Yongmei Xia

Jiangnan University

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i-10 index

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Yun Fang

Jiangnan University

Xueyi Hu

Institute of Oceanology

Haijun Wang

Jiangnan University

Xiang Liu

Quzhou University

Fan Ye

Yangtze University

Xiang Liu

Hefei University of Technology

Zhuoyu Zhou

State Key Laboratory of Food Science and Technology

Haijun Wang

Jiangnan University

Qingrui Peng

Jiangnan University

Khaing zar Myint

State Key Laboratory of Food Science and Technology

Cooperative Institutions

Jiangnan University

157

State Key Laboratory of Food Science and Technology

Chinese Academy of Sciences

Wuxi Institute of Technology

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking University

Shanghai Jiao Tong University

Zhejiang University

Fudan University

University of Chinese Academy of Sciences

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The incorporated hydrogel of chitosan-oligoconjugated linoleic acid vesicles and the protective sustained release for curcumin in the gel

International Journal of Biological Macromolecules (2022)

Huan Liu Xinyu Meng Lei Li Yongmei Xia Xueyi Hu

10.1016/j.ijbiomac.2022.12.049

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Citations (11)

Metal-Free Three-Component Oxyazidation of Alkenes with Trimethylsilyl Azide andN-Hydroxyphthalimide

The Journal of Organic Chemistry (2014)

Xiao‐Feng Xia Zhen Gu Wentao Liu Haijun Wang Yongmei Xia

A novel and facile oxyazidation of alkenes under metal-free and mild conditions has been reported. A remarkable feature of the developed procedure is consecutive construction of C-O and C-N bonds in one step. The process allows quick and selective assembly of alkyl azide from readily available starting materials, where N-hydroxyphthalimide was used as an oxygen-radical precursor and TMSN3 as the N3 source. A range of aromatic alkenes bearing synthetically useful functional groups was tolerated.

Trimethylsilyl azide

Trimethylsilyl

Component (thermodynamics)

10.1021/jo502327r

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Citations (87)

The natural sweetener metabolite steviol inhibits the proliferation of human osteosarcoma U2OS cell line

Oncology Letters (2018)

Junming Chen Jue Zhang Yongmei Xia Xiaoxia Wang Jian Li

Steviol is the colonic metabolite of the natural sweetener steviol glycosides. It does not diffuse to the blood and the half maximal inhibitory concentration of steviol is longer compared with that of current chemotherapy agents, including 5-fluorouracil and doxorubicin. The present study demonstrated that steviol inhibits the proliferation of the human osteosarcoma U2OS cell line in a dose- and time-dependent manner, and that the inhibition rate is comparative with that of doxorubicin and 5-fluorouracil. The mechanism of this anticancer activity is also investigated. The results indicated that steviol inhibits U2OS cells through inducing G1 phase cell cycle arrest, downregulating the ability of colony formation via a mitochondrial apoptotic pathway, which was indicated by an increase of the Bax/Bcl-2 ratio and activation of cyclin-dependent kinase inhibitor 1, tumor protein 53 and cyclin-dependent kinase; whereas a Survivin and Caspase 3-independent mechanism was involved. Considering that steviol appears minimally in the plasma during metabolism, and possesses a median lethal dose of 100-fold greater compared with that of 5-fluorouracil, it may become a potential chemotherapy agent.

Steviol

Survivin

10.3892/ol.2018.7962

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Citations (21)

Steviol glycosides, an edible sweet surfactant that can modulate the interfacial and emulsifying properties of soy protein isolate solution

Journal of Food Engineering (2020)

Tongtong Zhang Qingrui Peng Yongmei Xia Yandong Zhang Khaing zar Myint

Steviol

Rebaudioside A

10.1016/j.jfoodeng.2020.110264

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Citations (28)

[Interaction between bovine serum albumin and umbelliferone with/without metal ions of Cu2+ or Zn2+].

