Miao Guo

Nankai University

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Nilay Shah

Nationwide Children's Hospital

Qihua Yang

Zhejiang Normal University

Koen H. van Dam

Imperial College London

Alex Durkin

Imperial College London

Xiaonan Wang

Tsinghua University

Richard Murphy

University of Surrey

Nilay Shah

The Ohio State University

David C. Stuckey

Imperial College London

He Li

Guangdong Pharmaceutical University

Xiaomin Ren

Kunming University of Science and Technology

Cooperative Institutions

Chinese Academy of Sciences

125

Imperial College London

University of Chinese Academy of Sciences

Soochow University

Tsinghua University

University of Maryland, College Park

Shanghai Jiao Tong University

University of Science and Technology of China

Zhejiang University

Dalian Institute of Chemical Physics

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Multipronged Design of Light-Triggered Nanoparticles To Overcome Cisplatin Resistance for Efficient Ablation of Resistant Tumor

ACS Nano (2015)

Yanli Li Yibin Deng Xin Tian Hengte Ke Miao Guo

Chemotherapeutic drugs frequently encounter multiple drug resistance in the field of cancer therapy. The strategy has been explored with limited success for the ablation of drug-resistant tumor via intravenous administration. In this work, the rationally designed light-triggered nanoparticles with multipronged physicochemical and biological features are developed to overcome cisplatin resistance via the assembly of Pt(IV) prodrug and cyanine dye (Cypate) within the copolymer for efficient ablation of cisplatin-resistant tumor. The micelles exhibit good photostability, sustained release, preferable tumor accumulation, and enhanced cellular uptake with reduced efflux on both A549 cells and resistant A549R cells. Moreover, near-infrared light not only triggers the photothermal effect of the micelles for remarkable photothermal cytotoxicity, but also leads to the intracellular translocation of the micelles and reduction-activable Pt(IV) prodrug into cytoplasm through the lysosomal disruption, as well as the remarkable inhibition on the expression of a drug-efflux transporter, multidrug resistance-associated protein 1 (MRP1) for further reversal of drug resistance of A549R cells. Consequently, the multipronged effects of light-triggered micelles cause synergistic cytotoxicity against both A549 cells and A549R cells, and thus efficient ablation of cisplatin-resistant tumor without regrowth. The multipronged features of light-triggered micelles represent a versatile synergistic approach for the ablation of resistant tumor in the field of cancer therapy.

Efflux

10.1021/acsnano.5b05097

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Citations (145)

Hollow Pt skim-sandwiched Cu spheres supported on reduced graphene oxide-carbon nanotube architecture for efficient methanol electrooxidation

International Journal of Hydrogen Energy (2019)

Miao Guo Qianyang Tu Longlu Wang Yanhong Tang Hejie Song

Bimetallic strip

Chloroplatinic acid

Methanol fuel

Galvanic cell

10.1016/j.ijhydene.2019.01.175

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Citations (17)

Emerging supply chain of utilising electrical vehicle retired batteries in distributed energy systems

Advances in Applied Energy (2020)

Rui Jing Junyao Wang Nilay Shah Miao Guo

Increasing electric vehicles (EV) penetration leads to significant challenges in EV battery disposal. Reusing retired batteries in distributed energy systems (DES) offers resource-circular solutions. We propose an optimisation framework to model the emerging supply chains and design strategies for reusing the retired EV batteries in DES. Coupling a supply chain profit-allocation model with a DES design optimisation model, the framework maximises the whole chain profit and enables fair profit distribution between three interactive sectors, i.e., EV, DES, dismantling and recycle (D&R) sectors. Our research highlights the system implications of retired batteries on DES design and new modelling insights into incentive policy effectiveness. Our case study suggests significant potential value chain profits (2.65 million US$) achieved by deploying 10.7 MWh of retired batteries in the DES application with optimal retired battery price of 138 US$/kWh. The revenue support on D&R sector is suggested as a promising incentive scheme than tariff support.

