МY

М. Yu. Valkov

Northern State Medical University

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МВ

М. В. Макарова

Northern State Medical University

Claudia Allemani

London School of Hygiene & Tropical Medicine

Michel P. Coleman

London School of Hygiene & Tropical Medicine

L. E. Valkova

Northern State Medical University

M Matz

London School of Hygiene & Tropical Medicine

Rafael Marcos‐Gragera

Institut Català d'Oncologia

MŠ

Mario Šekerija

Hrvatski zavod za javno zdravstvo

Charles Stiller

National Cancer Registration Service

Nora Eisemann

University of Lübeck

Eunice Sirri

London School of Hygiene & Tropical Medicine

Cooperative Institutions

London School of Hygiene & Tropical Medicine

445

London Cancer

210

Cancer Institute (WIA)

116

Swiss Cancer League

109

Institut National du Cancer

107

Fondazione IRCCS Istituto Nazionale dei Tumori

106

Cancer Research Foundation

102

Centre International De Reference Chantal Biya

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública

Inserm

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MULTIPARAMETRIC MRI IN PATIENTS WITH LOCALIZED PROSTATE CANCER AFTER RADICAL EXTERNAL RADIOTHERAPY

Diagnostic radiology and radiotherapy (2019)

M. V. Krupina Т. Н. Трофимова М. Yu. Valkov

Prostate cancer (PC) is the one of the most common and socially significant malignancies in men. Radiotherapy is currently one of the leading conservative special treatments for a localized and locally advanced PC. The frequency of biochemical recurrence after external beam radiotherapy (EBRT) is high. One of the main problems is a differentiation between local and systemic relapse of PC. Nevertheless, a local recurrence of PC after radiotherapy can occur without increasing PSA. Magnetic resonance imaging (MRI) is a highly informative imaging method, however, currently it is used mostly for the primary diagnosis and is not included into the recommendations for detecting recurrent prostate cancer after treatment. MR-pattern of the local progression after radical EBRT can be similar to that of primary PC. It is also difficult to diagnose local relapse of prostate cancer in some cases. Multiparametric MRI (mpMRI) has the greatest prospects in the diagnosis of local tumor recurrence in prostate cancer patients after radical external beam radiotherapy. The article provides an overview of domestic and foreign literature, in which we attempted to systematize current knowledge about the possibilities of the mpMRI in diagnosing local recurrence after radical EBRT and, based on the results of published studies, identify directions for further application of this approach.

External beam radiotherapy

External beam radiation

10.22328/2079-5343-2019-10-3-32-41

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Characteristics of Polyhandicapped Patients. About a 875 Patients Cohort

Neuropediatrics (2019)

Thierry de Villemeur Marie‐Christine Rousseau Karine Baumstarck М. Yu. Valkov S. Khaldi

Objectives: Polyhandicap (PLH) is a complex disability condition corresponding to a chronic affliction occurring in an immature brain, leading to a combination of a profound mental retardation and a serious motor deficit, resulting in an extreme restriction of autonomy and communication. These patients are completely dependent on human and technical assistance. To improve the knowledge concerning this population of patients we implemented a cohort study, the aim of this cohort was to describe the characteristics of patients with severe PLH.

10.1055/s-0039-1685438

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Worldwide trends in esophageal cancer survival, by sub‐site, morphology, and sex: an analysis of 696,974 adults diagnosed in 60 countries during 2000‐2014 (CONCORD‐3)

Cancer Communications (2023)

