Hedayat Sahraei

Baqiyatallah University of Medical Sciences

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Gholam Hossein Meftahi

Baqiyatallah University of Medical Sciences

Masoomeh Kazemi

University of North Carolina at Chapel Hill

Homeira Zardooz

Shahid Beheshti University of Medical Sciences

Hassan Ghoshooni

Baqiyatallah University of Medical Sciences

H Ghoshouni

Baqiyatallah University of Medical Sciences

Mohammad‐Reza Zarrindast

Tehran University of Medical Sciences

Boshra Hatef

Baqiyatallah University of Medical Sciences

Gila Pirzad Jahromi

Baqiyatallah University of Medical Sciences

Elaheh Tekieh

Baqiyatallah University of Medical Sciences

Hamed Aliyari

The University of Texas Southwestern Medical Center

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Baqiyatallah University of Medical Sciences

172

Shahid Beheshti University of Medical Sciences

Tehran University of Medical Sciences

University of Tehran

Islamic Azad University North Tehran Branch

Shahid Beheshti University

Islamic Azad University, Tehran

Iran University of Medical Sciences

Tarbiat Modares University

Islamic Azad University, Science and Research Branch

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Involvement of nucleus accumbens in L-arginine-induced conditioned place preference in rats

Behavioural Pharmacology (2004)

Hedayat Sahraei Gilla Pirzadeh-Jahromi Maryam Noorbakhshnia Alireza Asgari Ali Haeri-Rohani

In the present study, the effects of intraperitoneal, intra-accumbal and intra-ventral tegmental area administration of L-arginine and N(G)-nitro-L-arginine methyl-ester (L-NAME) on conditioned place preference behavior were studied. Intraperitoneal (i.p.; 0.5, 1 and 5 mg/kg) and intra-accumbal (intra-NAc; 0.3, 1 and 3 microg/rat), but not intra-ventral tegmental area (intra-VTA; 0.3, 1 and 3 microg/rat) administrations of L-arginine produced a significant place conditioning. Similar injections of L-NAME did not produce any response. However, intraperitoneal pretreatment of the animals with L-NAME (5, 10 and 20 mg/kg), 30 min before L-arginine administration, significantly abolished the acquisition of place conditioning induced by either intraperitoneal or intra-accumbal injection of L-arginine. Moreover, injection of L-NAME (5, 10 and 20 mg/kg) on the test day did not alter the L-arginine response. The results may indicate that L-arginine induces conditioned place preference via an increase in nitric oxide (NO) in the nucleus accumbens.

Conditioned place preference

Intraperitoneal injection

10.1097/00008877-200411000-00003

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Citations (7)

Effect of proximity to high-voltage fields: results of the neural network model and experimental model with macaques

International Journal of Environmental Science and Technology (2018)

Hamed Aliyari Seyed Hossein Hosseinian Hedayat Sahraei M B Menhaj

10.1007/s13762-018-1830-8

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Citations (9)

Anxiogenic and anxiolytic effects of memantine injected into the ventral hippocampus in male stressed mice

Journal of Complementary and Integrative Medicine (2021)

Mohammad Sahraei Hedayat Sahraei Masoomeh Rahimi Maryam Khosravi Mahin Ganjkhani

The effects of intra-ventral hippocampal memantine administration in male NMRI stressed mice were studied.Two stainless steel gauge 23 guide cannulas were placed in the middle part of the mice ventral hippocampus using stereotaxic coordination. Seven days later, the animals were undergone to the stress protocol as follows: They experience four consecutive electro-foot shock stress sessions lasting for 10 min. Five or 30 min before each stress session, the animals received intra-ventral hippocampal (0.1, 1 and, 5 µg/mouse) or intraperitoneal (1, 5, and 10 mg/kg) memantine respectively. Eight days after stress termination, the animals were tested either for the maintenance of either anxiety (elevated plus maze) or depression (forced swimming test).Animals show anxiety eight days after stress termination. Intra-ventral hippocampal infusion of memantine (5 µg/mouse) 5 min before stress inhibited the anxiety-like behaviors. However, other doses of the drug exacerbate the stress effect. The drug, when injected peripherally exacerbated the stress effect in all doses. The drug by itself had no effect. In addition, animals also show depression nine days after stress termination and memantine (0.1, 1, and 5 µg/mouse) reduced the stress effect. The drug (0.1 µg/mouse) by itself induced depression in the animals. However, the drug when injected peripherally reduced the stress effect in all doses.It could be concluded that NMDA glutamate receptors in the ventral hippocampus may play a pivotal role in the mediation of maintenance of anxiety and depression induced by stress in the mice.

