Yongbo Cheng

Army Medical University

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Chao‐Jun Yan

Army Medical University

Sanjiu Yu

Army Medical University

Huajie Zheng

Army Medical University

De-Qing Lin

Army Medical University

Ping He

Army Medical University

Wei Cheng

Army Medical University

Xian‐Pu Zhang

Army Medical University

Jun Li

Sun Yat-sen University

Deqing Lin

Affiliated Eye Hospital of Wenzhou Medical College

Jun Li

Army Medical University

Cooperative Institutions

Army Medical University

Southwest Hospital

Wuhan University

Chinese Academy of Sciences

Renmin Hospital of Wuhan University

Huazhong University of Science and Technology

University of Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Sun Yat-sen University

Zhongnan Hospital of Wuhan University

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Clinical impact of baseline mitral regurgitation on outcomes after transcatheter aortic valve replacement for severe aortic stenosis

IJC Heart & Vasculature (2024)

Huajie Zheng Xin Liu De-Qing Lin Yongbo Cheng Chao‐Jun Yan

The clinical impact of baseline mitral regurgitation (MR) on the outcomes after transcatheter aortic valve replacement (TAVR) is not clear. This study sought to assess the clinical impact of baseline MR on outcomes after TAVR.

Valve replacement

Interquartile range

10.1016/j.ijcha.2024.101348

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Citations (1)

Prognostic Value of 18-FDG Uptake in Early Stage NSCLC

The Thoracic and Cardiovascular Surgeon (2009)

J.-C. Chen Tsai-Wang Huang Yongbo Cheng H. Chang C. Tzao

Background: We assessed whether the standard uptake of 18-fluorodeoxyglucose (18-FDG) in non-small cell lung cancers (NSCLC) differed between stage I and non-stage I tumors. Methods: We reviewed 163 patients with NSCLC who underwent surgical lymph node dissection after tumor resection in 2002–2003. Patients with clinical stage I NSCLC who were investigated with preoperative positron emission tomography integrated computed tomography (PET‐CT) scans using 18-FDG uptake were included; those with N2 disease were excluded. We reviewed 55 patients with a mean follow-up of 68 months. Results: We analyzed 36 patients with stage I (Group 1) and 19 patients with non-stage I NSCLC (Group 2; 8 stage II, 7 stage III and 4 stage IV). There were no statistical differences in sex, age, tumor size, histological type, location or tumor differentiation between the groups. Group 1 had lower maximum standard 18-FDG uptake values (SUVmax) than Group 2 (4.9 ± 2.7 vs. 8.1 ± 3.8; p = 0.001). Using multiple logistic regression, patients with higher preoperative SUVmax and serum carcinoembryonic antigen (CEA) levels showed advanced tumor stages postoperatively (SUVmax > 4.7, odds ratio 7.65; CEA > 3.5 ng/mL, odds ratio 8.39). High 18-FDG uptake was significantly associated with reduced median survival (62.69 months for SUVmax < 4.7 and 40.89 months for SUVmax > 4.7). Conclusions: High preoperative 18-FDG uptake of tumors was significantly associated with reduced overall patient survival. The SUVmax of the tumor and serum CEA levels demonstrated aggressive tumors and could be helpful preoperatively when considering patients for induction therapy or resection.

Carcinoembryonic antigen

Standardized uptake value

Fluorodeoxyglucose

T-stage

10.1055/s-0029-1185733

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Citations (12)

Prognostic impact of new permanent pacemaker implantation following transcatheter aortic valve replacement

Catheterization and Cardiovascular Interventions (2023)

Hua‐Jie Zheng Chao‐Jun Yan D J Lin Yongbo Cheng Sanjiu Yu

Conduction disturbances requiring permanent pacemaker implantation (PPI) are common following transcatheter aortic valve replacement (TAVR). There were conflicting data regarding the impact of new PPI on clinical outcomes after TAVR.The study sought to evaluate the impact of new PPI on clinical outcomes in patients undergoing TAVR.This study was a retrospective analysis of prospectively collected data. Data were from 210 consecutive patients without prior PPI who underwent TAVR due to severe symptomatic aortic stenosis at our center between June 2018 and July 2020. Clinical, echocardiographic, and pacing data were assessed at 30-day, 1- and 2-year follow-up.New PPI was required in 35 (16.7%) patients within 30 days after TAVR. The median time from TAVR to PPI was 3 days. The most common indication for PPI was high-degree or complete atrioventricular block. The median follow-up was 798.0 (interquartile range, 669.0-1115.0) days. There were no differences in all-cause mortality (adjusted hazard ratio [HR]: 1.18; 95% confidence interval [CI]: 0.85-2.36; p = 0.415) and cardiovascular mortality (adjusted HR: 0.92; 95% CI: 0.57-1.89; p = 0.609) between groups. However, PPI group had a higher risk of heart failure (HF) rehospitalization (adjusted HR: 1.53; 95% CI: 1.26-2.28; p = 0.027). Echocardiography showed no significant improvement of LVEF over time in patients with PPI. At the latest follow-up, 31.3% of patients exhibited low (≤10%) pacing burdens, whereas 28.1% of patients had near constant (>90%) right ventricular pacing.New PPI within 30 days following TAVR was not associated with an increased risk of all-cause or cardiovascular mortality. However, patients with PPI had a higher risk of HF rehospitalization and lack of LVEF improvement.

