Tatiane A. Paíxão

Universidade Federal de Minas Gerais

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Renato L. Santos

University of California, Davis

154

ÉC

É.A. Costa

Universidade Federal de Minas Gerais

Herlandes Penha Tinoco

Museu de Ciências Naturais da Fundação Zoobotânica do Rio Grande do Sul

Ayisa Rodrigues Oliveira

Universidade Federal de Minas Gerais

Thaynara Parente de Carvalho

University of California, Davis

Juliana Pinto da Silva Mol

Universidade Federal de Minas Gerais

Daniel Oliveira dos Santos

Universidade Federal de Minas Gerais

Angela Tinoco Pessanha

Museu de Ciências Naturais da Fundação Zoobotânica do Rio Grande do Sul

Daniel Assis Santos

Universidade Federal de Minas Gerais

Luciana Fachini da Costa

Universidade Federal de Minas Gerais

Cooperative Institutions

Universidade Federal de Minas Gerais

317

Universidade de São Paulo

University of California, Davis

Fundação Oswaldo Cruz

Universidade Estadual Paulista (Unesp)

Centro Universitário de Belo Horizonte

Fundação de Estudo e Pesquisa em Medicina Veterinária e Zootecnia

University of California Davis Medical Center

Ministry of Agriculture, Livestock, and Food Supply

Universidade Federal do Rio de Janeiro

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Modelo de infecção gastrintestinal e o papel do LPS, urease e sistema de secreção do tipo 4 da Brucella melitensis em camundongos

Tatiane A. Paíxão

A brucelose humana e causada principalmente pela infeccao por Brucella melitensis adquirida frequentemente atraves da ingestao de leite e produtos derivados de cabra ou ovelhas. Fatores de virulencia bacterianos requeridos durante a infeccao oral por B. melitensis sao pouco investigados. Neste estudo, um modelo de infeccao gastrintestinal em camundongo foi desenvolvido para verificar o papel da urease, do sistema de secrecao do tipo 4 (SST4) e do lipopolissacarideo (LPS) no estabelecimento da infeccao por B. melitensis. Camundongos BALB/c femeas foram inoculados intragastricamente por sonda gastrica com 1x1010 UFC de amostra virulenta de B. melitensis 16M ou amostras mutantes, sendo que fragmentos de orgaos foram coletados para bacteriologia. B. melitensis 16M foi consistentemente isolada de linfonodo mesenterico, baco e figado a partir do 3o ou 7o dpi. Ocorreu diminuicao marcante e progressiva no numero de UFC no intestino ate 21 dpi. Nenhuma lesao inflamatoria foi observada no ileo ou colon durante a infeccao. Amostras mutantes carreando delecao da subunidade do ure1 operon, delecao do virB2, ou delecao do pmm foram construidos e comparadas com amostra virulenta 16M. O mutante ure1 foi atenuado no baco (p<0,05). Ja os mutantes virB2 e pmm foram atenuados no baco (p<0,05) e linfonodo mesenterico (p<0,001). Amostra virulenta e amostras mutantes tiveram resistencia semelhante em baixo pH e sais biliares sugerindo que a reduzida colonizacao pelos mutantes nao foi resultado de resistencia reduzida a pH acido e a sais biliares. Os resultados indicam que urease, SST4 e LPS sao requeridos para infeccao de B. melitensis via trato digestivo

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Espondilolistese em frango de corte no Brasil

Arquivo Brasileiro de Medicina Veterinária e Zootecnia (2007)

Tatiane A. Paíxão B.R.C. Ribeiro Frederic J. Hoerr Renato L. Santos

Eight 28-day-old broiler chickens of both sexes were examined.Clinical signs, gross findings, radiological, and histopathological changes were described.Spondylolisthesis was characterized by dorsal displacement of the sixth and seventh thoracic vertebrae, resulting in compression of the spinal cord.The major clinical manifestation was paraplegia.Risk factors such as genetics, nutrition, stress, rate of growth, and age were discussed.