M Matz М. Yu. Valkov Mario Šekerija Sabine Luttman Adele Caldarella

Esophageal cancer survival is poor worldwide, though there is some variation. Differences in the distribution of anatomical sub-site and morphological sub-type may help explain international differences in survival for all esophageal cancers combined. We estimated survival by anatomic sub-site and morphological sub-type to understand further the impact of topography and morphology on international comparisons of esophageal cancer survival.We estimated age-standardized one-year and five-year net survival among adults (15-99 years) diagnosed with esophageal cancer in each of 60 participating countries to monitor survival trends by calendar period of diagnosis (2000-2004, 2005-2009, 2010-2014), sub-site, morphology, and sex.For adults diagnosed during 2010-2014, tumors in the lower third of the esophagus were the most common, followed by tumors of overlapping sub-site and sub-site not otherwise specified. The proportion of squamous cell carcinomas diagnosed during 2010-2014 was generally higher in Asian countries (50%-90%), while adenocarcinomas were more common in Europe, North America and Oceania (50%-60%). From 2000-2004 to 2010-2014, the proportion of squamous cell carcinoma generally decreased, and the proportion of adenocarcinoma increased. Over time, there were few improvements in age-standardized five-year survival for each sub-site. Age-standardized one-year survival was highest in Japan for both squamous cell carcinoma (67.7%) and adenocarcinoma (69.0%), ranging between 20%-60% in most other countries. Age-standardized five-year survival from squamous cell carcinoma and adenocarcinoma was similar for most countries included, around 15%-20% for adults diagnosed during 2010-2014, though international variation was wider for squamous cell carcinoma. In most countries, survival for both squamous cell carcinoma and adenocarcinoma increased by less than 5% between 2000-2004 and 2010-2014.Esophageal cancer survival remains poor in many countries. The distributions of sub-site and morphological sub-type vary between countries, but these differences do not fully explain international variation in esophageal cancer survival.

Morphology

10.1002/cac2.12457

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Erratum to “The histology of ovarian cancer: Worldwide distribution and implications for international survival comparisons (CONCORD-2)” [Gynecol. Oncol. 144 (2017) 405–413]

Gynecologic Oncology (2017)

M Matz Michel P. Coleman Milena Sant María Dolores Chirlaque Otto Visser

Histology

10.1016/j.ygyno.2017.06.032

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Epidemiological survival predictors of cancer of the corpus uteri: a population-based analysis

Siberian Journal of Oncology (2023)

Анастасия Светлакова D. D. Gromov O. V. Chemakina A. V. Agayeva L. E. Valkova

Cancer of the corpus uteri (CCU) is one of the most common gynecological malignancies in high- and middleincome countries. The objective of the study was to evaluate the factors predicting survival in CCU patients over the period 2000-2021 using the data of population-based cancer registry of the Arkhangelsk region. Material and Methods . Cancer-specific survival (CSS) of patients with CCU for the period 2000-21 was evaluated using life tables and Kaplan-Mayer methods with a log-rank test. The Cox proportional hazards regression model was used to assess the effect of prognostic factors on survival time. Results . A total of 3272 cases were selected for the analysis. The 5-year survival rates improved from 70.6 % in 2000-04 to 75.6 % in 2015-19. In stage I, II, III, and IV CUN, the 5-year survival rates were 90.8 % (95 % CI 89.3-92.0 %), 71.1 (95 % CI 66.3-75.4 %), 46.7 (95 % CI 41.4-51.8 %), and 3.9 (95 % CI 1.5-7.5 %), respectively; p<0.001. In the multivariate regression model, for stage II, III, and IV CCU, the hazard ratios for death from cancer were respectively 2.69 (2.14-3.39), 5.73 (4.66-7.03), and 20.26 (16.13-25.44) compared to stage I. The risk of death from CCU was 2.0-2.7 times higher in patients with aggressive histological subtypes and sarcomas compared to that in patients with endometrioid adenocarcinoma; 2.0-2.8 times higher in patients older than 60 years compared to younger patients, and 1.3 times higher in rural patients compared to urban patients (p<0.05). There was no increase in the risk of death from CCU over the period of COVID-19 pandemic. Conclusion . In this population-based study, we have found that the survival of patients with CCU is significantly affected by age and place of residence, which may indicate a limited access of some patients to effective treatment and requires further analysis. No increased risk of death from CCU during the COVID-19 pandemic was found.

