diet Effects?

Nutrients (2024)

Mojgan Morvaridzadeh Nada Zoubdane Javad Heshmati Mehdi Alami Hicham Berrougui

Cardiovascular diseases (CVDs) have become the leading global cause of mortality, prompting a heightened focus on identifying precise indicators for their assessment and treatment. In this perspective, the plasma levels of HDL have emerged as a pivotal focus, given the demonstrable correlation between plasma levels and cardiovascular events, rendering them a noteworthy biomarker. However, it is crucial to acknowledge that HDLs, while intricate, are not presently a direct therapeutic target, necessitating a more nuanced understanding of their dynamic remodeling throughout their life cycle. HDLs exhibit several anti-atherosclerotic properties that define their functionality. This functionality of HDLs, which is independent of their concentration, may be impaired in certain risk factors for CVD. Moreover, because HDLs are dynamic parameters, in which HDL particles present different atheroprotective properties, it remains difficult to interpret the association between HDL level and CVD risk. Besides the antioxidant and anti-inflammatory activities of HDLs, their capacity to mediate cholesterol efflux, a key metric of HDL functionality, represents the main anti-atherosclerotic property of HDL. In this review, we will discuss the HDL components and HDL structure that may affect their functionality and we will review the mechanism by which HDL mediates cholesterol efflux. We will give a brief examination of the effects of aging and diet on HDL structure and function.

High-density lipoprotein

Reverse cholesterol transport

10.3390/nu16050653

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Citations (8)

Omega-3 fatty acids supplementation and oxidative stress parameters: A systematic review and meta-analysis of clinical trials

Pharmacological Research (2019)

Javad Heshmati Mojgan Morvaridzadeh Saman Maroufizadeh Abolfazl Akbari Mahsa Yavari

Malondialdehyde

10.1016/j.phrs.2019.104462

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Citations (134)

The Effects of Probiotics or Synbiotics Supplementation in Women with Polycystic Ovarian Syndrome: a Systematic Review and Meta-Analysis of Randomized Clinical Trials

Probiotics and Antimicrobial Proteins (2018)

Javad Heshmati Farnaz Farsi Somaye Yosaee Maryam Razavi Mahroo Rezaeinejad

Synbiotics

Homeostatic model assessment

10.1007/s12602-018-9493-9

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Citations (60)

Effect of omega-3 fatty acid plus vitamin E Co-Supplementation on lipid profile: A systematic review and meta-analysis

Diabetes & Metabolic Syndrome Clinical Research & Reviews (2019)

Mahdi Sepidarkish Mojgan Morvaridzadeh Maryam Akbari‐Fakhrabadi Amir Almasi‐Hashiani Mahroo Rezaeinejad

Dyslipidemia

Lipid Profile

10.1016/j.dsx.2019.03.018

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Citations (30)

The association between fat mass and the risk of breast cancer: A systematic review and meta-analysis

Clinical Nutrition (2018)

Nazli Namazi Pardis Irandoost Javad Heshmati Bagher Larijani Leila Azadbakht

10.1016/j.clnu.2018.09.013

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Citations (21)

Effect of omega-3 fatty acids supplementation on cardio-metabolic and oxidative stress parameters in patients with chronic kidney disease: a systematic review and meta-analysis

BMC Nephrology (2021)

Siavash Fazelian Fatemeh Moradi Shahram Agah Akramsadat Hoseini Hafez Heydari

Abstract Background Omega-3 fatty acids ( FAs) have been suggested as a beneficial supplement in chronic kidney disease (CKD) patients, but the results of randomized clinical trials (RCTs) are controversial. We conducted a systematic review and meta-analysis to evaluate all the RCTs about the impact of omega-3 FAs supplementation on cardiometabolic outcomes and oxidative stress parameters in patients with CKD. Methods We performed a systematic database search in PubMed/MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Central, up to May 2020. We included all placebo-controlled randomized trials that assessed the effect of omega-3 FAs supplementation on any cardiometabolic outcomes : blood pressure, total cholesterol (TC), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) or triglycerides (TG) and oxidative stress parameters. Data were pooled using DerSimonian–Laird’s random-effects model. Results Finally, thirteen articles met the inclusion criteria for this review omega-3 FAs supplementation significantly decrease TC (SMD: -0.26; 95% CI: − 0.51, − 0.02; I 2 = 52.7%), TG (SMD: -0.22; 95% CI: − 0.43, − 0.02; I 2 = 36.0%) and Malondialdehyde (MDA) levels (SMD: -0.91; 95% CI: − 1.29, − 0.54; I 2 = 00.0%) and also significantly increase superoxide dismutase (SOD) (SMD: 0.58; 95% CI: 0.27, 0.90; I 2 = 00.0%) and Glutathione peroxidase (GPx) (SMD: 0.50; 95% CI: 0.14, 0.86; I 2 = 00.0%) activities. However our results show that omega-3 FAs supplementation have no significant effects on HDL, LDL and blood pressure. Conclusion This systematic review and meta-analysis supports current evidence for the clinical benefit of omega-3 FAs intake to improve cardiometabolic parameters in CKD patients. However, well-designed RCTs still needed to provide a conclusive picture in this field.