Interquartile range

Valve replacement

Atrioventricular block

Permanent pacemaker

10.1002/ccd.30788

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Citations (6)

A novel FUZZY-FMEA method for risk assessment of In-vehicle information system under uncertainty

International Journal of Productivity and Quality Management (2024)

Qiaoke Zhang Liangqi Wan Xiao Liu Yongbo Cheng

10.1504/ijpqm.2024.10063855

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A modified prosthesis eversion technique for proximal anastomosis in ascending aorta replacement

Journal of Thoracic Disease (2023)

Huajie Zheng Xian‐Pu Zhang Sanjiu Yu De-Qing Lin Yongbo Cheng

One of the crucial aspects of ascending aorta replacement is to achieve hemostasis of the proximal anastomosis. This study aimed to describe a modified prosthesis eversion technique for proximal anastomosis in ascending aorta replacement and compare its operative outcomes with the conventional prosthesis eversion technique.We conducted a retrospective analysis of all consecutive patients who had ascending aortic aneurysm and underwent ascending aorta replacement with the modified or conventional prosthesis eversion technique between January 2019 and December 2022 in our center.A total of 108 patients were included: 55 in the modified group and 53 in the conventional group. The durations of cardiopulmonary bypass, aortic cross-clamping and total operation in the conventional group were longer than those in the modified group. Furthermore, perioperative blood loss and the incidence of re-exploration for bleeding were significantly lower in the modified group. Accordingly, patients in the conventional group accepted more blood transfusion. The modified group had a shorter duration in intensive care unit (ICU) and hospital, and lower total hospitalization costs than those in the conventional group.The modified prosthesis eversion technique is an effective alternative for proximal anastomosis in ascending aorta replacement, with less blood loss, shorter operation time, and lower rate of postoperative complications compared with the conventional technique.

10.21037/jtd-23-550

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Citations (1)

Effect of High-Flow Nasal Cannula for Hypoxemia Following Sun's Procedure in Acute Aortic Dissection Type a Patients

Frontiers in Surgery (2021)

Chao‐Jun Yan Jianrong Zhang Yi Wu Jie Yao Jun Li

Background: Patients with acute aortic dissection type A (AADA) often have hypoxemia (partial pressure of oxygen [PaO 2 ]/fraction of inspired oxygen [FiO 2 ] <300 mmHg) before weaning in the intensive care unit (ICU). This study compared the efficacy of high-flow nasal cannula (HFNC) with that of conventional oxygen therapy (COT) in patients with AADA following Sun's procedure. Methods: The medical records of 87 adult patients with AADA who underwent Sun's procedure and met the inclusion criteria (PaO 2 /FiO 2 <300 mmHg before weaning) were retrospectively analyzed. After surgery, 41 patients were treated with HFNC and 46 were treated with COT. The oxygenation level, FiO 2 , partial pressure of carbon dioxide, heart rate, respiratory rate, subjective discomfort, and reintubation rate were recorded. The difference in lung volume loss between the HFNC and COT groups was assessed using the radiological atelectasis score (chest radiograph) or calculated from three-dimensional (3D) reconstructed computed tomography (CT) images. Results: From day 1 to day 5 after weaning, there was no significant difference in PaO 2 /FiO 2 between the HFNC and COT groups, although the FiO 2 was significantly lower in the HFNC group than in the COT group ( P < 0.05). Further studies indicated that the percentage of lung volume loss (pleural effusion and/or pulmonary atelectasis) by 3D reconstruction of CT images at 4–8 days post-operation was significantly lower in the HFNC group ( P < 0.05). The subjective experience of breathing discomfort, reintubation rate, and length of stay in the ICU were significantly reduced in the HFNC group ( P < 0.05). There was no significant difference in readmission to the ICU and in-hospital mortality between the two groups. Conclusions: HFNC can be used as an effective oxygen therapy for AADA patients with hypoxemia after Sun's procedure.

Nasal cannula

Atelectasis

Respiratory Rate

Chest radiograph

10.3389/fsurg.2021.630624

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Citations (2)

[The effects of plasma from patients with severe hepatitis on the growth and function of porcine hepatocytes].

