Ailiman Abulaizi

Nanjing University

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Zi Xiong

Hubei University of Medicine

Shiqing Zhang

Zhejiang Chinese Medical University

Zhi Kai Guo

Chinese Academy of Tropical Agricultural Sciences

Hui Ming Ge

Hebei University of Technology

Shi Qing Zhang

Chinese Academy of Tropical Agricultural Sciences

Zhi‐Kai Guo

Chinese Academy of Tropical Agricultural Sciences

La Ying Yang

Environment and Plant Protection Research Institute

Yang Yang

Zhejiang University

Zijun Xiong

Chinese Academy of Tropical Agricultural Sciences

Bi-Ting Chen

Tropical Crops Genetic Resources Institute

Cooperative Institutions

Chinese Academy of Tropical Agricultural Sciences

Tropical Crops Genetic Resources Institute

Nanjing University

Chinese Academy of Sciences

Environment and Plant Protection Research Institute

Nanjing Drum Tower Hospital

Hainan University

Zhejiang University

Chinese Academy of Medical Sciences & Peking Union Medical College

Ministry of Agriculture and Rural Affairs

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Isolation and Identification of Secondary Metabolites Produced by Phytopathogenic Fungus Corynespora cassiicola from Hevea brasiliensis

Molecules (2022)

Xiaoyan Yang Zhi‐Kai Guo Yang Yang Ailiman Abulaizi Zijun Xiong

The secondary metabolites of the phytopathogenic fungus Corynespora cassiicola CC01 from Hevea brasiliensis were investigated. As a result, two new compounds, 5-acetyl-7-hydroxy-6- methoxybenzofuran-2(3H)-one (1) and (S)-2-(2,3-dihydrofuro [3,2-c]pyridin-2-yl)propan-2-ol (2), together with seven known compounds, 4,6,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one (3), 3,6,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one (4), curvulin acid (5), 2-methyl-5-carboxymethyl- 7-hydroxychromone (6), tyrosol (7), p-hydroxybenzoic acid (8) and cerevisterol (9), were isolated from the fermentation extract by comprehensive silica gel, reverse phase silica gel, Sephadex-LH20 column chromatography and high-performance liquid chromatography (HPLC). The structures of these compounds were identified by using high-resolution electrospray mass spectrometry (HRESIMS), nuclear magnetic resonance spectroscopy (NMR), optical rotation, ultraviolet and infrared spectroscopy techniques and a comparison of NMR data with those reported in the literature. Compounds 1 and 2 were new compounds, and compounds 3-9 were discovered from this phytopathogenic fungus for the first time. Compounds 1-9 were tested for phytotoxicity against the fresh tender leaf of Hevea brasiliensis, and the results show that none of them were phytotoxic. Additionally, these compounds were subjected to an antimicrobial assay against three bacteria (E. coli, methicillin-resistant Staphylococcus aureus and Micrococcus luteus), but they showed no activity.

Corynespora cassiicola

Micrococcus luteus

10.3390/molecules27217360

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Discovery of p-Terphenyl Metabolites as Potential Phosphodiesterase PDE4D Inhibitors from the Coral-Associated Fungus Aspergillus sp. ITBBc1

Marine Drugs (2022)

Zhi‐Kai Guo Ailiman Abulaizi Ling Huang Zijun Xiong Shiqing Zhang

Chemical investigation of the fermentation extract of the coral-associated fungus Aspergillus sp. ITBBc1 led to the discovery of five unreported p-terphenyl derivatives, sanshamycins A–E (1–5), together with five previously described analogues, terphenyllin (6), 3-hydroxyterphenyllin (7), candidusin A (8), 4,5-dimethoxycandidusin A (9), and candidusin C (10). Their structures were elucidated by HRESIMS data and NMR spectroscopic analysis. Compound 1 represents the first example of p-terphenyls with an aldehyde substitution on the benzene ring. Compounds 2–4 feature varying methoxyl and isopentenyl substitutions, while compound 5 features a five-membered lactone linked to a biphenyl. These findings expand the chemical diversity of the family of p-terphenyl natural products. Compounds 1–6 and 9 were evaluated for their inhibitory activity against type 4 phosphodiesterase (PDE4), which is a fascinating drug target for treatment of inflammatory, respiratory, and neurological diseases. Compound 3 was the most potent and exhibited PDE4D inhibitory activity with an IC50 value of 5.543 µM.

