BackgroundThis study examined the possible association between the prognostic nutritional index (PNI) and in-hospital mortality rates in cases with a high cardiovascular risk burden and hospitalized with the diagnosis of coronavirus disease 2019 (COVID-19).Material and MethodsThis retrospective and cross-sectional study included 294 COVID-19 patients hospitalized in a tertiary referral pandemic center. The study cohort was grouped into tertiles based on the initial PNI values as T1, T2, and T3. The PNI was calculated for each case and the prognostic value of this index was compared to CURB-65 and 4C mortality risk scores in predicting in-hospital mortality.ResultsPatients stratified into the T1 tertile had a lower lymphocyte count, serum albumin level, and PNI values. In a multivariate analysis, the PNI (OR: 0.688,%95CI: 0.586–0.808, p < 0.001) was an independent predictor for all-cause in-hospital death. After adjusting for confounding independent parameters, patients included in the T1 tertile were found to have 11.2 times higher rates of in-hospital mortality compared to the T3 group, which was presumed as the reference group. In addition, we found that the area under curve (AUC) value of PNI was significantly elevated than that of serum albumin level and total lymphocyte counts alone. [(AUC):0.79 vs AUC:0.75 vs AUC:0.69; respectively).ConclusionThis study demonstrated that the PNI is independently related with in-hospital mortality in patient with COVID-19 and cardiovascular risk factors. The power of the PNI was also validated using well-accepted risk scores of COVID-19 such as CURB-65 and 4C mortality risk scores.

Tertiary referral hospital

10.1016/j.hrtlng.2021.01.006

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Incidence and predictors of left atrium thrombus in acute ischemic stroke patients without atrial fibrillation: a single center cohort study

European Heart Journal (2020)

Tufan Çınar Mert İlker Hayıroğlu Vedat Çiçek Süha Asal Murat Mert Atmaca

Abstract Introduction The present study aimed to determine independent predictors of left atrial thrombus (LAT) in acute ischemic stroke patients without atrial fibrillation (AF) using transesophageal echocardiography (TEE). Material and methods In this single center, retrospective cohort study, we enrolled 149 consecutive acute ischemic stroke patients. All of the patients underwent TEE examination to detect LAT within 10 days following admission. Multivariate logistic regression analysis was performed to assess independent predictors of LAT. Results Among all cases, 14 patients (9.3%) had a diagnosis of LAT on TEE examination. In a multivariate analysis; a previous diagnosis of cerebrovascular accident, elevated mean platelet volume (MPV), low left ventricle ejection fraction (EF) and a reduced left atrium appendix (LAA) peak emptying velocity were independent predictors of LAT. The area of MPV under the receiver operating characteristic curve analysis was 0.70 (95% CI: 0.57–0.83; p=0.011). With the optimal cut-off value of 9.45, MPV had a sensitivity of 71.4% and a specificity of 63% to predict LAT. Conclusion Patients with low ventricle EF and elevated MPV should undergo further TEE examination for the possibility of cardio-embolic source. In addition, this research may provide novel information with respect to the applicability of MPV to predict LAT in acute ischemic stroke patients without AF. Figure 1 Funding Acknowledgement Type of funding source: None

Single Center

Stroke

10.1093/ehjci/ehaa946.0076

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Escherichia coli Infective Endocarditis Presented with Aorta-to-left Atrial Fistula and Mitral Valve Aneurysm Rupture: A Rare Clinical Finding

Journal of Cardiovascular Imaging (2019)

Tufan Çınar Mert İlker Hayıroğlu Vedat Çiçek Mehmet Uzun Ahmet Lütfullah Orhan

Infective Endocarditis

10.4250/jcvi.2019.0100

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Vergleich der Ergebnisse zwischen langem Einzelstent und überlappenden Stents: Metaanalyse der Literatur

Herz (2023)

Faysal Şaylık Tufan Çınar Murat Selçuk Vedat Çiçek Mert İlker Hayıroğlu

10.1007/s00059-022-05152-4

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Citations (8)

Letter: The Importance of Stress Hyperglycemia for Poor Outcomes in ST Elevation Myocardial Infarction Patients

Angiology (2022)

Tufan Çınar Almina Erdem Murat Selçuk Vedat Çiçek Süha Asal

Stress hyperglycemia

Elevation (ballistics)

ST elevation

10.1177/00033197221130569

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The effects of SGLT2 inhibitors on right ventricle functions in heart failure patients: update meta-analysis of the current literature

European Heart Journal (2024)

Tufan Çınar Faysal Şaylık Vedat Çiçek Levent Pay A Khachatryan

Abstract Background There is some discrepancy in the present studies concerning the effect of sodium-glucose cotransporter type 2 (SGLT2) inhibitors on right ventricular (RV) functions in heart failure (HF) patients. The current meta-analysis was focused on determining the impact of SGLT2 inhibitors on RV functions in such individuals. Methods Two independent investigators searched PubMed, Google Scholar, and the Cochrane Library for articles of interest. To analyze heterogeneity, Higgins' I2 as well as prediction intervals and Egger's test were utilized to assess heterogeneity. The Newcastle-Ottawa standard ratings approach was used to assess the quality of observational studies. The Robin-I risk of bias algorithm was used to assess the bias risks of randomized studies. Results This meta-analysis evaluated 8 studies in total. Over the follow-up time frame, patients who used SGLT-2 inhibitors had substantially lower systolic pulmonary artery pressure (sPAP) and higher TAPSE values (mean difference (MD) = 1.30 [0.78;1.82], p =0.002 and MD =-5.39 [-7.88; -2.89], p=0.003, respectively). There was no significant difference in RVS’ values between follow-up and baseline (MD=1.38 [-1.35;3.80], p=0.169). However, as compared to the baseline period, fractional area contraction (FAC) values were substantially larger at the end of the follow-up period (MD=5.40 [3.74;7.07], p=0.015). Conclusion To the best of our knowledge, this is the first meta-analysis assessing the impact of SGLT2 inhibitors on RV function in HF patients. Our findings suggest that SGLT2 inhibitors may improve RV performance in HF patients.

10.1093/eurheartj/ehae666.1035

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Unexpected Arrhythmia in a Young Patient: Hookah Smoking Triggered Atrial Fibrillation

Archives of Current Medical Research (2021)

Muhammed Keskin Tufan Çınar Murat Selçuk Selami Doğan Vedat Çiçek

Cardiac arrhythmia

10.47482/acmr.2021.27

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