Xueshi Huang

Northeastern University

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Li Han

Northeastern University

Yu Mu

Northeastern University

Liya Li

Zhejiang Ocean University

Yi Jiang

Huazhong Agricultural University

Peipei Guan

Hebei Agricultural University

Cheng‐Lin Jiang

Yunnan University

Isabel Sattler

Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)

Gui-Ding Li

Kunming Medical University

Dan Zheng

Monash University

Susanne Grabley

Leibniz Association

Cooperative Institutions

Northeastern University

Chinese Academy of Sciences

Yunnan University

China Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking University

University of Chinese Academy of Sciences

Huazhong University of Science and Technology

Sun Yat-sen University

Shanghai Jiao Tong University

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Chemical characterization, antiproliferative and antifungal activities of Clinacanthus nutans

Fitoterapia (2021)

Wen Xu Jiaying Li Dongli Li Junfeng Tan Hang Ma

10.1016/j.fitote.2021.105061

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Citations (7)

A new species of Gobiolagus (Lagomorpha, Mammalia) from the Middle Eocene of Shanxi Province, China

Annals of Carnegie Museum (2001)

Zhaoqun Zhang Mary R. Dawson Xueshi Huang

A new species of the relatively derived lagomorph Gobiolagus is reported from Irdinmanhan aged deposits of the Yuanqu Basin.The species is more primitive than other known species of the genus, which were known previously from Inner Mongolia and Mongolia.Gobiolagus is unique in the morphology of the maxilla and is precociously derived in its hypsodonty, but does not appear to be closely related to other known Eocene lagomorphs.A second, very incompletely represented, leporid is also present in the same locality.

10.5962/p.316107

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Citations (12)

ChemInform Abstract: New Derivatives of Nonactic and Homononactic Acids from Bacillus pumilus Derived from Breynia fruticosa.

ChemInform (2015)

Li Han Peiyuan Huo Huahong Chen Songtao Li Yi Jiang

Abstract isolation, structure and cytotoxicity

Bacillus pumilus

Isolation

10.1002/chin.201504224

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Citations (0)

Urolithins Attenuate LPS-Induced Neuroinflammation in BV2Microglia via MAPK, Akt, and NF-κB Signaling Pathways

Journal of Agricultural and Food Chemistry (2018)

Jialin Xu Chunhui Yuan Guihua Wang Jiaming Luo Hang Ma

Emerging data suggest that urolithins, gut microbiota metabolites of ellagitannins, contribute toward multiple health benefits attributed to ellagitannin-rich foods, including walnuts, red raspberry, strawberry, and pomegranate. However, there is limited data on whether the potential neuroprotective effects of these ellagitannin-rich foods are mediated by urolithins. Herein, we evaluated the potential mechanisms of antineuroinflammatory effects of urolithins (urolithins A, B, and C; 8-methyl-O-urolithin A; and 8,9-dimethyl-O-urolithin C) in BV2 murine microglia in vitro. Nitrite analysis and qRT-PCR suggested that urolithins A and B reduced NO levels and suppressed mRNA levels of pro-inflammatory genes of TNF-α, IL-6, IL-1β, iNOS, and COX-2 in LPS-treated microglia. Western blot revealed that urolithins A and B decreased phosphorylation levels of Erk1/2, p38 MAPK, and Akt, prevented IκB-α phosphorylation and degradation, and inhibited NF-κB p65 subunit phosphorylation and nuclear translocation in LPS-stimulated microglia. Our results indicated that urolithins A and B attenuated LPS-induced inflammation in BV2 microglia, which may be mediated by inhibiting NF-κB, MAPKs (p38 and Erk1/2), and Akt signaling pathway activation. The antineuroinflammatory activities of urolithins support their role in the potential neuroprotective effects reported for ellagitannin-rich foods warranting further in vivo studies on these ellagitannin gut microbial derived metabolites.

