Eleni Genitsaridi

University of Nottingham

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Natalia Trpchevska

Karolinska Institutet

Deborah A. Hall

University of Nottingham

Albi Dode

Universität Ulm

José L. Santacruz

University of Groningen

Nuwan Liyanage

University Hospital of Zurich

Matheus Lourenco

Maastricht University

Roshni Biswas

Rush University Medical Center

Constanze Riha

University of Zurich

Stefan Schoisswohl

Universität der Bundeswehr München

Christopher R. Cederroth

Karolinska Institutet

Cooperative Institutions

University of Nottingham

Rhodes University

Karolinska Institutet

University of Regensburg

Universität Ulm

Mario Negri Institute for Pharmacological Research

Nottingham Biomedical Research Centre

University Hospital Regensburg

Instituto de Investigación Biosanitaria de Granada

Klinik und Poliklinik für Psychiatrie und Psychotherapie

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European School for Interdisciplinary Tinnitus Research Screening Questionnaire

PsycTESTS Dataset (2019)

Eleni Genitsaridi Marta Partyka Silvano Gallus José A. López‐Escámez Martin Schecklmann

10.1037/t73305-000

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A Review and a Framework of Variables for Defining and Characterizing Tinnitus Subphenotypes

Brain Sciences (2020)

Eleni Genitsaridi Derek J. Hoare Theodore Kypraios Deborah A. Hall

Tinnitus patients can present with various characteristics, such as those related to the tinnitus perception, symptom severity, and pattern of comorbidities. It is speculated that this phenotypic heterogeneity is associated with differences in the underlying pathophysiology and personal reaction to the condition. However, there is as yet no established protocol for tinnitus profiling or subtyping, hindering progress in treatment development. This review summarizes data on variables that have been used in studies investigating phenotypic differences in subgroups of tinnitus, including variables used to both define and compare subgroups. A PubMed search led to the identification of 64 eligible articles. In most studies, variables for subgrouping were chosen by the researchers (hypothesis-driven approach). Other approaches included application of unsupervised machine-learning techniques for the definition of subgroups (data-driven), and subgroup definition based on the response to a tinnitus treatment (treatment response). A framework of 94 variable concepts was created to summarize variables used across all studies. Frequency statistics for the use of each variable concept are presented, demonstrating those most and least commonly assessed. This review highlights the high dimensionality of tinnitus heterogeneity. The framework of variables can contribute to the design of future studies, helping to decide on tinnitus assessment and subgrouping.

10.3390/brainsci10120938

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Citations (29)

An Albanian translation of a questionnaire for self-reported tinnitus assessment

Figshare (2021)

Eleni Genitsaridi Albi Dode Birkena Qirjazi Muntazir Mehdi Rüdiger Pryss

To our knowledge, there is no published study investigating the characteristics of people experiencing tinnitus in Albania. Such a study would be important, providing the basis for further research in this region and contributing to a wider understanding of tinnitus heterogeneity across different geographic locations. The main objective of this study was to develop an Albanian translation of a standardised questionnaire for tinnitus research, namely the European School for Interdisciplinary Tinnitus Research-Screening Questionnaire (ESIT-SQ). A secondary objective was to assess its applicability and usefulness by conducting an exploratory survey on a small sample of the Albanian tinnitus population. Three translators were recruited to create the Albanian ESIT-SQ translation following good practice guidelines. Using this questionnaire, data from 107 patients attending otolaryngology clinics in Albania were collected. Participants reporting various degrees of tinnitus symptom severity had distinct phenotypic characteristics. Application of a random forest approach on this preliminary dataset showed that self-reported hearing difficulty, and tinnitus duration, pitch and temporal manifestation were important variables for predicting tinnitus symptom severity. Our study provided an Albanian translation of the ESIT-SQ and demonstrated that it is a useful tool for tinnitus profiling and subgrouping.

