Dušica Simić

University Children's Hospital, Belgrade

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Ivana Budić

University of Nis

Marija Stević

University Children's Hospital, Belgrade

Vesna Marjanović

University of Nis

Irina Milojević

University Children's Hospital, Belgrade

Miodrag Milenović

Univerzitetski Klinički Centar Srbije

Irena Simić

University of Belgrade

Ivana Petrov

University of Belgrade

Novak Milović

Military Medical Academy

Vladimir Bančević

University of Defence

Vladimir Radlović

University of Belgrade

Cooperative Institutions

University of Belgrade

110

Boston Children's Hospital

University Children's Hospital, Belgrade

Univerzitetski Klinički Centar Srbije

Centar za Promociju Nauke

Istituti di Ricovero e Cura a Carattere Scientifico

University of Nis

Inserm

Military Medical Academy

European Society of Anaesthesiology

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P257 TAP block for ileostomy in a 900g neonate – a case report

Emil Bosinci Lazar Jakšić Vladimir Stranjanac Irina Milojević Selena Purić Racić

Ileostomy

10.1136/rapm-2024-esra.401

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The criteria for verifying brain death in children

Srpski arhiv za celokupno lekarstvo (2004)

Dušica Simić Milos Petkovic Irina Kovacevic Ivana Budić

The American Committee, followed by the British, consisting of experts in various fields, in 1968 and 1976, respectively, reached the following consensus: "If a brain stem is dead, a brain is dead, if a brain is dead, a person is dead..." In the last few years, definition of brain death was necessary due to organ transplantation. Most of criteria verifying brain death do not include the specific determinants of brain death in children. This paper specifies the most up-to-date guidelines for diagnosis of brain death in children of various ages.

Brain dead

10.2298/sarh04s1125s

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S137 Urological complications of kidney transplantation: 13 years’ experience

European Urology Supplements (2009)

Milena Jovanovic Novak Milović Z. Čampara Vladimir Bančević Predrag Marić

Sunflower oil

Speed of Sound

Vegetable oil

10.1016/s1569-9056(09)75018-3

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Procedural sedation and analgesia in the pediatric intensive care unit

Signa Vitae (2023)

Ivana Budić Vesna Marjanović Ivona Djordjević Marija Stević Dragoljub Živanović

Children frequently experience more painful, stressful, and traumatic medical procedures and treatments in the pediatric intensive care unit (PICU) than when they are hospitalized in general wards. An essential part of care in the PICU is providing critically ill children with appropriate sedation and analgesia. Finding the perfect combination of adequate analgesia and sufficient sedation in a patient group with a wide range of ages, sizes, and developmental stages can be challenging. Administration of sedatives and analgesics to critically ill patients may be challenging and complicated by unpredictable pharmacokinetics (PK) and pharmacodynamics (PD). It is important to keep in mind that optimal agents for procedural sedation and analgesia (PSA) differ from those used for long-term sedation in the PICU. In addition to pharmacological measures, different non-pharmacological methods can be applied and have been shown to be effective for pain relief in children. Efforts are being made to improve PSA management with the use of national surveys, recommendations, and guidelines.

Pharmacodynamics

10.22514/sv.2023.007

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Citations (1)

Oral premedication with benzodiazepines

Galenika Medical Journal (2023)

Dušica Simić Z. Stanković Marija Stević Ivana Petrov-Bojičić

Preoperative medication or premedication is the administration of medications before surgery, to reduce anxiety, which is common in these patients, and as prophylaxis of side effects of anesthesia like heart rhythm disorders, blood pressure variations, hypersalivation, etc. Benzodiazepines are the usual agents used in premedication to provide relief of anxiety, anterograde amnesia, and light sedation. The most common benzodiazepines used for premedication are midazolam, Diazepam and lorazepam. They are usually given intramuscularly or orally in children. The time of use should be correlated with the moment of maximum effect depending on the method of administration. Time varies from twenty minutes for intramuscularly administered midazolam to two hours for peroral administered lorazepam. The choice of a particular Benzodiazepine, used for premedication, depends on its effects, duration of action, active metabolites, and side effects. The dose should be carefully tailored to provide the expected reduction of anxiety and light sedation and to avoid sleep and especially respiratory depression.

Premedication

Lorazepam

Midazolam

Anterograde amnesia

Hypersalivation

10.5937/galmed2307041s

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Hemorrhagic shock

Acta chirurgica iugoslavica (2007)

V.M. Bumbasirevic B. Jovanovic Ivan Palibrk Aleksandar Karamarković Dejan Radenković

Hemorrhagic shock is a condition produced by rapid and significant loss of blood which lead to hemodynamic instability, decreases in oxygen delivery, decreased tissue perfusion, cellular hypoxia, organ damage and can be rapidly fatal. Despite improved understanding of the pathophysiology and significant advances in technology, it remains a serious problem associated with high morbidity and mortality. Early treatment is essential but is hampered by the fact that signs and symptoms of shock appear only after the state of shock is well establish and the compensatory mechanisms have started to fail. The primary goal is to stop the bleeding and restore the intravascular volume. This review addresses the pathophysiology and treatment of hemorrhagic shock.

