Mei Xu

Philadelphia College of Osteopathic Medicine

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Gary J. Bassell

Emory University

Kelly Lau

Princeton University

Sarah Chmielewski

Biocom

Yiding Zhao

Nankai University

Arthur W. English

Emory University

Mengyang Geng

Tianjin Central Hospital of Gynecology Obstetrics

Ling Shuai

Nankai University

Yee‐Kong Ng

National University of Singapore

Pak Lai Tang

Hong Kong Polytechnic University

Qian Gao

Tianjin Central Hospital of Gynecology Obstetrics

Cooperative Institutions

Philadelphia College of Osteopathic Medicine

University of Massachusetts Chan Medical School

Emory University

Sun Yat-sen University

Chinese Academy of Sciences

Huazhong University of Science and Technology

Southern Medical University

Nanjing Medical University

Nankai University

Anhui Medical University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

RESPIRATOR FIT AND PROTECTION THROUGH DETERMINATION OF AIR AND PARTICLE LEAKAGE

The Annals of Occupational Hygiene (1991)

Mei Xu Daewoo Han Sunil Hangal Klaus Willeke

A laboratory technique for determining the respirator protection factor from a test of fit is described. A dynamic pressure test quantifies the air flow through the leak. Calibration data, stored in a computer, relate the contaminant influx to this air flow, and a similar pressure test determines the flow through the respirator cartridges and, therefore, the dilution characteristics. Contaminant removal characteristics of the cartridges are stored in the computer. The contaminant penetration is calculated from these data on flow and removal efficiency. Through specification of the aerosol size.

Respirator

Cartridge

Leakage (economics)

Hydrostatic test

Penetration (warfare)

Dilution

10.1093/annhyg/35.1.13

Cite

Citations (8)

A Digital Atlas to Characterize the Mouse Brain Transcriptome

PLoS Computational Biology (2005)

James P. Carson Tao Ju Hui‐Chen Lu Christina Thaller Mei Xu

Massive amounts of data are being generated in an effort to represent for the brain the expression of all genes at cellular resolution. Critical to exploiting this effort is the ability to place these data into a common frame of reference. Here we have developed a computational method for annotating gene expression patterns in the context of a digital atlas to facilitate custom user queries and comparisons of this type of data. This procedure has been applied to 200 genes in the postnatal mouse brain. As an illustration of utility, we identify candidate genes that may be related to Parkinson disease by using the expression of a dopamine transporter in the substantia nigra as a search query pattern. In addition, we discover that transcription factor Rorb is down-regulated in the barrelless mutant relative to control mice by quantitative comparison of expression patterns in layer IV somatosensory cortex. The semi-automated annotation method developed here is applicable to a broad spectrum of complex tissues and data modalities.

Brain atlas

10.1371/journal.pcbi.0010041

Cite

Citations (60)

Induction of microglial reaction and expression of nitric oxide synthase I in the nucleus dorsalis and red nucleus following lower thoracic spinal cord hemisection

Brain Research (1998)

Mei Xu Yee‐Kong Ng Seng‐Kee Leong

Axotomy

Red nucleus

Nitrotyrosine

10.1016/s0006-8993(98)00787-2

Cite

Citations (24)

Fracture Mechanics Study on Subsurface Median Crack in Layered Structure Subjected to Mechanical Contact

Applied Mechanics and Materials (2011)

Yu Bao Jun Lv Ying–Jun Angela Zhang Mei Xu Guozhong Chai

The subsurface transverse median crack system due to spherical contact in brittle coating-bond -substrate sandwich structure is investigated with an emphasis on stress intensity factor near the crack front using finite element method. This crack system emanates from the lower surface of the brittle layer and extends transversely towards the top of contact surface, resulting in ultimate failure of the structures. In this paper, finite element mesh is designed, and the crack front mesh designing solution for a surface crack subjected to remote tension is validated with Newman and Raju empirical equation. Then the proposed crack front mesh design solution is applied to a typical sandwich structure of various modeling parameters to obtain the SIF with 3D-J integral.