Malondialdehyde

10.1186/s12882-021-02351-9

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Citations (30)

Effect of omega-3 fatty acids supplementation on adipokines: a systematic review and meta-analysis of randomized controlled trials

Critical Reviews in Food Science and Nutrition (2021)

Mahdi Sepidarkish Gholamreza Rezamand Mostafa Qorbani Hafez Heydari M. Dulce Estêvão

Background Although a large body of literature reported the beneficial effects of omega-3 fatty acids (omega-3 FAs) consumption on adipokines levels, but recent findings from clinical trials are not univocal. The aim of this systematic review and meta-analysis was to evaluate the effect of omega-3 FAs supplements on adipokines.Methods We searched Medline, Web of Science, Scopus, Embase, and Cochrane Library from inception to August 2020 without any particular language limitations. Outcomes were summarized as standardized mean difference (SMD) with 95% confidence intervals (CIs) estimated from Hedge's g and random effects modeling.Results Fifty-two trials involving 4,568 participants were included. Omega-3 FAs intake was associated with a significant increase in plasma adiponectin levels (n = 43; 3,434 participants; SMD: 0.21, 95% CI: 0.04, 0.37; p = 0.01; I2= 80.14%). This meta-analysis indicates that supplementing participants with omega-3 fatty acids more than 2000 mg daily and more than 10 weeks resulted in a significant and more favorable improvement in plasma adiponectin levels. However, omega-3 FAs intake had no significant effect on leptin levels (SMD: −0.02, 95% CI: −0.20, 0.17, I2= 54.13%).Conclusion The evidence supports a beneficial effect of omega-3 FAs intake on serum adiponectin levels but does not appear to impact on leptin concentrations. Larger well-designed RCTs are still required to evaluate the effect of omega-3 FAs on leptin in specific diseases.

10.1080/10408398.2021.1915743

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Citations (11)

Supplementation with Riboflavin (Vitamin B₂) for Migraine Prophylaxis in Adults and Children: A Review

International Journal for Vitamin and Nutrition Research (2015)

Nazli Namazi Javad Heshmati Ali Tarighat‐Esfanjani

Abstract. Background and Aim: Migraine is a unilateral and pulsating headache associated with nausea, photophobia, vomiting, and sensitivity to light. Low vitamin B 2 can lead to mitochondrial dysfunction and may have an effect on migraine pathogenesis. The aim of the present study was to carry out a review of existing evidence regarding the effects of riboflavin (vitamin B 2 ) supplementation on migraine prophylaxis in adults and children. Material and Methods: We searched the databases of PubMed, Science Direct, Google Scholar, and Springer between 1990 and December 2013. Key words included vitamin B 2 , riboflavin, migraine, vomiting headache, and prevention. We limited our search to human studies in the English language. Review articles and abstracts from symposiums and conferences were excluded. Results: Finally, eleven eligible articles were found: seven involved studies with adults and four involved studies with children. The results indicated that supplementation with vitamin B 2 in adults can play a positive role in reducing the frequency and duration of migraine attacks with no serious side effects. Conclusions: It seems that riboflavin is a safe and well-tolerated option for preventing migraine symptoms in adults, however, there is insufficient evidence to make recommendations regarding vitamin B 2 as an adjunct therapy in adults and children with migraine.

B vitamins

10.1024/0300-9831/a000225

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Citations (32)

Would creatine supplementation augment exercise performance during a low carbohydrate high fat diet?

Medical Hypotheses (2020)

Mojtaba Kaviani Azimeh Izadi Javad Heshmati

Creatine

Augment

Exertion

10.1016/j.mehy.2020.110369

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Citations (2)