Relative survival

10.21294/1814-4861-2023-22-3-16-24

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Epidemiology of malignant neoplasms in the main cities of the Siberian federal district

Ekologiya Cheloveka (Human Ecology) (2020)

Е. L. Choynzonov Л. Д. Жуйкова О. А. Ананина I. N. Odinstova М. Yu. Valkov

The aim: To analyze the incidence of malignant neoplasms in the main cities of the Siberian Federal District of Russia. Methods: Data were collected from annual forms of the Federal Statistical Monitoring N 7 "Information about Malignant Neoplasms" for the cities of Gorno-Altaisk, Ulan-Ude, Abakan, Barnaul, Chita, Krasnoyarsk, Irkutsk, Kemerovo, Novosibirsk, Omsk and Tomsk. Main epidemiological indicators were calculated by gender for the period from 2004-2018. Results. In 2018, 31 636 cases of cancer were registered in the cities which accounts for 39.9 % of the total number of the malignant neoplasms in whole District. The most common malignancies in male population were lung cancer (16.3 %), prostate cancer (12.5 %), skin melanoma (12.1 %), colorectal cancer (11.7 %) and stomach cancer (7.1 %). Among women, breast cancer (21.5 %), skin melanoma (17.3 %), colorectal cancer (11.5 %), uterine cancer (6.4 %) and cervical cancer (5.0 %) were the most common malignancies. Standardized rates of the increased overall cancer incidence from 271,0 to 287,2 %000 during the study period. The highest standardized incidence rate was observed in the cities of Ulan-Ude (267.9 %000), Chita (253.6 %000), Krasnoyarsk (308.2 %000) and Omsk (305.9 %000). According to prediction model, the cancer incidence may increase to 307.4 %000 by 2025. Conclusion. Urban population of Siberia has high incidence of malignant neoplasms. The incidence rate has been gradually increasing over the years and may further increase by 2025 if no measures are taken.

Cancer Incidence

10.33396/1728-0869-2020-11-53-59

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Citations (6)

A cross-national perspective of migration and cancer: incidence of five major cancer types among resettlers from the former Soviet Union in Germany and ethnic Germans in Russia

BMC Cancer (2019)

Philipp Jaehn Simone Kaucher L. V. Pikalova Sofia V. Mazeina Hiltraud Kajüter

Few studies compared cancer incidence among migrants both to their host countries and to their population of origin. We aimed to compare cancer incidence of ethnic Germans who migrated from the former Soviet Union to Germany (resettlers) to those living in Russia as well as to the German and the Russian general populations. The cancer registry of North Rhine-Westphalia identified incident cases of stomach, colorectal, lung, breast and prostate cancer in resettlers and the general population of the administrative district of Münster (Germany) between 2004 and 2013. The Tomsk cancer registry collected the same data in ethnic Germans and the general population of the Tomsk region (Russia). We used standardised incidence rate ratios (SIRs) to compare rates of resettlers and ethnic Germans with the respective general populations. The total number of person-years under risk was 83,289 for ethnic Germans, 8,006,775 for the population of Tomsk, 219,604 for resettlers, and 20,516,782 for the population of Münster. Incidence of the five investigated cancer types among ethnic Germans did not differ from incidence of the general population of Tomsk. Compared to the general population of Tomsk, incidence among resettlers was higher for colorectal cancer in both sexes (females: SIR 1.45 [95% CI 1.14–1.83], males: SIR 1.56 [95% CI 1.23–1.97]), breast cancer in females (SIR 1.65 [95% CI 1.40–1.95]), and prostate cancer (SIR 1.64 [95% CI 1.34–2.01]). Incidence rates of these cancer types among resettlers were more similar to rates of the general population of Münster. Incidence of stomach and lung cancer did not differ between resettlers and the general population of Tomsk. After an average stay of 15 years, we observed that incidence of colorectal, breast and prostate cancer among resettlers converged to levels of the general population of Münster. Resettler's incidence of stomach and lung cancer, however, was comparable to incidence in their population of origin. Causes must be investigated in subsequent analytical studies.