10.1590/s0102-09352007000200039

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Citations (8)

Alginate-chitosan microcapsules improve vaccine potential of gamma-irradiated Listeria monocytogenes against listeriosis in murine model

International Journal of Biological Macromolecules (2021)

Cláudia Emanuela Rocha Monique F. Silva Andressa Cristine Borges Guedes Thaynara Parente de Carvalho Camila Eckstein

Splenocyte

Inactivated vaccine

Intracellular parasite

10.1016/j.ijbiomac.2021.02.056

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Citations (19)

Mandibular squamous cell carcinoma in a captive Siberian tiger (Panthera tigris altaica)

Brazilian Journal of Veterinary Pathology (2018)

Ayisa Rodrigues Oliveira Tatiane Furtado de Carvalho Alexandre Arenales Herlandes Penha Tinoco Carlyle Mendes Coelho

Squamous cell carcinoma (SCC) is a common oral neoplasm in domestic cats, but there are only a few reports in wild felids.A captive 10-years-old, female Siberian tiger (Panthera tigris altaica), with history of chronic renal disease and serologically positive for Leishmania sp.developed a lytic mandibular nodule that was histologically diagnosed as SCC.At necropsy was also observed an exocrine pancreatic carcinoma, which was considered an incidental finding, and a chronic lympho-plasmocytic interstitial nephritis associated with a membranous glomerulopathy, compatible with the chronic renal disease presented by the animal.To the best of our knowledge this is the first report of an invasive and non-metastatic mandibular SCC in a Siberian tiger.

Tiger

10.24070/bjvp.1983-0246.v11i3p97-101

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Tissue distribution and cell tropism of Brucella canis in naturally infected canine foetuses and neonates

Scientific Reports (2018)

Tayse Domingues de Souza Tatiane Furtado de Carvalho Juliana Pinto da Silva Mol João Vítor Menezes Lopes Monique Ferreira Silva

Abstract Brucella canis infection is an underdiagnosed zoonotic disease. Knowledge about perinatal brucellosis in dogs is extremely limited, although foetuses and neonates are under risk of infection due to vertical transmission. In this study, immunohistochemistry was used to determine tissue distribution and cell tropism of B . canis in canine foetuses and neonates. Diagnosis of B . canis in tissues of naturally infected pups was based on PCR and sequencing of amplicons, bacterial isolation, and immunohistochemistry, whose specificity was confirmed by laser capture microdissection. PCR positivity among 200 puppies was 21%, and nine isolates of B . canis were obtained. Tissues from 13 PCR-positive puppies (4 stillborn and 9 neonates) presented widespread immunolabeling. Stomach, intestines, kidney, nervous system, and umbilicus were positive in all animals tested. Other frequently infected organs included the liver (92%), lungs (85%), lymph nodes (69%), and spleen (62%). Immunolabeled coccobacilli occurred mostly in macrophages, but they were also observed in erythrocytes, epithelial cells of gastrointestinal mucosa, renal tubules, epidermis, adipocytes, choroid plexus, ependyma, neuroblasts, blood vessels endothelium, muscle cells, and in the intestinal lumen. These results largely expand our knowledge about perinatal brucellosis in the dog, clearly demonstrating a pantropic distribution of B . canis in naturally infected foetuses and neonates.

10.1038/s41598-018-25651-x

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Citations (28)

Production of IL-1β, IL-6 and CXCL8 by endometrium of crossbred heifers stimulated with various pathogen-associated molecular patterns

Animal Reproduction Science (2021)

Philipe Pimenta Nunes Telma da Mata Martins Ana Carolina Leite Eliane Beatriz Magalhães Silva Tatiane A. Paíxão

Interleukin 8

10.1016/j.anireprosci.2021.106736

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N-acetylcysteine reduces amphotericin B deoxycholate nephrotoxicity and improves the outcome of murine cryptococcosis

Medical Mycology (2019)

Thaís Furtado Ferreira Magalhães Marliete Carvalho da Costa Rodrigo Assunção Holanda Gabriela Freitas Ferreira Vanessa S. D. Carvalho

