Miquel Sans

Hospital Quirón Teknon

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Co-Authors

Julían Panés

Hospital Clínic de Barcelona

Josep M. Piqué

University of Andorra

Silvio Danese

IRCCS Ospedale San Raffaele

Séverine Vermeire

KU Leuven

Tiago Nunes

San Antonio College

Meritxell Gironella

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Manuel Barreiro–de Acosta

Complejo Hospitalario Universitario de Santiago

Daniel Ginard

Hospital Universitario Son Espases

María Josefina Etchevers

Hospital Italiano de Buenos Aires

Montserrat Aceituno

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Cooperative Institutions

Universitat de Barcelona

154

Hospital Clínic de Barcelona

154

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

150

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

147

Centro de Investigación Biomédica en Red

107

Instituto de Salud Carlos III

Universitat Autònoma de Barcelona

Istituti di Ricovero e Cura a Carattere Scientifico

Inserm

University Gastroenterology

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Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

WOS (2013)

Jimmy Z. Liu Johannes R. Hov Trine Folseraas Eva Ellinghaus Simon Rushbrook

Primary Sclerosing Cholangitis

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Citations (1)

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

Nature (2012)

Luke Jostins Stephan Ripke Rinse K. Weersma Richard H. Duerr Dermot McGovern

Inflammatory Bowel Diseases

Genetic architecture

10.1038/nature11582

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Citations (4,442)

The role of MAPK in governing lymphocyte adhesion to and migration across the microvasculature in inflammatory bowel disease

European Journal of Immunology (2009)

Franco Scaldaferri Miquel Sans Stefania Vetrano Carmen Correale Vincenzo Arena

Abstract Lymphocyte recruitment is a key pathogenic event in inflammatory bowel disease (IBD). Adhesion of T cells to human intestinal microvascular endothelial cells (HIMEC) is mediated by ICAM‐1, VCAM‐1 and fractalkine (FKN), but the signaling molecules that orchestrate this process have yet to be identified. Because MAPK play an important role in the response of many cell types to pro‐inflammatory stimuli, we assessed the functional role of p38 MAPK, p42/44 MAPK and JNK in the regulation of lymphocyte adhesion to and chemotaxis across the microvasculature in IBD. We found that the MAPK were phosphorylated in the bowel microvasculature and human intestinal fibroblasts of patients with IBD but not of healthy individuals. Stimulation of HIMEC with TNF‐ α triggered phosphorylation of the MAPK, and up‐regulation of VCAM‐1, FKN and ICAM‐1. Blockade of p38 decreased the expression of all MAPK by 50% ( p <0.01), whereas inhibition of p42/44 decreased the expression of ICAM‐1 and FKN by 50% ( p <0.01). Treatment of human intestinal fibroblasts with TNF‐ α elicited production of IL‐8 and MCP‐1, which was reduced ( p <0.05) by blockade of p38 and p42/44. Finally, blockade of p38 and p42/44 reduced lymphocyte adhesion to ( p <0.05) and transmigration across ( p <0.05) HIMEC monolayers. These findings suggest a critical role for MAPK in governing lymphocyte influx into the gut in IBD patients, and their blockade may offer a molecular target for blockade of leukocyte recruitment to the intestine.

10.1002/eji.200838316

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Citations (57)

Nitric oxide supplementation ameliorates DSS-induced colitis in mice

Gastroenterology (2000)

Azucena Salas Julían Panés Meritxell Gironella Antonio Soriano Miquel Sans

10.1016/s0016-5085(00)84444-3

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Usefulness of Serum and Faecal Pancreatitis-Associated Protein Dosage to Predict Disease Relapse in Inflammatory Bowel Disease Patients

Gastroenterology (2011)

María Josefina Etchevers Tiago Nunes Susana Pinó Donnay Teddy Grandjean María Pellisé

10.1016/s0016-5085(11)61831-3

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Randomized clinical trial: Randomized, controlled, single-blind, three-way crossover study to evaluate the efficacy and safety of a new preparation for post- prandial heartburn

International Research Journal of Medicine and Medical Sciences (2015)

Gordana Bothe Miquel Sans Udo Bongartz Ralf Uebelhack

Heartburn is a prevalent symptom related to gastro-oesophageal reflux. Its treatment includes, amongst others, the use of alginates, which combine a rapid onset of action with a longer duration of symptom relief than antacids. The aim of this study was to investigate the time to onset of action of two alginate preparations, Reduflux® liquid sachets (RL) and Reduflux® chewable tablets (RT). This was a randomized, placebo-controlled, single-blind, three-way crossover clinical investigation with subjects prone to suffer from post-prandial heartburn. Heartburn was triggered by a refluxogenic meal and subjects were randomized to receive RL, RT or placebo. Subjects identified the onset of perception of soothing and cooling effects in the throat and oesophagus, by using a previously described dual-stopwatch method. 48 subjects were screened, 42 were randomized and 41 completed the study. Mean time to onset of soothing was 1.71, 1.92, and 29.43 min, for RL, RT and placebo, respectively (p < 0.001). Mean time to onset of cooling was 0.76, 0.78, and 28.83 min, for RL, RT and placebo, respectively (p < 0.001). Only 1 out of 41 subjects experienced reappearance of heartburn in the 4 h after symptoms relief in each of the RL and RT groups. RL and RT were considered highly efficacious and safe by both the investigator and subjects. In conclusion, Reduflux® chewable tablet and liquid sachet were efficacious in the treatment of post-prandial heartburn, providing a quick onset and a long duration of action, with sustained symptoms relief in 97% of the subjects.

Heartburn

Onset of action

Crossover study

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Human Head Yaw Estimation Based on Two 3-Axis Accelerometers

IEEE Sensors Journal (2022)

Vincent Grimaldi Laurent Simon Miquel Sans Gilles Courtois Hervé Lissek

The estimation of the orientation of an object, and a human head in particular, can be defined by the Euler angles: the yaw, pitch and roll. The robust and drift-free estimation of those angles is usually achieved with the data from several sensors such as accelerometers, gyroscopes and magnetometers, processed with sensor fusion algorithms. However, wearable devices such as hearing instruments are rarely equipped with all those sensors, and might usually only have a single accelerometer embedded per device. While it is possible to retrieve a correct estimation of the roll and pitch using only a single accelerometer, estimating the yaw is a more challenging task as accelerations around the gravity vector cannot be detected by an accelerometer. In the context of binaural communication devices and spatial hearing, the yaw of the head is a key information that helps achieving dynamic binaural synthesis. This work proposes an algorithm that aims at estimating the yaw of a human head by using only two 3-axis accelerometers that are placed at each side of the head. The algorithm is evaluated with acceleration measurements of human subjects achieving a realistic task. The results suggest that the strategy used is promising as a good performance can be achieved for a majority of the measures as long as an individualized set of parameters can be selected. The results also suggest that the performance of the current implementation is sensitive to sensor displacement after calibration or a wrong estimation during initialization.

Sensor Fusion

10.1109/jsen.2022.3185712

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Citations (2)

M2073 NOD2/CARD15, Toll-Like Receptor 4, and Toll-Like Receptor 9 Gene Polymorphisms in Spanish and Dutch Patients with Inflammatory Bowel Disease

Gastroenterology (2008)

Miquel Sans Carolina Figueroa Bart Crusius Marta Artieda Ad A. van Bodegraven

10.1016/s0016-5085(08)62166-6

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Citations (1)

Treatment of Intestinal Fibrosis With Tocotrienols in an Optimized Rat Model

Gastroenterology (2011)