Diamantis Almaliotis

Aristotle University of Thessaloniki

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Vasileios Karampatakis

Aristotle University of Thessaloniki

Stavroula Almpanidou

Aristotle University of Thessaloniki

Leonidas Karamitopoulos

Aristotle University of Thessaloniki

Thomas Siempis

Gartnavel General Hospital

Fotis Topouzis

AHEPA University Hospital

E. Nakos

424 General Military Hospital

Eleni P. Papadopoulou

Aristotle University of Thessaloniki

Pavlos Michailopoulos

424 General Military Hospital

Paschalina Giouleka

National and Kapodistrian University of Athens

Athanasios Karamitsos

Papageorgiou General Hospital

Cooperative Institutions

Aristotle University of Thessaloniki

AHEPA University Hospital

G. Papanikolaou General Hospital

Papageorgiou General Hospital

National and Kapodistrian University of Athens

Creative Commons

Democritus University of Thrace

University of Thessaly

Ippokrateio General Hospital of Thessaloniki

Athens Eye Hospital

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Evaluation of Clinical and Histological Outcomes of Adipose-Derived Mesenchymal Stem Cells in a Rabbit Corneal Alkali Burn Model

Stem Cells International (2021)

Diamantis Almaliotis Angelos Thomas Anastasia Komnenou Eleni Gounari Stavroula Almpanidou

To assess effects of adipose-derived mesenchymal stem cells (AMSCs) in corneal alkali injuries in an experimental animal model. Twenty white New Zealand rabbits were included in the study. The animal models were randomly divided into 2 groups. Rabbits in the AMSC group (

n = 10

) received an intrastromal, a subconjunctival injection, and topical instillation of 0.5 ml totally of phosphate-buffered saline (PBS) containing

2 \times 10^{6}

AMSCs. In the control group (

n = 10

), rabbits received only 0.5 ml of PBS using the same methods. A masked investigator measured the corneal sensation, anterior chamber Inflammation (ACI), and conjunctival congestion. Additionally, a blind histological and immunohistochemical evaluation was made. In the AMSC group, the central corneal sensation was increased whereas ACI and conjunctival congestion were reduced compared to the control group in the 28 days of follow-up (

p < 0.05

). A statistically significant difference (

p < 0.05

) was noted between the two groups as recorded in the above parameters. Histological analysis showed that pathological vascularization was markedly reduced in the AMSC group which was consistent with the absence of factor VIII in the immunohistochemistry sections. There is a trend towards improved clinical outcomes including corneal sensation as well as acceleration in the restoration of normal corneal architecture in corneal alkali burns treated with AMSCs, results that support the need for further research in the field.

10.1155/2021/6610023

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Analysis of central macular thickness in patients with dry Age related Macular Degenaration and cardiovascular risk factors

Stavroula Almpanidou Diamantis Almaliotis Eleni Papadopoulou Leonidas Karamitopoulos Fotis Topouzis

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The effects of thermal sources emitted infrared radiation (IR) on rabbit corneal and crystalline lens extracellular molecules and the influence of cyclooxygenase (COX) inhibition

Acta Ophthalmologica (2011)

Diamantis Almaliotis Panagiotis Dadoukis Vasileios Karampatakis George Karakioulakis E Papaconstantinou

Abstract Purpose To investigate the effect of acute and chronic exposure to IR on rabbit corneal and lens metalloproteinase‐2 (MMP‐2), MMP‐9 and glycosaminoglycans (GAGs) and the influence of COX inhibition. Methods Fourteen (14) New Zealand rabbits were used totally. Chronic exposure to IR included 4 month irradiation of 3 rabbits, whereas 3 animals were the control group. Regarding acute exposure, 8 rabbits were used, diclofenac sodium eye drops 0.1% were instilled in their right eyes and 4 of them were irradiated for 12 hours. By comparing the left irradiated with the left non‐irradiated eyes, the effect of IR exposure was investigated. COX inhibition role with and without IR exposure was determined, by comparing the left with the right eyes of the irradiated and the non‐irradiated rabbits separately.The cornea and lens were extracted, followed by gelatin zymography to determine MMP‐2 and MMP‐9 activity, GAGs isolation, measurement of uronic acids and electrophoresis on cellulose acetate membranes for GAGs analysis. Results Chronic IR exposure induced the activity of corneal and lens pro‐MMP‐2 activity but did not affect GAGs. Acute exposure increased corneal and lens pro‐MMP‐2 activity and lens heparan sulfate amount, whereas the use of diclofenac sodium was unable to influence these effects. Conclusion Corneal and lens acute and chronic IR exposure induced the activity of pro‐MMP‐2. Acute exposure, also, increased lens heparan sulfate amount.