Memantine

Elevated plus maze

Anxiogenic

10.1515/jcim-2021-0159

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Citations (1)

Identification of Site of Morphine Action in Pregnant Wistar Rat Placenta Tissue: A C14-Morphine Study

DOAJ (DOAJ: Directory of Open Access Journals) (2012)

Leila Dehghani Hedayat Sahraei Masoomeh Kazemi

Site of action

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The Relationship between the Severity of the COVID-19 Disease, Temperament and Psychological Factors

Iranian Journal of Psychiatry (2022)

Ahmad Afzali Hedayat Sahraei Boshra Hatef Gholam Hossein Meftahi Shima Shayad

Objective: The coronavirus (COVID-19) pandemic negatively affects public mental health around the world. Individuals' reactions to COVID-19 vary depending on their temperament, individual differences, and personality traits. Therefore, the current study is conducted to assess the association of demographical features, Persian temperament, and psychological characteristics with the severity of COVID-19. Method: An online survey was sent to COVID-19 patients to collect their demographic information, COVID-19 symptoms, and clinical data. The Depression, Anxiety and Stress Scale (DAAS-21) questionnaire, Beck Depression Inventory (BDI-II), Spiel Berger State-Trait Anxiety Inventory (STAI) , Pittsburgh Sleep Quality Inventory (PSQI), and Persian general and brain temperament Questionnaire were also completed by 258 participants (127 men and 131 women) 45 days after recovery from COVID-19. Non-parametric analysis was used for statistical analysis. Results: Results showed the significant relationship of demographic factors such as weight, age and gender with the severity of the COVID-19 (P < 0.05). Mean scores of brain temperament (warm/cold) in the severe group were significantly lower than the moderate and mild groups (P < 0.05). There was a significant increase in the dry/wet temperament of the brain in the severe and moderate groups compared to the mild group (P < 0.05). The results of DASS-21 showed a significantly higher anxiety in patients with severe COVID-19 compared with moderate and mild groups (P < 0.05). The severe group was found to be significantly different compared to moderate group in the results of BDI-II (P < 0.05). The result of STAI (state and trait) showed a significant difference between the severe group and the mild and moderate groups. The score of PSQI between the moderate and mild groups was significant (P < 0.05). Conclusion: These results indicate the relationship between demographic factors such as weight, age and gender, brain temperament, as well as some psychological factors such as sleep quality and anxiety with the severity of the COVID-19 disease.

Depression

Beck Anxiety Inventory

10.18502/ijps.v17i4.10696

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Citations (2)

The role of dopamine D2 receptors in the amygdala in metabolic and behavioral responses to stress in male Swiss-Webster mice

Frontiers in Biology (2017)

Maryam Hassantash Hedayat Sahraei Zahra Bahari Gholam Hossein Meftahi R. Vesali

Sulpiride

Corticosterone

Freezing behavior

10.1007/s11515-017-1455-1

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Citations (9)

Interaction effects of intracerebroventricular injection of crocin with the α2-adrenoceptors on memory deficit and hippocampal synaptic plasticity following chronic pain in rat

Brain Research Bulletin (2022)

Lida Tahmasebi Farideh Bahrami Hedayat Sahraei Zeinab Shankayi Shima Shahyad

Population spike

Elevated plus maze

10.1016/j.brainresbull.2022.10.007

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Citations (3)

