M. Sreelekshmy

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M. Karikalan

Indian Veterinary Research Institute

R. Somvanshi

Indian Veterinary Research Institute

A.M. Pawde

Indian Veterinary Research Institute

Ajay Sharma

Lovely Professional University

Rahul G. Kadam

Topiwala National Medical College & BYL Nair Charitable Hospital

S. Mohan

SRM Institute of Science and Technology

Z.A. War

Indian Veterinary Research Institute

Roshan Pathak

Tribhuvan University Teaching Hospital

A.G. Telang

Indian Veterinary Research Institute

R. B. Bind

Indian Veterinary Research Institute

Cooperative Institutions

Indian Veterinary Research Institute

Indian Council of Agricultural Research

All India Institute of Medical Sciences

Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences

Guru Angad Dev Veterinary and Animal Sciences University

Kerala Veterinary and Animal Sciences University

Indian Council of Medical Research

Pennsylvania State University

Chungnam National University

Tamil Nadu Veterinary and Animal Sciences University

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Spontaneous cutaneous lesions in equines with special reference to neoplasms: An etiopathological study

Indian Journal of Veterinary Pathology (2015)

M. Sreelekshmy Ksh. Achouba Singh Virender Singh Roshan Pathak A.M. Pawde

The aim of present study was to get a better insight to the prevalence of skin lesions specifically neoplasms in Indian horses. Out of the total 19 cases studied, squamous cell carcinoma and equine sarcoid were diagnosed in 8 and 4 cases, respectively. The remaining cases were diagnosed as chronic inflammatory lesions, granuloma and necrotizing dermatitis. Ultrastructurally, sarcoid sample revealed presence of fibroblasts with pleomorphic nuclei and abundance of RER with dilated cisternae. All these samples were screened for Bovine papilloma virus-1, -2 and-13 and Equus caballus papilloma virus-2, -3 and-4. Seven samples showed positivity for both BPV-1 and-2 while 3 samples for BPV-2 alone. In the squamous cell carcinoma samples, immunohistochemical expression of connexin 26 was attempted and positivity was observed in 4 of the 6 samples which are considered more invasive and metastatic.

10.5958/0973-970x.2015.00050.4

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Canine oral tumours: A report of five cases

Indian Journal of Veterinary Pathology (2018)

Z.A. War M. Sreelekshmy Mudasir Ahmad Shah M. Karikalan Pawan Kumar

The present study describes five cases of canine oral tumours presented in the veterinary polyclinic IVRI. Grossly, the tumour masses were observed as gingival enlargement or papillary growths with or without ulcerations.The biopsy samples were collected in 10% NBF for histopathological diagnosis. Histopathologically, one case of acanthomatous ameloblastoma and two cases each of odontogenic fibroma and malignant melanoma were diagnosed.

10.5958/0973-970x.2018.00027.5

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Vulvar squamous cell carcinoma in a cow: A case report

Indian Journal of Veterinary Pathology (2014)

M. Sreelekshmy Waseem A Tailie A.M. Pawde R. Somvanshi

A rare case of squamous cell carcinoma in vulva of an 11 years old cow was diagnosed. Grossly, the growth was large, ulcerated, bleeding and occupying the whole vulva. The biopsy examination revealed well differentiated squamous cell cords with hyperchromatia and keratin pearl formation. At places, hemorrhage, mononuclear cell infiltration and necrosis were observed. The tissue sample on PCR was found negative for BPV-1 and 2.