Terphenyl

Biphenyl

10.3390/md20110679

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Isolation and Biological Activity of Six New Polyketide and Terpenoid Derivatives from Neopestalotiopsis Clavispora Al01

Zhi Kai Guo Ailiman Abulaizi Zijun Xiong Ziru Wang Yang Yang

Download This Paper Open PDF in Browser Add Paper to My Library Share: Permalink Using these links will ensure access to this page indefinitely Copy URL Copy DOI

Isolation

10.2139/ssrn.4764956

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Draft genomic DNA sequence of strain Halomonas sp. FS-N4 exhibiting high catalase activity

Marine Genomics (2014)

Jie Pan Ailiman Abulaizi Cong Sun Hong Cheng Min Wu

Halomonas

Strain (injury)

genomic DNA

10.1016/j.margen.2014.08.002

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Secondary Metabolites with Agricultural Antagonistic Potential from Aspergillus sp. ITBBc1, a Coral-Associated Marine Fungus

Marine Drugs (2024)

Ailiman Abulaizi Rong Wang Zi Xiong Shiqing Zhang Yuanchao Li

A marine-derived fungal strain,

Marine fungi

10.3390/md22060270

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Isolation and biological activity of six new polyketide and terpenoid derivatives from Neopestalotiopsis Clavispora AL01

Fitoterapia (2024)

Ailiman Abulaizi Zi Xiong Zi Ru Wang Yang Yang Shi Qing Zhang

Isolation

10.1016/j.fitote.2024.106130

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Overexpression of CgbHLH001, a Positive Regulator to Adversity, Enhances the Photosynthetic Capacity of Maize Seedlings under Drought Stress

Agronomy (2022)

Haiju Zhao Ailiman Abulaizi Changhai Wang Haiyan Lan

Drought is a major environmental factor limiting crop productivity. Photosynthesis is very sensitive to drought. Basic helix-loop-helix (bHLH) transcription factors (TFs) are important in response to abiotic stress. However, their functions remain unclear. Herein, we generated CgbHLH001 (a TF gene from halophyte Chenopodium glaucum)-overexpressed (OE) and ZmbHLH-RNA interference (Ri) maize lines to investigate their photosynthesis-associated indexes under drought conditions. The photosynthetic capacity was increased in OE lines under drought stress compared with that in non-transgenic (NT) and Ri plants. A greater root biomass, higher root/shoot ratio, and a relatively lower leaf area reduction ratio was also observed in OE plants. Compared to NT and Ri plants, OE lines showed a higher chlorophyll content and net photosynthetic rate and better chlorophyll fluorescence parameters under drought conditions. Fructose and glucose contents were also significantly elevated in OE lines. Moreover, under stressful conditions, CgbHLH001 overexpression increased the expression of genes related to photosynthesis. Transcriptomic data showed that many differentially expressed genes were enriched in the photosynthetic system in OE and Ri plants under drought conditions and were prone to being upregulated under drought stress in OE plants. Therefore, our results suggest that CgbHLH001 improves photosynthetic efficiency under drought stress and confers drought tolerance in maize seedlings.

Drought Tolerance

Photosynthetic capacity

Photosynthetic efficiency

10.3390/agronomy12051149

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CCDC 2235102: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Zhi Kai Guo Yong Chao Wang Ying Zi Tan Ailiman Abulaizi Zi Xiong

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2f0t2c

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Nagimycins A and B, Antibacterial Ansamycin-Related Macrolactams from Streptomyces sp. NA07423

Organic Letters (2023)

Zhi Kai Guo Yong Chao Wang Ying Tan Ailiman Abulaizi Zi Xiong

Chemical investigation of Streptomyces sp. NA07423 led to the discovery of two unreported macrolactams, nagimycins A (1) and B (2). Their structures were elucidated by NMR, HRESIMS, X-ray crystallography, and comparison of experimental and theoretical ECD spectra. The nagimycins have a unique butenolide moiety rarely found in ansamycin antibiotics. Genome analysis revealed the putative biosynthetic gene cluster for nagimycins, and a likely biosynthetic pathway was proposed. Notably, compounds 1 and 2 exhibited potent antibacterial activity against two pathogenic Xanthomonas bacteria.

Butenolide

Moiety

Gene cluster

Pathogenic bacteria

10.1021/acs.orglett.3c01539

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Citations (5)