Hemorrhagic shock

Pathophysiology

Hypoxia

Tissue hypoxia

Intravascular volume status

Oxygen delivery

10.2298/aci0701063b

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Congenital diaphragmatic hernia – a Belgrade single center experience

Journal of Perinatal Medicine (2016)

Jasna Kalanj Petar Salević Snežana Rsovac Biljana Medjo Sanja Sindjic Antunovic

Abstract Objective: Though the outcome for children with congenital diaphragmal hernia (CDH) is improving, management of seriously compromised respiratory and cardiovascular function remains a great challenge. The aim of this study was to review a tertiary center experience in treating children with CDH. Design: Retrospective observational study from January 2005 to December 2014. Setting: Neonatal Intensive Care Unit (NICU) of University Children Hospital (UCH), Belgrade, Serbia. Patients: Children with CDH. Results: The CDH was diagnosed prenatally in 23% patients. An overall survival rate was 62%. Among those patients who underwent surgical repair 29 (90%) survived. There was statistically significant difference in survival rate between operated patients and total examined population (P=0.020). Prenatally diagnosed neonates with CDH had significantly lower survival rate comparing to those who were postnatally diagnosed (20% vs. 75%; P=0.002). Fatal outcome was more frequent in patients with small birth weight comparing to those with normal birth weight (67% vs. 30%; P=0.046). Conclusions: Our center survival rate for CDH is in accordance with other reported studies. Based on our experience there are potential points for further improvement. First, further increase of prenatal detection, planning for delivery, and coordinated transfer to tertiary institution, in order to avoid transfer of near death patients. Second, preoperative management in the NICU. This could be done by more uniform implementation of current consensual guidelines in monitoring, mechanical ventilation and circulatory support of these delicate patients, together with rationale use of newer therapeutic resources.

Single Center

Neonatology

10.1515/jpm-2015-0333

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Citations (11)

Day surgery anaesthesia in children

Srpski arhiv za celokupno lekarstvo (2004)

Irina Kovacevic Dušica Simić Milos Petkovic

The progress of anesthesiology and surgery makes it possible for most of the interventions to be preformed during day surgery. The objective of this study was, by the analysis of patients who had undergone day surgery and with respect of procedure and patients selection criteria, to show that this mode of treatment is efficient, safe and money saving. Retrospective study consisted of 2078 children, aged 6 months to 14 years, ASA I-II, subjected to various interventions at the Day Surgical Department of the University Children?s Hospital in Belgrade. The analysis of the results demonstrated that just few patients had postoperative complications, unrelated to applied anesthesia and premedication. No case was reported to be hospitalized due to postoperative complications. Temporary and rare postoperative complications, short separation of children from their parents, and reduced treatment costs indicate that such trend of management should be continued.

Premedication

10.2298/sarh04s1054k

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Acute diarrhea in children

Srpski arhiv za celokupno lekarstvo (2015)

Nedeljko Radlović Zoran Leković Biljana Vuletić Vladimir Radlović Dušica Simić

Acute diarrhea (AD) is the most frequent gastroenterological disorder, and the main cause of dehydration in childhood. It is manifested by a sudden occurrence of three or more watery or loose stools per day lasting for seven to 10 days, 14 days at most. It mainly occurs in children until five years of age and particularly in neonates in the second half-year and children until the age of three years. Its primary causes are gastrointestinal infections, viral and bacterial, and more rarely alimentary intoxications and other factors. As dehydration and negative nutritive balance are the main complications of AD, it is clear that the compensation of lost body fluids and adequate diet form the basis of the child?s treatment. Other therapeutic measures, except antipyretics in high febrility, antiparasitic drugs for intestinal lambliasis, anti-amebiasis and probiotics are rarely necessary. This primarily regards uncritical use of antibiotics and intestinal antiseptics in the therapy of bacterial diarrhea. The use of antiemetics, antidiarrhetics and spasmolytics is unnecessary and potentially risky, so that it is not recommended for children with AD.

Acute diarrhea

10.2298/sarh1512755r

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Citations (61)

DIFFERENCES IN PHARMACOTHERAPEUTIC APPROACH IN THE TREATMENT OF SOME MEDICAL EMERGENCIES

Elsevier eBooks (1978)

B Vrhovać Zvonko Rumboldt I Bakran Dušica Simić M. Stanulvić

10.1016/b978-0-08-023768-8.52487-7

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