Xuefeng Liu Yongmei Xia Yun Fang Lu Zou Lingling Liu

The interaction between bovine serum albumin (BSA) a nd umbelliferone, an active component of Chinese herbs, with or without metal ions was investigated using fluorescence spectroscopy (FS) and UV. The experimental results showed that the umbelliferone molecules inserted into the hydrophobic pockets of BSA and quenched the intrinsic fluorescence of BSA by forming umbelliferone-BSA complex. The mechanism of fluorescence quenching was confirmed combining by both static quenching and nonradiative energy transferring. It was discovered that the apparent association constant (K(A)) increases in the presence of Cu2+ and Zn2+, whereas the spatial-distance (r) between umbelliferone molecule and fluorescent amino acid residues of the BSA and the binding sites (n) of umbelliferone molecules on BSA have no obviously change. Binding of umbelliferone molecules to BSA was a spontaneous supramolecular interaction in which entropy increased and Gibbs free energy decreaed. The interaction of the umbelliferone-BSA was driven mainly by electrostatic force which was enhanced by Cu2+ and Zn2+, thus the contribution of AH to AG increased in the presence of metal ions.

Umbelliferone

Bovine serum albumin

Binding constant

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Citations (2)

Synthesis of M_4IDP and Optimum Labeling Conditions of ~(99)Tc~m-M_4IDP

Tongweisu (2010)

Yongmei Xia

1-Hydroxy-2-(4-methyl-1H-imidazoleyl)-ethylidene-1,1-bisphosphonic(M4IDP)was prepared by three steps of N-alkylation、ester hydrolation and phosphoric acid acylation from the raw material 4-methyl-1H-imidazole.The structures of intermediate and target compounds were identified by Elemental Analysis、IR、MS and 1H NMR.Then M4IDP was directly labeled by Na99TcmO4 to afford 99Tcm-M4IDP.The results showed that the best labeling conditions were 30 minutes reaction time,pH 6,100 μg SnCl2·2H2O,and 5 mg M4IDP.In this condition,the labeling yield was more than 95% and 99Tcm-M4IDP showed good biological stability in vitro.

Imidazole

Proton NMR

Phosphoric acid

Source

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Citations (3)

Nonthermal Effect of Microwave Irradiation in Nonaqueous Enzymatic Esterification

Applied Biochemistry and Biotechnology (2012)

Hui-da Wan Shiyu Sun Xueyi Hu Yongmei Xia

Caprylic acid

Solvatochromism

Enzyme Catalysis

Reaction rate

10.1007/s12010-012-9539-5

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Citations (20)

Fabrication and anti-corrosion performances of robust superhydrophobic surface on NAB via solution-etching

Digest Journal of Nanomaterials and Biostructures (2024)

Ke Chen G.D. Fan Yongmei Xia J. F. Ou

A labyrinth microstructure interconnected by micron and submicron acicular structures was successfully prepared by immersing nickel-aluminum bronze in 9 wt% FeCl3·6H2O solution at room temperature for 40 min. After being modified with 1H, 1H, 2H, 2H-perfluorodecyltriethoxysilane (FAS-17), the microstructure surface displays robustly low-adhesion superhydrophobicity, and the water contact angle is above 160 ° on it. In addition, the superhydrophobic surface exhibits excellent corrosion resistance and stability in 3.5wt % NaCl aqueous solution and corrosion solution with different pH values.

10.15251/djnb.2024.191.337

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Citations (0)

A DFT study of hydrogen bond interactions between oxidative 2′-deoxyadenosine nucleotides and RNA nucleotides

Structural Chemistry (2012)

Jie Shen Haijun Wang Yongmei Xia

Natural bond orbital

Deoxyadenosine

Atoms in molecules

10.1007/s11224-012-0108-x

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Citations (5)

A Computational Approach to Understanding and Predicting the Edulcorant Profile of Glucosyl Steviol Glycosides

Foods (2024)

Zhuoyu Zhou Wei Li Haijun Wang Yongmei Xia

Understanding the edulcorant profile of synthetic glucosyl steviol glycosides (GSGs) and rare natural steviol glycosides (SGs) is challenging due to their numerous species and rareness. This study developed a computational model based on the interactions of SG molecules with human sweet and bitter taste receptors (hSTR/hBTR). The models demonstrated a high correlation between the cumulative interaction energies and the perceived sweetness of SGs (R2 = 0.97), elucidating the mechanism of the diverse sweetness of SGs. It also revealed that more (within three) glucose residues at the C-13 position of the SG molecule yield stronger sweetness and weaker bitterness. Furthermore, the computational prediction was consistently validated with the known sweetness of GSG and also aligned well with that of several natural mogrosides. Thus, this model possesses a potential to predict the sweetness of SGs, GSGs, and mogrosides, facilitating the application or targeted synthesis of GSGs with desired sensory profiles.

Sweetness

Steviol

Bitter Taste

10.3390/foods13121798

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Citations (0)