Swapnil Garde

Gauhati Medical College and Hospital

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Lokendra Dave

Hamidia Hospital

Ozair Ahmad Ansari

Nishant Shrivastava

Mahatma Gandhi Mission's Dental College and Hospital

Romar Dabu

Gauhati Medical College and Hospital

Mohammad Ghaznavi Idris

Gauhati University

P. Bhattacharyya

Institute of Post Graduate Medical Education and Research

Gautam Hazarika

Gauhati University

V. K. Sharma

Indian Agricultural Research Institute

Yogesh Varma

Tokyo Women's Medical University

Amit S. Barpha

Christian Medical College & Hospital

Cooperative Institutions

Gandhi Medical College

Gauhati Medical College and Hospital

Gauhati University

Hamidia Hospital

Mahatma Gandhi Mission's Dental College and Hospital

Institute of Post Graduate Medical Education and Research

Assam Medical College

Indian Agricultural Research Institute

National Health Systems Resource Centre

Ministry of Health and Family Welfare

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To study the serum C-reactive protein level and its correlation with prognostic variables in stable COPD patients

International Journal of Medical Research and Review (2015)

Nishant Srivastava Lokendra Dave Shivani Chaturvedi Timothy Dube Swapnil Garde

Introduction: C-reactive protein is a stable and excellent biomarker of systemic inflammation which is easy to measure. COPD is an inflammatory disorder of lung with widespread Systemic manifestations and associated Systemic inflammatory response. C-reactive protein levels are increased in COPD patients. Present study investigated C-reactive protein level in stable COPD patients and its relation with clinically important outcome variable, exercise capacity. Method: Study included 56 stable COPD patients with mild to moderate severity in age group 40-70 years and 56 nonsmoking controls in the same age group. Clinical and physiological characteristics were determined and C-reactive protein levels were measured. Result: This study confirms the finding of higher C-reactive protein levels in smoker COPD patients (4.9 vs 4.0 mg-L-1) as compared to nonsmoker COPD patients. It also confirms that level of C-reactive protein in ex-smoker COPD population remains significantly higher than nonsmoker control group (4.9±0.5 vs 3.1mg/l). Conclusion: C-reactive protein level was strongly associated and correlated with 6 minute walk distance, FEV1 and GOLD stages, so C-reactive protein level can indirectly reflect prognosis of COPD patient and his exercise capacity. We recommend that measurement of C-reactive protein levels may be a useful tool to predict the prognosis and patient outcome in COPD patients. It also provides strong argument to develop therapies aimed at decreasing inflammation independent of smoking cessation.

10.17511/ijmrr.2015.i8.160

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COPD, Metabolic syndrome.

Lokendra Dave Swapnil Garde Ozair Ahmad Ansari Nishant Shrivastava Vipin Kumar Sharma

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PM415 Cardiac chamber dimensions in chronic obstructive pulmonary disease

Global Heart (2014)

Yogesh Varma Swapnil Garde Virendra K. Sharma Lokendra Dave Raghvendra Singh Meena

Paricalcitol

Asymmetric dimethylarginine

Endothelial Dysfunction

10.1016/j.gheart.2014.03.1747

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Conduction block in acute coronary syndrome: a study on the pattern and in hospital outcomes from a tertiary care centre in Guwahati, Assam

Indian Heart Journal (2018)

Romar Dabu P. Bhattacharyya Farhin Iqbal Jogesh Chandra Barkataki Swapnil Garde

Tertiary care

10.1016/j.ihj.2018.10.269

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Study to establish genetic association of cardiac conduction defect in Indian patients undergoing pacemaker implantation

International Journal of Advances in Medicine (2021)

Swapnil Garde Pranab Jyoti Bhattacharyya Mohammad Ghaznavi Idris Romar Dabu Gautam Hazarika

Background: The aim was to study the genetic association of cardiac conduction defects (CCDs) by evaluating single nucleotide polymorphism (SNP) in genes of SCN1B and KCNJ2 and to evaluate baseline characteristics between cases and controls.Methods: Case group consisted of 81 individuals with diagnosis of conduction disturbances who underwent permanent pacemaker implantation. The control group consisted of 79 unrelated individuals above 18 years of age of the local population not having a present or past personal or family history (first degree relatives) of any cardiac ailment especially CCDs. Isolation of genomic deoxyribonucleic acid (DNA) from all samples was done, genomic DNA was checked to ensure the presence of intact DNA.Results: SCN1B: SNP rs55742440 had no bearing on the protein except in producing a splice variant. SNP rs67701503 does not lie in the splice-site region, thus not having any significance in the regulation of the gene as well. NetGene2 analysis of SNP rs67486287 negates its presence in the splice site. KCNJ2:SNP rs199473653 leads to a missense amino acid change, resulting in homozygous GG variant found in almost equal frequency in both groups. SNP rs199473653 gene has not been reported as a disease causing mutation.Conclusions: The alteration of nucleotide in SCN1B intron (SNP rs55742440, rs67701503, rs67486287) between cases and controls was found to have no odds of affecting the outcome of CCD. There was no variation or alteration in nucleotide bases of KCNJ2 (SNP rs786205813, rs199473653) between the groups.

SNP

splice

SNP array

Splice site mutation

SNP genotyping

10.18203/2349-3933.ijam20213171

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A STUDY OF ASSOCIATION BETWEEN METABOLIC SYNDROME AND COPD

Journal of Evolution of Medical and Dental Sciences (2014)

Lokendra Dave Swapnil Garde Ozair Ahmad Ansari Nishant Shrivastava V. K. Sharma

Objective: To evaluate the association between metabolic syndrome and Chronic obstructive Pulmonary Disease.METHODOLOGY: This was a prospective -observational cross sectional, analytical study, conducted in Department of Chest-TB and Medicine, Gandhi Medical College, Hamidia Hospital, Bhopal from November 2012 to December 2013.Patient having chronic obstructive pulmonary disease were subjected to this study.Age and sex matched controls were selected randomly.Purpose of study was explained and informed consent was obtained.RESULTS: Distribution of metabolic syndrome among COPD patients, according to sex (male: female) was 6:1 whereas 2.2:1 in controls (male preponderance).42% of COPD patients and 22% of control participants presented 3 or more determinants of the metabolic syndrome.Mean FBS was significantly different from controls with mean FBS value of 119.6±39.39 and 90.16±25.26respectively.Mean abdominal girth, systolic BP, diastolic BP, HDL levels, triglyceride and BMI were not significantly different between cases and controls.CONCLUSION: This study showed that there is strong association of COPD with metabolic syndrome.

Association (psychology)

10.14260/jemds/2014/2720

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