Gold nanoparticles (AuNPs) are considered nontoxic upon acute exposure, at least when they are equal or above 5 nm size. However, the safeguard mechanisms contributing to maintain cell viability are scarcely explored so far. Here, we investigated the cyto-protective role of Glyoxalase 1 (Glo1), a key enzyme involved in the control of deleterious dicarbonyl stress, in two human cell types of the respiratory tract, after an acute exposure to AuNPs with a main size of 5 nm. We found that the redox sensitive Nrf-2-mediated up-regulation of Glo1 was crucial to protect cells from AuNPs-induced toxicity. However, cells challenged with a pro-inflammatory/pro-oxidative insult become susceptible to the pro-apoptotic effect of AuNPs. Notably, the surviving cells undergo epigenetic changes associated with the onset of a partial epithelial to mesenchymal transition (EMT) process (metastable phenotype), driven by the increase in dicarbonyl stress, consequent to Glo1 inactivation. As a physiological respiratory epithelium is required for the normal respiratory function, the knowledge of the protective mechanisms avoiding or (when challenged) promoting its modification/damage might provide insight into the genesis, and, most importantly, prevention of potential health effects that might occur in subjects exposed to AuNPs, through targeted surveillance programs, at least under specific influencing factors.
The huge number of electronic devices called the Internet of Things requires miniaturized, autonomous and ecologically sustainable power sources. A viable way to power these devices is by converting mechanical energy into electrical through electro-active materials. The most promising and widely used electro-active materials for mechanical energy harvesting are piezoelectric materials, where the main one used are toxic or not biocompatible. In this work, we focus our attention on biocompatible and sustainable piezoelectric materials for energy harvesting. The aim of this work is to facilitate and expedite the effort of selecting the best piezoelectric material for a specific mechanical energy harvesting application by comprehensively reviewing and presenting the latest progress in the field. We also identify and discuss the characteristic property of each material for each class to which the material belong to, in terms of piezoelectric constants and achievable power.
Bone has a sophisticated architecture characterized by a hierarchical organization, starting at the sub-micrometre level. Thus, the analysis of the mechanical and structural properties of bone at this scale is essential to understand the relationship between its physiology, physical properties and chemical composition. Here, we unveil the potential of Brillouin–Raman microspectroscopy (BRaMS), an emerging correlative optical approach that can simultaneously assess bone mechanics and chemistry with micrometric resolution. Correlative hyperspectral imaging, performed on a human diaphyseal ring, reveals a complex microarchitecture that is reflected in extremely rich and informative spectra. An innovative method for mechanical properties analysis is proposed, mapping the intermixing of soft and hard tissue areas and revealing the coexistence of regions involved in remodelling processes, nutrient transportation and structural support. The mineralized regions appear elastically inhomogeneous, resembling the pattern of the osteons' lamellae, while Raman and energy-dispersive X-ray images through scanning electron microscopy show an overall uniform distribution of the mineral content, suggesting that other structural factors are responsible for lamellar micromechanical heterogeneity. These results, besides giving an important insight into cortical bone tissue properties, highlight the potential of BRaMS to access the origin of anisotropic mechanical properties, which are almost ubiquitous in other biological tissues.
In this study, we report the synthesis and photocatalytic performance of Co₃O₄-decorated hexagonal boron nitride (hBN) composites for degrading methylene blue (MB) and ibuprofen (IBF) under sunlight irradiation. Using a dry impregnation method, the composites were prepared with varying Co₃O₄ loadings (0.5%, 1%, 2%). Comprehensive characterization confirmed the successful incorporation and uniform distribution of Co₃O₄ on the hBN matrix. Photocatalytic experiments revealed that 1% Co₃O₄-hBN composite exhibited the highest activity, achieving nearly 100% MB degradation in 60 minutes and 90% IBF degradation in 120 minutes. The enhanced photocatalytic efficiency is attributed to the synergistic effects between Co₃O₄ and hBN, which extend light absorption and promote charge separation. Our findings demonstrate the potential of Co
In this paper, we studied an efficient protocol of reductive carbonylation of two aryl iodides, namely 2-iodo-5-ethylthiofene and 5-iodobenzo[d][1,3] dioxole, employing formic acid, propylphosphonic anhydride (T3P) and a base, to afford aldehydes used as such as industrial flavors/fragrances or as key intermediates for some APIs and other fragrances. Our approach, comparing to the previously described protocol [1], not only avoids the use of unsafe reagents and/or solvents but, noteworthy, uses easily prepared heterogeneous catalysts with a low content of metal(s), such as 0.3 % Pd/Al2O3, (0.18 % Pd, 0.44 % Cu)/Al2O3 and 1 % Cu/Al2O3. These catalysts, as well as commercial Pd/C species tested here for a comparison, are also recyclable and have been characterized before and after use by FE-SEM, EDS and TEM spectroscopy. Noteworthy, both the bimetallic system Pd-Cu/Al2O3, containing a very low amount of expensive palladium (0.18 %) and Cu/Al2O3, containing no palladium at all, showed very high activities.
TiO2 powders can be employed as both photocatalytic and structural materials, leading to applications in external coatings or in interior furnishing devices, including cement mortar, tiles, floorings, and glass supports. The technology of photocatalytic building materials is connected with the widespread production of photocatalytic active tiles. All the techniques proposed in the study involve the employment of nanosized TiO2: this represents a new problem to be dealt with, as inhaling nanoparticles exposes workers during industrial production and people in everyday locations to their dangerousness. Only very recently the employment of microsized TiO2 has been proposed, and the authors in this manuscript report the use of micrometric titania materials, but employing a new deposition technique, which is digital inkjet printing. It represents an improvement of the classical spray coating methods, as it requires piezoelectric heads to precisely direct the deposition of the suspension with an electrostatic field. The mixture contains aqueous/organic components containing micrometric TiO2: to form a suspension, which is printed onto the surface of porcelain grès, large slabs using a digital printer. Many advantages are immediately evident, namely rapid and precise deposition, (almost) no waste of raw materials, thereby highlighting the economy, environmental friendliness, and sustainability of the process. All the materials we obtained have been thoroughly characterized by means of several experimental physico-chemical techniques, such as Raman microspectroscopy and scanning electron microscopy coupled with elemental analysis. Two different model VOCs, ethanol and toluene, and NOx have been selected to test the photocatalytic performances of the abovementioned tiles. Moreover, the antibacterial properties of the tiles have been determined, using Escherichia coli as example. Life cycle assessments (LCAs) for the two processes were modeled for 1 m2 of tiles produced in Modena, Italy. The impact assessments revealed that jet spraying exhibited uniformly greater impacts than digital inkjet printing and that the principal impacts were in human toxicity, cancer effects, freshwater ecotoxicity, and climate change. Most of the impacts were associated with the energy required for the production processes. Further considerations revealed that jet spraying is projected to generate twice as much CO2 and 30% more NOx than digital inkjet printing.
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