10.5958/0973-970x.2014.01191.2

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Papillary adenocarcinoma of sweat gland with multiorgan metastases in lion (Panthera leopersica)

Indian Journal of Veterinary Pathology (2018)

Rahul G. Kadam M. Karikalan Arvind Mathur M. Sreelekshmy S. Mohan

A big tumorous mass about 6 inches in diameter was observed on the ventral aspect of neck in a 23 years old lion. Histopathological examination of the biopsy sample revealed it to be adenocarcinoma involving sweat gland. The lion died after 10 days. Postmortem examination followed by histopathology of various organs revealed the neoplastic growth forming the acinar pattern with papillary projections not only in the dermis but also in intercostals skeletal muscles, lungs, liver, kidneys, spleen and intestinal wall. The nuclei of neoplastic cells were hyperchromatic and bizarre shaped with increased nucleus:cytoplasm ratio and had numerous mitotic figures. The neoplastic cells were also seen as emboli in blood vessels of these organs. The cytoplasm of the neoplastic cells was periodic acid-Schiff (PAS) positive. The pancytokeratin and proliferative cell nuclear antigen (PCNA) immune staining were positive in the neoplastic cells. Based on these observations the case was diagnosed as papillary adenocarcinoma of highly anaplastic grade with metastases.

Papillary adenocarcinoma

10.5958/0973-970x.2018.00030.5

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TP53 gene expression in benign and malignant canine mammary tumours

Indian Journal of Veterinary Pathology (2019)

M. Sreelekshmy Z.A. War M. Karikalan Divya Mohan S. Mohan

10.5958/0973-970x.2019.00028.2

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A case of concurrent pulmonary and renal cell carcinomas in a German shepherd dog

Indian Journal of Veterinary Pathology (2018)

M. Karikalan M. Sreelekshmy Aron Jacob Dileep Kumar Sharma Krishnan Mahendran

German Shepherd Dog

10.5958/0973-970x.2018.00029.9

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Studies on spontaneous pathological lesions in bovine and bubaline urinary bladders with reference to detection of Bovine Papillomaviruses (BPVs) and H-ras biomarker

Indian Journal of Veterinary Pathology (2017)

M. Sreelekshmy R. B. Bind Mugale Madhav Nilakanth C. Balachandran R. Somvanshi

Bovine papillomavirus

10.5958/0973-970x.2017.00059.1

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A case of hepato-renal syndrome associated with paratuberculosis in goat

Indian Journal of Veterinary Pathology (2018)

S. Vineetha Madhulina Maity Kiranjeet Singh Monalisa Sahoo M. Saminathan

Hepato-renal syndrome is a type of functional kidney failure due to acute or chronic liver diseases. A five year old female, crossbred goat was presented for post-mortem examination. On necropsy, icteric discoloration of carcass with enlarged liver, thickened jejunal and ileal mucosa and enlarged mesenteric lymph nodes were observed. Severe lipidosis of liver, hypertrophied hepatocytes, mononuclear cell infiltration of parenchyma and portal triads, fusion of villi, and extensive infiltration by mononuclear cells (epithelioid-macrophages, plasma cells and lymphocytes) and occasional giant cells were observed around a central caseated and calcified mass surrounded by fibrous tissue proliferation in the lamina propria of intestine. Calcification of the mesenteric lymph node was confirmed by Von Kossa staining as dark brown to black deposits. Severe glomerular and tubular degeneration, necrosis and presence of bile casts were observed in kidney, which was confirmed by Hall's staining. Diffuse golden yellow hemosiderin pigment deposits were observed in the splenic parenchyma, which wasconfirmedbyPerl's Prussianbluestainingasbluishblackpigments. Ziehl-Neelsenstainingrevealedacid-fastbacilli inthelamina propria of intestine. Immunohistochemistry (IHC) using anti-M. aviumsubspp. paratuberculosis immune serum showed positive brown signals intracellularly in the macrophages and epithelioid cells in the lamina propria of intestine. Demonstration of acid-fast organism and IHC confirmed paratuberculosisinfection and the cascade of injury consequent to the disease might have resulted in hepato-renal syndrome and death of the affected animal.

10.5958/0973-970x.2018.00024.x

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A combined outbreak of Clostridial enterotoxemia and HCN poisoning in laboratory rabbits

Indian Journal of Veterinary Pathology (2019)

R. Somvanshi M. Sreelekshmy Viswas Konasagara Nagaleekar A.G. Telang R. S. Singh

10.5958/0973-970x.2019.00007.5

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