10.6084/m9.figshare.14870132

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The spatial percept of tinnitus is associated with hearing asymmetry: Subgroup comparisons

Progress in brain research (2021)

Eleni Genitsaridi Theodore Kypraios Niklas K. Edvall Natalia Trpchevska Barbara Canlon

Percept

10.1016/bs.pbr.2021.04.006

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Citations (10)

Tinnitus Profiling in an Albanian Population (Preprint)

Albi Dode Eleni Genitsaridi Birkena Qirjazi Muntazir Mehdi Rüdiger Pryss

BACKGROUND Characteristics of tinnitus, the perception of sound in the absence of an external acoustic stimulus, can vary from one individual to another. This heterogeneity has been blamed for the lack of success in finding a cure. To our knowledge, no previous study on tinnitus in Albania has been published, although some studies in eastern Europe are available. A study investigating the characteristics of tinnitus in this region would be important, providing the basis for further research on tinnitus in Albania and contributing to a wider understanding of tinnitus heterogeneity across different geographic locations. OBJECTIVE The objective of this study was to develop an Albania translation of a standardized questionnaire for tinnitus research (the European School for Interdisciplinary Tinnitus Research-Screening Questionnaire - ESIT-SQ) and use it to investigate characteristics of tinnitus in the Albanian population. METHODS Three translators were recruited to create the Albanian ESIT-SQ translation following good practice guidelines for translating questionnaires. This questionnaire was subsequently used to collect data from people attending otolaryngology clinics in Albania. RESULTS Self-report data from 107 people with varying degrees of tinnitus severity were collected using the Albanian ESIT-SQ. Using a Random Forest approach, we found that self-reported hearing difficulty, tinnitus duration, tinnitus pitch, and temporal manifestation of tinnitus were predictive of tinnitus symptom severity (cross-validated accuracy of 0.64, confidence Interval 0.54-0.73). CONCLUSIONS Overall, our study in an Albanian sample demonstrated that the ESIT-SQ can be used to investigate phenotypical characteristics and subgroup distinctions.

10.2196/preprints.27152

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Impact of Temporomandibular Joint Complaints on Tinnitus-Related Distress

Frontiers in Neuroscience (2019)

Niklas K. Edvall Edis Gunan Eleni Genitsaridi Andra Lazar Golbarg Mehraei

There is increasing evidence of associations between the presence of temporomandibular joint (TMJ) disorders and tinnitus. It has been recently proposed that tinnitus patients with TMJ complaints could constitute a subtype, meaning a subgroup of tinnitus patients responsive to specific treatments. Tinnitus patients with TMJ complaints are often young women with somatosensory features of their tinnitus. Here, we investigate the socio-economic factors, phenotypic characteristics and psychological variables of tinnitus subjects from the Swedish Tinnitus Outreach Project, with (n=486) or without (n=1,996) TMJ complaints. The prevalence of TMJ complaints was greater in tinnitus subjects with severe tinnitus (36%) when compared to those with any tinnitus (19%), strongly indicating the contribution of TMJ problems to the severity of tinnitus. Comparing subgroups with or without TMJ complaints in the whole sample, differences were found regarding a large number of socioeconomic, phenotypic and psychological characteristics. Subjects with TMJ complaints were more often women, more often reported stress as the cause of tinnitus, were more severely affected by tinnitus, scored worse in measures of psychological well-being and life quality, and were more often affected by problems tolerating sounds, headache, vertigo/dizziness, and neck pain. In addition, they more often reported pulsating and tonal tinnitus, somatic modulation of tinnitus, and aggravation of tinnitus by loud sounds and stress. When focusing the analysis in subjects with tinnitus as a big problem using the Tinnitus Functional Index cut-off ≥ 48, or with severe tinnitus according to the Tinnitus Handicap Inventory cut-off ≥ 58, the impact of somatosensory modulations and stress on tinnitus were greater in subjects with TMJ complaints in comparison to those without. In light of these results, we hypothesize that stress could contribute to the co-occurrence of TMJ problems and tinnitus and also to the development of severe tinnitus. Our study supports the need of involving dental care and stress management in the holistic treatment of patients with severe tinnitus.

TMJ disorders

10.3389/fnins.2019.00879

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Low Evidence for Tinnitus Risk Factors: A Systematic Review and Meta-analysis

Journal of the Association for Research in Otolaryngology (2022)

Roshni Biswas Eleni Genitsaridi Natalia Trpchevska Alessandra Lugo Winfried Schlee

Identifying risk factors for tinnitus could facilitate not only the recommendations for prevention measures, but also identifying potential pathways for new interventions. This study reports the first comprehensive systematic review of analytical observational studies able to provide information about causality (i.e., case-control and cohort designs).

