Hubert Huras

Jagiellonian University

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Małgorzata Radoń-Pokracka

Cracow University of Technology

Andrzej Jaworowski

Jagiellonian University

Magdalena Kołak

Jagiellonian University

Robert Jach

Jagiellonian University

Mariusz Zimmer

Wroclaw Medical University

Piotr Sieroszewski

Medical University of Lodz

Alfred Reroń

Jagiellonian University

Mirosław Wielgoś

Ministry of Interior and Administration

Anna Wójtowicz

Jagiellonian University

Magda Rybak-Krzyszkowska

Society for the Investigation of Early Pregnancy

Cooperative Institutions

Jagiellonian University

218

Medical University of Warsaw

Medical University of Lodz

Krakow Cardiovascular Research Institute

Cracow University of Technology

Medical University of Silesia

Poznan University of Medical Sciences

Polish Mother’s Memorial Hospital Research Institute

Nicolaus Copernicus University

Pomeranian Medical University

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Prenatal diagnosis of isolated total anomalous pulmonary venous connection (TAPVC) to coronary sinus

Ginekologia Polska (2023)

Anna Wójtowicz Beata Załuska-Pitak Magdalena Juszczak Hubert Huras Sebastian Góreczny

10.5603/gpl.96430

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LC/MS/MS assessment of changes in placental angiotensin I metabolism in preeclampsia.

PubMed (2022)

Dominika Settner-Kołodziejska Beata Bujak-Giżycka Anna Wiśniewska Magdalena Łomnicka Michał Kołodziejski

Preeclampsia (PE) is a condition characterized by high blood pressure and significant proteinuria in pregnant women. It affects about 7% pregnancies and can be cause of fetal and maternal morbidity and mortality. During pregnancy, a physiological overexpression of the Renin-Angiotensin System (RAS) components is observed, including increased plasma Ang II level. Dysregulation of RAS in placenta may contribute to preeclampsia and uterine growth retardation. The aim of the study was to evaluate the Ang I metabolism in human preeclamptic placentas and to compare to normal pregnancies condition.Fragments of placental tissues were collected right after ceasarian section from PE and physiological pregnancies. Tissues were incubated in Krebs buffer in the presence of Ang I. Evaluation of Ang I metabolites in incubating fluid was performed by LC/MS/MS method. mRNA expression of main RAS components was measured by RT-PCR.Pattern of angiotensin metabolites did not differ between groups. The main products were Ang 1-7 and Ang II. Comparing to control group, more than 3-fold lower production of Ang II and Ang 1-7 in preeclampsia was observed. mRNA expressions of ACE and AT1 were significantly decreased in pre- eclamptic placentas, whereas higher expression of mRNA of ACE2 and MAS receptor were observed.Production of Ang 1-7 by PE placentas was significantly lower than in control group. Significantly decreased mRNA expression of ACE and AT1 receptor and lower production of Ang II in placentas of PE patients suggest that placental Ang II/ACE/AT1r pathway could be less important than Ang 1-7/ACE-2/MASr pathway in development of preeclampsia, but this requires further investigations.

10.24425/fmc.2022.141692

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Citations (1)

The 1st and 2nd trimester scan of the fetal heart in the case of interrupted aortic arch - case report

Kardiologia Prenatalna Echo Płodu (2014)

Anna Wójtowicz Hubert Huras

Interrupted aortic arch

Neonatology

Fetal heart

Fetal echocardiography

Cardiothoracic surgery

10.12847/06143

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Citations (1)

Czerniak złośliwy sromu z przerzutami do cewki moczowej u 64-letniej pacjentki – opis przypadku

DOAJ (DOAJ: Directory of Open Access Journals) (2011)

Paweł Basta Małgorzata Radoń-Pokracka Bartłomiej Galarowicz Marcin Mika Paulina Przybylska

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Evaluation of Pregnancy Outcomes at Advanced Maternal Age

Open Access Macedonian Journal of Medical Sciences (2019)

Małgorzata Radoń-Pokracka Beata Adrianowicz Magdalena Płonka Paulina Danił Magdalena Nowak

