Elena De Matteo

Consejo Nacional de Investigaciones Científicas y Técnicas

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María Victoria Preciado

Hospital General de Niños Ricardo Gutierrez

Paola Chabay

Hospital General de Niños Ricardo Gutierrez

Pamela Valva

Hospital General de Niños Ricardo Gutierrez

Mario Alejandro Lorenzetti

Consejo Nacional de Investigaciones Científicas y Técnicas

Melina Cohen

University of Buenos Aires

Cristina Galoppo

Hospital General de Niños Ricardo Gutierrez

Carol Lezama

Hospital General de Niños Ricardo Gutierrez

Marcela Galoppo

Hospital General de Niños Ricardo Gutierrez

Aldana Vistarop

Hospital General de Niños Ricardo Gutierrez

Paola Casciato

Hospital Italiano de Buenos Aires

Cooperative Institutions

Hospital General de Niños Ricardo Gutierrez

101

Consejo Nacional de Investigaciones Científicas y Técnicas

University of Buenos Aires

Hospital Italiano de Buenos Aires

Hospital Universitario Austral

Hospital de Clínicas "José de San Martín"

Instituto de Salud Carlos III

Hospital Británico de Buenos Aires

Centro Científico Tecnológico - San Juan

Experimental Medicine and Biology Institute

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New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans

PLoS ONE (2017)

María Eugenia Inzaugarat Elena De Matteo Plácida Baz Diego Lucero C. Garcia

Introduction The immune system acts on different metabolic tissues that are implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Leptin and linoleic acid have the ability to potentially affect immune cells, whereas curcumin is a known natural polyphenol with antioxidant and anti-inflammatory properties. Aims This study was designed to evaluate the pro-inflammatory and pro-oxidant effects of leptin and linoleic acid on immune cells from patients with NAFLD and to corroborate the modulatory effects of curcumin and its preventive properties against the progression of NAFLD using a high-fat diet (HFD)-induced NAFLD/nonalcoholic steatohepatitis mouse model. Results The ex vivo experiments showed that linoleic acid increased the production of reactive oxygen species in monocytes and liver macrophages, whereas leptin enhanced tumor necrosis factor-α (TNF-α) production in monocytes and interferon-γ production in circulating CD4+ cells. Conversely, oral administration of curcumin prevented HFD-induced liver injury, metabolic alterations, intrahepatic CD4+ cell accumulation and the linoleic acid- and leptin- induced pro-inflammatory and pro-oxidant effects on mouse liver macrophages. Conclusion Our findings provide new evidence for the therapeutic potential of curcumin to treat human NAFLD. However, the development of a preventive treatment targeting human circulating monocytes and liver macrophages as well as peripheral and hepatic CD4+ cells requires additional research.

10.1371/journal.pone.0172900

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Citations (59)

Changes in EBV Association Pattern in Pediatric Classic Hodgkin Lymphoma From a Single Institution in Argentina

Frontiers in Oncology (2019)

Elena De Matteo Mercedes García Lombardi María Victoria Preciado Paola Chabay

In classic Hodgkin lymphoma (cHL), Epstein Barr virus (EBV) association varies worldwide. Aims: Our aim was to analyze EBV association with pediatric cHL for the last 28 years. Methods: EBV presence was evaluated by EBERs in situ hybridization and LMP1 immunohistochemistry. Results: Until 2008, we found in pediatric cHL a similar percentage of EBV presence to those observed in adult cHL from developed populations. Nevertheless, in the last 8 years, an unexpected difference in cHL EBV association was proven, along with a slight bias of EBV association with the nodular sclerosis (NS) subtype. Concerning histological subtype distribution, even though MC still prevailed in the whole series, those cases diagnosed as NS showed a sustained rise from 1989 until today. Conclusion: Variations of EBV association of cHL related to geography, age, ethnicity, and histological type have been largely described when compared with different world regions, but interestingly, this single-center revised series brought to light the dynamic process behind the evolution of this relationship over time.