Causality

10.1007/s10162-022-00874-y

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Citations (34)

The spatial percept of tinnitus is associated with hearing asymmetry: subgroup comparisons

medRxiv (Cold Spring Harbor Laboratory) (2020)

Eleni Genitsaridi Theodore Kypraios Niklas K. Edvall Natalia Trpchevska Barbara Canlon

Abstract The spatial percept of tinnitus is hypothesized as an important variable for tinnitus subtyping. Hearing asymmetry often associates with tinnitus laterality, but not always. One of the methodological limitations for cross-study comparisons is how the variables for hearing asymmetry and tinnitus spatial perception are defined. In this study, data from two independent datasets were combined (n= 833 adults, age ranging from 20 to 91 years, 404 males, 429 females) to investigate characteristics of subgroups with different tinnitus spatial perception focusing on hearing asymmetry. Three principle findings emerged. First, a hearing asymmetry variable emphasizing the maximum interaural difference most strongly discriminated unilateral from bilateral tinnitus. Merging lateralized bilateral tinnitus (perceived in both ears but worse in one side) with unilateral tinnitus weakened this relationship. Second, there was an association between unilateral tinnitus and ipsilateral asymmetric hearing. Third, unilateral and bilateral tinnitus were phenotypically distinct, with unilateral tinnitus being characterized by older age, asymmetric hearing, more often wearing one hearing aid, older age at tinnitus onset, shorter tinnitus duration, and higher percentage of time being annoyed by tinnitus. We recommend that careful consideration is given to the definitions of hearing asymmetry and tinnitus spatial perception in order to improve the comparability of findings across studies.

Percept

10.1101/2020.05.05.20073999

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Doctoral Studies as part of an Innovative Training Network (ITN): Early Stage Researcher (ESR) experiences

Open Research Europe (2021)

Roshni Biswas Axel Schiller Chiara Casolani Elza Daoud Albi Dode

Background: The Marie-Skłodowska-Curie Actions’ (MSCA) Innovative Training Network (ITN) is a doctoral training programme jointly implemented by academic institutions and industries from countries across Europe and beyond. To our knowledge no study has examined the experience of students participating in MSCA-ITNs. This study aims to evaluate and report MSCA-ITN Early Stage Researcher (ESR) experiences. Methods: The Innovative Training Network - Evaluation Questionnaire (ITN-EQ) was developed to assess supervision, training, collaborations and experiences of ESRs and forwarded to two tinnitus-related ITNs and seven ITNs of other disciplines. Results: Key advantages identified included better career prospects, multidisciplinary research opportunities/ collaborations, international exposure, personal/ professional development, plus generous salaries and research budgets. However, lack of a common EU framework resulted in the experience being largely dependent on host institution, country and supervisor. Moreover, managing the dual requirements of ITNs and host institutions while completing a three-year PhD seemed challenging for most ESRs. ESR involvement in workshop and training school planning was desirable. More than 80% of ESRs rated the overall ITN experience favourably and 98.3% would recommend the same to prospective PhD students. Conclusions: This report could provide valuable insights in planning and management of future ITNs and could assist prospective students in their decision of joining an ITN for their PhD.

10.12688/openreseurope.13094.1

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Corrigendum: Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

Frontiers in Aging Neuroscience (2021)

Jorge Simões Elza Daoud Maryam Shabbir Sana Amanat Kelly K. S. Assouly

In the original article, there was an error.NMDA receptor antagonists (AM-101) have been discontinued in phase III for not meeting endpoints (van de Heyning et al., 2014).A correction has been made to section 6. Treatment Development, Subsection 6.4. Pharmacology-Based Interventions, paragraph 1 of the subsection.NMDA receptor antagonists (AM-101) did not meet the primary endpoint of improving minimum masking level in acute tinnitus in a phase II clinical trial but showed improvement for tinnitus loudness, annoyance, sleep difficulties, and tinnitus impact in patients with tinnitus after noise trauma or otitis media (Heyning et al., 2014).

Paragraph

10.3389/fnagi.2021.730758

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Citations (4)