C. E. Capjack

University of Alberta

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W. Rozmus

University of Alberta

H. J. J. Seguin

University of Alberta

V. Yu. Bychenkov

P.N. Lebedev Physical Institute of the Russian Academy of Sciences

C. R. James

University of Alberta

A. V. Brantov

P.N. Lebedev Physical Institute of the Russian Academy of Sciences

R. Fedosejevs

University of Alberta

R. D. Sydora

University of Alberta

V. T. Tikhonchuk

Université de Bordeaux

R. Rankin

University of Alberta

R. Marchand

University of Alberta

Cooperative Institutions

University of Alberta

Lawrence Livermore National Laboratory

Centre National de la Recherche Scientifique

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

École Polytechnique

University of British Columbia

Université de Bordeaux

Osaka University

National Research Council Canada

Centre Lasers Intenses et Applications

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Enhancing discharge uniformity in a multi-kilowatt radio frequency excited CO2 slab laser array

Applied Physics Letters (1996)

James D. Strohschein W. D. Bilida H. J. J. Seguin C. E. Capjack

A computational model is reported which is able to accurately predict discharge uniformity in large-area electrodes for transverse rf-excited CO2 lasers. The model has been employed in the development of a multi-kW radial slab array. Shunt inductors are resonated directly with the discharge impedance, thereby achieving excellent discharge uniformity while eliminating the need for frequency stabilized power sources. Experimental results suggest the model will generally be of major assistance in optimizing large-area electrodes designs, and specifically in scaling slab laser systems to multi-kW levels.

Slab

10.1063/1.116242

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Citations (16)

Numerical study of effects of cellular nanostructure on scattered light

C. Liu C. E. Capjack W. Rozmus Kirat Pal Singh C. Backhouse

A three dimensional code for solving the set of Maxwell equations with the finite-difference time-domain method is developed to simulate the propagation and scattering of light in biological cells for realistic conditions. The numerical techniques employed in this code include the Yee algorithm, the absorbing boundary conditions, the total-field/scattered-field formulation, the discrete Fourier transformation and the near-to-far field transform with the equivalent electric and magnetic currents. The code is capable of simulating light scattering from cells with complex internal nanostructures at all angles. The effects of cellular nanostructure on the scattered light are studied. It is shown that changes in cellular nanostructures could cause significant changes in the scattered light at particular angles.

10.1109/icmens.2003.1221984

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Citations (2)

Charge carrier dynamics of a CO2 laser plasma in a magnetized cathode glow

Applied Physics Letters (1986)

Rajender Razdan C. E. Capjack H. J. J. Seguin

A Monte Carlo simulation of a magnetized cathode-glow region for a carbon dioxide laser discharge has been undertaken. The computational findings appear to confirm recent observations that the magnetic stabilization effect is due primarily to a Lorentz driven mixing motion of charge carriers at or near the cathode electrode surface.

Glow discharge

Lorentz force

10.1063/1.96852

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Citations (2)

A microfluidic device with on-chip optical waveguide interrogation of individual biological cells for medical diagnostics

Kamal Deep Singh C. Liu C. E. Capjack W. Rozmus C. Backhouse

We present a microfluidic device for on-chip optical analysis and characterisation of biological cells. We employ a novel waveguiding technique for detection and analysis of the cells. This waveguiding technique is particularly well suited to this since a number of unique characteristics of the optical waveguide come together to enable detailed analysis of the very low level of scattered light. We are interested in the analysis and characterisation of sub-wavelength features such as nuclei and mitochondria within living cells. Such nanoscale probing of intracellular matter promises to offer reliable diagnostic procedures for biological cells. Of particular interest are the mitochondria, since the size and number of these can provide useful information as to the health of the cell. Mitochondria are the organelles in which energy production takes place, and as such are of vital importance. Mitochondrial abnormalities are often associated with serious diseases including cancer.

