Robin Ruthazer

Supplementary Figure Legends 1-3, Methods, Tables 1-4 from Alterations of the HBP1 Transcriptional Repressor Are Associated with Invasive Breast Cancer

YY1

10.1158/0008-5472.22367603

Cite

Citations (0)

Supplementary Figure 3 from Alterations of the HBP1 Transcriptional Repressor Are Associated with Invasive Breast Cancer

K. Eric Paulson Kimberly Rieger‐Christ Michael A. McDevitt Charlotte Kuperwasser Jiyoung Kim

Supplementary Figure 3 from Alterations of the HBP1 Transcriptional Repressor Are Associated with Invasive Breast Cancer

YY1

10.1158/0008-5472.22367606.v1

Cite

Citations (0)

Supplementary Figure 1 from Alterations of the HBP1 Transcriptional Repressor Are Associated with Invasive Breast Cancer

K. Eric Paulson Kimberly Rieger‐Christ Michael A. McDevitt Charlotte Kuperwasser Jiyoung Kim

Supplementary Figure 1 from Alterations of the HBP1 Transcriptional Repressor Are Associated with Invasive Breast Cancer

YY1

10.1158/0008-5472.22367612

Cite

Citations (0)

Sodium Homeostasis During Liver Transplantation and Correlation With Outcomes

Survey of Anesthesiology (2015)

Jana Hudcova Robin Ruthazer Iwona Bonney Roman Schumann

*Department of Surgical Critical Care, Lahey Hospital & Medical Center, Burlington; and †Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center; ‡Tufts Clinical and Translational Science Institute, Tufts University; and §Department of Anesthesiology, Tufts Medical Center, Boston, MA.

Biostatistics

Center (category theory)

10.1097/01.sa.0000464122.53127.14

Cite

Citations (3)

The Stroke Practice Improvement Network: A Quasiexperimental Trial of a Multifaceted Intervention to Improve Quality

Journal of Stroke and Cerebrovascular Diseases (2010)

Judith A. Hinchey Timothy J. Shephard Sarah T. Tonn Robin Ruthazer Richard C. Hermann

Stroke

10.1016/j.jstrokecerebrovasdis.2009.03.016

Cite

Citations (17)

Disturbances of Tryptophan Metabolism and Risk of Depression in HCV Patients Treated with IFN-Alpha

Journal of Infectious Diseases and Therapy (2014)

Gf Oxenkrug Waldemar A. Turski Wojciech Zgrajka Jv Weinstock Robin Ruthazer

Depression is a common side-effect of interferon (IFN)-alpha treatment of hepatitis C virus (HCV) infection and melanoma. Disturbances of tryptophan (TRP) metabolism might contribute to development of IFN-alpha-associated depression due to IFN-alpha-induced activation of indoleamine 2,3-dioxygenase (IDO), a rate-limiting enzyme of TRP-kynurenine (KYN) metabolism. The increased frequency of high producer (T) allele of IFN-gamma (IFNG) (+874) gene, that encodes IFNG production, in depressed patients suggested that increased IDO activity might be a risk factor for depression. The present study assessed KYN/TRP ratio (KTR) as a marker of IDO activity in American Caucasian HCV patients awaiting IFN-alpha treatment. KTR did not differ between 43 patients who did and 37 patients who did not develop depression. TRP concentrations were higher in patients who experienced depression. Odds of development of depression increased with elevation of serum TRP levels from 33% (TRP levels <12000 pmol/ml) to 68% (TRP levels > 16000 pmol/ml). Elevated serum TRP may reflect the impairment of TRP conversion into serotonin in agreement with suggested link between serotonin deficiency and depression. Up-regulation of IDO might be an additional risk factor of IFN-alpha-associated depression. Future studies shall explore the causes of elevated serum TRP in relation to IFN-alpha-associated depression.

Alpha (finance)

Depression

Tryptophan Metabolism

10.4172/2332-0877.1000131

Cite

Citations (19)

Robin Ruthazer

Papers

Citation

H-Index

i-10 index

Papers

Citation

H-Index

i-10 index