As the use of early coronary angiography and echocardiography become widely available in the setting of acute coronary syndrome, the gradual increase for variant forms of transient left ventricular (LV) apical ballooning syndrome have been recognized.This syndrome usually occurs in women and is frequently elicited by an intense emotional, psychological, and physical event.While the patients' characteristics between typical and non-typical LV ballooning syndrome seem to differ, the presentation, clinical features, and reversibility of LV wall motion abnormalities are similar.We present a middle-aged woman who experienced inverted takotsubo cardiomyopathy triggered by pulmonary embolism.To the best of our knowledge, this case is particularly unique and is rarely reported in the disease entity.(Korean
ABSTRACT Methamphetamine (MAP) is a commonly used, addictive drug, and a powerful stimulant that dramatically affects the central nervous system. In this study, we used the conditioned place preference (CPP) paradigm in order to study the reinforcing properties of MAP and the herewith associated changes in proteins within the mesolimbic dopamine system. A CPP was induced by MAP after three intermittent intraperitoneal injections (1 mg/kg) in rats and protein profiles in the nucleus accumbens, striatum, prefrontal cortex, cingulate cortex and hippocampus were compared with a saline-treated control group. In addition, a group of animals was run through extinction and protein profiles were compared with a non-extinguished group. Protein screening was conducted using two-dimensional electrophoresis analysis which identified 27 proteins in the group that showed MAP-induced CPP. Some of the proteins were confirmed by Western lot analysis. Identified proteins had functions related to the cytoskeleton, transport/endocytosis or exocytosis (e.g. profilin-2 and syntaxin-binding protein), and signal transduction, among others.
Abstract Background. Biomarkers for the diagnosis and prognosis of sepsis are urgently needed. Myokines secreted from muscles play a key role in the immune system. In the present study, we evaluated two myokines, brain-derived neurotrophic factor (BDNF) and oncostatin M, for their potential use as diagnostic and prognostic biomarkers for patients with sepsis. We also evaluated the association between myokines and muscle mass. Methods. BDNF and oncostatin M levels were measured upon the initial diagnosis of sepsis, and again at the end of treatment, in patients who visited the emergency room between January 2016 and January 2020. On abdomen/pelvis computed tomography (CT) performed during the hospital stay, muscle mass was measured as an index of the total abdominal muscle area index (TAMAI). We evaluated the relationship between mortality due to sepsis, myokine levels, and muscle mass. Results. A total of 210 participants (168 patients and 42 healthy controls) were enrolled in the present study. Median BDNF levels in patients diagnosed with sepsis and septic shock were significantly lower than in healthy controls. In contrast, median oncostatin M levels in patients with sepsis and septic shock were significantly higher than in healthy controls. BDNF and oncostatin M levels showed a statistically significant negative correlation. TAMAI in patients with sepsis and septic shock were 34.6 cm 2 /m 2 and 34.2 cm 2 /m 2 , respectively; however, the TAMAI had no correlation with either BDNF or oncostatin M levels. BDNF level was significantly higher in the 28-day survivors than in those that died. Increased oncostatin M levels were associated with higher 14- and 28-day mortalities. At the end of treatment, BDNF levels and muscle mass were significantly higher in survivors than in deceased patients. Conclusions. BDNF levels were significantly lower, and oncostatin M levels were significantly higher in patients with sepsis and septic shock than in healthy controls. Muscle mass was significantly lower in patients who died as the result of sepsis; however, the levels of myokines were not associated with muscle mass. These results highlight the potential of BDNF and oncostatin M as diagnostic and prognostic biomarkers of sepsis.
Methamphetamine, a commonly used addictive drug, is a powerful addictive stimulant that dramatically affects the CNS. Repeated METH administration leads to a rewarding effect in a state of addiction that includes sensitization, dependence, and other phenomena. It is well known that susceptibility to the development of addiction is influenced by sources of reinforcement, variable neuroadaptive mechanisms, and neurochemical changes that together lead to altered homeostasis of the brain reward system. These behavioral abnormalities reflect neuroadaptive changes in signal transduction function and cellular gene expression produced by repeated drug exposure. To provide a better understanding of addiction and the mechanism of the rewarding effect, it is important to identify related genes. In the present study, we performed gene expression profiling using microarray analysis in a reward effect animal model. We also investigated gene expression in four important regions of the brain, the nucleus accumbens, striatum, hippocampus, and cingulated cortex, and analyzed the data by two clustering methods. Genes related to signaling pathways including G-protein-coupled receptor-related pathways predominated among the identified genes. The genes identified in our study may contribute to the development of a gene modeling network for methamphetamine addiction.
영상 인식 기술은 평면 영상에 대해서 많이 연구되고 그 성능 또한 발전하고 있다. 그러나 평면 영상이 아닌 구면 파노라마 영상과 다양한 환경에서 주어지는 특수한 형태의 영상에 대한 인식은 평면과 다르게 기하학적인 왜곡으로 인해서 많은 어려움이 따른다. 본 논문에서는 평면영상의 인식 기술에서 최근 각광받는 훈련을 통한 신경망 인식 기법이 구면 파노라마 영상의 인식에서도 쓰일 수 있음을 보인다. 또한 구면 영상에 대한 기존 신경망 모델의 인식률을 높이기 위해서 큐브맵 변환을 활용하는 방법을 제시한다.
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