Haidi Yang

Sun Yat-sen Memorial Hospital

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Yiqing Zheng

Southwest Medical University

Hao Xiong

Huazhong Agricultural University

Suijun Chen

Sun Yat-sen Memorial Hospital

Yongkang Ou

South China Agricultural University

Yuexin Cai

Sun Yat-sen Memorial Hospital

Jiaqi Pang

Sun Yat-sen University

Lan Lai

Jiaxing University

Yongyi Ye

Northwestern Polytechnical University

Qiuhong Huang

Quanzhou Normal University

Fei Zhao

Cardiff Metropolitan University

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Sun Yat-sen University

104

Sun Yat-sen Memorial Hospital

Guangzhou Medical University

Chinese Academy of Sciences

State Key Laboratory of Respiratory Disease

Second Affiliated Hospital of Guangzhou Medical University

Peking University

Zhejiang University

Chinese Academy of Medical Sciences & Peking Union Medical College

First Affiliated Hospital of Jinan University

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Cochlear implantation in patients with Streptococcus suis meningitis: clinical characteristics and postoperative evaluation

Acta Oto-Laryngologica (2024)

Zhuoyi Chen Minqian Gao Xiaying Huang Xianghui Li Xiaotong Huang

Hearing loss is a common sequala of

Streptococcus suis

Cochlear Implantation

10.1080/00016489.2024.2323650

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The potassium channels: Neurobiology and pharmacology of tinnitus

Journal of Neuroscience Research (2023)

Haohong Lai Minqian Gao Haidi Yang

Abstract Tinnitus is a widespread public health issue that imposes a significant social burden. The occurrence and maintenance of tinnitus have been shown to be associated with abnormal neuronal activity in the auditory pathway. Based on this view, neurobiological and pharmacological developments in tinnitus focus on ion channels and synaptic neurotransmitter receptors in neurons in the auditory pathway. With major breakthroughs in the pathophysiology and research methodology of tinnitus in recent years, the role of the largest family of ion channels, potassium ion channels, in modulating the excitability of neurons involved in tinnitus has been increasingly demonstrated. More and more potassium channels involved in the neural mechanism of tinnitus have been discovered, and corresponding drugs have been developed. In this article, we review animal (mouse, rat, hamster, and guinea‐pig), human, and genetic studies on the different potassium channels involved in tinnitus, analyze the limitations of current clinical research on potassium channels, and propose future prospects. The aim of this review is to promote the understanding of the role of potassium ion channels in tinnitus and to advance the development of drugs targeting potassium ion channels for tinnitus.

10.1002/jnr.25281

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Diminished self-monitoring in hallucinations – Aberrant anterior insula connectivity differentiates auditory hallucinations in schizophrenia from subjective tinnitus

Asian Journal of Psychiatry (2020)

Haidi Yang Mingxia Wang Fengchun Wu Qingwei Li Yiqing Zheng

Auditory hallucination

Superior temporal gyrus

Misattribution of memory

10.1016/j.ajp.2020.102056

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Efficacy of balloon dilation in the treatment of symptomatic Eustachian tube dysfunction: One year follow-up study

American Journal of Otolaryngology (2015)

Hao Xiong Maojin Liang Zhigang Zhang Yaodong Xu Yongkang Ou

Valsalva maneuver

Eustachian tube

Balloon dilation

Hearing level

10.1016/j.amjoto.2015.10.010

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Citations (32)

Application of intraoperative ABR during middle ear surgery to predict improvement in hearing

Interdisciplinary Neurosurgery (2019)

Tianci Feng Yuebo Chen Hao Xiong Yiqing Zheng Haidi Yang

The present study was aimed to develop an intraoperative hearing monitoring method for surgeons to evaluate hearing improvement in the operating room under general anesthesia. Pure tone audiometry (PTA) and chirp auditory brainstem response (ABR) were evaluated for ears with normal hearing and conductive hearing loss before, immediately after, and 4 weeks after surgery. Our result showed that for ears with normal hearing or conductive hearing loss, preoperative chirp ABR threshold measured in the operating room under general anesthesia was highly linear correlated to 1000 Hz pure tone threshold and PTA threshold measured in the sound-proof chamber. Most interestingly, postoperative chirp ABR measured in the operating room under general anesthesia was also highly correlated with PTA threshold 1 month after surgery, which indicated that intraoperative chirp ABR can predict hearing improvement immediately after surgery. Our findings demonstrate an effective intraoperative intervention to assess hearing improvement under general anesthesia in real time which might help avoid revision surgery.

Auditory brainstem response

Pure tone audiometry

Chirp

10.1016/j.inat.2019.03.004

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Efficacy of an Integrative Treatment for Tinnitus Combining Music and Cognitive-Behavioral Therapy—Assessed With Behavioral and EEG Data

Frontiers in Integrative Neuroscience (2020)

Tianci Feng Mingxia Wang Hao Xiong Yiqing Zheng Haidi Yang

Chronic tinnitus is a prevalent condition that could cause severe negative impact on an individual's life. However, there has not been an established treatment due to a limited understanding of the pathophysiology of this multifarious disorder. In this study, we tested the efficacy of an integrative treatment, combining music therapy with cognitive-behavioral therapy (CBT). We collected three groups of patients receiving three different treatments: Music-CBT, music therapy and CBT. We used both subjective (i.e., questionnaires) and objective (i.e., resting-state EEG data) measurements to assess the behavioral and neural changes brought upon by the treatments. Analyses of the subjective measurements found a significant improvement of scale scores in Music-CBT and CBT, but not in the Music group. Analysis of the EEG data further showed increased powers in alpha and theta band after the Music-CBT treatment, and increased gamma power after CBT, whereas no significant difference was found for the music therapy. Further source localization analysis of alpha and theta changes in the Music-CBT group found that primary sources of the changes were located at auditory processing regions such as superior temporal gyrus, and higher emotional and cognitive processing regions such as ventromedial prefrontal cortex (vMPFC), lateral prefrontal cortex and parahippocampus. These results indicated that Music-CBT was effective in improving tinnitus symptoms on both a behavioral and neural level, which is more robust than the music therapy or CBT alone.

