Lorena Airaghi

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

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Anna Catania

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

A. Orsatti

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Marina Baldini

Azienda Sanitaria Unità Locale di Reggio Emilia

Silvia Fargion

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

James M. Lipton

Toronto General Hospital

Maria Grazia Manfredi

University of Milan

Rosa Lombardi

University of Milan

Anna Ludovica Fracanzani

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

C Zanussi

University of Milan

Gabriele Maffi

University of Milan

Cooperative Institutions

University of Milan

138

Ospedale Maggiore

105

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

104

Istituti di Ricovero e Cura a Carattere Scientifico

University of Verona

Sapienza University of Rome

Vita-Salute San Raffaele University

Luigi Sacco Hospital

Azienda Ospedaliera Universitaria Integrata Verona

Ferrari (Italy)

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Prevalence of metabolic syndrome in long-term survivors of hematopoietic stem cell transplantation

Bone Marrow Transplantation (2008)

C. Annaloro P. Usardi Lorena Airaghi Valeria Giunta Stella Forti

Resistin

Univariate analysis

10.1038/sj.bmt.1705972

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Citations (96)

The Anticytokine Neuropeptide α-Melanocyte-Stimulating Hormone in Synovial Fluid of Patients with Rheumatic Diseases: Comparisons with Other Anticytokine Molecules

NeuroImmunoModulation (1994)

Anna Catania Valeria Gerloni S Procaccia Lorena Airaghi Maria Grazia Manfredi

The aim of this study was to determine if the anticytokine neuropeptide α-melanocyte-stimulating hormone (α-MSH) occurs, along with interleukin 1 receptor antagonist (IL-1ra) and soluble tumor necrosis factor receptor (sTNFr), in synovial fluid of patients with rheumatoid arthritis (RA), juvenile chronic arthritis (JCA), or osteoarthritis. The data show that α-MSH does occur in the synovial fluid and its concentrations are greater in patients with RA than in those with osteoarthritis. Synovial fluid concentrations of IL-1ra and sTNFr were likewise greater in RA. Further, concentrations of α-MSH, IL-1ra, and sTNFr were greater in patients with polyarticular/systemic-onset JCA than in those with pauciarticular disease, that is in patients with greater joint inflammation. Concentrations of α-MSH were greater in synovial fluid than in plasma in a substantial proportion of patients, suggesting local production of the peptide; this is the first indication that the anticytokine molecule α-MSH is produced within a site of inflammation. Further, it appears that local production of α-MSH is induced particularly in those arthritic joints that have more intense inflammatory reactions. This finding, combined with previous evidence of the marked anti-inflammatory activity of α-MSH, suggests that the peptide acts locally to modulate proinflammatory influences in rheumatic diseases.

Melanocyte-stimulating hormone

10.1159/000097183

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Citations (52)

Resistance of beta-endorphin to dexamethasone inhibition in parkinson's and alzheimer's diseases

International Journal of Neuroscience (1991)

Lorena Airaghi Anna Catania Cristina Gramigna Maria Grazia Manfredi M. Franceschi

AbstractThe response of plasma beta-endorphin (beta-EP) to dexamethasone suppression was studied in 14 patients with Alzheimer's disease (AD), 14 patients with Parkinson's disease (PD), and 13 age-matched controls in order to evaluate whether an impairment of the opiate system is present in these neurodegenerative disorders. Basal circulating beta-EP was in normal range in all subjects, although the mean concentration was slightly reduced in the patients compared to controls. After 1 mg dexamethasone given at 11:00p.m. the night before, plasma beta-EP concentration measured at 08:00 a.m. and 04:00 p.m. was not inhibited in AD and PD patients while it was significantly reduced in controls. Circulating ACTH and Cortisol were similar in patients and controls and a normal inhibition of plasma Cortisol after dexamethasone was observed in 13/14 AD and 12/14PD patients. The resistance of beta-EP to dexamethasone inhibition is consistent with previous clinical and experimental data indicating a disorder of the opiate system in brain degenerative diseases.Key Words: beta-endorphinAlzheimer's diseaseParkinson's diseasesdexamethasone suppression

beta-Endorphin

Basal (medicine)

