N KuJan-Mar

Post Graduate Institute of Medical Education and Research

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Monika Gupta

Punjab Agricultural University

Melina I Sahay

Hindu Mission Hospital

Sudesh Prabhakar

Post Graduate Institute of Medical Education and Research

V.K. Bhargava

University of Delhi

Satish K. Garg

University of Colorado Denver

K. Panda Naresh

Post Graduate Institute of Medical Education and Research

Henry James

Ashford and St Peter's Hospitals NHS Foundation Trust

Rajender K. Motiani

Regional Centre for Biotechnology

Sheikh Quyoom Hussain

Government Medical College

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Maulana Azad Medical College

Govind Ballabh Pant Hospital

Post Graduate Institute of Medical Education and Research

All India Institute of Medical Sciences

Punjab Agricultural University

Sharda University

Government Medical College, Amritsar

Indian Agricultural Research Institute

Institute of Himalayan Bioresource Technology

Indian Institute of Technology Delhi

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Influence of kinnow juice on the bioavailability of carbamazepine in healthy male volunteers.

PubMed (1998)

Satish K. Garg V.K. Bhargava Henry James N KuJan-Mar Sudesh Prabhakar

Kinnow juice produces a marked and variable increase in carbamazepine bioavailability. The pharmacokinetics of carbamazepine was studied after drug administration with 300 ml water or kinnow juice in a randomized cross over trial on nine healthy male volunteers. With kinnow juice peak serum concentration (Cmax) and area under the serum concentration time curve (AUC) was significantly (P < 0.05) increased and time to reach peak serum concentration (tmax) was significantly decreased (p < 0.05) as compared with water. No change was observed in the elimination half life (t1/2) of drug. The mechanism by which kinnow juice enhances carbamazepine bioavailability could be due to inhibition of cytochrome P-450 enzyme, since kinnow juice contains naringin which is considered to be inhibitor of liver microsomal dihydropyridine oxidation.

Grapefruit juice

Naringin

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P300 as a marker of cognitive dysfunction in chronic epileptics.

PubMed (1996)

N KuJan-Mar Monika Gupta Melina I Sahay Rajender K. Motiani Sheikh Quyoom Hussain

P300 event related potential was done in 23 chronic epileptics (12M, 11F) to assess subclinical cognitive impairment. No patient had any obvious neurological abnormality or brain damage. All had normal CT Scans and a mini mental scale score of at least 25. Neuropsychological evaluation done included Bender Gestalt test, Bhatia Battery, Wecshler Memory scale. P 300 event related potential was determined using 'Odd ball paradigm'. P300 latency was significantly increased in chronic epileptics (PCO < 001) compared to controls. There was no relation between P300 latency and amplitude with seizure onset, duration frequency. Nor was there any association between the three neuropsychological parameters and P 300 latency. We conclude subclinical cognitivedysfunction is common in epileptics and P300 event related potential could serve as a marker of cognitive impairment.

Subclinical infection

Abnormality

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