William E. Ottinger

Keesler Medical Center

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Arthur D. Schaerdel

Keesler Medical Center

Raymond P. Ten Eyck

Wright State University

Yale H. Caplan

University of Maryland, Baltimore

Donald H. Marks

Cooper Green Mercy Hospital

A. Baethmann

Ludwig-Maximilians-Universität München

Roy B. Dawson

DEVCOM Army Research Laboratory

Raymond P. TenEyck

Keesler Medical Center

Janelle K. O’Connell

Hardin–Simmons University

William K. Kappel

Sigma Research (United States)

A. Unterberg

University Hospital Heidelberg

Cooperative Institutions

Keesler Medical Center

Penn State Milton S. Hershey Medical Center

Pennsylvania State University

Ludwig-Maximilians-Universität München

Chirurgische Universitätsklinik Heidelberg

Institut für Urheber- und Medienrecht

New York University

Mayo Clinic in Arizona

The University of Texas Health Science Center at Houston

Georgetown University

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Rat skeletal muscle phosphoglycerate kinase: Purification, characterization and comparison with the enzyme from rabbit skeletal muscle and brewer's yeast

Comparative Biochemistry and Physiology Part B Comparative Biochemistry (1974)

Louis F. Hass Carlos E. Caban William K. Kappel William E. Ottinger E. Lucile White

Phosphoglycerate kinase

Arginine kinase

Molecular mass

10.1016/0305-0491(74)90032-7

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Citations (6)

Therapeutic and Toxic Drug Concentrations in Post Mortem Blood: A Six Year Study in the State of Maryland

Journal of Analytical Toxicology (1983)

Yale H. Caplan William E. Ottinger C. Richard Crooks

A six-year study of therapeutic and toxic drug concentrations in the blood from medical examiner's cases in the State of Maryland is reported. Statistical means, ranges, and number of cases are presented for three categories of cases; single drug deaths (53 drugs and 5 metabolites), multiple drug deaths (40 drugs and 5 drug metabolites), and non-drug related deaths (49 drugs and 5 metabolites). Results are compared to previous studies from the literature to facilitate, augment, and improve the understanding of the concentrations of drugs consistent with therapy or death.

Forensic Toxicology

10.1093/jat/7.5.225

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Citations (13)

Control of red cell 2,3-DPG levels in vitro and a proposal for in vivo control in response to hypoxia and metabolic demand.

PubMed (1985)

Roy B. Dawson William E. Ottinger Wei-Lun Chiu A A Salib D S Fagan

Hypoxia

Metabolic control analysis

Source

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Stroma-Free Methemoglobin Solution as an Antidote for Cyanide Poisoning: A Preliminary Study

Journal of Toxicology Clinical Toxicology (1983)

Raymond P. TenEyck Arthur D. Schaerdel James E. Lynett Donald H. Marks Geoffrey A. Patrissi

Effective treatment of cyanide poisoning requires rapid diagnosis, good supportive treatment and the use of a specific antidote. The currently available antidotes offer demonstrated efficacy along with significant potential adverse side effects. We have investigated an alternate approach to antidote therapy for cyanide poisoning by using Stroma-Free Methemoglobin Solution ( SFMS ). Rats injected with an LD100 intravenous dose of cyanide were treated with SFMS equal to 1.5% of their total body hemoglobin. There was a highly significant increase in the survival rate of the treated group compared to saline controls. The potential advantages of SFMS over current antidotes include an immediate onset of action, rapid elimination of cyanide from the body and a mode of action that doesn't compromise any of the patients' oxygen carrying capacity. SFMS shows promise as a significant adjunct in the treatment of cyanide poisoning.