Nodular sclerosis

Association (psychology)

10.3389/fonc.2019.00881

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Citations (2)

Vulvar plasmablastic lymphoma in a HIV-positive child: a novel extraoral localisation

Journal of Clinical Pathology (2009)

Paola Chabay Elena De Matteo Mario Alejandro Lorenzetti María Paula Gutiérrez Marina Narbaitz

Plasmablastic lymphoma (PBL) has been characterised by the World Health Organization as a new entity. This report describes an unusual case of PBL in a 3-year-old HIV-infected patient showing a cutaneous vulvar lesion with 9 months of evolution and prolapsed vulvovaginal mucosa. Histopathological examination of a biopsy sample showed diffuse submucosal infiltration by large cells with a cohesive growth pattern, and round and vesicular nuclei with fine chromatin centrally or eccentrically placed with one or more prominent nucleoli. Immunohistochemical staining in neoplastic cells was positive for multiple melanoma oncogene (MUM1), CD138, CD45 and epithelial membrane antigen (EMA). The diagnosis was PBL, stage III. Epstein–Barr virus (EBV) expression was positive by EBV encoded RNAs in situ hybridisation. This is believed to be the third case of paediatric HIV-associated PBL reported in the literature, and the first with vulvar localisation, which is a new anatomical location for this entity.

Plasmablastic lymphoma

10.1136/jcp.2009.064758

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Citations (29)

Apoptosis markers in liver biopsy of nonalcoholic steatohepatitis in pediatric patients

Human Pathology (2008)

Pamela Valva Elena De Matteo Marcela Galoppo A. Pedreira G. Giacove

Steatosis

Steatohepatitis

10.1016/j.humpath.2008.04.022

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Citations (16)

Diagnóstico molecular en biopsias de sarcoma de Ewing y rabdomiosarcomas pediátricos: experiencia en el Hospital de Niños Dr. Ricardo Gutiérrez

Bioquímica y Patología Clínica/Bioquímica y patología clínica/Bioquímica y patología clínica (2021)

Carla Antonella Massone Sandra Colli Mercedes García Lombardi Elena De Matteo María Victoria Preciado

Introducción: los tumores de partes blandas representan el 6% de los cánceres pediátricos anuales, según el Registro Oncopediátrico Hospitalario Argentino. Para sarcoma de Ewing (SE) y rabdomiosarcoma (RMS) se describieron translocaciones cromosómicas específicas, aplicadas a la clasificación molecular, diagnóstico diferencial y/o pronóstico. Objetivos: realizar la clasificación molecular de casos con sospecha diagnóstica de SE y RMS y evaluar el impacto de conservación de biopsias sobre la integridad de ácidos nucleicos. Materiales y métodos: se enrolaron niños menores de 18 años con sospecha de SE y RMS. Se estudiaron biopsias de tumor primario, algunas conservadas a -70ºC y otras embebidas en parafina (FFEP) y, además, aspirados de médula ósea. Se extrajo el ARN con 1) Trizol y 2) Recover All Total Nucleic Acid Isolation. Se realizaron las técnicas de FISH (fluorescence in situ hybridization), RTPCR-secuenciación para EWS-FLI1[t(11;22)(q24;q12)]/EWS-ERG[t(21;22)(q22;q12)] en SE y PAX3-FOXO1[t(2;13) (q35;q14)]/PAX7-FOXO1[t(1;13)(p36;q14)] en RMS. Resultados: Se incluyeron pacientes con SE (n = 13) y RMS (n = 4). Se estudiaron 17 biopsias de tumor primario: 7 conservadas a -70ºC y 12 FFEP y 2 aspirados de médula ósea. Se detectó por FISH el rearreglo de EWRS1: 9/13 SE y FOXO1: 3/4 RMS. Se amplificó el gen PGK por RT-PCR y se obtuvo positivo en 8/12 biopsias FFEP y 7/7 muestras congeladas (5 biopsias y 2 aspirados medulares); se detectó RT-PCR en SE EWS-FLI1 en 7/8 muestras (2 tipo 1; 3 tipo 2; 1 tipo 4 y 1 translocación EWSexón7/FLI1exón4). En RMS se detectó FOXO1-PAX3 en 1/3 y FOXO1-PAX7, en 0/3.

