Sérgio Reis Soares

Pontifícia Universidade Católica do Rio Grande do Sul

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

António Pellicer

Universitat de València

Samuel Santos‐Ribeiro

University of Lisbon

Juan A. García-Velasco

Universidad Rey Juan Carlos

Nicolás Garrido

Instituto de Investigación Sanitaria La Fe

Carlos Simón

Universitat de València

José Remohı́

Universitat de València

Ana Raquel Neves

Hospital Universitario Dexeus

Sofía Nunes

Hospital de Dona Estefânia

Marcos Meseguer

Valencian Infertility Institute

José Bellver

Valencian Infertility Institute

Cooperative Institutions

Valencian Infertility Institute

Universitat de València

Guardia Civil

IVI Madrid Clinic

Instituto de Investigación Sanitaria La Fe

Vrije Universiteit Brussel

Universidade do Porto

Universitat Autònoma de Barcelona

Universidade de São Paulo

Universitair Ziekenhuis Brussel

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Age and Uterine Receptiveness: Predicting the Outcome of Oocyte Donation Cycles

The Journal of Clinical Endocrinology & Metabolism (2005)

Sérgio Reis Soares Carlos Troncoso Ernesto Bosch Vicente Serra Carlos Simón

The impact of advancing age on uterine receptiveness has always been a concern of the medical establishment. Oocyte donation (OD) is the perfect model for ascertaining the extent of this relationship, but the literature is somewhat unreliable, mainly due to the limited samples on which the studies are based and insufficient control of important variables such as embryo quality.The present work was developed in a private infertility clinic.We retrospectively evaluate the results of 3089 OD cycles that ended up in a d 3 embryo transfer. Severe male factor infertility was an exclusion criterion.The impact of patients' age on pregnancy, implantation, and miscarriage rates and obstetric outcome is analyzed, as is the relevance of endometrial thickness, serum estradiol levels, and duration of exogenous estrogen therapy to said rates.Pregnancy and implantation rates are significantly reduced and miscarriage rate is significantly increased from 45 yr of age onward. Concerning obstetric outcome, incidences of hypertension, proteinuria, premature rupture of membranes, second- and third-trimester hemorrhage, and preterm delivery are higher and mean birth weight is lower in this age group. With regard to endometrial preparation, estrogen therapy lasting more than 7 wk is associated with reduced PR and IR (P = 0.01 and P = 0.02, respectively).The results of OD cycles and obstetric outcome are significantly worse when recipients are 45 yr of age or older. Concerning endometrial preparation, results are significantly worse when estrogen therapy lasts more than 7 wk.

10.1210/jc.2004-2252

Cite

Citations (188)

P–615 The effect of late-follicular phase progesterone rise on embryo ploidy, embryo quality and cumulative live birth rates following a freeze-only strategy

Human Reproduction (2021)

Ana Raquel Neves Samuel Santos‐Ribeiro S Garcí. Martínez Sérgio Reis Soares Juan A. García-Velasco

Abstract Study question Is late-follicular phase progesterone elevation (PE) associated with a deleterious effect on embryo euploidy, embryo blastulation and cumulative live birth rates (CLBRs)? Summary answer Late-follicular phase PE has no impact on impact on embryo euploidy rate, embryo blastulation rate nor on the CLBR. What is known already The effect of PE in ART outcomes has been extensively studied, yielding so far conflicting results. While some authors claim it is only detrimental to endometrial receptivity, others have suggested that it may also impair oocyte/embryo quality. Moreover, little is known regarding the potential effect PE may have on embryo ploidy and, consequently, CLBR. Study design, size, duration A multicenter retrospective cross-sectional study was performed between August 2017 and December 2019. A total of 1495 ICSI cycles coupled with preimplantation genetic diagnosis for aneuploidies (PGT-A) and deferred frozen embryo transfer (FET) were analyzed. Participants/materials, setting, methods All patients underwent ovarian stimulation with GnRH antagonist protocol and performed a serum progesterone measurement at one of the participating private fertility clinics on the day of trigger. The sample was stratified according to the progesterone levels: normal (≤1.50 ng/ml) and high (>1.50 ng/ml). The primary outcome was the embryo euploidy rate. Secondary outcomes were the number of euploid blastocysts, the blastulation rate and CLBR. Main results and the role of chance Late-follicular phase PE was associated with higher late-follicular estradiol levels (2847.56±1091.10 pg/ml vs. 2240.94± 996.37 pg/ml, p < 0.001) and more oocytes retrieved (17.67±8.86 vs. 12.70±7.00, p < 0.001). The number of euploid embryos was higher in the PE group (2.32±1.74 vs. 1.86±1.42, p < 0.001), whereas the embryo euploidy rate (48.3% [44.9%–51.7%] vs. 49.1% [47.7%–50.6%] and blastulation rate (47.1% [43.7%–50.5%] vs. 51.0% [49.7%–52.4%]) were comparable between the two groups. Likewise, no significant differences were found regarding the live birth rate (LBR) after the first FET (34.1% vs. 31.1%, p = 0.427) nor the CLBRs (38.9% vs. 37.0%, p = 0.637). Mixed-model analysis was performed in order to account for the clustering of cycles in the same patient. Adjusting for patients’ age, PE and BMI, PE failed to demonstrate any effect on the embryo euploidy rate (OR 1.03 [95% CI 0.89–1.20]). Mixed-model analysis for the number of euploid embryos was also performed. After adjusting for PE, age, BMI and ovarian response, PE did not affect the number of euploid embryos (0.02 [95%CI –0.21;0.25]. Multivariate logistic regression adjusted for PE, age, BMI and ovarian response revealed that PE was not associated with the CLBR (adjOR 0.96 [95% CI 0.66–1.38]). Limitations, reasons for caution Limitations of the study include its retrospective nature. Moreover, including only GnRH antagonist protocol and ICSI does not allow the extrapolation of these results to other populations. Wider implications of the findings: Our findings question results from previous studies claiming a detrimental effect of PE on embryo implantation potential. According to our results, PE has no impact on embryo euploidy rate, blastulation rate nor on CLBRs. Trial registration number Not applicable