PubMed (2005)

Yongbo Cheng Yingjie Wang Shi-Chang Zhang Jun Liu Zhi Chen

Liver function

Source

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Transfemoral transcatheter aortic valve replacement for pure native aortic regurgitation: one-year outcomes of a single-center study

BMC Cardiovascular Disorders (2023)

Huajie Zheng Yongbo Cheng Chao‐Jun Yan De-Qing Lin Sanjiu Yu

Abstract Background Evidence about safety and efficacy of transcatheter aortic valve replacement (TAVR) with the Venus A-Valve system (Venus Medtech, Hangzhou, China) remains limited for patients with pure native aortic regurgitation (PNAR). Objectives The single-center study sought to report the one-year clinical outcomes of the Venus A-Valve in the treatment of PNAR. Methods This study was a retrospective analysis of prospectively collected data. Data was from all consecutive patients who had PNAR and underwent TAVR with the Venus A-Valve system at our center from July 2020 and June 2021. Procedural and clinical outcomes up to one year were analyzed using Valve Academic Research Consortium-2 criteria. Results A total of 45 consecutive patients with PNAR underwent transfemoral TAVR with the Venus A-Valve system. The Mean age was 73.5 ± 5.5 years and 26.7% were female. All the TAVR procedures were performed via transfemoral access. Implantations were successful in 44 cases (97.8%). Only one patient was converted to surgical aortic valve replacement. No patient died intraoperatively. No second valve was implanted. In-hospital mortality rate was 2.3%. The one-year all-cause mortality rate was 4.7% without cardiovascular related death. No patient had moderate or severe paravalvular leakage during follow-up. At one year, the mean pressure gradient was 8.8 ± 0.9 mmHg, and left ventricular ejection fraction increased to 61.5 ± 3.6%. Conclusions This single-center study demonstrated the safety and efficacy of transfemoral TAVR with the Venus A-Valve in the treatment of patients with PNAR.

Single Center

Valve replacement

Angiology

10.1186/s12872-023-03329-1

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Citations (5)

Telomerase and hTERT: Can they serve as markers for gastric cancer diagnosis?

World Journal of Gastroenterology (2014)

Yongbo Cheng

AIM:To investigate telomerase activity and human telomerase reverse transcriptase (hTERT) expression in normal human gastric mucosal epithelial cells (nhG-MECs) and fibroblasts (nhGMFs).METHODS: nhGMECs and nhGMFs were isolated and cultured from specimens obtained during routine surgery for bleeding peptic ulcer.Telomerase activity in nhGMFs, nhGMECs, and the tumor cell lines BGC-823, SGC-7901 and MKN-28 cells was analyzed using the telomeric repeat amplification protocol assay.hTERT protein was determined in nhGMECs, nhGMFs, BGC-823, SGC-7901 and MKN-28 cells by indirect immunofluorescence. RESULTS:A similar level of telomerase activity was ob-served in nhGMECs, nhGMFs and BGC-823, SGC-7901, MKN-28 cell lines.Positive hTERT immunostaining was detected in nhGMECs, nhGMFs, BGC-823, SGC-7901 and MKN-28 cell lines. CONCLUSION:The use of telomerase or hTERT as diagnostic markers for gastric cancer may require further studies.

Immunostaining

Immunofluorescence

10.3748/wjg.v20.i21.6615

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Citations (3)

Systematic review of the effect of cerebrospinal fluid drainage on outcomes after endovascular type B aortic dissection repair

Journal of Cardiothoracic Surgery (2024)

Huajie Zheng Deqing Lin Yongbo Cheng Chao‐Jun Yan Sanjiu Yu

Abstract Objective The aim of the present systematic review was to determine whether prophylactic use of cerebrospinal fluid drainage (CSFD) contributes to a lower rate of spinal cord ischemia (SCI) after thoracic endovascular aortic repair (TEVAR) for type B aortic dissection (TBAD). Methods PubMed, Embase, Web of Science and Cochrane Library databases were systematically searched to identify all relevant studies reported before May 7, 2023. A systematic review was conducted in accordance with PRISMA guidelines (PROSPERO registration no. CRD42023441392). The primary outcome was permanent SCI. Secondary outcomes were temporary SCI and 30-day/in-hospital mortality. The data were presented as the pooled event rates (ERs) and 95% confidence intervals (CIs). Results A total of 1008 studies were screened, of which 34 studies with 2749 patients were included in the present analysis. The mean Downs and Black quality assessment score was 8.71 (range, 5–12). The pooled rate of permanent SCI with prophylactic CSFD was identical to that without prophylactic CSFD (2.0%; 95% CI, 1.0–3.0; P = 0.445). No statistically significant difference was found between the rates of permanent SCI with routine vs. selective prophylactic CSFD ( P = 0.596). The pooled rate of temporary SCI was 1.0% (95% CI, 0.00–1.0%). The pooled rate for 30-day or in-hospital mortality was not significantly different ( P = 0.525) in patients with prophylactic CSFD (4.0, 95% CI 2.0–6.0) or without prophylactic CSFD (5.0, 95% CI 2.0–7.0). Conclusions The systematic review has shown that prophylactic CSFD was not associated with a lower rate of permanent SCI and 30-day or in-hospital mortality after TEVAR for TBAD.

10.1186/s13019-024-02603-3

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