Satoshi Watanabe

Sakurabashi Watanabe Hospital

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Evaluation of the Macular Choroidal Thickness in Highly Myopic Glaucoma Patients

Investigative Ophthalmology & Visual Science (2012)

Kazunori Tamaki Itaru Kimura Yutaka Imamura Satoshi Watanabe Yugo Nakazawa

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Pulmonary T-cell Lymphoma with Pulmonary Arterial Hypertension

Internal Medicine (2011)

Satoshi Watanabe Hazuki Takato Yuko Waseda Akira Tokuda Nobuyuki Katayama

We report on a 73-year-old man with systemic lymphadenopathy and chest computed tomography (CT) findings of bilateral diffuse ground-glass opacities and interlobular septal thickening. He also had pulmonary arterial hypertension (PAH). Several lymph node biopsies were attempted, without a definitive diagnosis. A thoracoscopic lung biopsy was performed, and the specimen was diagnosed as peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). Lymphoma cells had invaded lung vessels, resulting in PAH. We should include pulmonary lymphoma in the differential diagnosis of patients with PAH and chest CT findings of diffuse ground-glass opacities and interlobular septal thickening.

Lung biopsy

10.2169/internalmedicine.50.5329

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Citations (8)

Impaired Phagocytic Function in CX3CR1⁺ Tissue-Resident Skeletal Muscle Macrophages Prevents Muscle Recovery After Influenza A Virus-Induced Pneumonia in Aged Mice

Constance E. Runyan Lynn C. Welch Emilia Lecuona Masahiko Shigemura Raul Piseaux Aillon

CX3CR1

Muscle tissue

10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2970

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Relationship of thresholds of physical performance to nutritional status in older hospitalized male cardiac patients

Geriatrics and gerontology international/Geriatrics & gerontology international (2014)

Kazuhiro P. Izawa Satoshi Watanabe Koichiro Oka

Nutrition is the focus of a new treatment target in older hospitalized cardiac patients. However, little is known about the differences in nutritional status in relation to physical performance in these inpatients. We determined the differences in physical performance based on the Geriatric Nutritional Risk Index (GNRI) and physical performance cut-off values according to the GNRI in older male cardiac inpatients.We enrolled 251 Japanese male inpatients aged ≥65 years (mean age 74.7 years) with cardiac disease in the present cross-sectional study. We divided the patients into two groups according to GNRI: high-GNRI group (≥92 points; n=178) and low-GNRI group (<92 points; n=73). In-hospital physical performance as measured by handgrip strength (HG), knee extensor muscle strength (KEMS), gait speed (GS), and one-leg standing time (OLST) was assessed and compared between the two groups to determine cut-off values of physical performance.After adjustment for age, HG, KEMS, GS and OLST were significantly lower in the low-GNRI versus high-GNRI group. Cut-off values by receiver operating characteristic curve analysis were 25.75 kgf (area under the curve [AUC]=0.740; P<0.001) for HG strength, 46.1% for bodyweight (AUC=0.742; P<0.01) for KEMS, 1.45 m/s (AUC=0.782; P<0.01) for GS and 11.32 s (AUC=0.705; P<0.01) for OLST.The risk of poor nutrition, as shown by a low GNRI, could be a useful predictor of physical performance. The cut-off values determined in the present study might be expected minimum target values that can be attained by Japanese older male cardiac inpatients.

10.1111/ggi.12257

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Citations (30)

[A Case of Pneumatosis Cystoides Intestinalis Secondary to Gefitinib Therapy for Lung Adenocarcinoma].

PubMed (2015)

Takuya Ando Jun Sakata Tomohiro Maruyama Yuki Hirose Yasuyuki Okabe

Pneumatosis cystoides intestinalis (PCI) is a relatively rare condition, characterized by subserosal or submucosal air within the bowel wall. Herein, we report a rare case of PCI secondary to treatment with an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). A 71-year-old man, who had received gefitinib therapy for 2 years and 5 months for lung adenocarcinoma with metastases to the bones and brain, presented with abdominal pain, diarrhea, and vomiting. Computed tomography of the abdomen revealed intramural air in the small bowel, free air in the abdomen, and moderate ascites. A diagnosis of PCI was made, and the patient was managed conservatively by discontinuing gefitinib treatment, because his vital signs were stable and there was no sign of peritonitis. The patient's symptoms gradually improved, and follow-up CT after 1 week revealed that the initial findings had almost completely resolved. Clinicians should note that treatment with gefitinib might cause PCI.