The effects of nitric oxide on the acquisition and expression of nicotine-induced conditioned place preference in mice

European Journal of Pharmacology (2004)

Hedayat Sahraei Mansour Falahi Mohammad-Reaza Zarrindast Masoomeh Sabetkasaei Hassan Ghoshooni

Mecamylamine

Conditioned place preference

Preference test

Intraperitoneal injection

10.1016/j.ejphar.2004.08.054

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Citations (31)

What Is Thought: Take a Look at the Holy Quran and the Principles of Neuroscience

Iranian Red Crescent Medical Journal (2017)

Elaheh Tekieh Mohammad Hassan Nikbin Hedayat Sahraei Mostafa Ghaneyi Masoomeh Kazemi

Background: Human beings firmly obtain a better understanding of the creator, its aims and destination, natural phenomena as well as the surrounding concepts with the help of thoughts. Invitation towards contemplation is one of the principles of Holy Quran’s teachings. Thought is one of the best activities of the human being’s brain from the neuroscience point of view, which occurs in specific parts of the cerebral cortex. These areas consist of parts of the cerebral cortex, which either does not exist in other creatures or is not highly developed. Objectives: The purpose of this study was to investigate the importance of thought from the Holy Quran’s point of view and the Foundations of Neuroscience. Methods: This research was carried out during year 2015 in the city of Tehran (the capital city of Iran). In this qualitative study, data were collected based on the Holy Quran and the interpretation of authentic books of the Quran and matching interpretation of these verses with neuroscience articles and books in the field of thought. Results: Careful consideration of the data led to the identification of 18 verses of the Holy Quran that pointed directly to thinking, which were consistent with accepted principles in neuroscience. Conclusions: Scientific secrets of the Holy Quran can be easily revealed by making a connection between a medical sciences, basic sciences, and Quranic sciences. There is hope of greater connection between the community of researchers in different fields with Quranic scientists, which might lead to the discovery of the secrets of this scripture and deep realization of the mystery of permanence.

Kowsar

10.5812/ircmj.61689

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Citations (0)

Milled Stress Reduces Morphine-Induced Locomotion in F2 NMRI Mice.

PubMed (2011)

Hassan Ghoshooni Pooya Payandeh Mehr Seyyed Hosein Salimi Leila Golmanesh Ahamadreza Dehpour

In the present study, the effects of pregnant NMRI mice restraint stress on the responsibility of their children to the behavioral properties of morphine, sulpiride and dextromethorphan were investigated in the F2 generation.25 g) were divided into the experimental and control groups (n = 12/group). Animals in the experimental group were kept in the restraint cylinder (ID = 6 cm, L = 20 cm) for 60 min/day for 15 consecutive days, while the control group did not receive stress. On the 8(th) day, blood samples were taken from the retro-orbital of both groups for corticosterone measurement (ELYSA method). After the F2 weight gained 20-25 g, their tendency for right-handedness or Left-handedness and response to the new environment was determined by T-maze and open field method, respectively. In addition, the effects of morphine, sulpiride and dextromethorphan on the animals' motor activity were studied. Results showed that plasma corticosterone level in the experimental group was elevated significantly with respect to the controls. In the off-springs, left-handedness was more frequent in both the male and female animals whose mothers experienced restrained stress. In the open field paradigm, however, the females of experimental group showed more activity compared to the others. While the females of the control group showed more response to morphine (50 mg/Kg), interestingly, both male and female animals in the experimental group showed hypo activity to morphine (0.5, 5, and 50 mg/Kg). Similarly, sulpiride (25 and 50 mg/Kg) reduced the animals' activity in both groups, while dextromethorphan did not cause any difference. In conclusion, it can be summarized that stress during the gestation period may change the response to the morphine-induced motor activity, in a sex-dependent manner.

Sulpiride

Corticosterone

Adult male

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Citations (4)