Ellagitannin

IκBα

10.1021/acs.jafc.7b03285

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Citations (120)

New Diterpenoids from the Marine Mangrove Bruguiera gymnorrhiza

Journal of Natural Products (2004)

Li Han Xueshi Huang Isabel Sattler Hans‐Martin Dahse Hongzheng Fu

Phytochemical investigation of the stem of Bruguiera gymnorrhiza yielded three new ent-kaurane diterpenoids (1, 2, and 3) and one new ent-beyerane diterpenoid (4) together with nine known ent-kaurane diterpenoids. All structures and the relative stereochemistry of the new compounds were determined by NMR spectroscopic studies. The absolute stereochemistry of 4 was determined by CD data. Some of the compounds showed moderate cytotoxic properties.

Bruguiera

Phytochemical

Rhizophoraceae

Absolute Configuration

Terpene

10.1021/np040062t

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Citations (41)

Design, synthesis and antifungal evaluation of borrelidin derivatives

Bioorganic & Medicinal Chemistry (2018)

Caijuan Hu Hao Su Jinghan Luo Li Han Qingyin Liu

Candida parapsilosis

MTT assay

Broth microdilution

Docking (animal)

10.1016/j.bmc.2018.11.005

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Citations (10)

Diisonitrile Natural Product SF2768 Functions As a Chalkophore That Mediates Copper Acquisition in Streptomyces thioluteus

ACS Chemical Biology (2017)

Lijuan Wang Mengyi Zhu Qingbo Zhang Xu Zhang Panlei Yang

A nonribosomal peptide synthetase (NRPS) gene cluster (sfa) was identified in Streptomyces thioluteus to direct the biosynthesis of the diisonitrile antibiotic SF2768. Its biosynthetic pathway was reasonably proposed based on bioinformatics analysis, metabolic profiles of mutants, and the elucidation of the intermediate and shunt product structures. Bioinformatics-based alignment found a putative ATP-binding cassette (ABC) transporter related to iron import within the biosynthetic gene cluster, which implied that the product might be a siderophore. However, characterization of the metal-binding properties by high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), metal–ligand titration, thin-layer chromatography (TLC), and chrome azurol S (CAS) assays revealed that the final product SF2768 and its diisonitrile derivatives specifically bind copper, rather than iron, to form stable complexes. Inductively coupled plasma mass spectrometry (ICP-MS) analysis revealed that the intracellular cupric content of S. thioluteus significantly increased upon incubation with the copper–SF2768 complex, direct evidence for the copper acquisition function of SF2768. Further in vivo functional characterization of the transport elements for the copper–SF2768 complexes not only confirmed the chalkophore identity of the compound but also gave initial clues into the copper uptake mechanism of this nonmethanotrophic microorganism.

Natural product

Nonribosomal peptide

Gene cluster

10.1021/acschembio.7b00897

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Citations (87)

New Aromatic Compounds from the Marine MangroveBruguiera gymnorrhiza

Planta Medica (2005)

Li Han Xueshi Huang Isabel Sattler Ute Moellmann Hongzheng Fu

The phytochemical investigation of the stem of Bruguiera gymnorrhiza yielded five new aromatic compounds (1 - 5), of which the bruguierols A - C (1 - 3) represent a new structural skeleton in natural product chemistry. All structures have been determined by NMR spectroscopic studies. Among them, 3 showed moderate activity against Gram-positive and Gram-negative bacteria including mycobacteria and resistant strains (MICs 12.5 μg/mL).

Bruguiera

Phytochemical

Natural product

Rhizophoraceae

Gram

10.1055/s-2005-837784

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Citations (43)

Discovery, synthesis, and cytotoxic evaluation of isoquinolinequinones produced by Streptomyces albidoflavus derived from lichen

RSC Advances (2023)

Ying Jin Zixuan Wang Nuerbiye Aobulikasimu Yixuan Hu Zengguang Zhang

Mansouramycin derivatives caused S phase cell cycle arrest and induced apoptosis in MBA-MB-231 cells，and a piperazine moiety introduced into the amino group at C-7 could improve the activities of mansouramycins.

Moiety

Piperazine

10.1039/d3ra07416a

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Citations (1)

The Distal Gut Bacterial Community of Some Primates and Carnivora

Current Microbiology (2017)

Xiu Chen Qinyuan Li Gui-Ding Li Fang‐Ji Xu Li Han

Omnivore

10.1007/s00284-017-1368-x

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Citations (12)