The study aimed to investigate the association between advanced maternal age (AMA) and the risk of adverse maternal, perinatal and neonatal outcomes about parity in singleton pregnancies.We retrospectively analysed 950 women who gave birth in the Department of Obstetrics and Perinatology of the University Hospital in Kraków for six months (between 1st January and 30th June 2018). The patients were divided into 3 groups according to their age (30-34 years old, 35-39 years old and over 40 years old). Each of these groups was subsequently subdivided into 2 groups depending on parity (primiparae and multiparae). Maternal, perinatal and neonatal outcomes were compared between the groups and the subgroups.Comparison of the three age groups revealed that advanced maternal age might constitute a predisposing factor for preterm birth, caesarean section and large for gestational age (LGA). From these parameters, statistical significance was reached in case of greater risk of LGA (OR = 2.17), caesarean section (OR = 2.03) and elective C-section (OR = 1.84) in women over 40 years old when compared to the patients aged 30-34. Furthermore, AMA increases the risk of postpartum haemorrhage (OR = 6.43). Additionally, there is a negative correlation between maternal age and gestational age at delivery (R = -0.106, p < 0.05).Advanced maternal age can undoubtedly be associated with several adverse perinatal outcomes. At the same time, the risk of perinatal complications begins to increase after the age of 35 but becomes significant in women aged ≥ 40.

Advanced maternal age

Parity (physics)

Age groups

10.3889/oamjms.2019.587

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Citations (33)

Practice guidelines of the Polish Society of Gynecologists and Obstetricians - Ultrasound Section for ultrasound screening in uncomplicated pregnancy - 2020

Ginekologia Polska (2020)

Dariusz Borowski Marek Pietryga Paweł Basta Wojciech Cnota Bartosz Czuba

Section (typography)

Obstetric ultrasound

10.5603/gp.2020.0110

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Citations (18)

Polish Society of Gynecologists and Obstetricians Guidelines for the application of hysteroscopy in gynecology

Ginekologia Polska (2019)

Mariusz Zimmer Michał Pomorski Paweł Kamiński Jacek Doniec Hubert Huras

This guideline presents current management recommendations which may be modified and altered in justifiable cases, after careful analysis of a given clinical case, which in the future might constitute grounds for modification and updating. OBJECTIVESThe objective of this guideline is to present up-to-date knowledge about the application of hysteroscopy in gynecology, based on the experience of the authors and reliable sources from the literature.

10.5603/gp.2019.0083

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Citations (9)

Ginekologia Polska (2021)

Teresa Górnisiewicz Hubert Huras Katarzyna Kuśmierska-Urban Aleksander Gałaś

Objectives: The aim of the study was to evaluate whether the presence of the disease in pregnancy influences the effectiveness and safety of delivery preinduction with prostaglandins: misoprostol vaginal insert and dinoprostone vaginal gel. Material and methods: This is a retrospective cohort study conducted of 560 pregnant women. The concomitant diseases mainly recorded were diabetes mellitus, hypertensive diseases, intrahepatic cholestasis of pregnancy, asthma, thrombocytopenia, and hypothyroidism. The primary study outcome was a successful vaginal delivery. The study above others evaluates the time from treatment implementation to the beginning of a labor and to a final delivery, the rate of Cesarean sections, and the presence of delivery complications. Results: Among women with a concomitant disease, Caesarean section was observed more frequently in the misoprostol group. In the dinoprostone group, mothers with the concomitant disease as compared to healthy mothers required more time to the delivery and to achieve the beginning of labor. There were no differences in postpartum complications regardless of the prostaglandins, comorbidities or mothers’ age. Neonates of mothers ≥ 35 years old with concomitant disease had lower average Apgar scores. Conclusions: Our study showed that comorbidities seem to increase the caesarean section risk in the misoprostol preinduction group but in the dinoprostone group they prolong the time needed to achieve an active labour phase and a delivery.

Dinoprostone

Concomitant

Apgar score

10.5603/gp.a2021.0092

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Citations (3)

Computerized cardiotocography in obstetric practice

Kolposkopia (2004)

Alfred Reroń Zygmunt Madejski Hubert Huras

Cardiotocography

10.1066/s10014040040

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Rekomendacje Polskiego Towarzystwa Ginekologów i Położników dotyczące suplementacji u kobiet ciężarnych

Mariusz Zimmer Piotr Sieroszewski Przemysław Oszukowski Hubert Huras Tomasz Fuchs

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Citations (2)