Hahn Ef

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Jacqueline A. Fishman

Howard P. Roffwarg

University of Mississippi Medical Center

Norton Bi

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University of Mississippi Medical Center

State Street (United States)

University of Mississippi

Jackson Memorial Hospital

The University of Texas Southwestern Medical Center

University of Texas Health Science Center at Dallas

The University of Texas System

The University of Texas Health Science Center at Houston

Albert Einstein College of Medicine

Montefiore Hospital

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Morphine metabolism in opiate dependent and normal men by double isotope techniques.

PubMed (1977)

Hahn Ef Howard P. Roffwarg Jacqueline A. Fishman

A mixture of morphine-63H and morphine-N-14CH3 was administered to an opiate dependent and to a normal male subject. In both subjects the urinary excretion of radioactivity was rapid and exceeded 85% of the dose over 72 hours. The extent and time pattern of N-demethylation differed in the two subjects with N-demethylation of morphine being slower and less in the opiate addict. The use of the double isotope technique in detecting small changes in morphine metabolism is discussed.

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Nalorphine

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Citations (3)

PubMed (1976)

Hahn Ef Norton Bi Jacqueline A. Fishman

Rats were injected with morphine-6(3)H diluted with increasing amounts of non-radiolabelled morphine. The entry of the isotope into the brain and various tissues was measured by combustion in a tissue oxidizer. The relative distribution of morphine between the blood and brain remained constant at about 5.5:1 over the range of doses studied (0.07 - 10.0 mg/kg). No dose related differential effects on morphine uptake were evident in central tissues, with the exception of the hypothalamus which exhibited a disproportionately greater uptake. Among the noncentral tissues, kidney and liver showed the greatest dose related increases in uptake.

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