H. Oudadesse

Centre National de la Recherche Scientifique

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J.L. Irigaray

Centre National de la Recherche Scientifique

S. Terver

Centre Hospitalier Universitaire de Clermont-Ferrand

ÉJ

Édouard Jallot

Université Clermont Auvergne

Valérie Brun

Txcell (France)

Thierry Sauvage

Conditions Extrêmes et Matériaux Haute Température et Irradiation

G. Weber

Institute for Atomic and Molecular Physics

E. Chassot

Laboratoire de Physique Corpusculaire

Patrick Frayssinet

Artelia (France)

G. Blondiaux

Centre National de la Recherche Scientifique

Y. Barbotteau

Hôpital privé Clairval

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Centre National de la Recherche Scientifique

Université Clermont Auvergne

Inserm

Laboratoire de Physique Corpusculaire

Institut National de la Recherche Agronomique

Clermont Université

Université de Reims Champagne-Ardenne

Institut National de Physique Nucléaire et de Physique des Particules

Université Paris Cité

Université Toulouse III - Paul Sabatier

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Utilisation de la methode PIXE pour etudier la cinetique d'ossification de l'hydroxyapatite dopee en zinc

Édouard Jallot J.L. Irigaray H. Oudadesse G. Weber Patrick Frayssinet

L'hydroxyapatite est utilisee en tant que substitut osseux. Cette etude nous permet de mesurer la cinetique de transformation des elements mineraux d'un substitut osseux. L'hydroxyapatite a ete dopee en zinc, en esperant pouvoir accelerer l'ossification. Ainsi, nous pouvons etudier le role du zinc dans la cinetique de resorption des biomateriaux. L'utilisation de la methode d'analyse nucleaire P.I.X.E. (Particles Induced X-ray Emission) nous montre si l'hydroxyapatite, apres implantation, atteint une composition minerale comparable a celle de l'os. Nous avons mesure l'intensite des elements mineraux, apres differents delais d'implantation. La distribution des elements mineraux (Ca, P, Sr, Zn, Fe et Mn) dans l'implant, dans le site receveur et par consequent a l'interface, montre que la resorption de l'hydroxyapatite dopee en zinc commence a partir de 8 semaines d'implantation.

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Diffusion of mineral elements evaluated by PIXE at the bone-coral interface

Journal of Biomaterials Science Polymer Edition (1996)

J.L. Irigaray F. Braye H. Oudadesse Édouard Jallot G. Weber

Substituting the tissue of human organs with biomaterials is problematic. However, its importance and relevance justify all the efforts made. An interdisciplinary approach is required. We report on our study of a product for bone substitution. Coral is a natural product, the interest of which we have already demonstrated in our previous work. Following sterilization, natural coral was implanted in sheep femurs. We regularly extracted the implants from the femurs to study the kinetics of elemental mineral transformation of the bone substitutes. For the first time ever, and thanks to the PIXE method (particles induced X-ray emission), we were able to measure the concentration of mineral elements at different time intervals after implantation over a whole cross-section. We found a discontinuity of the mineral elements (Ca, P, Sr, Zn, Fe) at the interface between the implant and the receiver. This shows that the osseous attack is not global but, on the contrary, centripetal. Moreover, the fit of the concentration time course indicates that the kinetics of ossification are different for each atomic element and characterize a distinct biological phenomenon. Our analyses confirm the biocompatibility and the ossification of the implanted coral.

Biocompatibility

10.1163/156856296x00507

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Study of the mineralization of coral implanted in vivo by radioactive tracers

Journal of Radioanalytical and Nuclear Chemistry (1993)

J.L. Irigaray Thierry Sauvage H. Oudadesse H. El Fadl N. Deschamps

Neutron Activation Analysis

Biomaterial

10.1007/bf02040337

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TENTATIVE FOR TRACE ELEMENTS EVALUATION BY PIXE METHOD VERSUS DEPTH IN SOFT TISSUES NEAR METALLIC IMPLANTS

Journal of Trace and Microprobe Techniques (2002)

