Side-effects are frequently encountered in classic chemotherapy. However, the recent development of targeted treatments has resulted in a diminution of these. The most common side-effects are dermatological.
Although cardiac involvement is rarely seen in Behcet’s disease (BD), it is essential to detect subclinical left ventricular (LV) dysfunction for prognostic purposes. Herein we aimed to show the role of two dimensional (2D) speckle tracking echocardiography (STE) in determination of subclinical LV dysfunction in patients with BD. 30 patients diagnosed as BD due to International Study Group Behcet’s diagnostic criteria and 25 control subjects underwent Doppler echocardiography including pulsed tissue Doppler of the mitral annulus and speckle-tracking echocardiography. LV peak longitudinal strain and strain rate (SR) was calculated in four-chamber (4C), apical long-axis (LAX), and two-chamber (2C) views, and values of the three views were averaged LV global longitudinal strain (LV-GLS) and SR. LV torsion was determined as the net difference in the mean rotation between the apical and basal levels. There was not any significant difference in age and gender between groups. Patients with BD had significantly lower LV longitudinal strain and Sr measurements than the control group. Although LV basal rotation (LVR) basal values were similar in both groups, LVR-apical and LV torsion (LVTR) values were significantly higher in patient group. LVR-apical and LV-GLS were found to have a good positive corelation (r:0.44, p<0.001) (r: -0.56, r: -0.65,respectively. p<0.001). There was a weak positive correlation between LVTR and LV-GLS (r: 0.29, p<0.05). We demonstrated that combined assessement of LV-GLS, LV-GLSR, LVTR and LVR-apical values detected by STE can be useful in determination of subclinical left ventricular dysfunction in BD.
Human HIV-1 TAT interactive protein 2 (HTATIP2/TIP30) is a gene that is extensively expressed in human tissues as well as in tumor tissues. This study aimed to explore the potential role of HTATIP2/TIP30 in contact dermatitis (CD), which is one of the most common inflammatory cutaneous conditions.This cross-sectional study involved adult patients with acute contact dermatitis who were admitted to the outpatient dermatology clinic of a tertiary hospital and healthy adult volunteers without any cutaneous or systemic diseases. The blood concentration of HTATIP2/TIP30 was measured using ELISA kits.The research sample consisted of 31 patients with CD (18 males, 13 females) and 20 healthy control subjects (14 males, 6 females). The mean ages of the patients with CD and healthy volunteers were 37 and 30 years, respectively (p > 0.05). The mean value of serum HTATIP2/TIP30 levels in patients with CD was 1.65 ng ml–1, which is 0.60 ng ml–1 in the control group (p = 0.02)In this study, serum levels of HTATIP2/TIP30 were statistically significantly higher in patients with CD when compared to healthy controls. This outcome may indicate possible role of HTATIP2/TIP30 in the pathogenesis of CD.
Background and Design: Bullous pemphigoid is a rare autoimmune blistering disease.The aim of this study was to investigate the epidemiological characteristics and clinical, laboratory, and radiological features of patients with bullous pemphigoid in Erzurum and to evaluate the association of bullous pemphigoid with comorbid diseases.Methods and Methods: Medical records of 38 patients, who were diagnosed with bullous pemphigoid after biopsy and hospitalized in our clinic between 2003 and 2013, were retrospectively studied.Results: Fifteen (39.5%) of the 38 patients were male, and 23 (60.5%) were female.The mean age at the time of diagnosis was 62.4±21 years.Analyses of the results of direct immunofluorescence showed that the most common finding was the presence of IgG and C3 (42.1%).The average time since the first presentation until diagnosis was 72.7±104.3days.The mean initial dose of corticosteroid was 54.7±26.01mg/ day.The mean length of hospitalization for bullous pemphigoid was 22.6±23.5 days.We did not detect any malignancy or comorbid diseases associated with bullous pemphigoid.However, eosinophilia was detected.Conclusions: Routine laboratory and radiological investigations are not necessary to detect malignancy in patients with bullous pemphigoid.(Turkderm 2015; 49: 66-9)
Nitrojen kriyobiyoloji, kriyoterapi ve tarimda kullanilan kimyasal bir maddedir. Burada, cilek yapraklarina kullanilan nitrojen bazli gubreye maruz kalinmasi sonrasi her iki bacaginda ciddi bulloz lezyonlari gelisen, 19 yasinda erkek ciftci olgusunu sunduk. Literaturde gubrenin tetikledigi kontakt dermatitler cok nadirdir. Bu olguda mesleki gubreye temasin onlenmesinin onemini vurgulamak istedik.
