S Gratz

Praxis

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George M. Simpson

University of Southern California

M Jarnig

General Electric (Spain)

Hans Förstl

Technical University of Munich

U Hahn

Praxis

B Schneider

Universität Innsbruck

Jaclyn M. Schwarz

University of Delaware

Harun Evcimen

Philadelphia University

G. M. Simpson

University of Southern California

Mary Delaney

National Center for Advancing Translational Sciences

Richard P. Malone

59th Medical Wing

Cooperative Institutions

Drexel University

Technical University of Munich

Indiana University – Purdue University Indianapolis

Massachusetts General Hospital

Klinik und Poliklinik für Neurologie

Klinik und Poliklinik für Nuklearmedizin

University of Southern California

LAC+USC Medical Center

Harvard University

Klinikum rechts der Isar

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Psychopharmacology

Springer eBooks (1992)

S Gratz George M. Simpson

Psychopharmacology

10.1007/978-1-4899-0688-5_12

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Citations (1)

Stellenwert bildgebender Verfahren für die Therapie der Patienten mit Parkinsonsyndrom

DMW - Deutsche Medizinische Wochenschrift (2008)

Johannes Schwarz S Gratz U Hahn Hans Förstl M Jarnig

The accuracy of the diagnosis of Parkinson's disease early in the course of the disease remains a clinical challenge. Imaging of dopamine transporters with DatSCAN and SPEC tomography contributes to identifying patients without nigral degeneration and thus helps preventing unnecessary and potentially harmful treatments. The cost of these imaging procedures needs to be set against the cost of unnecessary medication.

10.1055/s-2008-1075679

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Erratum to: Neuroleptic malignant syndrome: diagnosis, epidemiology and treatment

CNS Drugs (1995)

S Gratz G. M. Simpson

Neuroleptic Malignant Syndrome

Psychopharmacology

10.1007/bf03259708

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Neuroleptic malignant syndrome

The British Journal of Psychiatry (1990)

S Gratz George M. Simpson

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Neuroleptic Malignant Syndrome

Content (measure theory)

10.1192/bjp.157.4.617

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Comparison of the pressor effect of tyramine after treatment with phenelzine and moclobemide in healthy male volunteers

Clinical Pharmacology & Therapeutics (1992)

George M. Simpson S Gratz

This study was conducted to establish the safety, tolerability, side effects, and pressor effects of tyramine on subjects treated with moclobemide, a short-acting reversible and preferential monoamine oxidase inhibitor, and to compare these responses with the responses of subjects treated with phenelzine. Twelve healthy male volunteers participated. An oral tyramine sensitivity test was performed on all subjects 24 hours before the start of a 28-day open-label treatment with phenelzine or moclobemide. A tyramine challenge was performed on day 28 on four subjects treated with phenelzine. The mean dose of oral tyramine required to increase systolic blood pressure by 30 mm Hg was 15 mg. The mean dose of tyramine that produced a clinical response (day 28) in subjects treated with moclobemide was 240 mg. No subject receiving moclobemide responded clinically on day 31 after receiving hourly doses of 20, 40, 80, 160, and 320 mg, respectively. These findings suggest that moclobemide may be used without stringent dietary precautions. Clinical Pharmacology and Therapeutics (1992) 52, 286–291; doi:10.1038/clpt.1992.143

Moclobemide

Phenelzine

Tyramine

Tolerability

10.1038/clpt.1992.143

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Citations (26)

Diagnostik bei Fieber unklarer Genese (FUO)

DMW - Deutsche Medizinische Wochenschrift (2009)

S Gratz B Kemke Werner M. Kaiser Ulrich Hahn B Erdtmann

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study

Occult

10.1055/s-0029-1241901

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Citations (2)

Neuroleptic Malignant Syndrome

CNS Drugs (1994)

S Gratz George M. Simpson

Neuroleptic Malignant Syndrome

Catatonia

10.2165/00023210-199402060-00004

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Citations (13)

Adult Baby Syndrome

Archives of Sexual Behavior (2006)

Harun Evcimen S Gratz

10.1007/s10508-005-9002-6

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Citations (16)

Advances in Drug Treatments for Children and Adolescents with Autism and Other Pervasive Developmental Disorders

CNS Drugs (2005)

Richard P. Malone S Gratz Mary Delaney Susan Hyman

Irritability

Pervasive developmental disorder

Akathisia

10.2165/00023210-200519110-00003

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Citations (45)

Demenz mit Lewy-Körperchen und verminderter Dopamin-Transporter-Bindung verweist auf Acetylcholin-Mangel

DMW - Deutsche Medizinische Wochenschrift (2008)

Hans Förstl S Gratz U Hahn Jaclyn M. Schwarz M Jarnig

Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia. It is usually caused by a mixture of symptoms of Parkinson's and Alzheimer's disease leading to a significant impairment of nigro-striatal dopaminergic and baso-cortical cholinergic neurotransmission with typical clinical symptoms of a fluctuating course, hallucinations, parkinsonism, REM-sleep disorder and neuroleptic hypersensitivity. If the clinical presentation of DLB is uncharacteristic, the demonstration of reduced presynaptic striatal dopamine transporter (DaT) sites supports a suspicion of DLB and may lead to important therapeutic consequences. In these circumstances this evidence for compromised dopaminergic neurotransmission also indicates a significant cholinergic deficit: both require diligent therapeutic attention.

Lewy body

10.1055/s-2008-1075680

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Citations (11)