Muhei Tanaka

Kyoto Prefectural University of Medicine

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Michiaki Fukui

Kyoto Prefectural University of Medicine

108

Goji Hasegawa

Japanese Red Cross Society Kyoto Daini Hospital

Masahiro Yamazaki

Kyoto Prefectural University of Medicine

Hiroshi Okada

Kyoto Prefectural University of Medicine

Yoshitaka Hashimoto

Matsushita Memorial Hospital

Mai Asano

Kyoto Prefectural University of Medicine

Naoto Nakamura

Kyushu University

Yohei Oda

Niigata University

Naoto Nakamura

Kobe University

Takafumi Senmaru

Kyoto Prefectural University of Medicine

Cooperative Institutions

Kyoto Prefectural University of Medicine

106

Kyoto first Red Cross hospital

Kyoto Prefectural University

Matsushita Memorial Hospital

Kyoto University

Japanese Red Cross Society Kyoto Daini Hospital

Kyoto City Hospital

The University of Tokyo

Kyoto Medical Center

University Hospital Kyoto Prefectural University of Medicine

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Relationship between cardio-ankle vascular index (CAVI) and coronary artery calcification (CAC) in patients with type 2 diabetes mellitus

Heart and Vessels (2011)

Yusuke Mineoka Michiaki Fukui Muhei Tanaka Ki-ichiro Tomiyasu Satoshi Akabame

Vascular surgery

Cardiothoracic surgery

10.1007/s00380-011-0138-0

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Citations (42)

Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes

Endocrine Journal (2012)

Takafumi Senmaru Michiaki Fukui Masaaki Kuroda Muhei Tanaka Emi Ushigome

Helicobacter pylori infection, which is a common cause of atrophic gastritis, has been reported to represent a causal factor increasing the vascular damage and consequent albuminuria. On the other hand, decreased serum pepsinogen (PG) I/II ratio can be used to assess gastric mucosal atrophy. To the best of our knowledge, there are no studies investigating the correlation between PG I/II ratio and diabetic nephropathy. Therefore, we investigated a relationship between PG I/II ratio and degree of urinary albumin excretion (UAE) in patients with type 2 diabetes. We evaluated relationships between PG I/II ratio and degree of UAE or estimated glomerular filtration rate as well as various factors, including age, body mass index, blood pressure, hemoglobin A1c, serum lipid concentrations, uric acid or C-reactive protein in 333 consecutive patients with type 2 diabetes. PG I/II ratio correlated positively with logarithm of UAE in all patients (r = 0.174, P = 0.0016) and in patients without Helicobacter pylori infection (r = 0.352, P < 0.0001). Multiple regression analysis identified that PG I/II ratio correlated independently with logarithm of UAE in all patients (β = 0.264, P = 0.0005) and in patients without Helicobacter pylori infection (β = 0.295, P = 0.0022). These data suggest that serum PG I/II ratio is correlated with diabetic nephropathy.

Albuminuria

Pepsin

10.1507/endocrj.ej12-0244

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Citations (12)

Decreased the creatinine to cystatin C ratio is a surrogate marker of sarcopenia in patients with type 2 diabetes

Diabetes Research and Clinical Practice (2018)

Takafumi Osaka Masahide Hamaguchi Yoshitaka Hashimoto Emi Ushigome Muhei Tanaka

Bioelectrical Impedance Analysis

10.1016/j.diabres.2018.02.025

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Citations (138)

Home blood pressure variability on one occasion is a novel factor associated with arterial stiffness in patients with type 2 diabetes

Hypertension Research (2012)

Michiaki Fukui Emi Ushigome Muhei Tanaka Masahide Hamaguchi Toru Tanaka

Prehypertension

Pulse pressure

10.1038/hr.2012.177

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Citations (56)

Divided consumption of late-night-dinner improves glucose excursions in young healthy women: A randomized cross-over clinical trial

Diabetes Research and Clinical Practice (2017)

Shizuo Kajiyama Saeko Imai Yoshitaka Hashimoto Chikako Yamane Takashi Miyawaki

Crossover study

10.1016/j.diabres.2017.11.033

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Citations (14)

Plasma serotonin is a predictor for deterioration of urinary albumin excretion in men with type 2 diabetes mellitus

Metabolism (2009)

Michiaki Fukui Emi Shiraishi Muhei Tanaka Takafumi Senmaru Kazumi Sakabe

10.1016/j.metabol.2009.03.009

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Citations (13)

Dipeptidyl peptidase-4 inhibitors have adverse effects for the proliferation of human T cells

Journal of Clinical Biochemistry and Nutrition (2018)

Noriyuki Kitagawa Masahide Hamaguchi Saori Majima Takuya Fukuda Toshihiro Kimura

Dipeptidyl peptidase-4 (DPP-4) is a critical molecule for the metabolism of incretins. In addition, DPP-4 is known as CD26, the receptor of T cells, and plays important role in activation of T cells. Recently, DPP-4 inhibitors (DPP4i) are reported to have several immunologic effects beyond glycemic control. DPP4i seem to have anti-inflammatory effects in patients with type 2 diabetes. This might be direct effects on T cells. However, the close mechanism is not clear. To evaluate the possibility, we performed ex vivo assays by using primarily human CD4+ T cells (CD4) and CD8+ T cells (CD8). We purified primary naïve CD4 and CD8 from human peripheral blood. Then, we evaluated the effect of DPP4i on the proliferation of naïve T cells and the cytokine production in ex vivo experiments. The proliferation of CD4 and CD8 were suppressed by adding DPP4i in a dose dependent manner. However, DPP4i did not inhibit cytokine production from CD4. It was revealed by phospho-flow that the T cell receptor (TCR) signaling was attenuated in the presence of DPP4i. Taken together, DPP4i modulated TCR signaling, which contributed to attenuate the proliferation of CD4 and CD8. DPP4i have adverse effects for the proliferation of human T cells.