Microfluidic chip

Waveguide

Organelle

Lab-on-a-Chip

10.1109/icmens.2003.1222026

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Citations (3)

Label-free and noninvasive optical detection of the distribution of nanometer-size mitochondria in single cells

Journal of Biomedical Optics (2011)

Xuantao Su Yuanyuan Qiu Leah A. Marquez‐Curtis Manisha Gupta C. E. Capjack

A microfluidic flow cytometric technique capable of obtaining information on nanometer-sized organelles in single cells in a label-free, noninvasive optical manner was developed. Experimental two-dimensional (2D) light scattering patterns from malignant lymphoid cells (Jurkat cell line) and normal hematopoietic stem cells (cord blood CD34+ cells) were compared with those obtained from finite-difference time-domain simulations. In the simulations, we assumed that the mitochondria were randomly distributed throughout a Jurkat cell, and aggregated in a CD34+ cell. Comparison of the experimental and simulated light scattering patterns led us to conclude that distinction from these two types of cells may be due to different mitochondrial distributions. This observation was confirmed by conventional confocal fluorescence microscopy. A method for potential cell discrimination was developed based on analysis of the 2D light scattering patterns. Potential clinical applications using mitochondria as intrinsic biological markers in single cells were discussed in terms of normal cells (CD34+ cell and lymphocytes) versus malignant cells (THP-1 and Jurkat cell lines).

Jurkat cells

Organelle

Single-Cell Analysis

10.1117/1.3583577

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Citations (27)

Permittivity of plasma and nonstationary theory of nonlocal transport

Journal of Experimental and Theoretical Physics (2005)

A. V. Brantov V. Yu. Bychenkov W. Rozmus C. E. Capjack

Collision frequency

Wavenumber

Landau damping

Kinetic Theory

10.1134/1.1995800

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Citations (6)

Two-dimensional simulation of a plasma KrF pulse compressor

Journal of Applied Physics (1983)

R. Marchand C. E. Capjack C. R. James

Results from a two-dimensional simulation of a KrF laser pulse compression to parameters relevant to laser-driven fusion are presented. The amplifying medium consists of a fully ionized hydrogen plasma cylinder. The plasma density can be adjusted so as to radially confine the laser beams and thus, alleviate the constraints on the input beam divergences. Energy transfer efficiencies of order 50% are possible for experimentally feasible laser and plasma parameters.

10.1063/1.332793

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Citations (4)

Electron dynamics in magnetized CO2 laser and He discharges

Journal of Applied Physics (1990)

A. H. Labun C. E. Capjack H. J. J. Seguin

The energy density of the electron flux in magnetized 30-Torr He and He:N2:CO2 dc glow discharges was obtained by Monte Carlo simulation of the cathode region. The application of transverse magnetic fields to the cathode region caused an increase in collisions. This effect became increasingly important in the second half of the cathode region, where magnetic trapping of high-energy electrons occurred. Ionization was enhanced in the cathode region as well as the negative glow, with maximal electron multiplication observed for magnetic field strengths of approximately 0.1 T. This suggests both that a lower cathode fall may be possible in a magnetized discharge and that the electric field reversal in the negative glow will be accentuated. Thus, magnetization of the cathode region may improve the electrical efficiency of CO2 lasers.

Torr

Cold cathode

10.1063/1.346279

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Citations (9)

Numerical simulation of gas flow in a magnetically stabilized coaxial laser discharge

Applied Physics B Photophysics and Laser Chemistry (1987)

V. A. Seguin C. E. Capjack H. J. J. Seguin

Coaxial

Real gas

10.1007/bf00693943

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Citations (0)

Measurements of light scattering in an integrated microfluidic waveguide cytometer

Journal of Biomedical Optics (2008)

Xuantao Su Kirat Pal Singh C. E. Capjack Jiří Petráček C. Backhouse

An integrated microfluidic planar optical waveguide system for measuring light scattered from a single scatterer is described. This system is used to obtain 2D side-scatter patterns from single polystyrene microbeads in a fluidic flow. Vertical fringes in the 2D scatter patterns are used to infer the location of the 90-deg scatter (polar angle). The 2D scatter patterns are shown to be symmetrical about the azimuth angle at 90 deg. Wide-angle comparisons between the experimental scatter patterns and Mie theory simulations are shown to be in good agreement. A method based on the Fourier transform analysis of the experimental and Mie simulation scatter patterns is developed for size differentiation.

Forward scatter

Multiangle light scattering

Fluidics

Waveguide

10.1117/1.2909670

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Citations (50)