10.1186/s12885-019-6058-6

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Citations (6)

Three-dimensional conformal X-ray therapy of knee osteoarthritis: radiobiological prerequisites and analysis of dose distribution

Digital Diagnostics (2021)

М. В. Макарова D. Yu. Tretyakov М. Yu. Valkov

X-Ray Therapy

10.17816/dd83179

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Changes in breast cancer incidence may be attributed to implementation of all-national dispensarization: a population-based study from North-West Russia

Annals of Oncology (2016)

Laura Bakare М. Yu. Valkov

10.1093/annonc/mdw364.12

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Increment of the incidence of glioblastoma following decrease in the incidence of brain tumors in 2000-2020: a population-based registry study

Burdenko s Journal of Neurosurgery (2022)

K Kalyango Andrey Dyachenko D. V. Bogdanov E. F. Potekhina Merabishvili Vm

Prevalence and dynamics of certain morphological variants of neuroglial brain malignancies (ICD-10 C71) are unknown in the Russian Federation.To assess the incidence of neuroglial brain malignancies in 2000-2020 considering individual records of morphologically verified cases in the cancer registry of the Arkhangelsk region.We analyzed overall and age-adjusted incidence of neuroglial brain malignancies in 2000-2020 considering morphological subtypes of tumor. Incidence of morphologically verified glioblastoma was assessed in detail taking into account gender, age and place of residence. Segmented regression analysis was used to assess the dynamics and significance of linear trends.In total, there were 1699 brain malignancies for the period from 2000 to 2020. Morphological verification was obtained in 1289 (76%) patients including 467 (27%), 92 (5%) and 307 (18%) ones with glioblastoma, anaplastic G3 glioma and G2 glioma, respectively. Percentage of glioblastoma and anaplastic gliomas increased from 23.4% and 3.9% in 2000 to 55.3% and 9.2% in 2020, respectively. Age-adjusted incidence for the entire C71 group decreased from 5.2 to 3.2 cases per 100,000 after 2015 (annual decline 7.1%). However, incidence of glioblastoma monotonously increased from 1.0 to 2.1 per 100,000 (annual increment 6.2%). Incidence was similar in men and women. Age-adjusted incidence was 50-70% higher among rural population.Significant increase (>2 times) in the incidence of glioblastoma was found over the past twenty years. Probably, it is associated with improved diagnosis and registration of this disease. In-depth analysis of morbidity and survival of patients with rare neuroglial tumors is required.Распространенность и динамика отдельных морфологических вариантов нейроглиальных злокачественных новообразований головного мозга (ЗНО ГМ) (код С71 по МКБ-10) для популяции Российской Федерации неизвестна.Оценить динамику заболеваемости ЗНО ГМ в 2000—2020 гг. на основе индивидуальных записей морфологически верифицированных случаев в канцер-регистре Архангельской области.Рассчитаны «грубые» и стандартизованные по возрасту (СПВ) (стандарт ВОЗ 2000 г.) показатели заболеваемости ЗНО ГМ в период с 2000 по 2020 г. в целом по группе С70—С71 и с учетом морфологических подтипов опухоли. Заболеваемость морфологически верифицированной глиобластомой (ГБ) детально оценена с учетом пола, возраста, места проживания. Для оценки динамики и значимости линейных трендов использовали сегментированный регрессионный анализ.Всего за период с 2000 по 2020 г. выявлено 1699 случаев ЗНО ГМ, морфологическая верификация получена у 1289 (76%) больных, из них у 467 (27%), 92 (5%) и 307 (18%) выявлены ГБ, анапластические глиомы G3 и глиомы G2 соответственно. Доля ГБ и анапластических глиом возросла с 23,4% и 3,9% в 2000 г. до 55,3% и 9,2% в 2020 г. соответственно. На фоне снижения СПВ показателей для всей группы С71 после 2015 г. с 5,2 до 3,2 случая на 100 тыс. населения (ежегодная убыль 7,1%) заболеваемость ГБ монотонно возрастала — с 1,0 до 2,1 случая на 100 тыс. населения (ежегодный прирост 6,2%). Не выявлены различия в заболеваемости между мужчинами и женщинами. Уровни СПВ показателей заболеваемости были на 50—70% выше среди сельского населения.Выявлен статистически значимый рост заболеваемости глиобластомой — более чем в 2 раза за последние 20 лет, связанный, вероятно, с улучшением диагностики и регистрации этого заболевания. Требуется углубленный анализ заболеваемости и выживаемости при редких опухолях нейроглии.

Brain tumor

10.17116/neiro20228605128

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Citations (4)