Dipeptidyl peptidase-4 inhibitor

Ex vivo

10.3164/jcbn.17-64

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Citations (14)

Impact of low‐carbohydrate diet on body composition: meta‐analysis of randomized controlled studies

Obesity Reviews (2016)

Yoshitaka Hashimoto Takuya Fukuda Chikako Oyabu Muhei Tanaka Mai Asano

Summary The effect of low‐carbohydrate diet (LCD) on body composition, especially fat mass, in obese individuals remains to be elucidated. We performed a meta‐analysis to provide quantitative summary estimates of the mean change of body weight (kg) and fat mass (kg) in LCD comparing to those in control diet. Literature searches were performed using EMBASE, MEDLINE and Cochrane Library until Dec 2014. Fourteen randomized controlled studies were included in this meta‐analysis. Eight studies including very LCD (50 g carbohydrate or 10% calorie from carbohydrate) and seven studies including mild LCD (about 40% calorie from carbohydrate). Meta‐analysis carried out on data of 1416 obese individuals, showed that LCD was associated with decrease in body weight (−0.70 kg [95% CI −1.07/−0.33]) or fat mass (−0.77 kg [−1.55/−0.32]). Subgroup meta‐analysis of studies in over 12 months suggested that LCD was not associated with decrease in body weight (−0.44 kg [−0.94/0.07]), but LCD was associated with decrease in fat mass (−0.57 kg [−1.05/−0.09]). In addition, very LCD was associated with decrease in fat mass (−0.97 kg [−1.50/−0.44]), but mild LCD was not associated with decrease in fat mass (−0.43 kg [−1.15/0.33]). LCD, especially very LCD, might be effective for decrease in fat mass in obese individuals. © 2016 World Obesity

10.1111/obr.12405

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Citations (93)

Association between Hemoglobin Concentration and the Progression or Development of Albuminuria in Diabetic Kidney Disease

PLoS ONE (2015)

Hiroshi Okada Goji Hasegawa Muhei Tanaka Takafumi Osaka Yayoi Shiotsu

Aims Anemia, which might contribute to pathogenesis of kidney dysfunction, is a common finding in patients with type 2 diabetes. The aim of this study was to investigate if hemoglobin concentration is associated with the degree of change in urinary albumin-creatinine ratio or the development of albuminuria in patients with type 2 diabetes. Methods We measured hemoglobin concentration in 470 (296 men and 174 women) consecutive type 2 diabetic patients without albuminuria. We performed a follow-up study to assess the progression or development of albuminuria, the interval of which was 3.0 years. Then we evaluated relationships between hemoglobin concentration and albuminuria, using multivariate linear regression analyses and logistic regression analyses. Results Eighty four patients developed albuminuria during follow-up duration. In multivariate analyses, hemoglobin concentration was negatively associated with a change in urinary albumin-creatinine ratio in men (ß = -0.259, P = 0.0002) and women (ß = -0.194, P = 0.030). Moreover, multivariate adjusted odds ratio associated with 1 g/L in hemoglobin for the development of albuminuria was 0.93 (95% confidence interval; 0.89-0.96) in men and 0.94 (95% confidence interval; 0.88-0.99) in women, respectively. And, multivariate analyses revealed that adjusted odds ratios for the development of albuminuria were 4.78 (95% confidence interval; 1.65-13.91) in men and 4.62 (95% confidence interval; 1.34-16.68) in women with anemia (hemoglobin < 130 g/L for men and < 120 g/L for women), which were higher than those without anemia. Conclusions Low hemoglobin concentration could be a predictor for the progression and development of albuminuria in patients with type 2 diabetes.

Albuminuria

10.1371/journal.pone.0129192

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Citations (10)

Low Serum Testosterone Concentration in Middle-aged Men with Type 2 Diabetes

Endocrine Journal (2007)

Michiaki Fukui Jintetsu Soh Muhei Tanaka Yoshihiro Kitagawa Goji Hasegawa

Low concentrations of endogenous androgens have been linked with insulin resistance and atherosclerosis. Men with diabetes have been reported to have lower serum testosterone concentration than non-diabetic men; however, there has never been a large study. The aim of this study was to investigate if endogenous androgen concentration is certainly lower in a relatively large number of Japanese patients with type 2 diabetes compared with healthy men, and to identify what factors may be associated with low serum testosterone concentrations in men with type 2 diabetes. Serum free testosterone concentrations were measured in 524 healthy men and in 331 consecutive Japanese men with type 2 diabetes between 40 and 69 years old. In addition, we investigated the relationships between serum free testosterone concentration and luteinizing hormone (LH) concentration as well as major cardiovascular risk factors including age, blood pressure, plasma lipid concentration, glycemic control (HbA(1c)), and BMI. Serum free testosterone concentrations were lower in men with type 2 diabetes than in healthy men in the 40-49 years group (10.9 +/- 3.3 vs. 14.0 +/- 3.6 pg/ml, P<0.0001), in the 50-59 years group (10.4 +/- 3.2 vs. 12.1 +/- 2.9 pg/ml, P<0.0001), and in the 60-69 years group (9.5 +/- 2.6 vs. 10.5 +/- 2.9 pg/ml, P = 0.0104). A negative correlation was found between serum free testosterone and LH concentrations (r = -0.326, P<0.0001). In conclusion, serum free testosterone concentration is certainly lower in a relatively large number of Japanese patients with type 2 diabetes compared with healthy men with each decade of life between 40 and 69 years old.

Free testosterone

10.1507/endocrj.k07-077

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Citations (74)