Brittleness

Tension (geology)

10.4028/www.scientific.net/amm.121-126.3672

Cite

Citations (0)

Dysregulated Metabotropic Glutamate Receptor-Dependent Translation of AMPA Receptor and Postsynaptic Density-95 mRNAs at Synapses in a Mouse Model of Fragile X Syndrome

Journal of Neuroscience (2007)

Ravi S. Muddashetty Sofija Kelič Christina Groß Mei Xu Gary J. Bassell

Fragile X syndrome, a common form of inherited mental retardation, is caused by the loss of fragile X mental retardation protein (FMRP), an mRNA binding protein that is hypothesized to regulate local mRNA translation in dendrites downstream of gp1 metabotropic glutamate receptors (mGluRs). However, specific FMRP-associated mRNAs that localize to dendrites in vivo and show altered mGluR-dependent translation at synapses of Fmr1 knock-out mice are unknown so far. Using fluorescence in situ hybridization, we discovered that GluR1/2 and postsynaptic density-95 (PSD-95) mRNAs are localized to dendrites of cortical and hippocampal neurons in vivo . Quantitative analyses of their dendritic mRNA levels in cultured neurons and synaptoneurosomes did not detect differences between wild-type and Fmr1 knock-out (KO) mice. In contrast, PSD-95, GluR1/2, and calcium/calmodulin-dependent kinase IIα (CaMKIIα) mRNA levels in actively translating polyribosomes were dysregulated in synaptoneurosomes from Fmr1 knock-out mice in response to mGluR activation. [ 35 S]methionine incorporation into newly synthesized proteins similarly revealed impaired stimulus-induced protein synthesis of CaMKIIα and PSD-95 in synaptoneurosomes from Fmr1 KO mice. Quantitative analysis of mRNA levels in FMRP-specific immunoprecipitations from synaptoneurosomes demonstrated the association of FMRP with CaMKIIα, PSD-95, and GluR1/2 mRNAs. These findings suggest a novel mechanism whereby FMRP regulates the local synthesis AMPA receptor (AMPAR) subunits, PSD-95, and CaMKIIα downstream of mGluR-activation. Dysregulation of local translation of AMPAR and associated factors at synapses may impair control of the molecular composition of the postsynaptic density and consequently alter synaptic transmission, causing impairments of neuronal plasticity observed in Fmr1 knock-out mice and fragile X syndrome.

FMR1

Postsynaptic density

Fragile X Syndrome

10.1523/jneurosci.0937-07.2007

Cite

Citations (412)

Effects of Laminaria japonica polysaccharides on airway inflammation of lungs in an asthma mouse model

Multidisciplinary Respiratory Medicine (2015)

Rongjun Lin Xiaomei Liu Yan Meng Mei Xu Jianping Guo

Background: Asthma is a serious chronic inflammatory disease affecting 300 million people worldwide. This aim of this study to investigate the anti-inflammatory and anti-asthmatic effects of Laminaria japonica extract in the ovalbumin (OVA)-induced mouse asthma model. Methods: A mouse asthma model was established in SPF Kunming mice by OVA-sensitization followed by inhalation of aerosol allergen for two weeks. Laminaria japonica polysaccharides (LJPS) were given by gavage feeding at 50 mg/kg/day during OVA inhalation challenge period, and their effect on asthma was compared with the standard treatment of Budesonide inhalation. The total inflammatory cells and eosinophils in bronchoalveolar lavage fluid (BALF) were determined. Histopathological changes in lung tissue were studied and scored to determine the degree of inflammation. Levels of IL-12, IL-13, and TGF-β1 in BALF as well as serum levels of IgE were measured. Expressions of IL-12, IL-13, and TGF-β1 in lung tissues were assessed. Results: Highly inflammatory lungs infiltrated with significant increased eosinophils were observed in OVAinduced asthmatic mice. The OVA treated mice presented with a lower level of IL-12 and higher levels of IL-13 and TGF-β1 in BALF and lung tissues, as well as an increased level of the serum IgE. Treatment with LJPS (Group B) significantly decreased the numbers of eosinophils in the BALF (P<0.05) and alleviated lung inflammation compared to the untreated asthma mice (Group A). It also reduced the serum IgE levels, increased expression of IL-12, and decreased the expression of IL-13 and TGF-β1 in BALF and lung (Both P < 0.05) compared with the group A. Conclusions: LJPS can significantly inhibit airway inflammation of asthmatic mice, adjust the balance of cytokines, and improve the pulmonary histopathological condition. Our data suggested that LJPS might be a potential therapeutic reagent for allergic asthma.