Music Therapy

10.3389/fnint.2020.00012

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Citations (11)

Deviant Dynamics of Resting State Electroencephalogram Microstate in Patients With Subjective Tinnitus

Frontiers in Behavioral Neuroscience (2018)

Yuexin Cai Dong Huang Yanhong Chen Haidi Yang Chang‐Dong Wang

Given the importance of central reorganization and tinnitus, we undertook the current study to investigate changes to electroencephalogram (EEG) microstates and their association with the clinical symptoms in tinnitus. High-density (128 channel) EEG was used to explore changes in microstate features in 15 subjects with subjective tinnitus and 17 age-matched controls. Correlations between microstate parameters and subjective tinnitus symptoms were also analyzed. An increased presence of class A microstate and decreased presence of class D microstate were found in coverage and lifespan of microstate parameters in the tinnitus patients. Syntax analysis also demonstrated an aberrant pattern of activity, with reduced transitions from class D to class B in tinnitus patients. Moreover, a significant positive correlation of tinnitus loudness with increased lifespan of microstate class C was found. Significant differences in temporal characteristics and syntax of the EEG microstate classes were found at rest between tinnitus patients and the healthy subjects. Our study indicates that EEG microstates may provide a possible valuable method to study large-scale brain networks, which may in turn be beneficial to investigation of the neurophysiological mechanisms behind tinnitus.

Ministate

10.3389/fnbeh.2018.00122

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Citations (19)

Analysis and comparison of the masking and TRT for patients with subjective tinnitus

Journal of clinical otorhinolaryngology, head, and neck surgery (2010)

Haidi Yang Yiqing Zheng Zhigang Zhang Jun Lan Suijun Chen

OBJECTIVE To compare the effect of tinnitus masking and tinnitus retraining therapy (TRT) in patients with subjective tinnitus, and to analyze the effect of TRT within the positive or negative group of tinnitus masking test. METHOD The 217 patients from January, 2006 to April, 2008 in our hospital, were performed with the determination of tinnitus including pitch matching, intensity matching, Feldmann masking curve and residual inhibition test with Tinni Test. Of which 143 cases were positive and 74 were negative in tinnitus masking. The follow-up was 6 months and 10 cases were lost. 207 patients were divided into two groups for prospective study: 69 cases in tinnitus masking group and 138 cases in TRT group, The curative effect was evaluated according to tinnitus handicap inventory (THI) and Subjective Visual Tinnitus Scale (SVTS). RESULT Both masking treatment and TRT were effective for cases with tinnitus, there was significant difference of the score of THI and SVTS of tinnitus between pretherapy and posttherapy (P < 0.01). TRT therapy was more effective than masking therapy, there was significant difference of the THI score between TRT and masking group,but there was no significant difference of of the SVTS between them. TRT therapy was suitable for the patients with both positive effect and negative effect of masking test, and there was no significant difference between them. CONCLUSION Both TRT and masking therapy are the most important therapy for tinnitus patients, but TRT is much more effective than masking therapy in some aspects.

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Circulating miR-34a levels correlate with age-related hearing loss in mice and humans

Experimental Gerontology (2016)

Jiaqi Pang Hao Xiong Haidi Yang Yongkang Ou Yaodong Xu

Presbycusis

10.1016/j.exger.2016.01.009

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Citations (51)

Clinical feature analysis on 217 patients with subjective tinnitus

Guoji yiyao weisheng daobao (2011)

Ling Chen Haidi Yang Yongkang Ou

Objective To analysis the clinical feature and audiology feature of patients with subjective tinnitus,compare masking,screening effectiveness of various kinds tinnitus,and search for the individual treatment ways for subjective tinnitus.Methods 217 patients in our hospistor were performed pure tone test,DPOAE,tinnitus determination,and tinnitus masking including pitch matching,intensity matching,Feldmann masking curve,and residual inhibition test with TinniTestTM.Results The prevalence rate is higher in female (52％).Tinnitts occur to the left side more common (42％),followed by bilateral ears (30％) and the right side (28％).The urban population ( 77％ ) and mental worker ( 68％ ) were primary in patients.The patients with chronic tinnitus (duration＞ 1 year) counts for most proportion (46％).The most effective treatment was masking treatment for cases with high frequency tinnitus and low frequency tinnitus; the effective power is 71.6％ and 73.6％.The lowest effective treatment was masking treatment for cases with middle frequency tinnitus; the effective power is only 52.2％.The positive ratio of masking test for cases with type Ⅰ to type Ⅴ (Feldman Curve Type) decreased from 90％ to 10％ gradually.Conclusions The feature of cases with tinnitus had much more dependence on masking test and tinnitus frequency; it could be predictive factor for curative effect of tinnitus.Feldman curve type has large utilization value and directed significance on diagnosis and treatment for tinnitus.It is much more valuable for the selection of masking therapy; and is an important predicted factor for the effectiveness of masking therapy;and it is an important evidence for the selection of personal treatment. Key words: Subjective tinnitus; Tinnitus feature; Feldman curve; Tinnitus masking

10.3760/cma.j.issn.1007-1245.2011.20.018

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