Diclofenac Sodium

Sodium hyaluronate

10.1111/j.1755-3768.2011.212.x

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Randomized Controlled Trial Comparing Everting Sutures with a Lateral Tarsal Strip for Involutional Lower Eyelid Entropion

Ophthalmology and Therapy (2019)

E. Nakos Kostas Boboridis Angeliki A. Kakavouti-Doudou Diamantis Almaliotis Christos Sioulis

To compare the anatomical and functional outcome and changes in the quality of life (QoL) over time of the lateral tarsal strip (LTS) versus the Quickert everting sutures (ES) for the repair of primary involutional lower eyelid entropion. Forty-five patients (54 eyes) with primary involutional lower eyelid entropion were recruited in a prospective randomized clinical trial over 3-year period. Twenty-six eyes were randomized to the LTS technique and 28 to the ES procedure. Primary outcome was the anatomical correction of the eyelid at the final assessment in 1 year. Secondary outcomes were function and symptoms assessment with a QoL questionnaire at 6 months. Fisher's exact test was used for the statistical analysis of success rate and gender study and Mann–Whitney U test and logistic regression analysis were used for age study. The Wilcoxon and Mann–Whitney U tests were used for the analysis of the National Eye Institute Visual Functioning Questionnaire-25 (NEI VFQ-25). At the 6-month follow-up, 25 eyes (96.2%) of the LTS group and 20 (71.4%) of the ES group had favorable outcome (P = 0.025). There were one and eight eyes, respectively, with early recurrence. At the final 12-month evaluation, 23 eyes (88.5%) in the LTS group and 16 eyes (57.1%) in the ES group were successful. Three (11.5%) and 12 (42.9%) eyes respectively showed postoperative recurrence. There was a statistically significant difference between the two groups (P = 0.015) for the primary outcome, whereas age and gender did not influence success. The NEI VFQ-25 showed statistically significant subjective improvement from baseline in most categories of the QoL. No significant difference between the two procedures was detected at 6 months. This study suggests that the LTS procedure has a superior surgical success rate and reduction of symptoms compared with the ES for the repair of involutional lower eyelid entropion. Both procedures showed similar improvement of the postoperative QoL. International Clinical Trials Registry Platform identifier: ACTRN12616000620426.

Entropion

10.1007/s40123-019-0189-3

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Correlation between color vision, visual acuity, contrast sensitivity and photo-stress recovery in the visually impaired. A cross-sectional study

Annals of Medicine and Surgery (2023)

Diamantis Almaliotis Stavroula Almpanidou Theodosis Chatzimbalis Anna Nikolaidou Persefoni Talimtzi

To investigate the correlation of colour vision, visual acuity, contrast sensitivity, and photostress recovery time test scores in visually impaired patients.

Visual Impairment

10.1097/ms9.0000000000001522

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Dyschromatopsy and visual allesthesia in a glioblastoma multiforme patient

Acta Ophthalmologica (2011)

Diamantis Almaliotis Antonios Reptsis Iordanis Demirtzoglou Αθανάσιος Ν. Νικολακόπουλος Vasileios Karampatakis