10.1016/j.adapen.2020.100002

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Citations (37)

Surrogate-based optimisation of process systems to recover resources from wastewater

Computers & Chemical Engineering (2024)

Alex Durkin L. Otte Miao Guo

Wastewater systems are transitioning towards integrative process systems to recover multiple resources whilst simultaneously satisfying regulations on final effluent quality. This work contributes to the literature by bringing a systems-thinking approach to resource recovery from wastewater, harnessing surrogate modelling and mathematical optimisation techniques to highlight holistic process systems. A surrogate-based process synthesis methodology was presented to harness high-fidelity data from black box process simulations, embedding first principles models, within a superstructure optimisation framework. Modelling tools were developed to facilitate tailored derivative- free optimisation solutions widely applicable to black box optimisation problems. The optimisation of a process system to recover energy and nutrients from a brewery wastewater reveals significant scope to reduce the environmental impacts of food and beverage production systems. Additionally, the application demonstrates the capabilities of the modelling methodology to highlight optimal processes to recover carbon, nitrogen, and phosphorous resources whilst also accounting for uncertainties inherent to wastewater systems.

Scope (computer science)

10.1016/j.compchemeng.2024.108584

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Citations (2)

Innovativeness Scale—Adapted

PsycTESTS Dataset (2015)

Miao Guo Sylvia M. Chan‐Olmsted

10.1037/t44807-000

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Citations (0)

High-solids fermentation of food wastes for biogas recovery by using horizontal anaerobic reactor

Journal of Renewable and Sustainable Energy (2018)

Mingxing Zhao Lili Yang Miao Guo Zhenxing Huang Wansheng Shi

The biogas recovery from food wastes by anaerobic digestion was considered to be a feasible way for waste treatment. The system performance of high-solid anaerobic digestion of canteen food wastes by a horizontal reactor (8l) was investigated in this study. The TS of the reaction system was kept at 15%. The results indicated that biogas remained stable at about 650 ml/gTS when the volumetric loading rate (VLR) increased from 2 gTS/l.d to 8 gTS/l.d; however, it decreased at the VLR of 11 gTS/l.d. It suggested that VLR of 8 gTS/l.d was the optimal rate for this horizontal anaerobic reactor. After the adjustment of the running operation, the reactor remained stable with the accumulative biogas yield of 484 ml/gTS. The concentration of soluble chemical oxygen demand, ammonia nitrogen, volatile fatty acid, and alkalinity sharply increased to 41 024 mg/l, 2711 mg/l, 16 366 mg/l, and 14 250 mg/l at day 65 which reflected at the instable stage of the reactor, respectively. The maximum values of amylase and protease enzyme occurred at the initial stage of the reaction system with 1.42 U/ml (day 10) and 1.53 × 10−3 U/ml (day 17), respectively. After that, the two enzymes remained stable.

Biogas

Alkalinity

Food Waste

Biogas Production

10.1063/1.5032212

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Citations (2)

A new method for mammographic mass segmentation based on parametric active contour model

Miao Guo Mev Dong Zhaobev Wang Yide Ma Yanan Guo

Image segmentation is an important task in the analysis of mammograms and it is challenging because the masses are low contrast with ambiguous margins. The classical Vector Field Convolution (VFC) method has demonstrated its merits in image segmentation; however it is difficult to capture the ambiguous object boundaries. In this work, a new snake model is proposed to solve this problem, this proposed method combines the morphological filter with the laplacian operator. A new external force is calculated by convolving the edge map with the user-defined vector field kernel. The proposed algorithm is tested on the Mammographic Image Analysis Society (MIAS) database. The experimental results suggest that the proposed method can effectively locate ambiguous margins of the masses. Compared with gradient vector flow (GVF) snake and classical VFC snake, the proposed method shows its advantages, including the reduced computational cost and better performance.

Vector flow

Active contour model

Kernel (algebra)

Image gradient

Convolution (computer science)

10.1109/icwapr.2015.7295921

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Citations (4)

Thoughts on China’s Rural Ecological Security Construction from the Perspective of Overall National Security Concept

Journal of Innovation and Social Science Research (2021)

Yang Jian-lan Miao Guo

As a national security thought in the new era, the overall national security concept contains rich security governance theory and practical experience, which provides a scientific guide and program for the development of various security work in China. Rural ecological security, as an organic component of overall national security, interpenetrates and interacts with other areas of security, and counteracts the realization of overall national security. Based on the overall national security concept, the rural ecological security construction should adhere to the bottom line thinking, people-oriented, innovation-oriented and rule of law, and conceive an optimized path in the aspects of pre-prevention, public demand, talent integration, collaborative governance, technical means and legal system construction, which is of great significance to national development and people’s lives.

Critical security studies

Security convergence

Corporate security

Security engineering

Security through obscurity

10.53469/jissr.2021.08(09).26

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Citations (0)

End-of-Life Scenarios

Springer theses (2012)

Miao Guo

10.1007/978-3-642-35037-5_5