E. Chassot H. Oudadesse Y. Barbotteau J.L. Irigaray S. Terver

ABSTRACT Metallic prostheses are widely used in orthopaedic surgery. The degradation of these implants can induce metallic element transfers into biological tissues. The aim of this study is to determine concentration of metallic elements and to follow their migration from the prosthesis to the adjacent tissues. In order to quantify this phenomenon, we use PIXE method. Its feasibility is established. The samples were taken during surgical orthopaedic procedures performed on patients who have implants for a long time with or without adverse reactions. Analysed tissues were taken at the contact of the implants. We have used a Van de Graaff accelerator and the analyses have been made at the CENBG (Centre d’Etude Nucléaire de Bordeaux Gradignan). The experiment allows us to study the quantification of the contamination and the migration through tissues. We have scanned and obtained cartographies of the analysed surfaces which can show the correlation, between the location of different kind of elements in these samples. The difference of concentration in metallic elements between a reference sample and tissue at the contact of implant can be observed. The contamination is heterogeneous and depends on the state and type of the prostheses. We must consider the pathology of the patient which can induce some modifications in tissular behaviour and explain the reactivity of these elements in biological environment. Keywords: ProsthesesMetallic releaseIonic releasePIXE Acknowledgments

Trace element

10.1081/tma-120015618

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Citations (3)

Resorption kinetics of osseous substitute: natural coral and synthetic hydroxyapatite

Biomaterials (1996)

F. Braye J.L. Irigaray Édouard Jallot H. Oudadesse G. Weber

10.1016/s0142-9612(96)80013-5

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Citations (72)

Determination of metallic ion transfer from an implanted prosthesis by the PIXE method

Biological Trace Element Research (1999)

H. Oudadesse J.L. Irigaray Valérie Brun S. Terver G Vanneuville

Biomaterial

10.1007/bf02784248

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Природный фосфат K09 – новый многоразовый катализатор синтеза производных дигидропирано[2,3-C]пиразола при комнатной температуре

Кинетика и катализ (2019)

Khalid El Mejdoubi Brahim Sallek Khalid Digua Hassan Chaair H. Oudadesse

10.1134/s0453881119040117

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Study of matrix effects with the alpha parameter method to correct PIXE data for bioceramics embedded in resin

Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms (1998)

Édouard Jallot J.L. Irigaray H. Oudadesse Valérie Brun G. Weber

Matrix (chemical analysis)

Experimental data

10.1016/s0168-583x(98)00269-9

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Citations (5)

Study by PIXE method of trace elements transferred from prostheses to soft tissues and organs

Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms (2002)

H. Oudadesse Gérôme Guibert E. Chassot J.L. Irigaray S. Terver

TRACE (psycholinguistics)

10.1016/s0168-583x(01)01251-4

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Differentiation of biological hydroxyapatite compounds by infrared spectroscopy, x-ray diffraction and extended x-ray absorption fine structure

Journal of Applied Physics (2001)

E. Chassot H. Oudadesse J.L. Irigaray Emmanuel Curis S. Bénazeth

Pure hydroxyapatite (HAP) and HAP doped with 800 ppm of zinc were implanted in cortical bone of femur diaphysis of ovines [J. L. Irigaray et al., Mater. Clin. Appl. 28, 399 (1999)]. We observed that the doped HAP was better resorbed than pure HAP. The first hypothesis is that zinc acts as a stimulator on macrophage cells and improves quantity and quality of osteoblast cells. The second hypothesis is that zinc yields HAP structure that is better resorbed in biological field. For our experiment we used HAP doped with 3000 ppm of zinc in order to have a good sensitivity. In the present work, chemical studies by inductively coupled plasma absorption emission spectrometry, x ray diffraction, and infrared were carried out to determine the composition of major and trace elements in the doped hydroxyapatite, and the crystallographic structure. These studies can indicate possible modifications induced by the insertion of zinc. We used the extended x-ray absorption fine structure experimental station of LURE (Orsay, France) to try to clarify the atomic surroundings of zinc in doped HAP structure and transformations induced in initial lattice. Despite the low zinc concentration, we got good quality fluorescence mode spectra. These spectra showed medium range order of the material that is consistent with its crystalline form. To perform the analysis, we compared the result obtained with another models like β tricalcium phosphate and we created theoretical models of zinc in substitution of calcium in order to reproduce as well as possible the experimental spectrum. After this study, only two models are coherent with experimental spectrum, zinc in substitution of calcium in site I and zinc in the interstice between the two hydroxydes.

Lattice constant

10.1063/1.1408267

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Citations (11)