Usama Kanaan

Emory University

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Ritu Sachdeva

Children's Healthcare of Atlanta

Michael Kelleman

Navitas Systems (United States)

Richard U. Garcia

Emory University

Patricia Lawrence

Georgia State University

William L. Border

Children's Healthcare of Atlanta

Curtis Travers

University of Pennsylvania

Jeryl Huckaby

Emory University

Christopher J. Petit

Columbia University

Lokesh Guglani

Emory University

Timotheus Watson

Children's Healthcare of Atlanta

Cooperative Institutions

Emory University

Children's Healthcare of Atlanta

Boston Children's Hospital

Children's Hospital of Philadelphia

University of Pennsylvania

Harvard University

Baylor College of Medicine

Sibley Memorial Hospital

RELX Group (United States)

University of Colorado Denver

Author Statistics

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Aicardi goutières syndrome is associated with pulmonary hypertension

Molecular Genetics and Metabolism (2018)

Laura Adang David B. Frank Ahmed Gilani Asako Takanohashi Nicole Ulrick

Compound heterozygosity

10.1016/j.ymgme.2018.09.004

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Citations (42)

Oral treprostinil use in children: a multicenter, observational experience

Pulmonary Circulation (2019)

Usama Kanaan Nidhy P. Varghese Ryan Coleman Jeryl Huckaby Patricia Lawrence

Pulmonary arterial hypertension is a progressive, incurable disease that occurs in adults and children alike. Therapeutic options for children are limited and infrequently described, including newer agents such as treprostinil, an oral prostanoid. Herein, we describe the pooled pediatric experience in 28 patients from four pediatric pulmonary hypertension programs over two years. This descriptive, observational study describes the various methods of initiation of oral treprostinil in both prostanoid-naïve patients and those transitioning from parenteral or inhaled prostanoids. The youngest patient was four years old and the smallest weighed 16 kg. We describe adverse reactions and their management. Most patients in this study (27/28) were able to successfully initiate therapy. However, gastrointestinal adverse reactions were common; half of the patients started on this therapy had discontinued it within the two-year study period.

Treprostinil

10.1177/2045894019862138

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Citations (11)

Accelerated Intravenous Rehydration

Clinical Pediatrics (2003)

Usama Kanaan Katherine Mac Rae Dell Jason Hoagland Mary Ann O’Riordan Lydia Furman

To determine whether accelerated intravenous (i.v.) rehydration using a new Isotonic Dehydration Worksheet results in: (1) complications in serum sodium or volume status, and (2) decreased duration of i.v. fluid therapy or length of hospital stay, we conducted a retrospective cohort study utilizing chart review. An intervention group of 98 children, ages 1 month to 12 years, treated with the Isotonic Dehydration Worksheet from December 2000 through March 2001 was compared to a control group of 61 children treated from December 1999 through March 2000 before introduction of the Worksheet. Complication rates were low and did not differ between the 2 groups. Mean unadjusted lengths of i.v. therapy (35.3 vs. 33.7 hours) and of hospital stay (47.0 vs. 49.3 hours) were not significantly different between the 2 groups. Introduction of an accelerated rehydration protocol was well-tolerated by patients but did not result in a significant decrease in the outcome variables examined. Other factors may have a greater impact on the outcome variables, and a prospective study to address these questions is planned.

10.1177/000992280304200506

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Citations (1)

Continuing Medical Education Activity in Echocardiography

Echocardiography (2016)

Timotheus Watson Courtney McCracken Timothy Slesnick Usama Kanaan William L. Border

Atlanta

10.1111/echo.13203

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Citations (0)

Evaluation of clinical and echocardiographic factors associated with post-operative pulmonary arterial hypertension requiring medical therapy in infants with trisomy 21 undergoing atrioventricular septal defect repair

Progress in Pediatric Cardiology (2024)

Chau P. Nguyen Usama Kanaan Richard U. Garcia Matthew Ferguson Hunter C. Wilson

Atrioventricular Septal Defect

Trisomy

Medical Therapy

10.1016/j.ppedcard.2024.101801

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Citations (0)

Pulmonary Hypertension in Kawasaki Disease

Pediatric Cardiology (2012)

George T. Nicholson Cyrus Samai Usama Kanaan

Vascular surgery

Etiology

10.1007/s00246-012-0510-6

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Citations (7)

Improvement in Tricuspid Annular Plane Systolic Excursion with Pulmonary Hypertension Therapy in Pediatric Patients

Echocardiography (2014)

Maria Bano Usama Kanaan Alexandra Ehrlich Courtney McCracken Gemma Morrow

Tricuspid annular plane systolic excursion (TAPSE) has emerged as a novel and reliable measure of right ventricular (RV) function. The purpose of this study was to determine the effect of pulmonary hypertension (PH) therapy on TAPSE in pediatric patients and compare TAPSE to other quantitative measures of RV function.A retrospective review of medical records and echocardiograms of patients in the PH clinic from January 2011 to August 2013 was done. Echocardiograms were analyzed prior to initiation or addition of a PH drug and at least 8 weeks later. Following quantitative measures of RV function were compared: TAPSE, TAPSE age-based z-score, RV fractional area change (RVFAC), tricuspid annular S', tricuspid inflow E/tricuspid annular E' velocity (TV E/E'), and RV myocardial performance index (RVMPI).Of the 37 patients included in this study (median age 0.6 years), 23 (62.2%) were treatment naive and others had a new PH drug added to their regimen at the time of the baseline echocardiogram. The median duration between the baseline and follow-up echocardiogram was 8 (2-25) months. There was a significant improvement in TAPSE and TAPSE age-based z-score on the follow-up echocardiogram. RVFAC, tricuspid S', TV E/E', and RVMPI did not show a statistically significant change.In contrast to the other echocardiographic markers of RV function, TAPSE, and TAPSE age-based z-score significantly improve after initiation or addition of PH therapy and can be used for serial noninvasive monitoring of RV function in pediatric PH patients.

Ventricular Function

Tricuspid insufficiency

10.1111/echo.12835

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Citations (14)

Risk Factors for Adverse Events in Children with Pulmonary Hypertension Undergoing Cardiac Catheterization

Pediatric Cardiology (2021)

Danish Vaiyani Michael Kelleman Laura A. Downey Usama Kanaan Christopher J. Petit

Cardiac catheterization

Pulmonary wedge pressure

10.1007/s00246-020-02535-4

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Citations (9)

Cardiac Troponins in Pediatrics

Pediatric Emergency Care (2004)

Usama Kanaan Vincent W. Chiang

*Resident, Boston Combined Residency Program in Pediatrics, Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA; †Assistant Professor of Pediatrics, Children's Hospital Boston, Harvard Medical School, Boston, MA. Dr. Kanaan and Dr. Chiang have disclosed that they have no significant relationship with or financial interests in any commercial companies that pertain to this educational activity. Address correspondence and reprint requests to Vincent W. Chiang, MD, Department of Medicine, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115. E-mail: [email protected].

Reprint

10.1097/01.pec.0000125664.35690.51

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Citations (30)

New Paradigms for Pulmonary Vein Stenosis Treatment: When Surgery and Transcatheter Therapy Aren't Good Enough

The Journal of Pediatrics (2018)

Usama Kanaan William T. Mahle

Pulmonary vein stenosis

10.1016/j.jpeds.2018.01.082

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Citations (2)