Abstract Cryptococcosis is a life-threatening fungal infection, and its current treatment is toxic and subject to resistance. Drug repurposing represents an interesting approach to find drugs to reduce the toxicity of antifungals. In this study, we evaluated the combination of N-acetylcysteine (NAC) with amphotericin B (AMB) for the treatment of cryptococcosis. We examined the effects of NAC on fungal morphophysiology and on the macrophage fungicidal activity 3 and 24 hours post inoculation. The therapeutic effects of NAC combination with AMB were investigated in a murine model with daily treatments regimens. NAC alone reduced the oxidative burst generated by AMB in yeast cells, but did not inhibit fungal growth. The combination NAC + AMB decreased capsule size, zeta potential, superoxide dismutase activity and lipid peroxidation. In macrophage assays, NAC + AMB did not influence the phagocytosis, but induced fungal killing with different levels of oxidative bursts when compared to AMB alone: there was an increased reactive oxygen species (ROS) after 3 hours and reduced levels after 24 hours. By contrast, ROS remained elevated when AMB was tested alone, demonstrating that NAC reduced AMB oxidative effects without influencing its antifungal activity. Uninfected mice treated with NAC + AMB had lower concentrations of serum creatinine and glutamate-pyruvate transaminase in comparison to AMB. The combination of NAC + AMB was far better than AMB alone in increasing survival and reducing morbidity in murine-induced cryptococcosis, leading to reduced fungal burden in lungs and brain and also lower concentrations of pro-inflammatory cytokines in the lungs. In conclusion, NAC + AMB may represent an alternative adjuvant for the treatment of cryptococcosis.

Amphotericin B deoxycholate

10.1093/mmy/myz129

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Etiologic diagnosis of bovine infectious abortion by PCR

Ciência Rural (2009)

Teane Milagres Augusto da Silva Raquel G. Oliveira Juliana Pinto da Silva Mol Mariana N. Xavier Tatiane A. Paíxão

Infectious abortion is a significant cause of reproductive failure and economic losses in cattle. The goal of this study was to detect nucleic acids of several infectious agents known to cause abortion including Arcanobacterium pyogenes, Bovine Herpesvirus 1, Brucella abortus, Campylobacter fetus subsp. venerealis, Chlamydophila abortus, Leptospira sp., Listeria monocytogenes, Salmonella sp., Mycoplasma bovis, Mycoplasma bovigenitalium, Neospora caninum, and Tritrichomonas foetus. Tissue homogenates from 42 fetuses and paraffin-embedded tissues from 28 fetuses and 14 placentas/endometrium were included in this study. Brucella abortus was detected in 14.2% (12/84) of the samples. Salmonella sp. DNA was amplified from 2 fetuses, and there was one positive for Neospora caninum, and another for Listeria monocytogenes. This PCR-based approach resulted in identification of the etiology in 19% of samples, or 20% if considered fetal tissues only.

Tritrichomonas foetus

Aborted Fetus

Campylobacter fetus

10.1590/s0103-84782009000900028

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Citations (24)

Urethral obstruction secondary to Staphylococcus felis chronic urethritis and hepatoid gland adenoma in a captive ocelot (Leopardus pardalis)

Brazilian Journal of Veterinary Pathology (2023)

Mariana Ferreira de Castro Thaynara Parente de Carvalho Daniel Oliveira dos Santos Ayisa Rodrigues Oliveira Samantha Pinheiro Pimentel

A male adult ocelot (Leopardus pardalis) kept under human care developed anuria, which progressed to death. Grossly, the urinary bladder was markedly dilated and filled with red discolored urine containing blood clots. In addition, the animal had a hepatoid cell adenoma adjacent to the urethra, which likely caused partial urethral occlusion. Microscopically, there was a predominantly neutrophilic, fibrinous and hemorrhagic urethritis, cystitis, and pyelonephritis with intralesional gram-positive cocci. Microbiologic culture followed by MALDI-TOF MS analysis resulted in the identification of isolates from the urine and urethra as Staphylococcus felis.

Leopardus

10.24070/bjvp.1983-0246.v16i2p132-138

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Efficacy of strain RB51 vaccine in heifers against experimental brucellosis

Vaccine (2006)

Fernando Padilla Poester Vı́tor Salvador Picão Gonçalves Tatiane A. Paíxão Renato L. Santos Steven C. Olsen

Direct agglutination test

Tylosin

10.1016/j.vaccine.2006.04.020

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Citations (91)