Pneumatosis Cystoides Intestinalis

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OS27: Respiratory Infections (non‐tuberculosis) 2

Respirology (2013)

Keiko Muraki Hisao Imai Takehito Shukuya Reiko Yoshino Keita Mori

Background There is no standard therapy for relapsed patients who received post-operative platinum based adjuvant chemotherapy for resected non-small-cell lung cancer.We investigated the efficacy and safety of platinumcombination chemotherapy re-challenge for such patients.Methods Medical records were retrospectively reviewed in three institutions from April 2005 to July 2012.Patients who underwent complete surgical resection were eligible if they once received post-operative adjuvant chemotherapy of cisplatin plus vinorelbine and then re-challenge with platinumcombination chemotherapy.Results Sixteen patients were enrolled in this study.After re-challenge with platinum-combination chemotherapy, 5 cases showed PR and 8 cases SD.Overall response rate was 31.2% (5/16) and disease control rate was 81.2% (13/16) in the platinum-combination re-challenge patients.Median progression-free survival and overall survival from the start of the re-administration of platinum-combination chemotherapy were 6.5 and 28.0 months, respectively.The main grade 3 or more severe adverse events were neutropenia (31.2%), thrombocytopenia (31.2%), leukopenia (12.5%) and hyponatremia (12.5%).Frequently observed grade 2 or more severe nonhematological toxicities were anorexia (37.5%) and nausea (37.5%).No treatment-related deaths were noted in this study.Conclusion Re-challenge of platinum-combination chemotherapy was effective and safe, and therefore should be considered as one of treatment option for the NSCLC patients who relapsed after post-operative cisplatinum based adjuvant chemotherapy.

10.1111/resp.12183_27

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Monocyte-Derived Alveolar Macrophages Contribute to Formation of the Resident Alveolar Macrophage Pool During Postnatal Alveologenesis

Mary E. Robbins Satoshi Watanabe Ziyan Lu Joshua Taylor Rob Birkett

Alveolar macrophage

Monocyte

10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5981

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Postoperative Recurrence of Invasive Thymoma with Cold Agglutinin Disease and Autoimmune Hemolytic Anemia

Internal Medicine (2016)

Taro Yoneda Hayato Koba Kota Tanimura Naohiko Ogawa Satoshi Watanabe

A 50-year-old man presented to our hospital in 1995. Invasive thymoma was diagnosed and extended thymectomy and left upper lobe partial resection were performed. In 2013, he complained of dyspnea. Chest computed tomography showed postoperative recurrence of invasive thymoma. Several chemotherapies were administered. Severe anemia and an increase in the total bilirubin level were observed with chemotherapies. In additional, an examination showed that the direct Coombs test was positive. Cold agglutinin was also high. We herein experienced a rare case of postoperative recurrence of invasive thymoma with cold agglutinin disease and autoimmune hemolytic anemia.

Thymectomy

Cold agglutinin disease

Cold Agglutinin

10.2169/internalmedicine.55.6654

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Citations (3)

Multimodal treatment including N-cws/lipiodol immunotherapy for hepatocellular carcinomas. Its safety and therapeutic efficacy.

The Japanese Journal of Gastroenterological Surgery (1990)

Kazuo Watanabe Takehide Asano Munemasa Ryu Kaoru Sakamoto Yoshihiro Fujita

肝細胞癌24症例に対して, N-cws/Lipiodol動注免疫療法を試み, その安全性と治療効果を検討した.1) 発熱を主とし, 嘔吐, 一過性の血圧低下などあるも, 動脈阻血が無いため胃, 十二指腸潰瘍, 胆嚢炎などの合併症はなく, 特に肝障害を全く残さなかった.2) AFPの低下, 画像上での腫瘍陰影の縮小をもたらし, また投与局所に, リンパ球浸潤, 肉芽腫形成などの反応を惹起し, 同時に主腫瘍や門脈腫瘍栓の壊死をきたすなど宿主介在性と考えられる効果を認めた.3) 末梢血中のリンパ球サブセットは, 動注加療によりTs低下, Th/Ts比の上昇など, 免疫賦活の側へ変動した.以上の結果より本治療方法は安全であり, 投与した局所に十分な効果が期待できるとともに, その作用機序には, 抗腫瘍性に働く免疫の賦活の関与が示唆された.

Lipiodol

Therapeutic effect

10.5833/jjgs.23.1062

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A New, Simple Stapling Technique for Pulmonary Emphysema: Its Effects and Safety for Improving Respiratory Function

Surgery Today (2005)

Soichiro Yanagi Satoshi Watanabe Hidehiko Miura Satoshi Shimada Kazuaki Hazama

Thoracotomy

10.1007/s00595-004-2995-y

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Citations (1)