Lichen sclerosus is a chronic sclerosing inflammatory disease. The disease is 6-10 times more common in women and more frequent between the ages of 8-13 and 50-60 years. Etiology is unknown exactly. But autoimmunity, genetic, hormonal factors, infections and trauma may be responsible in etiology. A patient, a 53-year-old woman, admitted to our clinic with white papules on her wrists and feet dorsum. Emollients, high potency topical steroids, topical tacrolimus, antimalarial drugs, systemic or intralesional steroids, narrow band UVB, PUVA, carbon dioxide laser and surgery may be used in treatment. Cases of lichen sclerosus mimicking lichen planus are rarely seen in the literature and these situations may be confused with each other. We report this case for the unusual presentation of lichen sclerosus and hiperkeratotic form.
Pityriasis Iichenoides is a rare cutaneous disorder of clearly unknown etiology and speculated to be an infl ammatory response triggered by many infectious agents. We report a case of pityriasis lichenoides et varioliformis acuta (PLEVA) in a 7 year old boy. Lesions occurred abruptly aft er administration of combined diphtheria, tetanus, acellular pertussis and inactivated polio vaccine (DTaP/IPV). We want to emphasize that our case is the fi rst case report associated with this vaccine in literature and it is successfully treated with clarithromycin.
Liken sklerozus kronik inflamatuvar sklerozan bir hastaliktir. Kadinlarda 6-10 kat daha fazla ve 8-13 yas arasi ve 50-60 yas arasi daha sik gorulmektedir. Etyopatogenezi tam olarak bilinmemektedir. Fakat otoimmunite, genetik, hormonal faktorler, enfeksiyon ve travma uzerinde durulmaktadir. El ve ayaklarinda cok sayida deriden kabarik dokuntuler ile poliklinigimize muracaat eden 53 yasindaki kadin hastanin kliniginde beyaz renkte papulleri vardi. Tedavide emolyenler, yuksek potent topikal steroidler, topikal takrolimus, antimalaryal ilaclar, sistemik ya da intralezyonal steroid, darbant UVB, PUVA, karbondioksit lazer ve cerrahi uygulanabilir. Literaturde liken planusu taklit eden liken sklerozus vakalari nadir oldugu icin ve her iki durumun birbiriyle karisabilecegine dikkat cekmek amaciyla bu olguyu sunmayi uygun gorduk.
In this study we investigated both intact and adrenalectomized rats to determine whether or not the anti-inflammatory effects of indomethacin, diclofenac sodium, ibuprofen, nimesulide, tenoxicam and aspirin (IDINTA) are related to adrenal gland hormones in carrageenan-induced inflammation model of rats. Also, we investigated the anti-inflammatory action mechanism of hormones (adrenalin, cortisol) which perform a role in the anti-inflammatory effect of IDINTAon the adrenergic receptors. he results show that IDINTA produces significant anti-inflammatory effects in intact rats (ID(50): 9.82, 10.81, 95.21, 75.23, 8.21 and 61.84 mg/kg), but insignificant effects in adrenalectomized rats (ID(50): 152.97, 188.17, 1275.0, 433.67, 188.16 and 1028.17 mg/kg). In addition, adrenalin and prednisolone caused anti-inflammatory effect rates of 78.3% and 95.7% respectively in adrenalectomized rats. The anti-inflammatory effects of adrenalin and prednisolone did not change when prazosin (alpha(1)-receptor blocker), yohimbine (alpha(2)a2-receptor blocker) and phenoxybenzamine (alpha(2)- and alpha(2)-receptor blocker) were given to rat groups; however, in adrenalectomized rats administered with propranolol (a non-selective blocker of beta(1) and beta(2)-receptors) the anti-inflammatory effect of adrenalin was lost, and that of prednisolone decreased to 36.2%. It was also found that metoprolol (a selective blocker of beta(1)-receptors) did not alter the anti-inflammatory effects of the drugs. As a result, it was shown that anti-inflammatory effects of IDINTA are related to adrenalin and cortisol (corticosterone in rats). It was also determined for the first time that adrenalin (totally) and prednisolone (partially) triggered anti-inflammatory effects via the beta(2)-receptors but not via the alpha(1), alpha(2) and beta(1)-receptors.
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