The Sunshine and Love Free Clinic is China’s first and only student-run free clinic. Two successful outreach projects to a rural ethnic village, Dimen, by the volunteers of the clinic took place in 2015: a pilot project focusing on women’s health, and a larger medical service trip focusing on record building and clinical visits. While the indigenous healing is a great recourse, four major health-related issues were identified through these projects: women’s health and reproductive health; chronic illness care; a lack of formal medical training among the village clinic staff; and a lack of patient record system. This article proposes that a summer service trip model can be utilized by student-run free clinics in China to tackle these issues, and provide sustainable intermittent long term health care for the rural ethnic China in a culturally sensitive manner.
To explore the effects of reconstructing method (narrow gastric tube (NGT) versus whole stomach (WS)) on health-related quality of life (HRQL) in patients during a 3-year follow-up.In a prospective randomized single-center study from 2007 to 2008, 104 patients underwent esophagectomy for cancer. They were divided into NGT (n = 52) and WS (n = 52) groups. To assess HRQL, a questionnaire in references to EORTC-QLQ-C30 and QLQ-OES18 was administered at 3 weeks, 6 months, 1 year, 2 year and 3 years post-operation. Their clinical data were collected prospectively and follow-up was performed regularly.The patients in the NGT group reported significantly (P < 0.05) better average scores of HRQL at both 6 months and 1 year.However, no significant difference in average scores of HRQL was found at 3 years. Patients in the NGT group reported significantly (P < 0.05) better scores of reflux at 3 weeks, 6 months and 1 year.Nausea was the only item with significant difference on HRQL at 2 years and 3 years.No significant difference existed between two groups with regards to cumulative survival rate at 3 years.No significant difference existed between two groups with regards to cumulative survival rate at 3 years. The patients with gastric tube reconstruction after oncologic esophagectomy present better HRQL.Further studies are warranted to perform survival analysis beyond 3 year post-operation.
Ten new (1–10) and 26 known (11–36) compounds were isolated from Penicillium griseofulvum MCCC 3A00225, a deep sea-derived fungus. The structures of the new compounds were determined by detailed analysis of the NMR and HRESIMS spectroscopic data. The absolute configurations were established by X-ray crystallography, Marfey’s method, and the ICD method. All isolates were tested for in vitro anti-food allergic bioactivities in immunoglobulin (Ig) E-mediated rat basophilic leukemia (RBL)-2H3 cells. Compound 13 significantly decreased the degranulation release with an IC50 value of 60.3 μM, compared to that of 91.6 μM of the positive control, loratadine.
Objective To establish quality standard for Jiangtang Tongluo Granule. Method Rhizoma Anemarrhenae, Herba Gynostemmae and Radix Salviae Miltiorrhiizae were identified by TLC. Sarsasapogenin was determined by TLC-scanning. Results Rhizoma Anemarrhenae, Herba Gynostemmae and Radix Salviae Miltiorrhiizae can be identified by TLC. A good line relationship was noted at the range of 1.0～5.0 μg of sarsasapogenin (r =0.9996). The average recovery was 98.78%, and RSD was 0.73%. Conclusion The established methods can be used for the quality control of Jiangtang Tongluo Granule.
Topic: 4. Acute myeloid leukemia - Clinical Background: The prognosis of relapsed/refractory acute myeloid leukemia (R/R AML) is still poor and the treatment remains a challenging issue. Aims: To explore the efficacy and safety of donor-derived CLL-1 chimeric antigen receptor (CAR) T-cell therapy for R/R AML followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT) bridging upon remission. Methods: A young male patient (18 years old) was diagnosed with CEBPA double-mutated AML. After initial chemotherapy, he achieved minimal residual disease (MRD)-negative complete remission (CR), that was followed by auto-HSCT. His leukemia disease was relapsed 6 months later. The salvage therapy with azacitidine and venetoclax was not helpful and his disease was deteriorated with 61% blasts in bone marrow (BM) and 63.18% blasts detected by flow cytometry (FCM) with a phenotype positive for CD34, CD117, HLA-DR, CD13, CD33, CD38, CD123 and CLL-1 upon admission. CAR T-cells targeting CLL-1 were manufactured using peripheral blood from a haploidentical donor, he received a total of 0.5*106/kg CAR T-cells with informed consent. The vital signs, complete blood counts, cytokines, serum ferritin, peripheral blood (PB) CAR T-cell counts, BM aspirate and MRD by FCM were monitored. Allo-HSCT from the same donor was started immediately after CR upon BM evaluation. Blood counts, BM aspirate and MRD, graft-versus-host disease (GVHD), and chimerism status were routinely monitored. Results: The patient developed fever at day 8 after CAR T-cells infusion, which peaked at 39.2°C. After supportive care, the temperature returned to normal range at day 10. There were no episodes of hypoxia, hypotension or immune effector cell-associated neurotoxicity syndrome (ICANS). The cytokine release syndrome (CRS) was assessed as grade 1. CAR T-cells expanded in PB at the peak of 9.4% in the whole T cells at day 8. The patient achieved CR with 0.29% MRD in BM by FCM at day 11. He was then bridged to allo-HSCT immediately. He achieved neutrophil engraftment at day 18 and platelet engraftment at day 26 after transplantation. Complete donor chimerism was observed at day 23. MRD negative CR in BM was achieved at day 23. The patient is currently 6 months after transplantation, with sustain MRD negative CR in BM, and no extramedullary disease or GVHD. Summary/Conclusion: Donor-derived CLL-1 CAR T-cell is effective and safe for treating R/R AML. Bridging to allo-HSCT immediately following CR may improve prognosis in these patients' population. (www.chictr.org.cn number, ChiCTR2200058607.) Keywords: AML, CAR-T, Allogeneic stem cell transplant
Consumption of Pu-erh has been reported to result in numerous health benefits, but the mechanisms underlying purported weight-loss and lowering of lipid are poorly understood. Here, we used the nematode Caenorhaditis elegans to explore the water extract of Pu-erh tea (PTE) functions to reduce fat storage. We found that PTE down-regulates the expression of the master fat regulator SBP-1, a homologue of sterol regulatory element binding protein (SREBP) and its target stearoyl-CoA desaturase (SCD), a key enzyme in fat biosynthesis, leading to an increased ratio of stearic acid (C18:0) to oleic acid (C18:1n-9), and subsequently decreased fat storage. We also found that both the pharyngeal pumping rate and food uptake of C. elegans decreased with exposure to PTE. Collectively, these results provide an experimental basis for explaining the ability of Pu-erh tea in promoting inhibition of food uptake and the biosynthesis of fat via SBP-1 and SCD, thereby reducing fat storage.
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