Blastula

Live birth

Embryo quality

10.1093/humrep/deab130.614

Cite

Citations (1)

Modified natural cycle allows a window of 7 days for frozen embryo transfer planning

Reproductive BioMedicine Online (2023)

Carlos Alonso-Mayo Graciela Kohls Samuel Santos‐Ribeiro Sérgio Reis Soares Juan A. García-Velasco

Natural cycle

10.1016/j.rbmo.2023.103774

Cite

Citations (4)

Clinical factors affecting endometrial receptiveness in oocyte donation cycles

Fertility and Sterility (2008)

Sérgio Reis Soares Juan A. García-Velasco Manuel Fernández Sánchez Ernesto Bosch José Remohı́

Hydrosalpinx

10.1016/j.fertnstert.2008.01.080

Cite

Citations (60)

Does the blastocyst collapse respond to a biological need? The analysis of 1,952 embryos by time-lapse can give an answer

Fertility and Sterility (2017)

Marga Esbert Anabella Marconetto Sérgio Reis Soares Mariona Quera J. Molina

Blastocoel

Implantation failure

Live birth

10.1016/j.fertnstert.2017.07.473

Cite

Citations (2)

O-026 A new mNC protocol that allows a 7-day window for FET planning

Human Reproduction (2023)

Cristina Alonso Graciela Kohls S. Jaraba Caballero Samuel Santos‐Ribeiro Sérgio Reis Soares

Abstract Study question Is triggering necessary at 17 mm follicle diameter in a modified natural cycle (mNC), or does it allow flexible planning? Summary answer Embryo transfer can be scheduled when follicles measure 13 to 20 mm if endometrium is ready without impacting clinical outcome. What is known already Current practice is shifting, moving frozen embryo transfers (FET) from artificial cycles to natural cycles, which may complicate planning. The standard mean diameter to trigger in a mNC has classically been stablished in 17 mm, mimicking the size needed to obtain mature oocytes. Interestingly, research on triggering at different follicle sizes in a mNC has been limited. A previous study initiated progesterone based only on endometrial ultrasonographic characteristics and the presence of a dominant follicle of at least 12 mm and showed good results in ongoing pregnancy rates. However, it had a small sample size and rhCG was not administered. Study design, size, duration This is a multicenter, retrospective, observational study of 3,087 single frozen blastocyst transfers in mNCs carried out in 2,764 patients at our centers from January 2020 to September 2022. Participants/materials, setting, methods Selection criteria were the following: blastocyst on day 5/6 (minimum quality 3BB attending Gardner classification), regular menstrual cycles (26-35 days), normal uterine cavity assessed by ultrasound, serum progesterone <1.5 ng/mL and endometrial thickness ≥7 mm on the day of administration of rhCG, and absence of fluid in endometrial cavity. Triggering was done with a single dose of 250 µg sc rhCG, natural micronized progesterone 200mg bid was started two days later, then SET was performed. Main results and the role of chance Follicle size at time of triggering was stratified into three groups (13.0–15.9 mm; 16.0–18.9 mm; and ≥19.0 mm). No differences were seen regarding age, body mass index (BMI) and years of infertility, however, there were differences regarding egg donation (39.5%; 27.9%; and 27.4% respectively; p = 0.02) and the use of Preimplantational Genetic Testing for Aneuploidies (PGT-A) (19.4%; 34.01%; and 37.3%; p < 0.01). We found no differences in pregnancy rate (64.5%; 60.2%; and 57.4%; p = 0.19), clinical pregnancy rate (60.5%; 52.8%; and 50.6%; p = 0.10), implantation rate (62.10%; 52.9%; and 51.0%; p = 0.05) and miscarriage rate (15.0%; 22.2%; and 25.0%; p = 0.11), but differences were found in the ongoing pregnancy rate (OPR) (54.9%; 46.8%; and 43.1%; p = 0.02). however, those differences were not seen after adjusting for the use of PGT-A and egg donation: OPR at 16.0–18.9 mm vs 13.0–15.9 mm (aOR 2.37; 95% CI: 0.73–7.60; p = 0.15) and at 16.0–18.9 mm vs > 19mm (aOR 0.75; 95% CI: 0.54–1.05; p = 0.10). Finally, OPR was assessed by follicle size by each millimeter from 13 mm (80,0%; 95% CI 29.9—99.0%) to 22 mm (54.6%; 95% CI 39.0—69.3%). Limitations, reasons for caution Follicle size at time of triggering 15 to 19 mm accounted for 84.7% of the mNCs included in this study, which leaves only a minority of cases in which triggering was done at “non conventional” follicle sizes. This results need to be confirmed by future prospective studies. Wider implications of the findings Our findings show that rhCG could be administrated from a follicle size of 13 to 22mm. Considering a follicular growth rate of 1-1.5mm per day, this approach could allow a flexibility of five to seven days, facilitating the planning of mNC FET in clinical practice. Trial registration number Not applicable