10.62073/bypc.v85i2.137

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Demonstration of Epstein-Barr virus in carcinomas of various sites.

PubMed (2002)

Saúl Grinstein María Victoria Preciado Paolo Gattuso Paola Chabay William H. Warren

EBV is an etiological agent in infectious mononucleosis, is implicated in some malignant lymphomas and lymphoepithelioma-like carcinomas, and has been sporadically reported in carcinomas of the breast, lung, and other sites. We studied immunohistochemically benign and malignant tumors of the breast, lung, colon, and prostate and found EBV in some carcinomas of those sites. Also, EBV reactions were noted in hyperplasias and dysplasias, e.g., breast carcinomas in situ and prostatic intraepithelial neoplasia. Benign tumor counterparts were negative. PCR analysis of selected cases confirmed the presence of EBV. Our results suggest that EBV is not restricted to lymphoepithelioma-like carcinomas but may play an oncogenic role in frequent epithelial cancers and possibly also in hyperplasias and certain dysplasias preceding carcinomas.

Lymphoepithelioma-like carcinoma

Lymphoepithelioma

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Citations (171)

Granulomatous nephritis associated with R334Q mutation in NOD2.

PubMed (2007)

Silvia Meiorin Graciela Espada Christian Elías Costa Alejandra Tartara Elena De Matteo

Nephritis

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Citations (33)

Oncogene Expression in Tumour Cells of Pediatric Hodgkin's Disease in Argentina — Correlation with Epstein Barr Virus Presence

Pathology - Research and Practice (1998)

María Victoria Preciado Eva Cristóbal Javier Menárguez Juan Carlos Martinez Montero Blanca Diez

10.1016/s0344-0338(98)80008-3

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Citations (9)

Guía de diagnóstico y tratamiento del hígado graso no alcohólico. Asociación Argentina para el estudio de las enfermedades del hígado, año 2019.

Medicina-buenos Aires (2020)

E Fassio Melisa Dirchwolf Fernando J. Barreyro Raúl Adrover M. Inés Alonso

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Chronic hepatitis B: The interplay between intrahepatic lymphocyte population and viral antigens in relation to liver damage

Journal of Viral Hepatitis (2019)

Cecilia Graciela Giadans D Rios Beatriz Ameigeiras Adriana Pietrantonio Néstor Lucatelli

In Chronic hepatitis B (CHB) infection, virus and immune response interplay is thought to be responsible for pathogenesis. Yet, the impact of each immune cell population and viral protein expression in liver damage is still unknown. Our aim was to study the interplay between intrahepatic immune response and viral activity in relation to CHB liver damage. Immunostaining was performed in 29 liver biopsies from untreated CHB patients to characterize liver infiltrate [Th (CD4+), CTL (CD8+), Treg (FoxP3+), Th17 (IL-17A+) and Th1 (T-bet+)] and viral antigen expression (HBsAg and HBcAg). Inflammatory activity and fibrosis were assessed using the HAI and METAVIR scoring system. All studied populations were identified in the portal-periportal (P-P) areas with a CD4+ lymphocyte predominance, while only CD8+ and FoxP3+ cells were observed in the intralobular area. Both P-P CD4+ and intralobular CD8+ cell frequencies were increased among severe hepatitis cases. Concerning HBsAg and HBcAg expression, a mutually exclusive pattern was observed. HBcAg was mainly detected among HBeAg-positive patients and was associated with hepatitis severity and higher frequency of P-P FoxP3+, intralobular CD8+ and FoxP3+ cells. HBsAg was identified among HBeAg-negative cases with less severe hepatitis grade and lower frequency of P-P CD4+ and intralobular FoxP3+ lymphocytes. In conclusion, the HBV antigen profile expression seen during CHB infection may be reflecting different stages of viral replication which impacts the host immune response and liver damage process. While HBcAg might be an inducer of a regulatory microenvironment, the intralobular CTL population seemed to have a key role in hepatitis severity.

Liver damage

Hepatitis B

Viral Hepatitis

10.1111/jvh.13078

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Citations (9)