Abstract Purpose To report a case of glioblastoma multiforme with dyschromatopsy and visual allesthesia. Methods A 46 – year old male presented in emergency ophthalmologic department with recent color perception disturbance complaints noticed during his occupation (PC technician). The patient underwent a thorough ophthalmological examination and then he was referred to the neurological department for further management. Results Patient presented an atypical pattern of color perception disturbance revealed by color blindness Ishihara test and Fransworth‐Munsell D‐15 test. Patient’s best corrected visual acuity decreased progressively during his hospitalization and he also experienced paroxysmally illusory left homonymous transpositions of subjects viewed in the right homonymous visual field. The transposition occurred from normal to the defective visual field. This condition is called visual allesthesia. The visual field evaluation revealed homonymous left hemianopsia and magnetic resonance imaging revealed glioblastoma multiforme localized in the right occipital lobe with compressive effects on the occipital horn of the right lateral ventricle. The diagnosis was confirmed by biopsy. Conclusion A thorough ophthalmologic and neuro‐imaging control in patients with sudden color perception disturbance is suggested. Visual allesthesia is a rare condition experienced by patients with temporal or occipital cortex damage. Glioblastoma multiforme localized in the right occipital lobe was the underlined causative lesion.

Occipital lobe

Visual Disturbance

Hemianopsia

Fundus (uterus)

Cortical blindness

Blindsight

10.1111/j.1755-3768.2011.2263.x

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Causes of low vision in a Greek population

Acta Ophthalmologica (2021)

Stavroula Almpanidou Diamantis Almaliotis Leonidas Karamitopoulos Fotis Topouzis Georgios Labiris

Purpose Low vision (LV) is one of the major causes affecting detrimentally the quality of life of individuals. There are various underlying ocular pathologies resulting in LV. The purpose of this study is to determine the prevalence of the main causes of low vision in a population attended a university outpatient unit in Greece. Methods The records of all patients within a timeframe of about 18 months period were retrospectively reviewed. In this study, individuals with best‐corrected visual acuity (BCVA) of 3/60 to <6/18 were characterized as having LV, according to the World Health Organization (WHO) definition of LV. Results Two hundred thirty‐six LV patients were included—114 (48.3%) were males and 122 (51.7%) females. The age of patients ranged from ten to ninety‐nine, with a mean age of 70.9 ± 18.9 years. BCVA ranged from 1.32 logMAR to 0.33 logMAR, with a mean VA of 0.7152 ± 0.3146 logMAR in the better eye. The distribution of LV causes in this population was the following: Age‐related macular degeneration (AMD) accounting for 50.0% of the cases (118/236), diabetic retinopathy (DR) 19.9% (47/236) and glaucoma 7.2% (17/236). Other causes of LV included retinitis pigmentosa in a percentage of 5.3% and other hereditary retinal diseases (3%), previous retinal detachment (2.5%), other maculopathies (2.1%) and various other ocular diseases (9.7%). Out of 118 patients with AMD, 75 (64.1%) had the dry form and 42 (35.9%) had the wet form of the disease and among patients with diabetic retinopathy as underlying cause of LV, 31 (68.9%) had the proliferative and 14 (31.1%) had the non‐proliferative form of the disease. Conclusions Age‐related macular degeneration, diabetic retinopathy and glaucoma constituted the three main causes of low vision in the study population, followed by other ocular diseases.

Medical record

10.1111/j.1755-3768.2020.0254

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Visual Allesthesia in a Patient with Glioblastoma Multiforme

Open Journal of Ophthalmology (2012)

Antonios Reptsis Iordanis Demirtzoglou Αθανάσιος Ν. Νικολακόπουλος Diamantis Almaliotis Angeliki Cheva

Purpose: To report a rare case of visual allesthesia in a patient with glioblastoma multiforme. Material - Methods : A 46 – year old male presented in emergency ophthalmologic department complaining for difficulties in performing tasks related to color discrimination in his occupation (PC technician). The patient underwent a thorough ophthalmological examination and then he was referred to the neurological department for further evaluation. Results: The patient presented an atypical pattern of color perception disturbance. His best corrected visual acuity decreased progressively during hospitalization. He also experienced visual allesthesia paroxysmally (illusory left homonymous transpositions of subjects viewed in the right homonymous visual field). The visual field evaluation revealed homonymous left hemianopsia. Magnetic resonance imaging revealed glioblastoma multiforme confirmed by biopsy. Conclusions: A thorough ophthalmological and neuro-imaging control is suggested in patients with sudden color perception disturbance. Patients with temporal or occipital cortex damage may experience visual allesthesia.