BETA (programming language)

Endorphins

10.3109/00207459108985406

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Citations (4)

Subclinical cerebrovascular disease in NAFLD without overt risk factors for atherosclerosis

Atherosclerosis (2017)

Lorena Airaghi Mario Rango Diletta Maira Valentina Barbieri Luca Valenti

Subclinical infection

10.1016/j.atherosclerosis.2017.11.012

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Citations (24)

Extrapulmonary tuberculosis: an unusual presentation in an immunocompetent patient

BMJ Case Reports (2015)

Rosa Lombardi Serena Pelusi Lorena Airaghi Silvia Fargion

A 50-year-old Brazilian woman was admitted to our department because of pelvic pain irradiated to the lower left limb, ipsilateral ankle swelling and progressive weight loss. Doppler ultrasound demonstrated deep venous femoropopliteal thrombosis, while a thorax–abdomen CT scan showed multiple solid hypodense pulmonary lesions, a large hypodense lesion in the iliopsoas muscles bilaterally and a complex cystoid lesion at the hepatic hilum. These findings were better characterised as active inflammatory colliquated lymph nodes by positron emission tomography and echo-guided percutaneous fine-needle aspiration of the left iliopsoas abscessual lesion finally allowed the diagnosis of tubercular infection with positive cultures for Mycobacterium tuberculosis complex.

Iliopsoas

10.1136/bcr-2014-207146

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Citations (7)

Liver function tests do not predict liver damage in diabetes. Analysis of liver steatosis and fibrosis by transient elastography in routine diabetes care

Digestive and Liver Disease (2018)

Rosa Lombardi Lorena Airaghi V. Borroni C. Bertelli L. Burdick

Transient elastography

Steatosis

Liver disease

10.1016/j.dld.2018.01.069

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Citations (0)

Osteopathy in adult patients with beta-thalassaemia major

Marina Baldini Stella Forti A. Orsatti Fabio Massimo Ulivieri Lorena Airaghi

Osteopathy

Beta thalassemia

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High‐dose intravenous immunoglobulin in the treatment of acute myocarditis. A case report and review of the literature

Journal of Internal Medicine (2002)

A. Tedeschi Lorena Airaghi Sandra L. Giannini L Ciceri Ferdinando Maria Massari

Abstract. Tedeschi A, Airaghi L, Giannini S, Ciceri L, Massari FM (IRCCS Ospedale Maggiore Policlinico, Milan, Italy). High‐dose intravenous immunoglobulin in the treatment of acute myocarditis. A case report and review of the Literature. J Intern Med 2002; 251 : 169–173. A few reports have suggested the beneficial effect of high‐dose intravenous immunoglobulin (IVIG) in the treatment of acute myocarditis and cardiomyopathy. We describe a 49‐year‐old woman in which acute myocarditis was diagnosed on the basis of clinical and echocardiographic findings. Conventional treatment with captopril and frusemide was administered; intravenous heparin and, subsequently, oral anticoagulants were added because of the appearance of an apical thrombus. On the fifth day of hospitalization, treatment with high‐dose (400 mg kg −1 day −1 ) IVIG was started and prosecuted for 5 days. A dramatic improvement of clinical conditions was observed, with increase of the left ventricular ejection fraction (LVEF) from 30% to 75% within 1 week. One year after the diagnosis the patient is in good health, with steady normal LVEF. The rapid recovery, which was immediately subsequent to the administration of high‐dose IVIG, suggests that this kind of treatment has been effective in our patient with acute myocarditis.

Acute myocarditis

10.1046/j.1365-2796.2002.00929.x

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Citations (53)

A long story begun with a simple sore throat

Internal and Emergency Medicine (2010)

Giuseppina Pisano P. Bonara Paolo Rietti Lorena Airaghi L. Sinigaglia

Myopericarditis

Transthoracic echocardiogram

Sinus tachycardia

Interventricular septum

Sore throat