Antidote

Cyanide Poisoning

Methemoglobin

10.3109/15563658308990426

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Citations (8)

Antibody Response To Transfusion With Pyridoxalated Polymerized Hemoglobin Solution

Military Medicine (1987)

Donald H. Marks Daniel R. Brown William E. Ottinger M. Zouhair Atassi

We evaluated the antigenicity of pyridoxalated polymerized stroma-free human hemoglobin (SFHS-PP) under condition of anticipated emergency use (hemorrhagic shock). SFHS-PP was administered intravenously to two groups of dogs. One group was subjected to hemorrhagic shock (mean arterial pressure 40 torr for 30 min) prior to resuscitation with a volume of SFHS-PP equal to their blood loss. A second group of dogs was infused with 100 ml of SFHS-PP without prior bleeding. Six weeks after the initial infusion, both groups were drawn for antibody assay and reinfused with 100 ml of SFHS-PP. A final bleeding was performed at 10 weeks after primary infusion. Four of five dogs infused after hemorrhagic shock mounted an antibody response which was significantly greater (p < 0.02) than that observed in only two of four dogs in the non-shock group. SFHS-PP is antigenic when infused into normal animals and into animals under conditions which could impair the immune system (hypoperfusion and tissue hypoxia).

Mean arterial pressure

Hemorrhagic shock

10.1093/milmed/152.9.473

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Citations (18)

A Primary Intervention Program (Pilot Study) for Mexican American Children at Risk for Type 2 Diabetes

The Diabetes Educator (1998)

Shirlyn B. McKenzie Janelle K. O’Connell Linda Smith William E. Ottinger

Many chronic diseases that are leading causes of morbidity and mortality can be prevented or controlled by primary or secondary interventions. Type 2 diabetes with its complications constitutes a major health problem, especially among Mexican Americans. The purpose of this pilot study was to develop an age- and culturally appropriate primary intervention program for Mexican American children at risk of type 2 diabetes. The sample included 37 Mexican American children ages 7 to 12 years who had at least one parent or grandparent with type 2 diabetes. A health screen of physiologic risk factors, a nutritional assessment, and a diabetes knowledge test were administered before and after the program. The eight-session activity oriented educational program focused on nutrition, exercise, and diabetes knowledge. Due to small sample size and limited study time, changes in physiologic factors and diet were not analyzed for statistical significance. Analysis of individual factors showed a trend toward more normal values. Results of this pilot program indicated that health intervention projects may be effective in helping children at risk of type 2 diabetes adopt healthier lifestyles.

10.1177/014572179802400208

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Citations (10)

Corticosteroids Stimulate Cerebral Energy Metabolism; Support for a Metabolic Action of Steroids on Brain Edema

Advances in neurosurgery (1978)

A. Baethmann William E. Ottinger B Fleischer Kouzo Moritake F. Jesch

Brain Edema

Cerebral edema

10.1007/978-3-642-67082-4_33

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Citations (4)

CSF-Pressure of Rats During Ventriculo-Cisternal Perfusion with Potential Brain Edema Factors

Springer eBooks (1980)

A. Baethmann William E. Ottinger W. Rothenfusser Oliver Kempski A. Unterberg

Brain Edema

Brain tissue

Cerebral edema

Tissue fluid

10.1007/978-3-642-67543-0_64

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Citations (4)

Stroma-free methemoglobin solution: An effective antidote for acute cyanide poisoning

The American Journal of Emergency Medicine (1985)

Raymond P. Ten Eyck Arthur D. Schaerdel William E. Ottinger

Antidote

Methemoglobin

Cyanide Poisoning

10.1016/0735-6757(85)90163-9

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Citations (15)

Drug and Chemical Related Deaths: Incidence in the State of Maryland—1975 to 1980

Journal of Forensic Sciences (1985)

Yale H. Caplan William E. Ottinger Jeong Mi Park Toby O. Smith

The incidence of drug and chemical related deaths was studied over a six-year period in the State of Maryland. Deaths were classified into the following categories: alcohol, carbon monoxide (CO), single drugs, multiple drugs, and narcotism. The last three categories were further subdivided as to the specific drugs or chemicals involved. Over the six-year period the number of alcohol and CO deaths remained steady, the number of barbiturate and propoxyphene deaths declined, while the number of tricyclic antidepressant drug deaths increased.

Propoxyphene

Barbiturate

10.1520/jfs11043j

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Citations (21)