Visual Disturbance

Hemianopsia

Technician

10.4236/ojoph.2012.23021

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Citations (2)

Effects of acute in vivo exposure of rabbit cornea and conjunctiva to artificial sunlight

Acta Ophthalmologica (2013)

Diamantis Almaliotis Efterpi Varsamidou A. Goulas Soultana Markopoulou Georgia Karayannopoulou

Abstract Purpose Acute exposure of ocular and periocular tissues to natural or artificial light can induce inflammatory responses, attributed mainly to the UVB range of the spectrum. In this study, we have used a model of acute exposure of rabbit eyes to artificial sunlight, to study possible alterations in the architecture of corneal and conjunctival tissue as well as in the expression of tumor necrosis factor (TNF) and platelet activating factor (PAFR) in these tissues. Methods New Zealand albino rabbits were immobilized opposite a 300W light bulb and exposed for 30 min to an equivalent of 7,500 Jm‐1 of UVB irradiation, in the range of the reported threshold for corneal damage. Corneal and conjunctival tissue samples were removed from exposed eyes at 2, 6 and 24 hours following the end of the exposure to the bulb light, and were subsequently processed for histochemical staining or RNA extraction. The gene expression of TNF and PAFR was monitored with RT‐PCR. Results Histopathological examination revealed minor changes in the corneal architecture. A distinctive eosinophilic infiltration was observed, as early as 2 hrs post‐exposure, in the conjunctiva of the third eyelid, both in the epithelial layer and the basal lamina, which had apparently subsided by t = 24 hrs. The gene expression of TNF and PAFR was monitored with RT‐PCR. Conclusion Acute exposure to artificial sunlight caused a marked accumulation of eosinophils in rabbit conjunctival epithelium but only minor changes in the corneal epithelium. Neither TNF nor PAFR gene expression was affected appreciably

Infiltration (HVAC)

Cellular infiltration

10.1111/j.1755-3768.2013.s025.x

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Peripheral corneal ulceration associated with rheumatoid arthritis

Acta Ophthalmologica (2011)

Diamantis Almaliotis Vasileios Konidaris Konstantinos Stamoulas Aspasia Georgala Vasileios Karampatakis

Abstract Purpose To report a case of a patient with rheumatoid arthritis (RA) and associated peripheral corneal ulceration. Methods A 60 year old woman with RA diagnosed 15 years ago, and under immunosuppressive therapy (IV abatacept 250 mg / month), demonstrated blurring of vision in her right eye. Visual acuity was 6 / 10 in the right eye and 10 / 10 in the left eye. Slitlamp examination revealed a paracentral superior corneal melt in the right eye. Anterior chamber reaction was 2+. Laboratory investigations revealed negative Extractable Nuclear Antigens (ENA) Screen ELISA Test, negative anti‐Sm antibodies, positive serum IgG and IgA reactivities, and IgE and IgM within normal levels. Evaluation for the underlying connective tissue disease revealed highly elevated Rheumatoid Factor and C‐reactive protein (CRP) (955 IU/ml, normal range: 0‐20 IU/ml, and 1.59 mg/dl, normal range: 0‐0.8 respectively). The patient underwent extensive treatment with topical tobramycin and lubricants and oral prednisolone 60 mg/day with tapering doses, and methotrexate p.os. 15 mg / week was added. Results The condition was improved within a few days after the initiation of prednisolone treatment. Re‐epithelization occurred one week after the onset of the treatment and only punctate fluorescein dye uptake was detected in the margins of the lesion. Conclusion The effective control of the underlying disease and early diagnosis of the dry eye syndrome in RA patients may prevent serious corneal complications, such as corneal ulceration, which are difficult to treat. The initiation of treatment with steroids and immunosuppresants was found to halt the progression of keratolysis and assist re‐epithelization.

Prednisolone

Rheumatoid factor

10.1111/j.1755-3768.2011.412.x

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