10.4081/mrm.2015.296

Cite

Citations (2)

Analysis of Puerarin and Chemical Compositions Changes in Kudzu Root during Growth Period

Journal of Chemistry (2014)

Yiguo Zhao Mei Xu Zhinneg You Dongsheng Li Mingquan Zhou

The kudzu root is one of the earliest medicinal plants listed in traditional Chinese medicine. In this paper, chemical compositions changes of kudzu roots from one year old to five years old were analyzed with respect to puerarin, acid-insoluble polysaccharides, acid-soluble polysaccharides, reducing sugar, protein, free amino acids, and lipid. In addition, the puerarin content was determined by high performance liquid chromatography (HPLC) method. The results showed that acid-soluble polysaccharides content of kudzu root increased with each growth period. In contrast, the acid-insoluble polysaccharides decreased significantly. The contents of reducing sugar and puerarin in kudzu root decreased significantly during its growth period. Beyond that, the contents of protein, free amino acids, and lipid in kudzu root ranged from 31.8 to 45.8 g/kg, 2.21 to 4.33 g/kg, and 32.2 to 76.9 g/kg, respectively. The trend of protein content coincided with the total content of free amino acids, in contrast to lipid. This paper provides a set of data and the select of kudzu root for the processing and development of new products of kudzu root.

Kudzu

Puerarin

10.1155/2014/582176

Cite

Citations (15)

Atypical Intraparenchymal Meningioma with YAP1-MAML2 Fusion in a Young Adult Male: A Case Report and Mini Literature Review

International Journal of Molecular Sciences (2023)

A Nobee Mei Xu Anjali Seth Yuan Rong

Oncogenic Yes-associated protein (YAP) 1 fusions have been recently identified in several cases of meningioma mostly involving pediatric patients. The meningiomas harboring YAP1-MAML2, which is the most frequent fusion subtype, exhibit activated YAP1 signaling and share similarities with NF2 (neurofibromatosis type 2 gene) mutant meningiomas. We reported a rare case of atypical intraparenchymal meningioma with YAP1-MAML2 fusion in a 20-year-old male. The patient presented with an episode of seizure without a medical history. MRI revealed a lesion in the right temporal lobe without extra-axial involvement. The radiological and morphological findings, however, were indistinctive from other intracranial diseases, e.g., vascular malformation and glioma. Immunohistochemical results confirmed the presence of abundant meningothelial cells in the tumor and indicated brain invasion, supporting the diagnosis of atypical intraparenchymal meningioma. Targeted RNA fusion analysis further identified a YAP1-MAML2 rearrangement in the tumor. Non-dural-based intraparenchymal meningiomas are uncommon, and the careful selection of specific tumor markers is crucial for an accurate diagnosis. Additionally, the detection of the fusion gene provides valuable insights into the oncogenic mechanism of meningioma.

Intraparenchymal hemorrhage

Brain tumor

10.3390/ijms241612814

Cite

Citations (4)

Neuroprotective and Neurodestructive Functions of Nitric Oxide after Spinal Cord Hemisection

Experimental Neurology (2000)

Mei Xu Yee‐Kong Ng Seng‐Kee Leong

Axotomy

10.1006/exnr.1999.7278

Cite

Citations (30)