Menstrual bleeding

10.1093/humrep/dead093.026

Cite

Citations (1)

Parenteral nutrition (tpn) does not stimulate experimental cancer growing

Journal of Parenteral and Enteral Nutrition (1990)

Dan Linetzky Waitzberg E. Lima Gonçalves Nagamassa Yamaguchi Sérgio Reis Soares L R Bevilacqua

Source

Cite

Citations (0)

Cigarette smoking and reproductive function

Current Opinion in Obstetrics & Gynecology (2008)

Sérgio Reis Soares Marco Melo

To perform a systematic review of the literature on the relationship between cigarette smoking and reproductive function. Whenever possible, this review is focused on the most recently published studies (mainly the past 2 years). Nevertheless, in many instances older literature was too relevant not to be taken into account.

10.1097/gco.0b013e3282fc9c1e

Cite

Citations (207)

Adverse reproductive health outcomes in a cohort of young women with breast cancer exposed to systemic treatments

Journal of Ovarian Research (2019)

Cristina Silva Ana Cristina Ribeiro Rama Sérgio Reis Soares Mariana Moura‐Ramos Teresa Almeida‐Santos

Breast cancer is the most common cancer in young women. Fortunately current survival rates of BC are significant which makes future fertility very important for quality of life of BC survivors. Chemotherapy carries a significant risk of infertility in BC patients so it is important to support fertility preservation decisions in premenopausal women. Amenorrhea has long been used as a surrogate marker of infertility in cancer patients but more reliable ovarian reserve (OR) markers are available. This study aimed to prospectively measure levels of OR in a cohort of young women with breast cancer exposed to chemotherapy, to identify adverse reproductive health outcomes in this population and to assess the influence of patient and treatment-related factors in those outcomes.This prospective observational study included premenopausal women with breast cancer aged 18-40 years at diagnosis and proposed for (neo) adjuvant chemotherapy. Patients were evaluated before, during and a minimum of 9 months after the end of chemotherapy. Reproductive health outcomes: menses, hormonal and ultrasound OR markers, recovery of ovarian function and Premature Ovarian Insufficiency (POI).A total of 38 patients were included (mean age 32.9 ± 3.5 years). Levels of OR significantly decreased during the study. At the last follow up, 35 patients had AMH below the expected values for age; eight presented postmenopausal FSH; ten had not recovered their ovarian function and five met the defined criteria for POI. Age and baseline AMH were positively correlated with AMH at the last follow-up. AMH levels were higher in the group of patients treated with trastuzumab and lower in those under hormonal therapy, at the last follow-up.Significant effects of systemic treatments on several reproductive outcomes and a strong relation of those outcomes with patient's age and baseline level of AMH were observed. Our results point to a possible lower gonadotoxicity when treatment includes targeted therapy with trastuzumab. Also, this investigation highlights the lack of reliable OR markers in women under hormonal therapy.

Ovarian Reserve

Anti-Müllerian hormone

Premature ovarian insufficiency

10.1186/s13048-019-0581-6

Cite

Citations (20)

Cigarette smoking affects uterine receptiveness

Human Reproduction (2006)

Sérgio Reis Soares Carlos Simón José Remohı́António Pellicer

Cigarette smoking has long been known to have an effect on female fertility. The existence of an ovarian factor is clear when one considers that the mean age of the menopause is lower and IVF cycle outcome is worse in heavy smokers. The hypothesis of a concomitant uterine effect is raised by indirect evidence from in vitro and in vivo studies, but as yet, no direct evidence has been gained to confirm its existence. In this work, we analyse the association between smoking habit in oocyte recipients and cycle outcome.We have retrospectively analysed the outcome of all oocyte donation cycles performed in our clinic from January 2002 to June 2005 from which there was available information regarding patient current smoking status. Husband and donor smoking status were controlled variables, as well as donor and recipient age, patient body mass index, embryo number and quality and duration of endometrial priming.Pregnancy rate (PR) in non-heavy smokers (0-10 cigarettes/day) was significantly higher than in heavy smokers (>10 cigarettes/day) (52.2 versus 34.1%, respectively). Interestingly, multiple PR was significantly higher in heavy smokers (60 versus 31%).Tobacco consumption determines reduced uterine receptiveness and an increased risk of multiple pregnancies. This last issue remains to be clarified.

10.1093/humrep/del394

Cite

Citations (134)