Extensive research efforts have been dedicated to elucidating the intricate pathways by which gastrointestinal microbiota and their metabolites exert influence on the processes of bone formation. Nonetheless, a notable gap exists in the literature concerning a bibliometric analysis of research trends at the nexus of gastrointestinal microbiota and bone metabolism.
Abstract Objectives Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with an unsatisfactory state of treatment. We aim to explore novel targets for SLE from a genetic standpoint. Methods Cis-expression quantitative trait loci (eQTLs) for whole blood from 31,684 samples provided by the eQTLGen Consortium as well as two large SLE cohorts were utilized for screening and validating genes causally associated with SLE. Colocalization analysis was employed to further investigate whether changes in the expression of risk genes, as indicated by GWAS signals, influence the occurrence and development of SLE. Targets identified for drug development were evaluated for potential side effects using a phenome-wide association study (PheWAS). Based on the multiple databases, we explored the interactions between drugs and genes for drug prediction and the assessment of current medications. Results The analysis comprised 5427 druggable genes in total. The two-sample Mendelian randomization (MR) in the discovery phase identified 20 genes causally associated with SLE and validated 8 genes in the replication phase. Colocalization analysis ultimately identified five genes ( BLK , HIST1H3H , HSPA1A , IL12A , NEU1 ) with PPH4 > 0.8. PheWAS further indicated that drugs acting on BLK and IL12A are less likely to have potential side effects, while HSPA1A and NEU1 were associated with other traits. Four genes ( BLK , HSPA1A , IL12A , NEU1 ) have been targeted for drug development in autoimmune diseases and other conditions. Conclusions .This study identified five genes as therapeutic targets for SLE. Repurposing and developing drugs targeting these genes is anticipated to improve the existing treatment state for SLE. Key Points • We identified five gene targets of priority for the treatment of SLE, with BLK and IL12A indicating fewer side effects. • Among the existing drugs that target these candidate genes, Ustekinumab , Ebdarokimab, and Briakinumab (targeting the IL12 gene) and CD24FC (targeting HSPA1A) may potentially be repurposed for the treatment of SLE.
Background Central nervous system tumor (CNST) is one of the most complicated and lethal forms of human tumors with very limited treatment options. In recent years, growing evidence indicates that oncolytic virotherapy (OVT) has emerged as a promising therapeutic strategy for CNSTs. And a considerable amount of literature on OVT-CNSTs has been published. However, there are still no studies summarizing the global research trends and hotspots of this field through a bibliometric approach. To fulfill this knowledge gap, bibliometric analysis was conducted based on all publications relating to OVT-CNSTs since 2000s. Methods We searched the Web of Science Core Collection for all relevant studies published between 2000 and 2022. Four different tools (online analysis platform, R-bibliometrix, CiteSpace and VOSviewer) were used to perform bibliometric analysis and network visualization, including annual publication output, active journals, contribution of countries, institutions, and authors, references, as well as keywords. Results A total of 473 articles and reviews were included. The annual number of publications on OVT-CNSTs showed a significant increasing trend. Molecular Therapy and Cancer Research were the most active and co-cited journals, respectively. In terms of contributions, there is no doubt that the United States occupied a leading position with the most publications (n=307, 64.9%) and the highest H-index (57). The institution and author that contributed the largest number of publications were Ohio State University and Chiocca EA, respectively. As can be seen from citation analysis, the current studies mainly focused on preclinical and phase I/II clinical results of various oncolytic virus for CNSTs treatment. Keywords co-occurrence and burst analysis revealed that the following research topics including immunotherapy, T-cells, tumor microenvironment, vaccine, blood-brain-barrier, checkpoint inhibitors, macrophage, stem cell, and recurrent glioblastoma have been research frontiers of this field and also have great potential to continue to be research hotspots in the future. Conclusion There has been increasing attention on oncolytic viruses for use as CNSTs therapeutics. Oncolytic immunotherapy is a topic of great concern in this field. This bibliometric study provides a comprehensive analysis of the knowledge base, research hotspots, development perspective in the field of OVT-CNSTs, which could become an essential reference for scholars in this area.
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We recently read the publication by Miao et al., "A bibliometric analysis of ferroptosis, necroptosis, pyroptosis, and cuproptosis in cancer from 2012 to 2022" [1] with great interest.This study aimed to elucidate the knowledge structures, development trends and research hotspots of ferroptosis, necroptosis, pyroptosis, and cuproptosis in cancer.Given the importance of these cell death modalities in cancer, the study's significance merits recognition [2,3].However, we have some suggestions regarding the retrieval strategies employed in this study.For bibliometric study, the search strategy is very important.The authors mentioned that the original data were acquired from Web of Science Core Collection (WoSCC).To our knowledge, WoSCC comprises several sub-databases, including SCI-Expanded, SSCI, A&HCI, CPCI-S, CPCI-SSH, and others.Previous studies and our experience suggest that not all sub-databases are appropriate for bibliometric analysis [4].Among them, SCI-Expanded is the most appropriate and widely used one.Therefore, the author should clearly specify which database they utilized for data repeatability.Additionally, several researchers argue that the Topic Search (TS) is not suitable for bibliometric analysis.TS considers a study to be the target study when search terms appear in "Title (TI)", "Abstract (AB)", "Author keywords (AK)", or "Keywords plus".However, "Keywords plus" is generated by an automatic computer algorithm of WoSCC, not from the authors.Including "Keywords Plus" during the search process may result in the inclusion of many unrelated publications [4,5].In our experience, using "TI", "AB", and "AK" as the qualification maybe the best option.Moreover, if the search formula is overly simplistic and omits related keywords, it may overlook many relevant publications.For example, in this study, the author used only "cancer" and "tumor" to identify cancer-related literature.We contend that this is insufficient for locating all cancer-related studies.Our previous work offers a detailed example of searching for cancer-related studies using the following terms: "cancer* OR anticancer* OR tumor* OR tumour* OR oncology OR neoplasm* OR carcinoma*
Objective
To investigate the trajectory , morphology, attachment point anatomy and histological characteristics of femoral round ligaments.
Methods
A prospective study was conducted on the 25 patients with femoral neck fractures who underwent arthroplasty at the Department of Orthopaedics, Wuhan General Hospital of the People's Liberation Army from August 2017 to June 2018, aged 63-88 years, mean 78 years, 15 males and 10 females. Firstly, the round ligament was close to the concave attachment point of the femoral head. After the femoral head was removed, the fixation point of the round ligament on the acetabulum and the characteristic of its movement was observed.Then the round ligaments were slowly excised by an electric knife at the attachment point of acetabular fossa.The length of the round ligament of the femoral head was measured and the tissue was observed
Results
All 25 cases of femoral head round ligament originated from the acetabular transverse ligament, which was divided into anterior and posterior bundles to the femoral head concave. The anterior bundle was marked by depression and then divided into two bundles. The depression was temporarily named Cai's . The posterior bundle was attached to the acetabular transverse ligament around the acetabular horseshoe fossa and covered the acetabular horseshoe fossa with sucker-like covering the acetabular horseshoe fossa The length of the round ligament of the femoral head was (24.8±3.8) mm. The round ligament of femoral head consists of collagen, adipose tissue, synovial tissue and blood vessels.
Conclusions
As the only connection between the square area of the acetabulum and the femoral head, the round ligament of the femoral head can well resist traction and has strong biomechanical functions.
Key words:
Ligaments; Round ligaments of the femoral head; Anatomy; Histology
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